# PDRN Page: https://lovi.care/skincare/uk/ingredients/pdrn The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom. Topical application of Low-Peony PDRN and polydeoxyribonucleotide-spermidine nanoparticles helps strengthen the skin barrier, improves periorbital skin elasticity, and supports anti-aging efficacy by enhancing cell migration and percutaneous permeability. This ingredient suits both dry skin and oily skin particularly well when applied in lightweight [serums](https://lovi.care/skincare/uk/ingredients/serum). Furthermore, it integrates smoothly into daily regimens because it layers easily with other products. [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/) [International Journal of Biological Macromolecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40840755/) This page shows PDRN products with a Lovi page. For every product, and a routine built for your skin, use the Lovi app. ### Popular PDRN products - [VT Cosmetics PDRN Essence 100](https://lovi.care/skincare/uk/p/vt-cosmetics/pdrn-essence-100/for/mature-skin) — Superior fit — [£24.95 at Amazon](https://www.amazon.co.uk/dp/B0CRKPZ9PQ?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1) - [Medicube PDRN PINK CICA SOOTHING TONER](https://lovi.care/skincare/uk/p/medicube/pdrn-pink-cica-soothing-toner/for/acne-prone-skin) — High fit — [£20.50 at Notino](https://www.notino.co.uk/medicube/pdrn-pink-cica-soothing-toner-brightening-facial-toner-with-firming-effect/p-16329865/) - [REJURAN Rejuran® Healer Turnover Ampoule](https://lovi.care/skincare/uk/p/rejuran/healer-turnover-ampoule/for/dry-skin) — High fit — [£44.00 at Amazon](https://www.amazon.co.uk/dp/B08BZCY3Y1?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1) - [Genabelle PDRN Vita Toning Ampoule](https://lovi.care/skincare/uk/p/genabelle/pdrn-vita-toning-ampoule/for/mature-skin) — Superior fit — [£23.99 at Amazon](https://www.amazon.co.uk/dp/B0DL8PSG8Z?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1) - [IOPE PDRN Caffeine Shot Serum](https://lovi.care/skincare/uk/p/iope/pdrn-caffeine-shot-serum/for/mature-skin) — High fit — [£39.03 at Amazon](https://www.amazon.co.uk/dp/B0BJQ86VNH?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1) ### Other PDRN products - [VT Cosmetics PDRN Essence 100](https://lovi.care/skincare/uk/p/vt-cosmetics/pdrn-essence-100/for/mature-skin) — Superior fit — [£24.95 at Amazon](https://www.amazon.co.uk/dp/B0CRKPZ9PQ?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1) - [REJURAN Rejuran® Healer Turnover Ampoule](https://lovi.care/skincare/uk/p/rejuran/healer-turnover-ampoule/for/dry-skin) — High fit — [£44.00 at Amazon](https://www.amazon.co.uk/dp/B08BZCY3Y1?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1) - [Genabelle PDRN Vita Toning Ampoule](https://lovi.care/skincare/uk/p/genabelle/pdrn-vita-toning-ampoule/for/mature-skin) — Superior fit — [£23.99 at Amazon](https://www.amazon.co.uk/dp/B0DL8PSG8Z?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1) - [IOPE PDRN Caffeine Shot Serum](https://lovi.care/skincare/uk/p/iope/pdrn-caffeine-shot-serum/for/mature-skin) — High fit — [£39.03 at Amazon](https://www.amazon.co.uk/dp/B0BJQ86VNH?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1) - [Medicube PDRN PINK CICA SOOTHING TONER](https://lovi.care/skincare/uk/p/medicube/pdrn-pink-cica-soothing-toner/for/acne-prone-skin) — High fit — [£20.50 at Notino](https://www.notino.co.uk/medicube/pdrn-pink-cica-soothing-toner-brightening-facial-toner-with-firming-effect/p-16329865/) ## What reviewers say about popular PDRN products The highlight reviewers mention most for each popular PDRN product on Lovi. - VT Cosmetics PDRN Essence 100 Hydration and glow ★4.8 · 1.6k+ reviews Fragrance-free Good texture “deeply moisturizing” [What people say about PDRN Essence 100](https://lovi.care/skincare/uk/p/vt-cosmetics/pdrn-essence-100/for/mature-skin) - Medicube PDRN PINK CICA SOOTHING TONER Lightweight texture ★4.6 · 800+ reviews Soothing and calming Barrier support “absorbs quickly” [What people say about PDRN PINK CICA SOOTHING TONER](https://lovi.care/skincare/uk/p/medicube/pdrn-pink-cica-soothing-toner/for/acne-prone-skin) - REJURAN Rejuran® Healer Turnover Ampoule Hydration and glow ★4.8 · 500+ reviews Absorbs quickly Smoother texture “leaves my skin glowy and plump” [What people say about Rejuran® Healer Turnover Ampoule](https://lovi.care/skincare/uk/p/rejuran/healer-turnover-ampoule/for/dry-skin) - Genabelle PDRN Vita Toning Ampoule Lightweight texture ★4.7 · 200+ reviews Deep hydration Gentle and soothing “Lightweight and silky” [What people say about PDRN Vita Toning Ampoule](https://lovi.care/skincare/uk/p/genabelle/pdrn-vita-toning-ampoule/for/mature-skin) - IOPE PDRN Caffeine Shot Serum Lightweight texture ★4.8 · 1.5k+ reviews Reduces puffiness Expensive product “absorbs like water” [What people say about PDRN Caffeine Shot Serum](https://lovi.care/skincare/uk/p/iope/pdrn-caffeine-shot-serum/for/mature-skin) ### PDRN for dry skin - [Genabelle PDRN Vita Toning Ampoule](https://lovi.care/skincare/uk/p/genabelle/pdrn-vita-toning-ampoule/for/dry-skin) — High fit — [£23.99 at Amazon](https://www.amazon.co.uk/dp/B0DL8PSG8Z?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1) - [VT Cosmetics PDRN Essence 100](https://lovi.care/skincare/uk/p/vt-cosmetics/pdrn-essence-100/for/dry-skin) — High fit — [£24.95 at Amazon](https://www.amazon.co.uk/dp/B0CRKPZ9PQ?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1) - [REJURAN Rejuran® Healer Turnover Ampoule](https://lovi.care/skincare/uk/p/rejuran/healer-turnover-ampoule/for/dry-skin) — High fit — [£44.00 at Amazon](https://www.amazon.co.uk/dp/B08BZCY3Y1?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1) - [IOPE PDRN Caffeine Shot Serum](https://lovi.care/skincare/uk/p/iope/pdrn-caffeine-shot-serum/for/dry-skin) — Average fit — [£39.03 at Amazon](https://www.amazon.co.uk/dp/B0BJQ86VNH?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1) - [Medicube PDRN PINK CICA SOOTHING TONER](https://lovi.care/skincare/uk/p/medicube/pdrn-pink-cica-soothing-toner/for/dry-skin) — Average fit — [£20.50 at Notino](https://www.notino.co.uk/medicube/pdrn-pink-cica-soothing-toner-brightening-facial-toner-with-firming-effect/p-16329865/) ### PDRN for oily skin - [Genabelle PDRN Vita Toning Ampoule](https://lovi.care/skincare/uk/p/genabelle/pdrn-vita-toning-ampoule/for/oily-skin) — High fit — [£23.99 at Amazon](https://www.amazon.co.uk/dp/B0DL8PSG8Z?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1) - [IOPE PDRN Caffeine Shot Serum](https://lovi.care/skincare/uk/p/iope/pdrn-caffeine-shot-serum/for/oily-skin) — High fit — [£39.03 at Amazon](https://www.amazon.co.uk/dp/B0BJQ86VNH?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1) - [VT Cosmetics PDRN Essence 100](https://lovi.care/skincare/uk/p/vt-cosmetics/pdrn-essence-100/for/oily-skin) — Average fit — [£24.95 at Amazon](https://www.amazon.co.uk/dp/B0CRKPZ9PQ?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1) - [REJURAN Rejuran® Healer Turnover Ampoule](https://lovi.care/skincare/uk/p/rejuran/healer-turnover-ampoule/for/oily-skin) — Average fit — [£44.00 at Amazon](https://www.amazon.co.uk/dp/B08BZCY3Y1?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1) - [Medicube PDRN PINK CICA SOOTHING TONER](https://lovi.care/skincare/uk/p/medicube/pdrn-pink-cica-soothing-toner/for/oily-skin) — Average fit — [£20.50 at Notino](https://www.notino.co.uk/medicube/pdrn-pink-cica-soothing-toner-brightening-facial-toner-with-firming-effect/p-16329865/) ### PDRN for combination skin - [Genabelle PDRN Vita Toning Ampoule](https://lovi.care/skincare/uk/p/genabelle/pdrn-vita-toning-ampoule/for/combination-skin) — High fit — [£23.99 at Amazon](https://www.amazon.co.uk/dp/B0DL8PSG8Z?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1) - [VT Cosmetics PDRN Essence 100](https://lovi.care/skincare/uk/p/vt-cosmetics/pdrn-essence-100/for/combination-skin) — High fit — [£24.95 at Amazon](https://www.amazon.co.uk/dp/B0CRKPZ9PQ?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1) - [Medicube PDRN PINK CICA SOOTHING TONER](https://lovi.care/skincare/uk/p/medicube/pdrn-pink-cica-soothing-toner/for/combination-skin) — High fit — [£20.50 at Notino](https://www.notino.co.uk/medicube/pdrn-pink-cica-soothing-toner-brightening-facial-toner-with-firming-effect/p-16329865/) - [IOPE PDRN Caffeine Shot Serum](https://lovi.care/skincare/uk/p/iope/pdrn-caffeine-shot-serum/for/combination-skin) — Average fit — [£39.03 at Amazon](https://www.amazon.co.uk/dp/B0BJQ86VNH?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1) - [REJURAN Rejuran® Healer Turnover Ampoule](https://lovi.care/skincare/uk/p/rejuran/healer-turnover-ampoule/for/combination-skin) — Average fit — [£44.00 at Amazon](https://www.amazon.co.uk/dp/B08BZCY3Y1?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1) ### PDRN for sensitive skin - [VT Cosmetics PDRN Essence 100](https://lovi.care/skincare/uk/p/vt-cosmetics/pdrn-essence-100/for/sensitive-skin) — High fit — [£24.95 at Amazon](https://www.amazon.co.uk/dp/B0CRKPZ9PQ?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1) - [Genabelle PDRN Vita Toning Ampoule](https://lovi.care/skincare/uk/p/genabelle/pdrn-vita-toning-ampoule/for/sensitive-skin) — High fit — [£23.99 at Amazon](https://www.amazon.co.uk/dp/B0DL8PSG8Z?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1) - [Medicube PDRN PINK CICA SOOTHING TONER](https://lovi.care/skincare/uk/p/medicube/pdrn-pink-cica-soothing-toner/for/sensitive-skin) — High fit — [£20.50 at Notino](https://www.notino.co.uk/medicube/pdrn-pink-cica-soothing-toner-brightening-facial-toner-with-firming-effect/p-16329865/) - [REJURAN Rejuran® Healer Turnover Ampoule](https://lovi.care/skincare/uk/p/rejuran/healer-turnover-ampoule/for/sensitive-skin) — Average fit — [£44.00 at Amazon](https://www.amazon.co.uk/dp/B08BZCY3Y1?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1) - [IOPE PDRN Caffeine Shot Serum](https://lovi.care/skincare/uk/p/iope/pdrn-caffeine-shot-serum/for/sensitive-skin) — Average fit — [£39.03 at Amazon](https://www.amazon.co.uk/dp/B0BJQ86VNH?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1) ### PDRN for acne-prone skin - [Genabelle PDRN Vita Toning Ampoule](https://lovi.care/skincare/uk/p/genabelle/pdrn-vita-toning-ampoule/for/acne-prone-skin) — High fit — [£23.99 at Amazon](https://www.amazon.co.uk/dp/B0DL8PSG8Z?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1) - [Medicube PDRN PINK CICA SOOTHING TONER](https://lovi.care/skincare/uk/p/medicube/pdrn-pink-cica-soothing-toner/for/acne-prone-skin) — High fit — [£20.50 at Notino](https://www.notino.co.uk/medicube/pdrn-pink-cica-soothing-toner-brightening-facial-toner-with-firming-effect/p-16329865/) - [VT Cosmetics PDRN Essence 100](https://lovi.care/skincare/uk/p/vt-cosmetics/pdrn-essence-100/for/acne-prone-skin) — Average fit — [£24.95 at Amazon](https://www.amazon.co.uk/dp/B0CRKPZ9PQ?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1) - [IOPE PDRN Caffeine Shot Serum](https://lovi.care/skincare/uk/p/iope/pdrn-caffeine-shot-serum/for/acne-prone-skin) — Average fit — [£39.03 at Amazon](https://www.amazon.co.uk/dp/B0BJQ86VNH?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1) - [REJURAN Rejuran® Healer Turnover Ampoule](https://lovi.care/skincare/uk/p/rejuran/healer-turnover-ampoule/for/acne-prone-skin) — Average fit — [£44.00 at Amazon](https://www.amazon.co.uk/dp/B08BZCY3Y1?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1) ### PDRN for mature skin - [VT Cosmetics PDRN Essence 100](https://lovi.care/skincare/uk/p/vt-cosmetics/pdrn-essence-100/for/mature-skin) — Superior fit — [£24.95 at Amazon](https://www.amazon.co.uk/dp/B0CRKPZ9PQ?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1) - [Genabelle PDRN Vita Toning Ampoule](https://lovi.care/skincare/uk/p/genabelle/pdrn-vita-toning-ampoule/for/mature-skin) — Superior fit — [£23.99 at Amazon](https://www.amazon.co.uk/dp/B0DL8PSG8Z?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1) - [IOPE PDRN Caffeine Shot Serum](https://lovi.care/skincare/uk/p/iope/pdrn-caffeine-shot-serum/for/mature-skin) — High fit — [£39.03 at Amazon](https://www.amazon.co.uk/dp/B0BJQ86VNH?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1) - [Medicube PDRN PINK CICA SOOTHING TONER](https://lovi.care/skincare/uk/p/medicube/pdrn-pink-cica-soothing-toner/for/mature-skin) — Average fit — [£20.50 at Notino](https://www.notino.co.uk/medicube/pdrn-pink-cica-soothing-toner-brightening-facial-toner-with-firming-effect/p-16329865/) - [REJURAN Rejuran® Healer Turnover Ampoule](https://lovi.care/skincare/uk/p/rejuran/healer-turnover-ampoule/for/mature-skin) — Average fit — [£44.00 at Amazon](https://www.amazon.co.uk/dp/B08BZCY3Y1?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1) ## Questions and answers ### What does PDRN do for the skin? PDRN helps enhance skin barrier recovery and improves skin elasticity. It may also provide anti-aging benefits. [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/) [International Journal of Biological Macromolecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40840755/) ### How do you use PDRN? PDRN is applied topically to enhance skin barrier recovery and improve skin elasticity. It may be used regularly as part of an anti-aging skincare routine. [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/) [International Journal of Biological Macromolecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40840755/) ### Should you use PDRN in the morning or at night? You can use PDRN at any time of day as part of your routine. Studies show that topical PDRN helps enhance skin barrier recovery and improves skin elasticity. [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/) [International Journal of Biological Macromolecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40840755/) ### Can you use PDRN every day? Yes, you can use PDRN daily as topical application helps enhance barrier recovery and improve skin elasticity. [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/) [International Journal of Biological Macromolecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40840755/) ### Does PDRN cause purging or irritation? PDRN is unlikely to cause purging or irritation. Topical application of PDRN helps enhance barrier recovery while improving skin elasticity. [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/) ### Which skin types is PDRN best for? PDRN is well suited for mature skin, where VT Cosmetics PDRN Essence 100 and Genabelle PDRN Vita Toning Ampoule earn a Superior fit rating on Lovi. It is also a High fit for dry, oily, combination, sensitive, and acne-prone skin types. ## Research on PDRN - [Anti-Aging Efficacy of Low-Molecular-Weight Polydeoxyribonucleotide Derived from Paeonia lactiflora](https://pubmed.ncbi.nlm.nih.gov/41516097/) PDRN · International Journal of Molecular Sciences, 2025 - [Polydeoxyribonucleotide-spermidine nanoparticles: Preparation, characterization, and verification of skin anti-aging efficacy](https://pubmed.ncbi.nlm.nih.gov/40840755/) PDRN · International Journal of Biological Macromolecules, 2025 ## Brands with PDRN - Korean skincare: [VT Cosmetics](https://lovi.care/skincare/uk/brands/vt-cosmetics) - Korean skincare: [REJURAN](https://lovi.care/skincare/uk/brands/rejuran) - Korean skincare: [Medicube](https://lovi.care/skincare/uk/brands/medicube) - Korean skincare: [Genabelle](https://lovi.care/skincare/uk/brands/genabelle) - Korean skincare: [IOPE](https://lovi.care/skincare/uk/brands/iope) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi checks every ingredient with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this ingredient guide: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/ingredients/pdrn - United Kingdom: https://lovi.care/skincare/uk/ingredients/pdrn (this page) - Ireland: https://lovi.care/skincare/ie/ingredients/pdrn - Germany: https://lovi.care/skincare/de/ingredients/pdrn - France: https://lovi.care/skincare/fr/ingredients/pdrn - Italy: https://lovi.care/skincare/it/ingredients/pdrn - Netherlands: https://lovi.care/skincare/nl/ingredients/pdrn - Spain: https://lovi.care/skincare/es/ingredients/pdrn - Canada: https://lovi.care/skincare/ca/ingredients/pdrn - Australia: https://lovi.care/skincare/au/ingredients/pdrn - Singapore: https://lovi.care/skincare/sg/ingredients/pdrn - Saudi Arabia: https://lovi.care/skincare/sa/ingredients/pdrn - United Arab Emirates: https://lovi.care/skincare/ae/ingredients/pdrn