# Avène Cleanance Comedomed Anti-Blemish Concentrate for acne-prone skin

**Lovi Fit: Average fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/uk/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

Brand: [Avène](https://lovi.care/skincare/uk/brands/avene)
Category: [Serums and treatments](https://lovi.care/skincare/uk/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for acne-prone skin; other serums fit it better.

## Why this fit

- Offers moderate benefits for your combination skin, as isopropyl alcohol and silybum marianum fruit extract help regulate oil and mildly exfoliate to reduce acne lesions.
- The formulation is safe for your acne-prone skin, with no harsh ingredients that could cause irritation.
- This product provides targeted benefits for your acne, blemishes, and breakouts.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/uk/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/uk/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dry-skin): Caution
- [Combination skin](https://lovi.care/skincare/uk/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/combination-skin): Low
- [Sensitive skin](https://lovi.care/skincare/uk/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/sensitive-skin): Low
- [Acne-prone skin](https://lovi.care/skincare/uk/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/acne-prone-skin): Average (this page)
- [Skin with dark spots](https://lovi.care/skincare/uk/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dark-spots): Low
- [Mature skin](https://lovi.care/skincare/uk/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/uk/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/uk/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/oily-acne-prone-skin): Average

## Key ingredients

Avène Thermal Spring Water, Silybum Marianum Fruit Extract, Glycerin, Isopropyl Alcohol, Silica

## What the research says

- Malaysian thermal spring water as an adjunct to standard acne therapy improved skin hydration, reduced dryness and stinging, enhanced overall tolerability, and improved the acne disability index in patients with mild to moderate acne. ([The Medical Journal of Malaysia, 2024](https://pubmed.ncbi.nlm.nih.gov/38553920/))
- Etoricoxib-loaded mesoporous silica nanoparticles laden gel demonstrated significantly higher sustained release, enhanced anti-inflammatory effect with reduced IL-1beta and TNF-alpha levels, and no skin toxicity compared to pure etoricoxib gel. ([Drug Development and Industrial Pharmacy, 2025](https://pubmed.ncbi.nlm.nih.gov/40192336/))
- Balneotherapy with thermal water altered specific skin microbiota at genus and species levels in healthy female volunteers compared to tap water, which produced no significant microbiome changes. ([Life, 2023](https://pubmed.ncbi.nlm.nih.gov/36983902/))
- A 2% Sphingomonas xenophaga ferment extract cream applied twice daily for 4 weeks significantly decreased facial vascular disorder scores compared to vehicle in 86 Caucasian female subjects, alongside dose-dependent inhibition of pre-kallikrein activity in vitro. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/40545753/))
- A formulation containing vitamin C, biopeptides, hyaluronic acid, and mineralizing water accelerated cell turnover to 17.1 days versus 19.2 days for untreated skin, and reduced crow's-feet, forehead, and nasolabial folds by 9%, 11%, and 5% respectively after 28 days in female subjects. ([International Journal of Cosmetic Science, 2021](https://pubmed.ncbi.nlm.nih.gov/33038010/))
- Silybum marianum flower extract increased human hair follicle dermal papilla cell proliferation and VEGF production while suppressing cellular senescence, and in a clinical study using hair shampoo, it significantly increased hair density and total hair count at 16 and 24 weeks compared with a placebo group. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37675655/))
- Topical 0.5% silymarin-loaded antioxidant serum applied twice daily significantly reduced clinical acne severity, lesion counts, and melanin pigmentation in 22 Korean acne patients over 4 weeks without associated adverse events. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36204969/))
- Topical silymarin cream 1.4% showed comparable results to salicylic acid 30% peels in reducing acne severity in 30 patients with mild to moderate acne vulgaris. ([Journal of Cutaneous Medicine and Surgery, 2024](https://pubmed.ncbi.nlm.nih.gov/37942562/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- The use of 70% isopropyl alcohol in conjunction with scrubbing with a bristled brush significantly reduced positive bacterial cultures at the nail fold compared to povidone-iodine with soft sponges in volunteers. ([The Journal of Bone and Joint Surgery. American Volume, 2005](https://pubmed.ncbi.nlm.nih.gov/15866960/))
- Friction with 70% ethyl or isopropyl alcohol immediately eliminates the heart-shaped pigmented lesion characteristic of terra firma-forme dermatosis in a 14-year-old boy. ([Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/38826967/))
- Rubbing 70% isopropyl alcohol wipes cleared persistent reticulated brown patches in five patients with terra firma-forme dermatosis. ([Skinmed, 2016](https://pubmed.ncbi.nlm.nih.gov/27871345/))
- A functional cosmetic cream containing bioactive materials from Streptomyces sp. T65 embedded in SBA-15 decreased skin roughness by 4.670% and increased skin brightness by 0.472% after 4 weeks of application, while demonstrating antimicrobial, antioxidant, anti-aging, and whitening activities. ([Antioxidants, 2020](https://pubmed.ncbi.nlm.nih.gov/32224894/))
- Film-forming formulations containing porous silica achieved skin permeation rates comparable to immediate release formulations while confirming prolonged drug availability and causing no skin irritation in healthy volunteers. ([European Journal of Pharmaceutical Sciences, 2017](https://pubmed.ncbi.nlm.nih.gov/28546105/))
- Topical treatment with silica mud and microalgae extracts from the Blue Lagoon improved skin barrier function by inducing epidermal gene expression and reducing transepidermal water loss in healthy humans, while preventing skin aging markers in vitro. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18312388/))

## What reviewers say

Based on a very large amount of data, this concentrate is highly effective for oily and acne-prone skin, significantly reducing active breakouts and preventing future blemishes. Users frequently praise its lightweight, fast-absorbing, and mattifying texture. A strong alcohol scent is commonly noted, and some users experience initial dryness or purging.

- Liked: Lightweight & fast-absorbing (mostly mentioned)
- Liked: Reduces blemishes (mostly mentioned)
- Disliked: Strong alcohol scent (mostly mentioned)
- Liked: Controls oil (often mentioned)
- Liked: Prevents breakouts (sometimes noted)
- Disliked: Drying or peeling (sometimes noted)
- Disliked: Initial skin purging (rarely noted)
- Disliked: Stinging sensation (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Avène Cleanance Comedomed work for acne-prone skin?

This product works moderately well for your acne-prone skin by helping regulate oil and reduce breakouts. To fit this skin even better, an acne treatment needs soothing and balancing ingredients like niacinamide, zinc PCA, or propolis for optimal hydration and oil control.
Sources: [The Medical Journal of Malaysia, 2024](https://pubmed.ncbi.nlm.nih.gov/38553920/)

### Which ingredients make this treatment a good fit for acne-prone skin?

This treatment is a moderate fit for your acne-prone skin because isopropyl alcohol and silybum marianum fruit extract help regulate oil and mildly exfoliate to reduce acne lesions, while avène thermal spring water helps calm the skin and improve tolerability. A product of this type needs effective ingredients like niacinamide, zinc pca, and propolis to balance combination skin, provide optimal hydration, and target breakouts without causing excess oiliness or dryness.
Sources: [The Medical Journal of Malaysia, 2024](https://pubmed.ncbi.nlm.nih.gov/38553920/)

### What does Avène Thermal Spring Water do for acne-prone skin?

Avène Thermal Spring Water helps calm acne-prone skin by reducing dryness, stinging, pain, and itching when used alongside your regular acne treatments. It improves overall skin comfort and tolerability while keeping your face feeling soft and smooth.
Sources: [The Medical Journal of Malaysia, 2024](https://pubmed.ncbi.nlm.nih.gov/38553920/)

### What does Milk Thistle Fruit Extract do for acne-prone skin?

Milk Thistle Fruit Extract helps calm acne-prone skin and reduces breakouts while soothing redness. Studies show it helps lessen acne severity and dark spots similarly to other common treatments, with very good skin tolerability.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36204969/), [Journal of Cutaneous Medicine and Surgery, 2024](https://pubmed.ncbi.nlm.nih.gov/37942562/)

### Where does it go in a skincare routine for acne-prone skin?

Apply this treatment in the evening, as Lovi routines place treatments then for simplicity and extra safety around sun exposure. This product helps regulate oil and mildly exfoliate to reduce acne lesions, though acne-prone skin needs products that combine targeted blemish-clearing ingredients with gentle, non-irritating hydration.

### Can I use this treatment with retinol, and in what order?

You can use this treatment with retinol by applying it after your cleanser and before your moisturizer, but because it may cause irritation, you should introduce them slowly. An acne-prone skin routine needs soothing ingredients like thermal spring water alongside oil-regulating and exfoliating agents to keep skin calm and clear while managing breakouts.
Sources: [The Medical Journal of Malaysia, 2024](https://pubmed.ncbi.nlm.nih.gov/38553920/)

### How often should I use it?

This treatment is used in the evening routine. A product of this type for acne-prone skin needs ingredients that help regulate oil, mildly exfoliate, and soothe breakouts.

### Can this treatment clog pores, cause breakouts or purging for acne-prone skin?

This treatment is unlikely to clog pores, and initial purging is only a low possibility for acne-prone skin. While it helps reduce blemishes, some users may experience moderate dryness or peeling from the formula.

### Is it fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (isopropyl alcohol).

## Alternatives for acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/uk/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/acne-prone-skin) — Superior fit — £36.96 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/uk/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/acne-prone-skin) — Superior fit — £24.20 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/uk/p/skinceuticals/c-e-ferulic/for/acne-prone-skin) — Superior fit — £143.35 at Amazon

## Pairs well with

- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/uk/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — £8.13 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/uk/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — £13.98 at Amazon
- Moisturizer: [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/uk/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — £11.90 at Amazon

## Where to buy

- Amazon.co.uk: £22.95 (https://www.amazon.co.uk/dp/B0FGK543DF?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- Notino: £21.50 (https://www.notino.co.uk/avene/cleanance-comedomed-intensive-cream-against-imperfections-in-acne-prone-skin/p-16274731/)
Prices checked 10 Oct – 6 Nov 2026.

## Ingredients

Avène Thermal Spring Water Avène Aqua, Isopropyl Alcohol, Peg-6, Glycerin, Silybum Marianum Fruit Extract, Silica, Polyacrylate-13, Polyisobutene, Polysorbate 20, Sorbitan Isostearate, Water
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/acne-prone-skin (this page)
- Ireland: https://lovi.care/skincare/ie/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/acne-prone-skin