# Vitamin E and palmitoyl pentapeptide-4 Page: https://lovi.care/skincare/uk/ingredients/vitamin-e-and-palmitoyl-pentapeptide-4 The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom. Work well together Use them together in the same routine by applying the antioxidant [vitamin E](https://lovi.care/skincare/uk/ingredients/vitamin-e) first, followed by the peptide. Vitamin E protects the peptide from breaking down, which helps keep your skin looking firm and youthful. You do not need to change anything since this combination is gentle and works great together. - [All about vitamin E](https://lovi.care/skincare/uk/ingredients/vitamin-e) - [All about palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/palmitoyl-pentapeptide-4) ### [Vitamin E](https://lovi.care/skincare/uk/ingredients/vitamin-e) products - [Rhode Glazing Milk](https://lovi.care/skincare/uk/p/rhode/glazing-milk/for/dry-skin) — Superior fit - [Olay Regenerist Micro-Sculpting Cream](https://lovi.care/skincare/uk/p/olay/regenerist-micro-sculpting-cream/for/mature-skin) — Superior fit — [£24.99 at Amazon](https://www.amazon.co.uk/dp/B0012J30LY?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1) - [The Ordinary Azelaic Acid Suspension 10%](https://lovi.care/skincare/uk/p/the-ordinary/azelaic-acid-suspension-10/for/acne-prone-skin) — High fit — [£8.88 at Amazon](https://www.amazon.co.uk/dp/B0BBLZ2YBP?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1) - [Olay Super Serum](https://lovi.care/skincare/uk/p/olay/super-serum/for/dry-skin) — High fit — [£24.05 at Amazon](https://www.amazon.co.uk/dp/B0DTV267RW?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1) - [Palmer's Cocoa Butter](https://lovi.care/skincare/uk/p/palmer-s/cocoa-butter/for/dry-skin) — Average fit - [Caudalie Vinoperfect Radiance Serum](https://lovi.care/skincare/uk/p/caudalie/vinoperfect-radiance-serum/for/dry-skin) — Average fit — [£52.00 at Amazon](https://www.amazon.co.uk/dp/B0GVTK7Y56?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1) - [Aquaphor Lip Repair](https://lovi.care/skincare/uk/p/aquaphor/lip-repair/for/dry-skin) — Superior fit - [Clinique Take The Day Off Cleansing Balm](https://lovi.care/skincare/uk/p/clinique/take-the-day-off-cleansing-balm/for/dry-skin) — Average fit — [£24.00 at Amazon](https://www.amazon.co.uk/dp/B07D5C86RX?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1) - [EltaMD UV Clear Broad-Spectrum SPF 46](https://lovi.care/skincare/uk/p/eltamd/uv-clear-broad-spectrum-spf-46/for/oily-acne-prone-skin) — Superior fit - [Cetaphil Moisturizing Lotion](https://lovi.care/skincare/uk/p/cetaphil/moisturizing-lotion/for/sensitive-skin) — Average fit — [£13.00 at Amazon](https://www.amazon.co.uk/dp/B09VH78W52?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1) - [Bio-Oil Skincare Oil](https://lovi.care/skincare/uk/p/bio-oil/skincare-oil/for/dry-skin) — Average fit — [£17.25 at Amazon](https://www.amazon.co.uk/dp/B00129XP8M?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1) - [NIVEA MEN Sensitive Post Shave Balm](https://lovi.care/skincare/uk/p/nivea-men/sensitive-post-shave-balm/for/sensitive-skin) — Superior fit ### [Palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/palmitoyl-pentapeptide-4) products - [Olay Eye Lifting Serum](https://lovi.care/skincare/uk/p/olay/eye-lifting-serum/for/dry-skin) — High fit — [£19.15 at Amazon](https://www.amazon.co.uk/dp/B0FYJ6XPFP?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1) ## Questions and answers ### Can you use vitamin E and palmitoyl pentapeptide-4 together? Yes, [vitamin E](https://lovi.care/skincare/uk/ingredients/vitamin-e) and [palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/palmitoyl-pentapeptide-4) work well together because antioxidants stabilize peptides and enhance anti-aging performance. Lovi rates this combination as High. ### Which goes first, vitamin E or palmitoyl pentapeptide-4? Vitamin E and palmitoyl pentapeptide-4 work well together because the antioxidant helps stabilize the peptide and enhances anti-aging performance. ### Are vitamin E and palmitoyl pentapeptide-4 good for sensitive skin? Yes, vitamin E and palmitoyl pentapeptide-4 work well together to provide synergistic protection against oxidative degradation, making them beneficial for stressed and mature skin. ## Research on vitamin E and palmitoyl pentapeptide-4 - [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Vitamin E · Journal of Cosmetic Dermatology, 2020 - [Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin](https://pubmed.ncbi.nlm.nih.gov/18492182/) Palmitoyl pentapeptide-4 · International Journal of Cosmetic Science, 2005 - [Topical alpha-tocotrienol supplementation inhibits lipid peroxidation but fails to mitigate increased transepidermal water loss after benzoyl peroxide treatment of human skin](https://pubmed.ncbi.nlm.nih.gov/12521598/) Vitamin E · Free Radical Biology & Medicine, 2003 - [Fatty acids based α-Tocopherol loaded nanostructured lipid carrier gel: In vitro and in vivo evaluation for moisturizing and anti-aging effects](https://pubmed.ncbi.nlm.nih.gov/32129554/) Vitamin E · Journal of Cosmetic Dermatology, 2020 - [Tocotrienol-rich fraction attenuates UV-induced inflammaging: A bench to bedside study](https://pubmed.ncbi.nlm.nih.gov/28952200/) Vitamin E · Journal of Cosmetic Dermatology, 2018 - [Clinical evaluation of photoprotective effect by a topical antioxidants combination (tocopherols and tocotrienols)](https://pubmed.ncbi.nlm.nih.gov/21917024/) Vitamin E · Journal of the European Academy of Dermatology and Venereology, 2012 - [Efficacy of a topical serum containing L-ascorbic acid, neohesperidin, pycnogenol, tocopherol, and hyaluronic acid in relation to skin aging signs](https://pubmed.ncbi.nlm.nih.gov/35150043/) Vitamin E · Journal of Cosmetic Dermatology, 2022 - [Development of stable tocopherol succinate-loaded ethosomes to enhance transdermal permeation: In vitro and in vivo characterizations](https://pubmed.ncbi.nlm.nih.gov/35274433/) Vitamin E · Journal of Cosmetic Dermatology, 2022 - [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Vitamin E · Arzneimittel-Forschung, 1998 - [Tocopherol succinate-loaded ethosomal gel synthesized by cold method technique: Deeper biophysical characterizations for translational application on human skin](https://pubmed.ncbi.nlm.nih.gov/38268219/) Vitamin E · Journal of Cosmetic Dermatology, 2024 - [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Vitamin E · Scientific Reports, 2025 - [Sustained effect of two antioxidants (oxothiazolidine and δ-tocopheryl glucoside) for immediate and long-term sun protection in a sunscreen emulsion based on their different penetrating properties](https://pubmed.ncbi.nlm.nih.gov/33848378/) Vitamin E · International Journal of Cosmetic Science, 2021 - [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Vitamin E · Contemporary Clinical Trials Communications, 2021 - [Use of a Serum With the Infinite Glow® Device Improves Signs of Facial Aging: A Split-Face Case Report Using VISIA Analysis](https://pubmed.ncbi.nlm.nih.gov/42500768/) Palmitoyl pentapeptide-4 · Cureus, 2026 ## Other combinations - Keep them apart: [Adapalene and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/adapalene-and-palmitoyl-pentapeptide-4) - Keep them apart: [Granactive retinoid and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/granactive-retinoid-and-palmitoyl-pentapeptide-4) - Keep them apart: [Hydroxypinacolone retinoate and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/hydroxypinacolone-retinoate-and-palmitoyl-pentapeptide-4) - Keep them apart: [Pro-retinol and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/pro-retinol-and-palmitoyl-pentapeptide-4) - Keep them apart: [Retinal and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/retinal-and-palmitoyl-pentapeptide-4) - Keep them apart: [Retinoid blend and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/retinoid-blend-and-palmitoyl-pentapeptide-4) - Depends on the strength: [Retinol and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/retinol-and-palmitoyl-pentapeptide-4) - Keep them apart: [Tretinoin and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/tretinoin-and-palmitoyl-pentapeptide-4) - Keep them apart: [Vitamin A and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/vitamin-a-and-palmitoyl-pentapeptide-4) - Work well together: [Liposome and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/liposome-and-palmitoyl-pentapeptide-4) - Work well together: [Microcapsule and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/microcapsule-and-palmitoyl-pentapeptide-4) - Depends on the strength: [Vitamin C and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/vitamin-c-and-palmitoyl-pentapeptide-4) - Work well together: [Betaine and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/betaine-and-palmitoyl-pentapeptide-4) - Work well together: [Glycerin and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/glycerin-and-palmitoyl-pentapeptide-4) - Work well together: [Hyaluronic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/hyaluronic-acid-and-palmitoyl-pentapeptide-4) - Work well together: [Vitamin E and hyaluronic acid](https://lovi.care/skincare/uk/ingredients/vitamin-e-and-hyaluronic-acid) - Depends on the strength: [Niacinamide and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/niacinamide-and-palmitoyl-pentapeptide-4) - Work well together: [Panthenol and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/panthenol-and-palmitoyl-pentapeptide-4) - Work well together: [Bakuchiol and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/bakuchiol-and-palmitoyl-pentapeptide-4) - Work well together: [Retinol and vitamin E](https://lovi.care/skincare/uk/ingredients/retinol-and-vitamin-e) - Work well together: [Arginine and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/arginine-and-palmitoyl-pentapeptide-4) - Work well together: [GABA and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/gaba-and-palmitoyl-pentapeptide-4) - Work well together: [Silk amino acids and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/silk-amino-acids-and-palmitoyl-pentapeptide-4) - Work well together: [Taurine and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/taurine-and-palmitoyl-pentapeptide-4) - Work well together: [Palmitoyl pentapeptide-4 and theanine](https://lovi.care/skincare/uk/ingredients/palmitoyl-pentapeptide-4-and-theanine) - Keep them apart: [AHA blend glycolic and citric acids and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/aha-blend-glycolic-and-citric-acids-and-palmitoyl-pentapeptide-4) - Keep them apart: [Citric acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/citric-acid-and-palmitoyl-pentapeptide-4) - Keep them apart: [Glycolic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/glycolic-acid-and-palmitoyl-pentapeptide-4) - Keep them apart: [Lactic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/lactic-acid-and-palmitoyl-pentapeptide-4) - Keep them apart: [Mandelic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/mandelic-acid-and-palmitoyl-pentapeptide-4) - Work well together: [Vitamin E and acetyl hexapeptide-3](https://lovi.care/skincare/uk/ingredients/vitamin-e-and-acetyl-hexapeptide-3) - Work well together: [Bio-placenta peptides and vitamin E](https://lovi.care/skincare/uk/ingredients/bio-placenta-peptides-and-vitamin-e) - Work well together: [Vitamin E and collagen peptide](https://lovi.care/skincare/uk/ingredients/vitamin-e-and-collagen-peptide) - Work well together: [Vitamin E and copper peptide](https://lovi.care/skincare/uk/ingredients/vitamin-e-and-copper-peptide) - Work well together: [Vitamin E and hexapeptide](https://lovi.care/skincare/uk/ingredients/vitamin-e-and-hexapeptide) - Work well together: [Vitamin E and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/vitamin-e-and-hexapeptide-9) - Work well together: [Coenzyme Q10 and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/coenzyme-q10-and-palmitoyl-pentapeptide-4) - Work well together: [Green tea and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/green-tea-and-palmitoyl-pentapeptide-4) - Work well together: [Vitamin E and palmitoyl tripeptide-1](https://lovi.care/skincare/uk/ingredients/vitamin-e-and-palmitoyl-tripeptide-1) - Work well together: [Vitamin E and peptide-rich plasma](https://lovi.care/skincare/uk/ingredients/vitamin-e-and-peptide-rich-plasma) - Work well together: [Vitamin E and triple peptide blend](https://lovi.care/skincare/uk/ingredients/vitamin-e-and-triple-peptide-blend) - Work well together: [Vitamin E and tri-ceramide complex](https://lovi.care/skincare/uk/ingredients/vitamin-e-and-tri-ceramide-complex) - Work well together: [Beta-sitosterol and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/beta-sitosterol-and-palmitoyl-pentapeptide-4) - Work well together: [Ceramide-building complex and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/ceramide-building-complex-and-palmitoyl-pentapeptide-4) - Work well together: [Cholesterol and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/cholesterol-and-palmitoyl-pentapeptide-4) - Work well together: [Phytosphingosine and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/phytosphingosine-and-palmitoyl-pentapeptide-4) - Work well together: [Phytosterol and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/phytosterol-and-palmitoyl-pentapeptide-4) - Work well together: [Squalene and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/squalene-and-palmitoyl-pentapeptide-4) - Work well together: [Tri-ceramide complex and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/tri-ceramide-complex-and-palmitoyl-pentapeptide-4) - Keep them apart: [Salicylic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/salicylic-acid-and-palmitoyl-pentapeptide-4) - Keep them apart: [Baking soda and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/baking-soda-and-palmitoyl-pentapeptide-4) - Keep them apart: [Bleach and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/bleach-and-palmitoyl-pentapeptide-4) - Keep them apart: [Potassium hydroxide and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/potassium-hydroxide-and-palmitoyl-pentapeptide-4) - Keep them apart: [Behenyl alcohol and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/behenyl-alcohol-and-palmitoyl-pentapeptide-4) - Keep them apart: [Isopropyl alcohol and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/isopropyl-alcohol-and-palmitoyl-pentapeptide-4) - Keep them apart: [Polyvinyl alcohol and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/polyvinyl-alcohol-and-palmitoyl-pentapeptide-4) - Work well together: [AHA blend glycolic and citric acids and vitamin E](https://lovi.care/skincare/uk/ingredients/aha-blend-glycolic-and-citric-acids-and-vitamin-e) - Work well together: [Vitamin E and citric acid](https://lovi.care/skincare/uk/ingredients/vitamin-e-and-citric-acid) - Work well together: [Glycolic acid and vitamin E](https://lovi.care/skincare/uk/ingredients/glycolic-acid-and-vitamin-e) - Work well together: [Vitamin E and lactic acid](https://lovi.care/skincare/uk/ingredients/vitamin-e-and-lactic-acid) - Work well together: [Vitamin E and mandelic acid](https://lovi.care/skincare/uk/ingredients/vitamin-e-and-mandelic-acid) - Keep them apart: [Copper and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/copper-and-palmitoyl-pentapeptide-4) - Work well together: [Niacinamide and vitamin E](https://lovi.care/skincare/uk/ingredients/niacinamide-and-vitamin-e) - Keep them apart: [Benzoyl peroxide and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/benzoyl-peroxide-and-palmitoyl-pentapeptide-4) - Keep them apart: [Magnesium and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/magnesium-and-palmitoyl-pentapeptide-4) - Keep them apart: [Zinc and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/zinc-and-palmitoyl-pentapeptide-4) - Keep them apart: [Zinc sulfate and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/zinc-sulfate-and-palmitoyl-pentapeptide-4) - Work well together: [Vitamin C and vitamin E](https://lovi.care/skincare/uk/ingredients/vitamin-c-and-vitamin-e) - Keep them apart: [Azelaic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/azelaic-acid-and-palmitoyl-pentapeptide-4) - Work well together: [Salicylic acid and vitamin E](https://lovi.care/skincare/uk/ingredients/salicylic-acid-and-vitamin-e) - Keep them apart: [Protease and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/protease-and-palmitoyl-pentapeptide-4) - Keep them apart: [Superoxide dismutase and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/superoxide-dismutase-and-palmitoyl-pentapeptide-4) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/ingredients/vitamin-e-and-palmitoyl-pentapeptide-4 - United Kingdom: https://lovi.care/skincare/uk/ingredients/vitamin-e-and-palmitoyl-pentapeptide-4 (this page) - Ireland: https://lovi.care/skincare/ie/ingredients/vitamin-e-and-palmitoyl-pentapeptide-4 - Germany: https://lovi.care/skincare/de/ingredients/vitamin-e-and-palmitoyl-pentapeptide-4 - France: https://lovi.care/skincare/fr/ingredients/vitamin-e-and-palmitoyl-pentapeptide-4 - Italy: https://lovi.care/skincare/it/ingredients/vitamin-e-and-palmitoyl-pentapeptide-4 - Netherlands: https://lovi.care/skincare/nl/ingredients/vitamin-e-and-palmitoyl-pentapeptide-4 - Spain: https://lovi.care/skincare/es/ingredients/vitamin-e-and-palmitoyl-pentapeptide-4 - Canada: https://lovi.care/skincare/ca/ingredients/vitamin-e-and-palmitoyl-pentapeptide-4 - Australia: https://lovi.care/skincare/au/ingredients/vitamin-e-and-palmitoyl-pentapeptide-4 - Singapore: https://lovi.care/skincare/sg/ingredients/vitamin-e-and-palmitoyl-pentapeptide-4 - Saudi Arabia: https://lovi.care/skincare/sa/ingredients/vitamin-e-and-palmitoyl-pentapeptide-4 - United Arab Emirates: https://lovi.care/skincare/ae/ingredients/vitamin-e-and-palmitoyl-pentapeptide-4