# BIOEFFECT EGF Power Serum for skin with dark spots

**Lovi Fit: High fit for skin with dark spots.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/uk/p/bioeffect/egf-power-serum/for/dark-spots

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

Brand: [BIOEFFECT](https://lovi.care/skincare/uk/brands/bioeffect)
Category: [Serums and treatments](https://lovi.care/skincare/uk/best/serums)

This fit is calculated for the concerns frequently associated with dark spots: hyperpigmentation, sun spots, and uneven skin tone. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best serums for skin with dark spots.

## Why this fit

- Offers excellent skin regeneration for your normal skin due to Rh-Oligopeptide-1 Barley Sh-Oligopeptide-1 and Kgf Barley Sh-Polypeptide-3, which smooth texture and stimulate collagen. Glycerin and Sodium Hyaluronate provide hydration, but these ingredients are not directly targeted for your main goal of pigmentation.
- The serum is highly suitable for normal skin due to its humectant properties and collagen-stimulating peptides.
- The safety profile is excellent, with no risks of irritation for your normal skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/uk/p/bioeffect/egf-power-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/uk/p/bioeffect/egf-power-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/uk/p/bioeffect/egf-power-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/uk/p/bioeffect/egf-power-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/uk/p/bioeffect/egf-power-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/uk/p/bioeffect/egf-power-serum/for/dark-spots): High (this page)
- [Mature skin](https://lovi.care/skincare/uk/p/bioeffect/egf-power-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/uk/p/bioeffect/egf-power-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/uk/p/bioeffect/egf-power-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Rh-Oligopeptide-1, Sodium Hyaluronate, Acetyl Glucosamine, Hordeum Vulgare Seed Extract, Glycerin

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Epidermal growth factor stimulates keratinocyte proliferation, migration, and differentiation markers resembling wounded epidermis, whereas keratinocyte growth factor maintains a healthy native epidermal architecture and turnover. ([Wound Repair and Regeneration, 2000](https://pubmed.ncbi.nlm.nih.gov/10886810/))
- Topical epidermal growth factor combined with silver sulfadiazine accelerated the rate of epidermal regeneration and significantly decreased healing time by approximately 1 to 1.5 days across all stages of healing in skin-graft-donor sites of 12 patients compared to silver sulfadiazine alone. ([The New England Journal of Medicine, 1989](https://pubmed.ncbi.nlm.nih.gov/2659995/))
- Topical recombinant human epidermal growth factor combined with ablative fractional carbon dioxide laser significantly improved striae surface texture and showed significantly greater participant satisfaction regarding marked improvement compared to ablative fractional carbon dioxide laser combined with Aloe vera gel in patients with striae alba. ([Lasers in Surgery and Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/30614013/))
- Topical EGF combined with fractional CO2 laser significantly improves the clinical appearance of atrophic acne scars and decreases skin pigmentation compared to fractional CO2 laser alone in patients with atrophic acne scars. ([The Journal of Clinical and Aesthetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35942017/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical 2% N-acetyl glucosamine reduced facial hyperpigmentation in an 8-week split-face clinical test, with an even greater effect observed when combined with 4% niacinamide. ([Journal of Cosmetic Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17348991/))
- N-acetyl-glucosamine-loaded nanostructured lipid carriers successfully delivered the hydrophilic agent through the skin and reduced melanin distribution in healthy volunteers. ([Advanced Pharmaceutical Bulletin, 2016](https://pubmed.ncbi.nlm.nih.gov/28101465/))
- Topical cosmetic products containing hyaluronic acid, N-acetyl glucosamine, and gamma-amino butyric acid improved skin hydration by 24.28% to 33.60%, elasticity by 11.98%, and skin lightening by 5.26% over 2 months in 20 female participants. ([Journal of Cosmetic and Laser Therapy, 2019](https://pubmed.ncbi.nlm.nih.gov/30040516/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))

## What reviewers say

This serum is highly effective for mature, dry, and aging skin, with users frequently reporting improvements in texture, firmness, and radiance. Based on limited data, the product is praised for visibly reducing fine lines and hyperpigmentation, leaving the complexion plumper and more even-toned. Some users note a tacky feel after application and that results require patience, while the high price point is a common concern.

- Liked: Improves skin texture (mostly mentioned)
- Disliked: High price point (mostly mentioned)
- Liked: Boosts skin radiance (often mentioned)
- Liked: Reduces fine lines (often mentioned)
- Liked: Deeply hydrating (sometimes noted)
- Liked: Gentle formula (sometimes noted)
- Disliked: Requires patience (sometimes noted)
- Disliked: Tacky skin feel (sometimes noted)
- Disliked: Limited care feeling (rarely noted)

## How to apply

- Apply this serum as part of your PM routine starting 3x/week and build up to daily use if your skin likes it.
- Place the serum after cleansing and toning, but before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute for it to absorb.
- Apply the serum on dry skin to help fade pigmentation effectively.
- Avoid the eye area and always use SPF 30+ during the day.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes BIOEFFECT Power Serum a great fit for skin with dark spots?

This serum is a great fit because it offers wonderful skin renewal to help smooth texture and stimulate collagen using growth factors, while glycerin and sodium hyaluronate keep skin feeling soft and hydrated. It has a very safe profile with no harsh ingredients, meaning it is unlikely to cause irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Wound Repair and Regeneration, 2000](https://pubmed.ncbi.nlm.nih.gov/10886810/)

### Which ingredients make this serum a good fit for skin with dark spots?

Rh-Oligopeptide-1 Barley Sh-Oligopeptide-1 and Kgf Barley Sh-Polypeptide-3 make this serum a great fit by smoothing texture and stimulating collagen, while Glycerin and Sodium Hyaluronate provide hydration to keep your skin soft and smooth. It is very unlikely to cause irritation due to the absence of harsh ingredients.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Wound Repair and Regeneration, 2000](https://pubmed.ncbi.nlm.nih.gov/10886810/)

### What does EGF do for skin with dark spots?

Epidermal growth factor may help fade dark spots on some skin types, but results vary depending on the treatment and individual skin response. While some studies show it can help reduce dark spots and prevent discoloration after procedures, other research finds no significant difference compared to standard care.
Sources: [Dermatologic Surgery, 2015](https://pubmed.ncbi.nlm.nih.gov/25551327/), [Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/33022197/)

### What does Hyaluronic Acid do for skin with dark spots?

Hyaluronic acid is unlikely to directly fade dark spots, but it helps keep dry and uneven skin plump and deeply hydrated. To effectively target dark spots, this type of skin needs brightening ingredients like vitamin C or niacinamide alongside your hydrator.

### Where does this serum go in a skincare routine for skin with dark spots?

This treatment serum goes in the evening routine after cleansing and before moisturizing, which keeps things simple and safe around sun exposure. It brings great texture-smoothing peptides and hydration to your routine, though it is not directly targeted for dark spots.

### Can I use this serum with retinol, and in what order?

You can use this treatment in your evening routine after cleansing and before your moisturizer. It is unlikely to cause irritation for normal skin due to the absence of harsh ingredients.

### How often should I use this serum?

Apply this treatment in the evening, as Lovi routines suggest placing serums with actives at night for simplicity and extra safety around sun exposure. The gentle formula has a very safe profile, making it unlikely to cause irritation on normal skin.

### Can this serum clog pores, cause breakouts or purging for skin with dark spots?

This serum is unlikely to cause breakouts or clog pores for skin with dark spots because it has a very safe formula with no harsh or heavy ingredients that typically block pores. Its gentle mix helps keep skin feeling smooth and calm without irritation.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for skin with dark spots

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/uk/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/dark-spots) — High fit — £36.96 at Amazon
- [Guerlain Abeille Royale Double R Renew & Repair Serum](https://lovi.care/skincare/uk/p/guerlain/abeille-royale-double-r-renew-and-repair-advanced-serum/for/dark-spots) — High fit — £107.78 at Amazon
- [La Mer The Regenerating Serum](https://lovi.care/skincare/uk/p/la-mer/the-regenerating-serum/for/dark-spots) — High fit — £372.06 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/uk/p/cerave/foaming-facial-cleanser/for/dark-spots) — Superior fit — £8.29 at Amazon
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/uk/p/pyunkang-yul/calming-deep-moisture-toner/for/dark-spots) — Superior fit — £11.65 at Amazon
- Moisturizer: [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/uk/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/dark-spots) — Superior fit — £11.90 at Amazon

## Where to buy

No store in United Kingdom has a checked price for this product, so the page shows none.

## Ingredients

Glycerin, Water, Sodium Citrate, Acetyl Glucosamine Nag, Isopentyldiol, Phenoxyethanol, Sodium Chloride, Sodium Hyaluronate, Citric Acid, Hordeum Vulgare Seed Extract, Rh-Oligopeptide-1 Barley Sh-Oligopeptide-1, Kgf Barley Sh-Polypeptide-3
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/bioeffect/egf-power-serum/for/dark-spots
- United Kingdom: https://lovi.care/skincare/uk/p/bioeffect/egf-power-serum/for/dark-spots (this page)
- Ireland: https://lovi.care/skincare/ie/p/bioeffect/egf-power-serum/for/dark-spots
- Germany: https://lovi.care/skincare/de/p/bioeffect/egf-power-serum/for/dark-spots
- France: https://lovi.care/skincare/fr/p/bioeffect/egf-power-serum/for/dark-spots
- Italy: https://lovi.care/skincare/it/p/bioeffect/egf-power-serum/for/dark-spots
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- Canada: https://lovi.care/skincare/ca/p/bioeffect/egf-power-serum/for/dark-spots
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