# Retinol and hexapeptide-9

Page: https://lovi.care/skincare/uk/ingredients/retinol-and-hexapeptide-9

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

Depends on the strength

Use them at different times of day with the peptide [serum](https://lovi.care/skincare/uk/ingredients/serum) in the morning and the [retinol](https://lovi.care/skincare/uk/ingredients/retinol) at night, because combining them in the exact same routine can cause irritation. Retinol speeds up skin renewal while [hexapeptide-9](https://lovi.care/skincare/uk/ingredients/hexapeptide-9) helps firm the skin, which can sometimes be too much for sensitive skin when mixed together. You can switch to a gentler retinol strength or wait longer between applying the two products if your skin feels irritated.

- [All about retinol](https://lovi.care/skincare/uk/ingredients/retinol)
- [All about hexapeptide-9](https://lovi.care/skincare/uk/ingredients/hexapeptide-9)

### [Retinol](https://lovi.care/skincare/uk/ingredients/retinol) products

- [CeraVe Resurfacing Retinol Serum](https://lovi.care/skincare/uk/p/cerave/resurfacing-retinol-serum/for/dark-spots) — High fit — [£15.64 at Amazon](https://www.amazon.co.uk/dp/B0B913JC2W?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- [RoC Retinol Correxion Deep Wrinkle Night Cream](https://lovi.care/skincare/uk/p/roc/retinol-correxion-deep-wrinkle-night-cream/for/dark-spots) — High fit — [£19.34 at Amazon](https://www.amazon.co.uk/dp/B0GXBBV93V?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- [Paula's Choice 1% Retinol Treatment](https://lovi.care/skincare/uk/p/paula-s-choice/1-retinol-treatment/for/dark-spots) — Superior fit — [£39.97 at Amazon](https://www.amazon.co.uk/dp/B00L5O31VK?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- [RoC Retinol Correxion Line Smoothing Eye Cream](https://lovi.care/skincare/uk/p/roc/retinol-correxion-line-smoothing-eye-cream/for/mature-skin) — High fit — [£17.99 at Amazon](https://www.amazon.co.uk/dp/B08GGD7NRN?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- [Good Molecules Gentle Retinol Cream](https://lovi.care/skincare/uk/p/good-molecules/gentle-retinol-cream/for/mature-skin) — High fit — [£12.03 at Amazon](https://www.amazon.co.uk/dp/B09BST7MMP?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- [La Roche-Posay Retinol B3 Serum](https://lovi.care/skincare/uk/p/la-roche-posay/retinol-b3-serum/for/dark-spots) — Average fit — [£38.39 at Amazon](https://www.amazon.co.uk/dp/B07Z9Y4M3C?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- [DRMTLGY Retinol Body Lotion](https://lovi.care/skincare/uk/p/drmtlgy/retinol-body-lotion/for/mature-skin) — Average fit
- [RoC Retinol Correxion Deep Wrinkle Serum](https://lovi.care/skincare/uk/p/roc/retinol-correxion-deep-wrinkle-serum/for/oily-skin) — Average fit — [£18.49 at Amazon](https://www.amazon.co.uk/dp/B0GQZ5J61H?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- [CeraVe Skin Renewing Retinol Serum](https://lovi.care/skincare/uk/p/cerave/skin-renewing-retinol-serum/for/dark-spots) — Average fit — [£19.29 at Amazon](https://www.amazon.co.uk/dp/B0FM8S8JZY?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- [Olay Regenerist Retinol 24 Night Moisturizer](https://lovi.care/skincare/uk/p/olay/regenerist-retinol-24-night-moisturizer/for/mature-skin) — Superior fit — [£19.73 at Amazon](https://www.amazon.co.uk/dp/B0852NRDYN?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- [cocokind Retinol Body Cream](https://lovi.care/skincare/uk/p/cocokind/retinol-body-cream/for/mature-skin) — Average fit
- [Neutrogena Rapid Wrinkle Repair Regenerating Cream](https://lovi.care/skincare/uk/p/neutrogena/rapid-wrinkle-repair-regenerating-cream/for/mature-skin) — High fit — [£36.99 at Amazon](https://www.amazon.co.uk/dp/B01HOHBS6G?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)

### [Hexapeptide-9](https://lovi.care/skincare/uk/ingredients/hexapeptide-9) products

- [Elemis Pro-Collagen Night Cream](https://lovi.care/skincare/uk/p/elemis/pro-collagen-night-cream/for/dry-sensitive-skin) — Superior fit — [£96.00 at Amazon](https://www.amazon.co.uk/dp/B00175YVOS?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- [Murad Cellular Hydration Repair Serum](https://lovi.care/skincare/uk/p/murad/cellular-hydration-repair-serum/for/acne-prone-skin) — High fit
- [MARY & MAY 6 Peptide Complex Serum](https://lovi.care/skincare/uk/p/mary-and-may/6-peptide-complex-serum/for/mature-skin) — High fit — [£12.76 at Amazon](https://www.amazon.co.uk/dp/B095YHYF33?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)

## Questions and answers

### Can you use retinol and hexapeptide-9 together?

Using [retinol](https://lovi.care/skincare/uk/ingredients/retinol) and [hexapeptide-9](https://lovi.care/skincare/uk/ingredients/hexapeptide-9) together depends on the strength, as combining strong retinoids with peptides may increase irritation. You can safely use them by alternating usage, such as applying your retinoid in the PM and peptides in the AM, or by layering them carefully for tolerance.

### Which goes first, retinol or hexapeptide-9?

It depends on the strength, as strong retinoids should be separated from peptides like hexapeptide-9 to avoid irritation. You can alternate usage by applying your retinoid in the evening and peptides in the morning.

### Are retinol and hexapeptide-9 good for sensitive skin?

Using retinol and hexapeptide-9 together depends on the strength because combining strong retinoids with peptides may increase irritation on sensitive skin. Alternate usage by applying your retinoid in the evening and peptides in the morning.

## Research on retinol and hexapeptide-9

- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [Encapsulation and controlled release of retinol from silicone particles for topical delivery](https://pubmed.ncbi.nlm.nih.gov/29604311/) Retinol · Journal of Controlled Release, 2018
- [A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen](https://pubmed.ncbi.nlm.nih.gov/20374604/) Retinol · The British Journal of Dermatology, 2010
- [Topical application of retinyl propionate, 4 hexyl resorcinol, and niacinamide reverses molecular and clinical features of ageing](https://pubmed.ncbi.nlm.nih.gov/38685700/) Retinol · International Journal of Cosmetic Science, 2024
- [Novel Cyclized Hexapeptide-9 Outperforms Retinol Against Skin Aging: A Randomized, Double-Blinded, Active- and Vehicle-Controlled Clinical Trial](https://pubmed.ncbi.nlm.nih.gov/40586182/) Hexapeptide-9 · Journal of Cosmetic Dermatology, 2025

## Other combinations

- Depends on the strength: [Retinol and niacinamide](https://lovi.care/skincare/uk/ingredients/retinol-and-niacinamide)
- Keep them apart: [Retinol and isopropyl alcohol](https://lovi.care/skincare/uk/ingredients/retinol-and-isopropyl-alcohol)
- Keep them apart: [Retinol and sodium lauryl sulfate](https://lovi.care/skincare/uk/ingredients/retinol-and-sodium-lauryl-sulfate)
- Keep them apart: [Retinol and aha blend glycolic and citric acids](https://lovi.care/skincare/uk/ingredients/retinol-and-aha-blend-glycolic-and-citric-acids)
- Keep them apart: [Retinol and citric acid](https://lovi.care/skincare/uk/ingredients/retinol-and-citric-acid)
- Keep them apart: [Glycolic acid and retinol](https://lovi.care/skincare/uk/ingredients/glycolic-acid-and-retinol)
- Keep them apart: [Retinol and lactic acid](https://lovi.care/skincare/uk/ingredients/retinol-and-lactic-acid)
- Keep them apart: [Retinol and mandelic acid](https://lovi.care/skincare/uk/ingredients/retinol-and-mandelic-acid)
- Keep them apart: [Retinol and salicylic acid](https://lovi.care/skincare/uk/ingredients/retinol-and-salicylic-acid)
- Keep them apart: [Vitamin C and retinol](https://lovi.care/skincare/uk/ingredients/vitamin-c-and-retinol)
- Depends on the strength: [Retinol and acetyl hexapeptide-3](https://lovi.care/skincare/uk/ingredients/retinol-and-acetyl-hexapeptide-3)
- Depends on the strength: [Retinol and bio-placenta peptides](https://lovi.care/skincare/uk/ingredients/retinol-and-bio-placenta-peptides)
- Depends on the strength: [Retinol and collagen peptide](https://lovi.care/skincare/uk/ingredients/retinol-and-collagen-peptide)
- Depends on the strength: [Retinol and copper peptide](https://lovi.care/skincare/uk/ingredients/retinol-and-copper-peptide)
- Depends on the strength: [Retinol and hexapeptide](https://lovi.care/skincare/uk/ingredients/retinol-and-hexapeptide)
- Keep them apart: [Adapalene and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/adapalene-and-hexapeptide-9)
- Keep them apart: [Granactive retinoid and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/granactive-retinoid-and-hexapeptide-9)
- Keep them apart: [Hydroxypinacolone retinoate and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/hydroxypinacolone-retinoate-and-hexapeptide-9)
- Keep them apart: [Pro-retinol and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/pro-retinol-and-hexapeptide-9)
- Keep them apart: [Retinal and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/retinal-and-hexapeptide-9)
- Keep them apart: [Retinoid blend and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/retinoid-blend-and-hexapeptide-9)
- Keep them apart: [Tretinoin and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/tretinoin-and-hexapeptide-9)
- Keep them apart: [Vitamin A and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/vitamin-a-and-hexapeptide-9)
- Depends on the strength: [Retinol and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/retinol-and-palmitoyl-pentapeptide-4)
- Depends on the strength: [Retinol and palmitoyl tripeptide-1](https://lovi.care/skincare/uk/ingredients/retinol-and-palmitoyl-tripeptide-1)
- Depends on the strength: [Retinol and peptide-rich plasma](https://lovi.care/skincare/uk/ingredients/retinol-and-peptide-rich-plasma)
- Depends on the strength: [Retinol and triple peptide blend](https://lovi.care/skincare/uk/ingredients/retinol-and-triple-peptide-blend)
- Work well together: [Liposome and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/liposome-and-hexapeptide-9)
- Work well together: [Microcapsule and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/microcapsule-and-hexapeptide-9)
- Depends on the strength: [Vitamin C and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/vitamin-c-and-hexapeptide-9)
- Work well together: [Betaine and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/betaine-and-hexapeptide-9)
- Work well together: [Glycerin and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/glycerin-and-hexapeptide-9)
- Work well together: [Hyaluronic acid and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/hyaluronic-acid-and-hexapeptide-9)
- Depends on the strength: [Niacinamide and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/niacinamide-and-hexapeptide-9)
- Work well together: [Panthenol and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/panthenol-and-hexapeptide-9)
- Work well together: [Bakuchiol and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/bakuchiol-and-hexapeptide-9)
- Work well together: [Retinol and bakuchiol](https://lovi.care/skincare/uk/ingredients/retinol-and-bakuchiol)
- Work well together: [Retinol and coenzyme q10](https://lovi.care/skincare/uk/ingredients/retinol-and-coenzyme-q10)
- Work well together: [Retinol and green tea](https://lovi.care/skincare/uk/ingredients/retinol-and-green-tea)
- Work well together: [Retinol and vitamin E](https://lovi.care/skincare/uk/ingredients/retinol-and-vitamin-e)
- Work well together: [Arginine and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/arginine-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and GABA](https://lovi.care/skincare/uk/ingredients/hexapeptide-9-and-gaba)
- Work well together: [Silk amino acids and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/silk-amino-acids-and-hexapeptide-9)
- Work well together: [Taurine and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/taurine-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and theanine](https://lovi.care/skincare/uk/ingredients/hexapeptide-9-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/aha-blend-glycolic-and-citric-acids-and-hexapeptide-9)
- Keep them apart: [Citric acid and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/citric-acid-and-hexapeptide-9)
- Keep them apart: [Glycolic acid and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/glycolic-acid-and-hexapeptide-9)
- Keep them apart: [Lactic acid and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/lactic-acid-and-hexapeptide-9)
- Keep them apart: [Mandelic acid and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/mandelic-acid-and-hexapeptide-9)
- Work well together: [Coenzyme Q10 and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/coenzyme-q10-and-hexapeptide-9)
- Work well together: [Green tea and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/green-tea-and-hexapeptide-9)
- Work well together: [Vitamin E and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/vitamin-e-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and beta-sitosterol](https://lovi.care/skincare/uk/ingredients/hexapeptide-9-and-beta-sitosterol)
- Work well together: [Ceramide-building complex and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/ceramide-building-complex-and-hexapeptide-9)
- Work well together: [Cholesterol and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/cholesterol-and-hexapeptide-9)
- Work well together: [Phytosphingosine and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/phytosphingosine-and-hexapeptide-9)
- Work well together: [Phytosterol and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/phytosterol-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and squalene](https://lovi.care/skincare/uk/ingredients/hexapeptide-9-and-squalene)
- Work well together: [Hexapeptide-9 and tri-ceramide complex](https://lovi.care/skincare/uk/ingredients/hexapeptide-9-and-tri-ceramide-complex)
- Keep them apart: [Salicylic acid and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/salicylic-acid-and-hexapeptide-9)
- Keep them apart: [Hexapeptide-9 and baking soda](https://lovi.care/skincare/uk/ingredients/hexapeptide-9-and-baking-soda)
- Keep them apart: [Bleach and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/bleach-and-hexapeptide-9)
- Keep them apart: [Potassium hydroxide and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/potassium-hydroxide-and-hexapeptide-9)
- Keep them apart: [Hexapeptide-9 and behenyl alcohol](https://lovi.care/skincare/uk/ingredients/hexapeptide-9-and-behenyl-alcohol)
- Keep them apart: [Hexapeptide-9 and isopropyl alcohol](https://lovi.care/skincare/uk/ingredients/hexapeptide-9-and-isopropyl-alcohol)
- Keep them apart: [Polyvinyl alcohol and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/polyvinyl-alcohol-and-hexapeptide-9)
- Keep them apart: [Copper and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/copper-and-hexapeptide-9)
- Keep them apart: [Benzoyl peroxide and retinol](https://lovi.care/skincare/uk/ingredients/benzoyl-peroxide-and-retinol)
- Keep them apart: [Benzoyl peroxide and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/benzoyl-peroxide-and-hexapeptide-9)
- Keep them apart: [Magnesium and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/magnesium-and-hexapeptide-9)
- Keep them apart: [Zinc and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/zinc-and-hexapeptide-9)
- Keep them apart: [Zinc sulfate and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/zinc-sulfate-and-hexapeptide-9)
- Work well together: [Retinol and ceramide-building complex](https://lovi.care/skincare/uk/ingredients/retinol-and-ceramide-building-complex)
- Work well together: [Retinol and tri-ceramide complex](https://lovi.care/skincare/uk/ingredients/retinol-and-tri-ceramide-complex)
- Keep them apart: [Azelaic acid and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/azelaic-acid-and-hexapeptide-9)
- Keep them apart: [Hexapeptide-9 and protease](https://lovi.care/skincare/uk/ingredients/hexapeptide-9-and-protease)
- Keep them apart: [Superoxide dismutase and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/superoxide-dismutase-and-hexapeptide-9)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/retinol-and-hexapeptide-9
- United Kingdom: https://lovi.care/skincare/uk/ingredients/retinol-and-hexapeptide-9 (this page)
- Ireland: https://lovi.care/skincare/ie/ingredients/retinol-and-hexapeptide-9
- Germany: https://lovi.care/skincare/de/ingredients/retinol-and-hexapeptide-9
- France: https://lovi.care/skincare/fr/ingredients/retinol-and-hexapeptide-9
- Italy: https://lovi.care/skincare/it/ingredients/retinol-and-hexapeptide-9
- Netherlands: https://lovi.care/skincare/nl/ingredients/retinol-and-hexapeptide-9
- Spain: https://lovi.care/skincare/es/ingredients/retinol-and-hexapeptide-9
- Canada: https://lovi.care/skincare/ca/ingredients/retinol-and-hexapeptide-9
- Australia: https://lovi.care/skincare/au/ingredients/retinol-and-hexapeptide-9
- Singapore: https://lovi.care/skincare/sg/ingredients/retinol-and-hexapeptide-9
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/retinol-and-hexapeptide-9
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/retinol-and-hexapeptide-9