# Hydroxypinacolone retinoate and hexapeptide-9

Page: https://lovi.care/skincare/uk/ingredients/hydroxypinacolone-retinoate-and-hexapeptide-9

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

Keep them apart

Use them at different times of day by applying [hexapeptide-9](https://lovi.care/skincare/uk/ingredients/hexapeptide-9) in the morning and [hydroxypinacolone retinoate](https://lovi.care/skincare/uk/ingredients/hydroxypinacolone-retinoate) at night, to avoid extra skin irritation. Both ingredients work hard to smooth the skin, and using them together can cause redness and irritation. The shopper can prevent this by using them in separate routines or switching to a gentler formula.

- [All about hydroxypinacolone retinoate](https://lovi.care/skincare/uk/ingredients/hydroxypinacolone-retinoate)
- [All about hexapeptide-9](https://lovi.care/skincare/uk/ingredients/hexapeptide-9)

### [Hydroxypinacolone retinoate](https://lovi.care/skincare/uk/ingredients/hydroxypinacolone-retinoate) products

- [The Ordinary Granactive Retinoid 2% Emulsion](https://lovi.care/skincare/uk/p/the-ordinary/granactive-retinoid-2-emulsion/for/oily-skin) — High fit — [£8.80 at Amazon](https://www.amazon.co.uk/dp/B071HHSMTT?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- [IOPE Retinol Super Bounce Serum](https://lovi.care/skincare/uk/p/iope/retinol-super-bounce-serum/for/dark-spots) — Average fit — [£56.69 at Amazon](https://www.amazon.co.uk/dp/B0CKGSMMSB?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- [BYOMA Sensitive Retinol Oil](https://lovi.care/skincare/uk/p/byoma/sensitive-retinol-oil/for/dry-skin) — Average fit — [£17.95 at Amazon](https://www.amazon.co.uk/dp/B0CSDWY381?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- [Medicube Deep Vita A Retinol Serum](https://lovi.care/skincare/uk/p/medicube/deep-vita-a-retinol-serum/for/acne-prone-skin) — Average fit — [£14.80 at Amazon](https://www.amazon.co.uk/dp/B0FPFDSC7X?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- [Sunday Riley A+ High-Dose Retinoid Serum](https://lovi.care/skincare/uk/p/sunday-riley/a-high-dose-retinoid-serum/for/oily-acne-prone-skin) — High fit — [£127.42 at Amazon](https://www.amazon.co.uk/dp/B08D7GVPXS?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)

### [Hexapeptide-9](https://lovi.care/skincare/uk/ingredients/hexapeptide-9) products

- [Elemis Pro-Collagen Night Cream](https://lovi.care/skincare/uk/p/elemis/pro-collagen-night-cream/for/dry-sensitive-skin) — Superior fit — [£96.00 at Amazon](https://www.amazon.co.uk/dp/B00175YVOS?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- [Murad Cellular Hydration Repair Serum](https://lovi.care/skincare/uk/p/murad/cellular-hydration-repair-serum/for/acne-prone-skin) — High fit
- [MARY & MAY 6 Peptide Complex Serum](https://lovi.care/skincare/uk/p/mary-and-may/6-peptide-complex-serum/for/mature-skin) — High fit — [£12.76 at Amazon](https://www.amazon.co.uk/dp/B095YHYF33?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)

## Questions and answers

### Can you use hydroxypinacolone retinoate and hexapeptide-9 together?

It is best to keep [hydroxypinacolone retinoate](https://lovi.care/skincare/uk/ingredients/hydroxypinacolone-retinoate) and [hexapeptide-9](https://lovi.care/skincare/uk/ingredients/hexapeptide-9) apart in your routine because combined stimulation may increase skin irritation. You can alternate their usage by applying your retinoid in the evening and peptides in the morning.

### Which goes first, hydroxypinacolone retinoate or hexapeptide-9?

Keep hydroxypinacolone retinoate and hexapeptide-9 apart in the same routine, using hydroxypinacolone retinoate in the evening and hexapeptide-9 in the morning to avoid increased skin irritation. Combining them may overstimulate the skin because both ingredients activate dermal remodeling pathways.

### Are hydroxypinacolone retinoate and hexapeptide-9 good for sensitive skin?

No, you should keep hydroxypinacolone retinoate and hexapeptide-9 apart in your routine because combined stimulation may increase irritation, especially for sensitive skin. Instead, alternate your usage by applying your retinoid in the evening and peptides in the morning.

## Research on hydroxypinacolone retinoate and hexapeptide-9

- [Characterization of Acne-Prone Skin with Reflectance Confocal Microscopy and Optical Coherence Tomography and Modifications Induced by Topical Treatment and Probiotic Supplementation](https://pubmed.ncbi.nlm.nih.gov/37510902/) Hydroxypinacolone retinoate · Journal of Clinical Medicine, 2023
- [The synergistic effect of retinyl propionate and hydroxypinacolone retinoate on skin aging](https://pubmed.ncbi.nlm.nih.gov/36762391/) Hydroxypinacolone retinoate · Journal of Cosmetic Dermatology, 2023
- [Efficacy of Topical Hydroxypinacolone Retinoate-Peptide Product Versus Fractional CO2 Laser in Facial Aging](https://pubmed.ncbi.nlm.nih.gov/39394831/) Hydroxypinacolone retinoate · Journal of Cosmetic Dermatology, 2025
- [Novel Cyclized Hexapeptide-9 Outperforms Retinol Against Skin Aging: A Randomized, Double-Blinded, Active- and Vehicle-Controlled Clinical Trial](https://pubmed.ncbi.nlm.nih.gov/40586182/) Hexapeptide-9 · Journal of Cosmetic Dermatology, 2025

## Other combinations

- Keep them apart: [Acetyl hexapeptide-3 and hydroxypinacolone retinoate](https://lovi.care/skincare/uk/ingredients/acetyl-hexapeptide-3-and-hydroxypinacolone-retinoate)
- Keep them apart: [Bio-placenta peptides and hydroxypinacolone retinoate](https://lovi.care/skincare/uk/ingredients/bio-placenta-peptides-and-hydroxypinacolone-retinoate)
- Keep them apart: [Hydroxypinacolone retinoate and collagen peptide](https://lovi.care/skincare/uk/ingredients/hydroxypinacolone-retinoate-and-collagen-peptide)
- Keep them apart: [Hydroxypinacolone retinoate and copper peptide](https://lovi.care/skincare/uk/ingredients/hydroxypinacolone-retinoate-and-copper-peptide)
- Keep them apart: [Hexapeptide and hydroxypinacolone retinoate](https://lovi.care/skincare/uk/ingredients/hexapeptide-and-hydroxypinacolone-retinoate)
- Keep them apart: [Adapalene and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/adapalene-and-hexapeptide-9)
- Keep them apart: [Granactive retinoid and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/granactive-retinoid-and-hexapeptide-9)
- Keep them apart: [Pro-retinol and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/pro-retinol-and-hexapeptide-9)
- Keep them apart: [Retinal and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/retinal-and-hexapeptide-9)
- Keep them apart: [Retinoid blend and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/retinoid-blend-and-hexapeptide-9)
- Depends on the strength: [Retinol and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/retinol-and-hexapeptide-9)
- Keep them apart: [Tretinoin and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/tretinoin-and-hexapeptide-9)
- Keep them apart: [Vitamin A and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/vitamin-a-and-hexapeptide-9)
- Keep them apart: [Hydroxypinacolone retinoate and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/hydroxypinacolone-retinoate-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Hydroxypinacolone retinoate and palmitoyl tripeptide-1](https://lovi.care/skincare/uk/ingredients/hydroxypinacolone-retinoate-and-palmitoyl-tripeptide-1)
- Keep them apart: [Hydroxypinacolone retinoate and peptide-rich plasma](https://lovi.care/skincare/uk/ingredients/hydroxypinacolone-retinoate-and-peptide-rich-plasma)
- Keep them apart: [Hydroxypinacolone retinoate and triple peptide blend](https://lovi.care/skincare/uk/ingredients/hydroxypinacolone-retinoate-and-triple-peptide-blend)
- Work well together: [Liposome and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/liposome-and-hexapeptide-9)
- Work well together: [Microcapsule and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/microcapsule-and-hexapeptide-9)
- Depends on the strength: [Vitamin C and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/vitamin-c-and-hexapeptide-9)
- Depends on the strength: [Niacinamide and hydroxypinacolone retinoate](https://lovi.care/skincare/uk/ingredients/niacinamide-and-hydroxypinacolone-retinoate)
- Work well together: [Betaine and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/betaine-and-hexapeptide-9)
- Work well together: [Glycerin and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/glycerin-and-hexapeptide-9)
- Work well together: [Hyaluronic acid and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/hyaluronic-acid-and-hexapeptide-9)
- Depends on the strength: [Niacinamide and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/niacinamide-and-hexapeptide-9)
- Work well together: [Panthenol and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/panthenol-and-hexapeptide-9)
- Work well together: [Bakuchiol and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/bakuchiol-and-hexapeptide-9)
- Work well together: [Arginine and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/arginine-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and GABA](https://lovi.care/skincare/uk/ingredients/hexapeptide-9-and-gaba)
- Work well together: [Silk amino acids and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/silk-amino-acids-and-hexapeptide-9)
- Work well together: [Taurine and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/taurine-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and theanine](https://lovi.care/skincare/uk/ingredients/hexapeptide-9-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/aha-blend-glycolic-and-citric-acids-and-hexapeptide-9)
- Keep them apart: [Citric acid and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/citric-acid-and-hexapeptide-9)
- Keep them apart: [Glycolic acid and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/glycolic-acid-and-hexapeptide-9)
- Keep them apart: [Lactic acid and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/lactic-acid-and-hexapeptide-9)
- Keep them apart: [Mandelic acid and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/mandelic-acid-and-hexapeptide-9)
- Work well together: [Coenzyme Q10 and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/coenzyme-q10-and-hexapeptide-9)
- Work well together: [Green tea and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/green-tea-and-hexapeptide-9)
- Work well together: [Vitamin E and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/vitamin-e-and-hexapeptide-9)
- Keep them apart: [AHA blend glycolic and citric acids and hydroxypinacolone retinoate](https://lovi.care/skincare/uk/ingredients/aha-blend-glycolic-and-citric-acids-and-hydroxypinacolone-retinoate)
- Keep them apart: [Hydroxypinacolone retinoate and citric acid](https://lovi.care/skincare/uk/ingredients/hydroxypinacolone-retinoate-and-citric-acid)
- Keep them apart: [Glycolic acid and hydroxypinacolone retinoate](https://lovi.care/skincare/uk/ingredients/glycolic-acid-and-hydroxypinacolone-retinoate)
- Keep them apart: [Lactic acid and hydroxypinacolone retinoate](https://lovi.care/skincare/uk/ingredients/lactic-acid-and-hydroxypinacolone-retinoate)
- Keep them apart: [Mandelic acid and hydroxypinacolone retinoate](https://lovi.care/skincare/uk/ingredients/mandelic-acid-and-hydroxypinacolone-retinoate)
- Work well together: [Hexapeptide-9 and beta-sitosterol](https://lovi.care/skincare/uk/ingredients/hexapeptide-9-and-beta-sitosterol)
- Work well together: [Ceramide-building complex and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/ceramide-building-complex-and-hexapeptide-9)
- Work well together: [Cholesterol and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/cholesterol-and-hexapeptide-9)
- Work well together: [Phytosphingosine and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/phytosphingosine-and-hexapeptide-9)
- Work well together: [Phytosterol and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/phytosterol-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and squalene](https://lovi.care/skincare/uk/ingredients/hexapeptide-9-and-squalene)
- Work well together: [Hexapeptide-9 and tri-ceramide complex](https://lovi.care/skincare/uk/ingredients/hexapeptide-9-and-tri-ceramide-complex)
- Keep them apart: [Salicylic acid and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/salicylic-acid-and-hexapeptide-9)
- Keep them apart: [Salicylic acid and hydroxypinacolone retinoate](https://lovi.care/skincare/uk/ingredients/salicylic-acid-and-hydroxypinacolone-retinoate)
- Keep them apart: [Vitamin C and hydroxypinacolone retinoate](https://lovi.care/skincare/uk/ingredients/vitamin-c-and-hydroxypinacolone-retinoate)
- Keep them apart: [Hexapeptide-9 and baking soda](https://lovi.care/skincare/uk/ingredients/hexapeptide-9-and-baking-soda)
- Keep them apart: [Bleach and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/bleach-and-hexapeptide-9)
- Keep them apart: [Potassium hydroxide and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/potassium-hydroxide-and-hexapeptide-9)
- Keep them apart: [Hexapeptide-9 and behenyl alcohol](https://lovi.care/skincare/uk/ingredients/hexapeptide-9-and-behenyl-alcohol)
- Keep them apart: [Hexapeptide-9 and isopropyl alcohol](https://lovi.care/skincare/uk/ingredients/hexapeptide-9-and-isopropyl-alcohol)
- Keep them apart: [Polyvinyl alcohol and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/polyvinyl-alcohol-and-hexapeptide-9)
- Keep them apart: [Copper and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/copper-and-hexapeptide-9)
- Keep them apart: [Benzoyl peroxide and hydroxypinacolone retinoate](https://lovi.care/skincare/uk/ingredients/benzoyl-peroxide-and-hydroxypinacolone-retinoate)
- Keep them apart: [Benzoyl peroxide and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/benzoyl-peroxide-and-hexapeptide-9)
- Keep them apart: [Magnesium and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/magnesium-and-hexapeptide-9)
- Keep them apart: [Zinc and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/zinc-and-hexapeptide-9)
- Keep them apart: [Zinc sulfate and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/zinc-sulfate-and-hexapeptide-9)
- Keep them apart: [Azelaic acid and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/azelaic-acid-and-hexapeptide-9)
- Keep them apart: [Hexapeptide-9 and protease](https://lovi.care/skincare/uk/ingredients/hexapeptide-9-and-protease)
- Keep them apart: [Superoxide dismutase and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/superoxide-dismutase-and-hexapeptide-9)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/hydroxypinacolone-retinoate-and-hexapeptide-9
- United Kingdom: https://lovi.care/skincare/uk/ingredients/hydroxypinacolone-retinoate-and-hexapeptide-9 (this page)
- Ireland: https://lovi.care/skincare/ie/ingredients/hydroxypinacolone-retinoate-and-hexapeptide-9
- Germany: https://lovi.care/skincare/de/ingredients/hydroxypinacolone-retinoate-and-hexapeptide-9
- France: https://lovi.care/skincare/fr/ingredients/hydroxypinacolone-retinoate-and-hexapeptide-9
- Italy: https://lovi.care/skincare/it/ingredients/hydroxypinacolone-retinoate-and-hexapeptide-9
- Netherlands: https://lovi.care/skincare/nl/ingredients/hydroxypinacolone-retinoate-and-hexapeptide-9
- Spain: https://lovi.care/skincare/es/ingredients/hydroxypinacolone-retinoate-and-hexapeptide-9
- Canada: https://lovi.care/skincare/ca/ingredients/hydroxypinacolone-retinoate-and-hexapeptide-9
- Australia: https://lovi.care/skincare/au/ingredients/hydroxypinacolone-retinoate-and-hexapeptide-9
- Singapore: https://lovi.care/skincare/sg/ingredients/hydroxypinacolone-retinoate-and-hexapeptide-9
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/hydroxypinacolone-retinoate-and-hexapeptide-9
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/hydroxypinacolone-retinoate-and-hexapeptide-9