# Bioderma Sensibio Defensive for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/uk/p/bioderma/sensibio-defensive/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

Brand: [Bioderma](https://lovi.care/skincare/uk/brands/bioderma)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/uk/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other moisturizers fit it better.

## Why this fit

- Offers moderate moisturizing for your normal skin, with glycerin and xylitol providing adequate hydration and enhancing barrier resilience.
- While Laminaria Ochroleuca Extract offers general skincare benefits, it is not directly targeted towards addressing your wrinkles and fine lines.
- The product is safe for your normal skin, as it lacks harsh ingredients and includes soothing components like tocopherol and glycyrrhetinic acid.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/uk/p/bioderma/sensibio-defensive/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/uk/p/bioderma/sensibio-defensive/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/uk/p/bioderma/sensibio-defensive/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/uk/p/bioderma/sensibio-defensive/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/uk/p/bioderma/sensibio-defensive/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/uk/p/bioderma/sensibio-defensive/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/uk/p/bioderma/sensibio-defensive/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/uk/p/bioderma/sensibio-defensive/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/uk/p/bioderma/sensibio-defensive/for/oily-acne-prone-skin): Average

## Key ingredients

Glycerin, Glycyrrhetinic Acid, Laminaria Ochroleuca Extract, Tocopherol, Fructooligosaccharides

## What the research says

- A formulation containing glycerol (5%) and xylitol (5%) applied twice daily for 14 days increased skin hydration, filaggrin protein quantity, interdigitation index, and biomechanical properties, and decreased transepidermal water loss compared to untreated and vehicle-treated skin in twelve volunteers with dry skin. ([Acta Dermato-venereologica, 2017](https://pubmed.ncbi.nlm.nih.gov/27349297/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Topical application of a cream containing 2.5% glycyrrhetinic acid significantly reduced thigh fat thickness and circumference compared to placebo in healthy women. ([Steroids, 2005](https://pubmed.ncbi.nlm.nih.gov/15894038/))
- A dermo-cosmetic formula containing 2% enoxolone significantly reduced erythema at 24 hours and pain at 30 minutes following non-ablative fractional laser treatment in 10 healthy subjects compared to a moisturizer control. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38622995/))
- Topical application of B-Resorcinol and Glycyrrhetinic acid effectively lightens hand solar lentigines after 4 weeks of treatment both with and without prior fractional laser photothermolysis, showing no statistical difference between the two approaches. ([Journal of Cosmetic Dermatology, 2016](https://pubmed.ncbi.nlm.nih.gov/27325103/))
- Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40642809/))
- Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate. ([Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/))
- Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590207/))

## Why other moisturizers fit mature skin better

- Topical application of Lactobacillus plantarum-GMNL6 enhanced collagen synthesis and SPTSSA gene expression while reducing melanin synthesis, Staphylococcus aureus biofilm, and Cutibacterium acnes proliferation, leading to clinical improvements in skin moisture, color, spots, wrinkles, UV spots, and porphyrins in human volunteers. ([International Journal of Medical Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/33526970/))
- Nanoemulsions containing Macadamia integrifolia seed oil successfully enhanced skin hydration and reduced wrinkles in human volunteers, outperforming conventional emulsions in skin hydration enhancement. ([Nanomaterials, 2024](https://pubmed.ncbi.nlm.nih.gov/38668218/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Bioderma Sensibio Defensive work for mature skin?

Bioderma Sensibio Defensive works adequately for mature skin, providing moderate hydration and a safe, soothing feel without focusing on wrinkles and fine lines. A product of this type needs potent anti-aging ingredients like peptides and antioxidants, along with rich moisture-balancing components, to truly fit mature skin.
Sources: [Acta Dermato-venereologica, 2017](https://pubmed.ncbi.nlm.nih.gov/27349297/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this cream a good fit for mature skin?

Glycerin and xylitol make this cream a good fit for mature skin by providing moderate moisture and helping keep the skin calm and hydrated. A product of this type needs potent ingredients for wrinkles and fine lines, along with peptides and antioxidants to properly nourish mature skin.
Sources: [Acta Dermato-venereologica, 2017](https://pubmed.ncbi.nlm.nih.gov/27349297/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Glycerin do for mature skin?

Glycerin helps keep mature skin feeling soft and smooth by drawing moisture into the outer layer and locking it in. This daily hydration boost supports the skin barrier, keeping dry areas comfortable and protected against irritation.
Sources: [The British Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18510666/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Glycyrrhetinic Acid do for mature skin?

Glycyrrhetinic acid helps calm redness and soothe irritation in mature skin, making it feel more comfortable. It is often paired with gentle hydrators and soothing ingredients to support a healthy skin barrier.

### Where does this cream go in a skincare routine for mature skin?

Apply this moisturizing treatment as the last step of your evening routine after your treatment serum. This helps lock in hydration while keeping your skin calm, though mature skin also needs ingredients that specifically target wrinkles and fine lines.

### Can I use this cream with retinol, and in what order?

You can use this cream with retinol by applying the retinol first, letting it absorb, and then following with the cream to keep your skin calm and hydrated. Using a barrier-enhancing moisturizer alongside retinoids helps reduce dryness and irritation while supporting your treatment.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this cream?

You can use this moisturizing treatment daily to keep your skin hydrated and calm. For mature skin, a product of this type needs targeted ingredients like peptides or retinoids to help smooth out fine lines and wrinkles.
Sources: [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/), [Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/14571069/)

### Can this cream clog pores, cause breakouts or purging for mature skin?

This cream is unlikely to clog pores or cause breakouts on mature skin, as it is free of harsh ingredients and safe for normal skin. To better care for mature skin, a product of this type needs targeted ingredients that actively smooth wrinkles and fine lines.

### Can I use this cream around the eyes or on my body?

You can safely use this cream around your eyes and on your body, as it contains soothing components like tocopherol and glycyrrhetinic acid without harsh ingredients. However, mature skin needs targeted anti-aging ingredients and rich moisturizers to effectively smooth fine lines and address thinner areas.

### Is this cream fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (parfum). Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for mature skin

- [SKIN1004 Madagascar Centella Probio-Cica Enrich Cream](https://lovi.care/skincare/uk/p/skin1004/madagascar-centella-probio-cica-enrich-cream/for/mature-skin) — Superior fit — £14.74 at Amazon
- [L'Occitane Immortelle Divine Cream](https://lovi.care/skincare/uk/p/l-occitane/immortelle-divine-cream/for/mature-skin) — Superior fit — £61.50 at Amazon
- [Kate Somerville K8 Peptide Intensive Cream](https://lovi.care/skincare/uk/p/kate-somerville/peptide-k8-power-cream/for/mature-skin) — Superior fit — £102.47 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/uk/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — £14.99 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/uk/p/some-by-mi/snail-truecica-miracle-repair-toner/for/mature-skin) — Superior fit — £13.98 at Amazon
- SPF: [Torriden DIVE-IN Mild Sunscreen](https://lovi.care/skincare/uk/p/torriden/dive-in-mild-sunscreen/for/mature-skin) — Superior fit — £22.00 at Amazon

## Where to buy

No store in United Kingdom has a checked price for this product, so the page shows none.

## Ingredients

Water, Glycerin, Cetearyl Isononanoate, Cetearyl Alcohol, Glyceryl Stearate, Peg-100 Stearate, Mannitol, Xylitol, Rhamnose, Fructooligosaccharides, Laminaria Ochroleuca Extract, Tocopherol, Glycyrrhetinic Acid, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Sodium Hydroxide, Caprylic Capric Triglyceride, 1,2-Hexanediol, Caprylyl Glycol, Pentylene Glycol, Xanthan Gum, Disodium Edta, Parfum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/bioderma/sensibio-defensive/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/bioderma/sensibio-defensive/for/mature-skin (this page)
- Ireland: https://lovi.care/skincare/ie/p/bioderma/sensibio-defensive/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/bioderma/sensibio-defensive/for/mature-skin
- France: https://lovi.care/skincare/fr/p/bioderma/sensibio-defensive/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/bioderma/sensibio-defensive/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/bioderma/sensibio-defensive/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/bioderma/sensibio-defensive/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/bioderma/sensibio-defensive/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/bioderma/sensibio-defensive/for/mature-skin
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- United Arab Emirates: https://lovi.care/skincare/ae/p/bioderma/sensibio-defensive/for/mature-skin