# APLB Collagen EGF Peptide Ampoule Serum for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: Superior · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/uk/p/aplb/collagen-egf-peptide-ampoule-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

Brand: [APLB](https://lovi.care/skincare/uk/brands/aplb)
Category: [Serums and treatments](https://lovi.care/skincare/uk/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for mature skin; a few serums fit it even better.

## Why this fit

- Offers excellent treatment for your wrinkles and fine lines, as hydrolyzed collagen and Rh-Oligopeptide-1 promote collagen synthesis and skin elasticity, which is highly suitable for your normal skin.
- Glycerin and sodium hyaluronate provide effective humectant action, supporting skin hydration and barrier repair for your normal skin.
- The formula is safe for your normal skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/uk/p/aplb/collagen-egf-peptide-ampoule-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/uk/p/aplb/collagen-egf-peptide-ampoule-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/uk/p/aplb/collagen-egf-peptide-ampoule-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/uk/p/aplb/collagen-egf-peptide-ampoule-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/uk/p/aplb/collagen-egf-peptide-ampoule-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/uk/p/aplb/collagen-egf-peptide-ampoule-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/uk/p/aplb/collagen-egf-peptide-ampoule-serum/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/uk/p/aplb/collagen-egf-peptide-ampoule-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/uk/p/aplb/collagen-egf-peptide-ampoule-serum/for/oily-acne-prone-skin): High

## Key ingredients

Collagen, Rh-Oligopeptide-1, Peptides

## What the research says

- Both oral and topical collagen supplements help delay the skin aging process by improving moisture, elasticity, and hydration, with no differences arising between the two types of collagen. ([Dermatology Practical & Conceptual, 2022](https://pubmed.ncbi.nlm.nih.gov/35223163/))
- The use of cosmetic products containing collagen or its peptides improves the general condition of the skin, reduces wrinkle depth, improves hydration and density, reduces transepithelial water loss, and delays the aging process, while oral bioactive collagen peptides also reduce nail breakage. ([Current Issues in Molecular Biology, 2024](https://pubmed.ncbi.nlm.nih.gov/38534748/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Topical epidermal growth factor combined with silver sulfadiazine accelerated the rate of epidermal regeneration and significantly decreased healing time by approximately 1 to 1.5 days across all stages of healing in skin-graft-donor sites of 12 patients compared to silver sulfadiazine alone. ([The New England Journal of Medicine, 1989](https://pubmed.ncbi.nlm.nih.gov/2659995/))
- Topical recombinant human epidermal growth factor combined with ablative fractional carbon dioxide laser significantly improved striae surface texture and showed significantly greater participant satisfaction regarding marked improvement compared to ablative fractional carbon dioxide laser combined with Aloe vera gel in patients with striae alba. ([Lasers in Surgery and Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/30614013/))
- Topical EGF combined with fractional CO2 laser significantly improves the clinical appearance of atrophic acne scars and decreases skin pigmentation compared to fractional CO2 laser alone in patients with atrophic acne scars. ([The Journal of Clinical and Aesthetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35942017/))

## What reviewers say

Based on limited data, users with dry, sensitive, and aging skin frequently report noticeable improvements in hydration and skin plumpness, often describing a "bouncy" or firming effect. The fragrance-free formula is widely praised for being gentle and absorbing well, though a minority of users find the texture slightly tacky or report that anti-aging results are subtle.

- Liked: Fast absorption (often mentioned)
- Liked: Hydration & Plumping (often mentioned)
- Liked: Excellent value (sometimes noted)
- Liked: Fragrance-free (sometimes noted)
- Liked: Soothing & Gentle (sometimes noted)
- Disliked: Average results (rarely noted)
- Disliked: Tacky finish (rarely noted)
- Disliked: Thick consistency (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes APLB Collagen EGF Peptide Ampoule Serum a great fit for mature skin?

This serum is a great fit because hydrolyzed collagen and Rh-Oligopeptide-1 help smooth out wrinkles and fine lines by supporting skin elasticity. Glycerin and sodium hyaluronate keep your skin hydrated and help repair the skin barrier, while the gentle formula is very unlikely to cause irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Dermatology Practical & Conceptual, 2022](https://pubmed.ncbi.nlm.nih.gov/35223163/)

### Which ingredients make this serum a good fit for mature skin?

Hydrolyzed collagen, Rh-oligopeptide-1, and palmitoyl pentapeptide-4 make this serum a great fit for mature skin by supporting skin elasticity and helping smooth out wrinkles and fine lines. Additionally, glycerin and sodium hyaluronate provide deep hydration to keep your skin plump and soft.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Dermatology Practical & Conceptual, 2022](https://pubmed.ncbi.nlm.nih.gov/35223163/)

### What does Collagen do for mature skin?

Collagen helps smooth mature skin by reducing wrinkles, improving hydration, and keeping the skin firm and plump. It is a weak fit for your skin, so a product of this type needs added hyaluronic acid, antioxidants, and peptides to properly nourish and support aging skin.
Sources: [Dermatology Practical & Conceptual, 2022](https://pubmed.ncbi.nlm.nih.gov/35223163/), [Current Issues in Molecular Biology, 2024](https://pubmed.ncbi.nlm.nih.gov/38534748/)

### What does EGF do for mature skin?

For mature skin, epidermal growth factor helps smooth fine lines, improve firmness, and support a more youthful look by encouraging skin renewal. It works best when paired with ingredients that deeply hydrate and protect against moisture loss to keep the skin feeling soft and smooth.
Sources: [Journal of Cosmetic Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/24305427/), [International Journal of Molecular Medicine, 2017](https://pubmed.ncbi.nlm.nih.gov/28204807/)

### Where does it go in a skincare routine for mature skin?

This treatment goes in your evening routine, applied after cleansing and before your moisturizer. Putting it at night keeps things simple and avoids extra safety concerns around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the retinol first, letting it absorb, and then following with this serum to help keep your skin hydrated. The gentle, safe formula is unlikely to cause irritation when layered this way.

### How often should I use it?

This treatment is used in the evening as part of your routine, applied after cleansing and before moisturizing. This timing keeps things simple and helps protect your skin around sun exposure, while ingredients like peptides and collagen help smooth out fine lines.

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores, cause breakouts, or lead to purging on mature skin. The formula is safe for your skin, with no risks of irritation due to the absence of harsh ingredients.

### Is it fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/uk/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — £143.35 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/uk/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — £25.95 at Amazon
- [La Mer The Regenerating Serum](https://lovi.care/skincare/uk/p/la-mer/the-regenerating-serum/for/mature-skin) — High fit — £372.06 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/uk/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — £14.99 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/uk/p/some-by-mi/snail-truecica-miracle-repair-toner/for/mature-skin) — Superior fit — £13.98 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/uk/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — £38.50 at Amazon

## Where to buy

- Amazon.co.uk: £8.99 (https://www.amazon.co.uk/dp/B0CN2YPQMZ?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
Prices checked 3 Nov 2026.

## Ingredients

Water, Glycerin, Butylene Glycol, Niacinamide, Hydrolyzed Collagen, Rh-Oligopeptide-1, Palmitoyl Pentapeptide-4, Sodium Hyaluronate, Beta-Glucan, Adenosine, Allantoin, Panthenol, Tocopheryl Acetate, Caprylyl Glycol, Ethylhexylglycerin, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/aplb/collagen-egf-peptide-ampoule-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/aplb/collagen-egf-peptide-ampoule-serum/for/mature-skin (this page)
- Ireland: https://lovi.care/skincare/ie/p/aplb/collagen-egf-peptide-ampoule-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/aplb/collagen-egf-peptide-ampoule-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/aplb/collagen-egf-peptide-ampoule-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/aplb/collagen-egf-peptide-ampoule-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/aplb/collagen-egf-peptide-ampoule-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/aplb/collagen-egf-peptide-ampoule-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/aplb/collagen-egf-peptide-ampoule-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/aplb/collagen-egf-peptide-ampoule-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/aplb/collagen-egf-peptide-ampoule-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/aplb/collagen-egf-peptide-ampoule-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/aplb/collagen-egf-peptide-ampoule-serum/for/mature-skin