# Panthenol and mandelic acid

Page: https://lovi.care/skincare/uk/ingredients/panthenol-and-mandelic-acid

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

Work well together

Use them together by applying the [mandelic acid](https://lovi.care/skincare/uk/ingredients/mandelic-acid) first and following with [panthenol](https://lovi.care/skincare/uk/ingredients/panthenol), because panthenol helps calm any irritation from the acid. Mandelic acid gently exfoliates the skin, while panthenol adds moisture and cools down redness. If your skin feels sensitive, you can use a lower strength or wait a little longer between applying them.

- [All about panthenol](https://lovi.care/skincare/uk/ingredients/panthenol)
- [All about mandelic acid](https://lovi.care/skincare/uk/ingredients/mandelic-acid)

### [Panthenol](https://lovi.care/skincare/uk/ingredients/panthenol) products

- [Cetaphil Gentle Skin Cleanser](https://lovi.care/skincare/uk/p/cetaphil/gentle-skin-cleanser/for/dry-skin) — Superior fit — [£13.00 at Amazon](https://www.amazon.co.uk/dp/B09ZF9X3R1?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- [La Roche-Posay Toleriane Hydrating Gentle Cleanser](https://lovi.care/skincare/uk/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/dry-skin) — Superior fit — [£16.60 at Amazon](https://www.amazon.co.uk/dp/B00BH4LNWM?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- [COSRX Advanced Snail 96 Mucin Power Essence](https://lovi.care/skincare/uk/p/cosrx/advanced-snail-96-mucin-power-essence/for/dry-skin) — Superior fit — [£12.21 at Amazon](https://www.amazon.co.uk/dp/B00PBX3L7K?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- [CeraVe Healing Ointment](https://lovi.care/skincare/uk/p/cerave/healing-ointment/for/dry-skin) — High fit
- [La Roche-Posay Cicaplast Baume B5+](https://lovi.care/skincare/uk/p/la-roche-posay/cicaplast-baume-b5/for/sensitive-skin) — Superior fit — [£15.91 at Amazon](https://www.amazon.co.uk/dp/B0BJFLVCZK?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- [Mederma Advanced Scar Gel](https://lovi.care/skincare/uk/p/mederma/advanced-scar-gel/for/sensitive-skin) — High fit
- [The Ordinary Hyaluronic Acid 2% + B5](https://lovi.care/skincare/uk/p/the-ordinary/hyaluronic-acid-2-b5/for/acne-prone-skin) — High fit — [£7.04 at Amazon](https://www.amazon.co.uk/dp/B01MYEZPC8?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- [NIVEA Creme](https://lovi.care/skincare/uk/p/nivea/creme/for/dry-skin) — High fit — [£4.75 at Amazon](https://www.amazon.co.uk/dp/B07YDVWL4J?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- [Aquaphor Lip Repair](https://lovi.care/skincare/uk/p/aquaphor/lip-repair/for/dry-skin) — Superior fit
- [Torriden Dive In Serum](https://lovi.care/skincare/uk/p/torriden/dive-in-serum/for/acne-prone-skin) — Superior fit — [£18.40 at Amazon](https://www.amazon.co.uk/dp/B07WZ2YTDP?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- [RoC Retinol Correxion Line Smoothing Eye Cream](https://lovi.care/skincare/uk/p/roc/retinol-correxion-line-smoothing-eye-cream/for/mature-skin) — High fit — [£17.99 at Amazon](https://www.amazon.co.uk/dp/B08GGD7NRN?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- [Cetaphil Daily Facial Cleanser](https://lovi.care/skincare/uk/p/cetaphil/daily-facial-cleanser/for/oily-skin) — Superior fit

### [Mandelic acid](https://lovi.care/skincare/uk/ingredients/mandelic-acid) products

- [The Ordinary Mandelic Acid 10% + HA](https://lovi.care/skincare/uk/p/the-ordinary/mandelic-acid-10-ha/for/acne-prone-skin) — Superior fit — [£5.92 at Amazon](https://www.amazon.co.uk/dp/B07BGJMNYL?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- [Nécessaire The Body Retinol](https://lovi.care/skincare/uk/p/necessaire/the-body-retinol/for/dark-spots) — Average fit
- [Glamglow Supermud Clearing Treatment](https://lovi.care/skincare/uk/p/glamglow/supermud-clearing-treatment/for/oily-skin) — High fit — [£88.88 at Amazon](https://www.amazon.co.uk/dp/B07DHSKYXR?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- [Dermalogica PowerBright Dark Spot Peel](https://lovi.care/skincare/uk/p/dermalogica/powerbright-dark-spot-peel/for/oily-skin) — Average fit
- [Cetaphil Gentle Exfoliating SA Lotion](https://lovi.care/skincare/uk/p/cetaphil/gentle-exfoliating-sa-lotion/for/combination-skin) — High fit — [£13.99 at Amazon](https://www.amazon.co.uk/dp/B0F43XRN4G?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- [SkinCeuticals Cell Cycle Catalyst](https://lovi.care/skincare/uk/p/skinceuticals/cell-cycle-catalyst/for/oily-acne-prone-skin) — Average fit
- [DIME TBT Serum](https://lovi.care/skincare/uk/p/dime/tbt-serum/for/dry-sensitive-skin) — High fit
- [Haruharu Wonder Black Rice Triple AHA Gentle Cleansing Gel](https://lovi.care/skincare/uk/p/haruharu-wonder/black-rice-triple-aha-gentle-cleansing-gel/for/oily-acne-prone-skin) — High fit — [£13.45 at Amazon](https://www.amazon.co.uk/dp/B0CKVL9PGY?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- [Neutrogena Bright Boost Gel Cream](https://lovi.care/skincare/uk/p/neutrogena/bright-boost-gel-cream/for/acne-prone-skin) — High fit
- [The INKEY List Mandelic Acid Treatment](https://lovi.care/skincare/uk/p/the-inkey-list/mandelic-acid-treatment/for/oily-acne-prone-skin) — High fit
- [Glow Recipe Strawberry Smooth BHA + AHA Salicylic Serum](https://lovi.care/skincare/uk/p/glow-recipe/strawberry-smooth-bha-aha-salicylic-serum/for/combination-skin) — Superior fit — [£38.00 at Amazon](https://www.amazon.co.uk/dp/B0B4F7W5JF?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- [Vivant 8% Mandelic Acid Serum](https://lovi.care/skincare/uk/p/vivant/8-mandelic-acid-serum/for/sensitive-skin) — High fit

## Questions and answers

### Can you use panthenol and mandelic acid together?

[Panthenol](https://lovi.care/skincare/uk/ingredients/panthenol) and [mandelic acid](https://lovi.care/skincare/uk/ingredients/mandelic-acid) work well together because panthenol helps support barrier recovery and soothe irritation from the acid. You can find them combined in products like Good Molecules Mandelic Acid [Serum](https://lovi.care/skincare/uk/ingredients/serum), By Wishtrend Mandelic Acid 5% Skin Prep [Water](https://lovi.care/skincare/uk/ingredients/water), and Sofie Pavitt Face Mandelic Clearing Serum.

[American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/) [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Which goes first, panthenol or mandelic acid?

Panthenol and mandelic acid work well together, and panthenol can be applied after mandelic acid or found combined in products like Good Molecules Mandelic Acid Serum, By Wishtrend Mandelic Acid 5% Skin Prep Water, and Sofie Pavitt Face Mandelic Clearing Serum. Panthenol helps support barrier recovery and reduces the risk of irritation from the acid.

[American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/) [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Are panthenol and mandelic acid good for sensitive skin?

Panthenol and mandelic acid work well together for sensitive skin because panthenol supports barrier recovery and helps reduce the irritation risk from mandelic acid. Products like Good Molecules Mandelic Acid Serum, By Wishtrend Mandelic Acid 5% Skin Prep Water, and Sofie Pavitt Face Mandelic Clearing Serum combine these ingredients.

[American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/) [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

## Research on panthenol and mandelic acid

- [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Panthenol · American Journal of Clinical Dermatology, 2002
- [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Panthenol · The Journal of Dermatological Treatment, 2017
- [Comparative study of efficacy and safety of 45% mandelic acid versus 30% salicylic acid peels in mild-to-moderate acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/31553119/) Mandelic acid · Journal of Cosmetic Dermatology, 2020
- [Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial](https://pubmed.ncbi.nlm.nih.gov/32683390/) Panthenol · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020
- [Chemical peels for acne vulgaris: a systematic review of randomised controlled trials](https://pubmed.ncbi.nlm.nih.gov/29705755/) Mandelic acid · BMJ Open, 2018
- [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Panthenol · Journal of Cosmetic Dermatology, 2025

## Other combinations

- Work well together: [Panthenol and salicylic acid](https://lovi.care/skincare/uk/ingredients/panthenol-and-salicylic-acid)
- Keep them apart: [Benzoyl peroxide and mandelic acid](https://lovi.care/skincare/uk/ingredients/benzoyl-peroxide-and-mandelic-acid)
- Keep them apart: [Retinol and mandelic acid](https://lovi.care/skincare/uk/ingredients/retinol-and-mandelic-acid)
- Depends on the strength: [Niacinamide and mandelic acid](https://lovi.care/skincare/uk/ingredients/niacinamide-and-mandelic-acid)
- Work well together: [Mandelic acid and sodium lactate](https://lovi.care/skincare/uk/ingredients/mandelic-acid-and-sodium-lactate)
- Work well together: [Mandelic acid and tromethamine](https://lovi.care/skincare/uk/ingredients/mandelic-acid-and-tromethamine)
- Work well together: [Mandelic acid and betaine](https://lovi.care/skincare/uk/ingredients/mandelic-acid-and-betaine)
- Work well together: [Glycerin and mandelic acid](https://lovi.care/skincare/uk/ingredients/glycerin-and-mandelic-acid)
- Depends on the strength: [Mandelic acid and hyaluronic acid](https://lovi.care/skincare/uk/ingredients/mandelic-acid-and-hyaluronic-acid)
- Work well together: [Panthenol and acetyl hexapeptide-3](https://lovi.care/skincare/uk/ingredients/panthenol-and-acetyl-hexapeptide-3)
- Work well together: [Panthenol and bio-placenta peptides](https://lovi.care/skincare/uk/ingredients/panthenol-and-bio-placenta-peptides)
- Work well together: [Panthenol and collagen peptide](https://lovi.care/skincare/uk/ingredients/panthenol-and-collagen-peptide)
- Work well together: [Panthenol and copper peptide](https://lovi.care/skincare/uk/ingredients/panthenol-and-copper-peptide)
- Work well together: [Panthenol and hexapeptide](https://lovi.care/skincare/uk/ingredients/panthenol-and-hexapeptide)
- Work well together: [Panthenol and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/panthenol-and-hexapeptide-9)
- Work well together: [Panthenol and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/panthenol-and-palmitoyl-pentapeptide-4)
- Work well together: [Panthenol and palmitoyl tripeptide-1](https://lovi.care/skincare/uk/ingredients/panthenol-and-palmitoyl-tripeptide-1)
- Work well together: [Panthenol and peptide-rich plasma](https://lovi.care/skincare/uk/ingredients/panthenol-and-peptide-rich-plasma)
- Work well together: [Panthenol and triple peptide blend](https://lovi.care/skincare/uk/ingredients/panthenol-and-triple-peptide-blend)
- Keep them apart: [Acetyl hexapeptide-3 and mandelic acid](https://lovi.care/skincare/uk/ingredients/acetyl-hexapeptide-3-and-mandelic-acid)
- Keep them apart: [Bio-placenta peptides and mandelic acid](https://lovi.care/skincare/uk/ingredients/bio-placenta-peptides-and-mandelic-acid)
- Keep them apart: [Carnosine and mandelic acid](https://lovi.care/skincare/uk/ingredients/carnosine-and-mandelic-acid)
- Keep them apart: [Mandelic acid and collagen peptide](https://lovi.care/skincare/uk/ingredients/mandelic-acid-and-collagen-peptide)
- Keep them apart: [Mandelic acid and copper peptide](https://lovi.care/skincare/uk/ingredients/mandelic-acid-and-copper-peptide)
- Keep them apart: [Hexapeptide and mandelic acid](https://lovi.care/skincare/uk/ingredients/hexapeptide-and-mandelic-acid)
- Keep them apart: [Mandelic acid and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/mandelic-acid-and-hexapeptide-9)
- Keep them apart: [Mandelic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/mandelic-acid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Mandelic acid and palmitoyl tripeptide-1](https://lovi.care/skincare/uk/ingredients/mandelic-acid-and-palmitoyl-tripeptide-1)
- Keep them apart: [Mandelic acid and peptide-rich plasma](https://lovi.care/skincare/uk/ingredients/mandelic-acid-and-peptide-rich-plasma)
- Keep them apart: [Mandelic acid and triple peptide blend](https://lovi.care/skincare/uk/ingredients/mandelic-acid-and-triple-peptide-blend)
- Keep them apart: [Adapalene and mandelic acid](https://lovi.care/skincare/uk/ingredients/adapalene-and-mandelic-acid)
- Keep them apart: [Mandelic acid and granactive retinoid](https://lovi.care/skincare/uk/ingredients/mandelic-acid-and-granactive-retinoid)
- Keep them apart: [Mandelic acid and hydroxypinacolone retinoate](https://lovi.care/skincare/uk/ingredients/mandelic-acid-and-hydroxypinacolone-retinoate)
- Keep them apart: [Pro-retinol and mandelic acid](https://lovi.care/skincare/uk/ingredients/pro-retinol-and-mandelic-acid)
- Keep them apart: [Retinal and mandelic acid](https://lovi.care/skincare/uk/ingredients/retinal-and-mandelic-acid)
- Keep them apart: [Mandelic acid and retinoid blend](https://lovi.care/skincare/uk/ingredients/mandelic-acid-and-retinoid-blend)
- Keep them apart: [Tretinoin and mandelic acid](https://lovi.care/skincare/uk/ingredients/tretinoin-and-mandelic-acid)
- Work well together: [Mandelic acid and gluconolactone](https://lovi.care/skincare/uk/ingredients/mandelic-acid-and-gluconolactone)
- Work well together: [Mandelic acid and lactobionic acid](https://lovi.care/skincare/uk/ingredients/mandelic-acid-and-lactobionic-acid)
- Work well together: [Mandelic acid and cholesterol](https://lovi.care/skincare/uk/ingredients/mandelic-acid-and-cholesterol)
- Work well together: [Mandelic acid and lauric acid](https://lovi.care/skincare/uk/ingredients/mandelic-acid-and-lauric-acid)
- Work well together: [Linoleic acid and mandelic acid](https://lovi.care/skincare/uk/ingredients/linoleic-acid-and-mandelic-acid)
- Keep them apart: [Mandelic acid and tri-ceramide complex](https://lovi.care/skincare/uk/ingredients/mandelic-acid-and-tri-ceramide-complex)
- Work well together: [Arginine and mandelic acid](https://lovi.care/skincare/uk/ingredients/arginine-and-mandelic-acid)
- Work well together: [Mandelic acid and GABA](https://lovi.care/skincare/uk/ingredients/mandelic-acid-and-gaba)
- Work well together: [Silk amino acids and mandelic acid](https://lovi.care/skincare/uk/ingredients/silk-amino-acids-and-mandelic-acid)
- Work well together: [Taurine and mandelic acid](https://lovi.care/skincare/uk/ingredients/taurine-and-mandelic-acid)
- Work well together: [Mandelic acid and theanine](https://lovi.care/skincare/uk/ingredients/mandelic-acid-and-theanine)
- Work well together: [Ferulic acid and mandelic acid](https://lovi.care/skincare/uk/ingredients/ferulic-acid-and-mandelic-acid)
- Work well together: [Vitamin E and mandelic acid](https://lovi.care/skincare/uk/ingredients/vitamin-e-and-mandelic-acid)
- Keep them apart: [Azelaic acid and mandelic acid](https://lovi.care/skincare/uk/ingredients/azelaic-acid-and-mandelic-acid)
- Keep them apart: [Salicylic acid and mandelic acid](https://lovi.care/skincare/uk/ingredients/salicylic-acid-and-mandelic-acid)
- Work well together: [Panthenol and aha blend glycolic and citric acids](https://lovi.care/skincare/uk/ingredients/panthenol-and-aha-blend-glycolic-and-citric-acids)
- Work well together: [Panthenol and citric acid](https://lovi.care/skincare/uk/ingredients/panthenol-and-citric-acid)
- Work well together: [Glycolic acid and panthenol](https://lovi.care/skincare/uk/ingredients/glycolic-acid-and-panthenol)
- Work well together: [Panthenol and lactic acid](https://lovi.care/skincare/uk/ingredients/panthenol-and-lactic-acid)
- Work well together: [Allantoin and mandelic acid](https://lovi.care/skincare/uk/ingredients/allantoin-and-mandelic-acid)
- Work well together: [Mandelic acid and bisabolol](https://lovi.care/skincare/uk/ingredients/mandelic-acid-and-bisabolol)
- Work well together: [Panthenol and hyaluronic acid](https://lovi.care/skincare/uk/ingredients/panthenol-and-hyaluronic-acid)
- Work well together: [Panthenol and tri-ceramide complex](https://lovi.care/skincare/uk/ingredients/panthenol-and-tri-ceramide-complex)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/panthenol-and-mandelic-acid
- United Kingdom: https://lovi.care/skincare/uk/ingredients/panthenol-and-mandelic-acid (this page)
- Ireland: https://lovi.care/skincare/ie/ingredients/panthenol-and-mandelic-acid
- Germany: https://lovi.care/skincare/de/ingredients/panthenol-and-mandelic-acid
- France: https://lovi.care/skincare/fr/ingredients/panthenol-and-mandelic-acid
- Italy: https://lovi.care/skincare/it/ingredients/panthenol-and-mandelic-acid
- Netherlands: https://lovi.care/skincare/nl/ingredients/panthenol-and-mandelic-acid
- Spain: https://lovi.care/skincare/es/ingredients/panthenol-and-mandelic-acid
- Canada: https://lovi.care/skincare/ca/ingredients/panthenol-and-mandelic-acid
- Australia: https://lovi.care/skincare/au/ingredients/panthenol-and-mandelic-acid
- Singapore: https://lovi.care/skincare/sg/ingredients/panthenol-and-mandelic-acid
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/panthenol-and-mandelic-acid
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/panthenol-and-mandelic-acid