# Hexapeptide and vitamin A

Page: https://lovi.care/skincare/uk/ingredients/hexapeptide-and-vitamin-a

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

Keep them apart

Use them at different times of day, applying [vitamin A](https://lovi.care/skincare/uk/ingredients/vitamin-a) at night and [hexapeptide](https://lovi.care/skincare/uk/ingredients/hexapeptide) in the morning, to prevent skin irritation. Both ingredients work hard to smooth the skin, which can sometimes be too much for it to handle all at once. You can make it work by using a gentler strength or waiting longer between applications.

- [All about hexapeptide](https://lovi.care/skincare/uk/ingredients/hexapeptide)
- [All about vitamin A](https://lovi.care/skincare/uk/ingredients/vitamin-a)

### [Hexapeptide](https://lovi.care/skincare/uk/ingredients/hexapeptide) products

- [SkinCeuticals P-TOX](https://lovi.care/skincare/uk/p/skinceuticals/p-tox/for/mature-skin) — High fit — [£135.00 at Lookfantastic](https://www.lookfantastic.com/p/skinceuticals-p-tiox-neuro-peptide-serum-30ml/15456548/)

### [Vitamin A](https://lovi.care/skincare/uk/ingredients/vitamin-a) products

- [Bio-Oil Skincare Oil](https://lovi.care/skincare/uk/p/bio-oil/skincare-oil/for/dry-skin) — Average fit — [£17.25 at Amazon](https://www.amazon.co.uk/dp/B00129XP8M?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- [ZO Skin Health Exfoliating Polish](https://lovi.care/skincare/uk/p/zo-skin-health/exfoliating-polish/for/mature-skin) — High fit
- [Peter Thomas Roth Instant FIRMx Eye Temporary Eye Tightener](https://lovi.care/skincare/uk/p/peter-thomas-roth/instant-firmx-eye-temporary-eye-tightener/for/mature-skin) — High fit — [£23.49 at Amazon](https://www.amazon.co.uk/dp/B0B8PXXPQN?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- [Peter Thomas Roth Instant FirmX Temporary Face Tightener](https://lovi.care/skincare/uk/p/peter-thomas-roth/instant-firmx-temporary-face-tightener/for/mature-skin) — Average fit
- [Augustinus Bader The Cream](https://lovi.care/skincare/uk/p/augustinus-bader/the-cream/for/mature-skin) — High fit — [£275.99 at Amazon](https://www.amazon.co.uk/dp/B0F15KCK1G?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- [U Beauty Resurfacing Compound](https://lovi.care/skincare/uk/p/u-beauty/resurfacing-compound/for/dark-spots) — High fit — [£184.00 at Amazon](https://www.amazon.co.uk/dp/B089B887ZZ?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- [Philosophy Hope In A Jar](https://lovi.care/skincare/uk/p/philosophy/hope-in-a-jar/for/dark-spots) — Average fit
- [SkinMedica TNS Eye Repair](https://lovi.care/skincare/uk/p/skinmedica/tns-eye-repair/for/mature-skin) — Superior fit
- [Dermalogica Multivitamin Power Recovery Masque](https://lovi.care/skincare/uk/p/dermalogica/multivitamin-power-recovery-masque/for/mature-skin) — High fit — [£18.00 at Amazon](https://www.amazon.co.uk/dp/B08C27VDH8?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- [BYOMA Sensitive Retinol Oil](https://lovi.care/skincare/uk/p/byoma/sensitive-retinol-oil/for/dry-skin) — Average fit — [£17.95 at Amazon](https://www.amazon.co.uk/dp/B0CSDWY381?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- [NatureWell Extra Virgin Coconut Oil Moisturizing Cream](https://lovi.care/skincare/uk/p/naturewell/extra-virgin-coconut-oil-moisturizing-cream/for/mature-skin) — Average fit
- [Murad Essential-C Cleanser](https://lovi.care/skincare/uk/p/murad/essential-c-cleanser/for/mature-skin) — High fit — [£36.00 at Amazon](https://www.amazon.co.uk/dp/B0DKM4RJLM?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)

## Questions and answers

### Can you use hexapeptide and vitamin A together?

Keep [hexapeptide](https://lovi.care/skincare/uk/ingredients/hexapeptide) and [vitamin A](https://lovi.care/skincare/uk/ingredients/vitamin-a) apart because combining strong retinoids with peptides may increase skin irritation. Instead, alternate your usage by applying the vitamin A product in the evening and the peptides in the morning.

### Which goes first, hexapeptide or vitamin A?

Keep hexapeptide and vitamin A apart by using them at different times of day, applying the vitamin A retinoid in the evening and the hexapeptide in the morning. Combining them together may increase skin irritation.

### Are hexapeptide and vitamin A good for sensitive skin?

Hexapeptide and vitamin A should be kept apart in a sensitive skin routine because combining them may increase irritation. Try using your retinoid in the evening and peptides in the morning.

## Research on hexapeptide and vitamin A

- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Vitamin A · International Journal of Cosmetic Science, 2017
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Vitamin A · The British Journal of Dermatology, 2019
- [Clinical Assessment of New Topical Cream Containing Two Essential Oils Combined with Tretinoin in the Treatment of Acne](https://pubmed.ncbi.nlm.nih.gov/32210603/) Vitamin A · Clinical, Cosmetic and Investigational Dermatology, 2020
- [Tailoring of Retinyl Palmitate-Based Ethosomal Hydrogel as a Novel Nanoplatform for Acne Vulgaris Management: Fabrication, Optimization, and Clinical Evaluation Employing a Split-Face Comparative Study](https://pubmed.ncbi.nlm.nih.gov/34211271/) Vitamin A · International Journal of Nanomedicine, 2021
- [Encapsulation and controlled release of retinol from silicone particles for topical delivery](https://pubmed.ncbi.nlm.nih.gov/29604311/) Vitamin A · Journal of Controlled Release, 2018
- [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Hexapeptide · American Journal of Clinical Dermatology, 2013
- [A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen](https://pubmed.ncbi.nlm.nih.gov/20374604/) Vitamin A · The British Journal of Dermatology, 2010
- [A randomized, single-blinded trial of a tripeptide/hexapeptide healing regimen following laser resurfacing of the face](https://pubmed.ncbi.nlm.nih.gov/28371204/) Hexapeptide · Journal of Cosmetic Dermatology, 2017
- [Structural characterization and in vivo evaluation of retinyl palmitate in non-ionic lamellar liquid crystalline system](https://pubmed.ncbi.nlm.nih.gov/21411295/) Vitamin A · Colloids and Surfaces. B, Biointerfaces, 2011
- [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Hexapeptide · Annals of Dermatology, 2019
- [A clinicopathological study of the effects of topical retinyl propionate cream in skin photoageing](https://pubmed.ncbi.nlm.nih.gov/9894360/) Vitamin A · Clinical and Experimental Dermatology, 1998
- [The effect of a vitamin A palmitate and antioxidant-containing oil-based moisturizer on photodamaged skin of several body sites](https://pubmed.ncbi.nlm.nih.gov/23438139/) Vitamin A · Journal of Cosmetic Dermatology, 2013
- [Topical application of retinyl propionate, 4 hexyl resorcinol, and niacinamide reverses molecular and clinical features of ageing](https://pubmed.ncbi.nlm.nih.gov/38685700/) Vitamin A · International Journal of Cosmetic Science, 2024
- [Retinyl propionate and climbazole combination demonstrates clinical improvement to the appearance of hyperpigmentation and deep wrinkling with minimal irritation](https://pubmed.ncbi.nlm.nih.gov/28733999/) Vitamin A · International Journal of Cosmetic Science, 2017
- [Microneedling and Topical Retinyl Palmitate for Acne Scars: A Preliminary Split-Face Study with Placebo Control](https://pubmed.ncbi.nlm.nih.gov/41899112/) Vitamin A · Journal of Clinical Medicine, 2026

## Other combinations

- Keep them apart: [Vitamin A and acetyl hexapeptide-3](https://lovi.care/skincare/uk/ingredients/vitamin-a-and-acetyl-hexapeptide-3)
- Keep them apart: [Bio-placenta peptides and vitamin A](https://lovi.care/skincare/uk/ingredients/bio-placenta-peptides-and-vitamin-a)
- Keep them apart: [Vitamin A and collagen peptide](https://lovi.care/skincare/uk/ingredients/vitamin-a-and-collagen-peptide)
- Keep them apart: [Vitamin A and copper peptide](https://lovi.care/skincare/uk/ingredients/vitamin-a-and-copper-peptide)
- Keep them apart: [Adapalene and hexapeptide](https://lovi.care/skincare/uk/ingredients/adapalene-and-hexapeptide)
- Keep them apart: [Hexapeptide and granactive retinoid](https://lovi.care/skincare/uk/ingredients/hexapeptide-and-granactive-retinoid)
- Keep them apart: [Hexapeptide and hydroxypinacolone retinoate](https://lovi.care/skincare/uk/ingredients/hexapeptide-and-hydroxypinacolone-retinoate)
- Keep them apart: [Hexapeptide and pro-retinol](https://lovi.care/skincare/uk/ingredients/hexapeptide-and-pro-retinol)
- Keep them apart: [Hexapeptide and retinal](https://lovi.care/skincare/uk/ingredients/hexapeptide-and-retinal)
- Keep them apart: [Hexapeptide and retinoid blend](https://lovi.care/skincare/uk/ingredients/hexapeptide-and-retinoid-blend)
- Depends on the strength: [Retinol and hexapeptide](https://lovi.care/skincare/uk/ingredients/retinol-and-hexapeptide)
- Keep them apart: [Tretinoin and hexapeptide](https://lovi.care/skincare/uk/ingredients/tretinoin-and-hexapeptide)
- Keep them apart: [Vitamin A and hexapeptide-9](https://lovi.care/skincare/uk/ingredients/vitamin-a-and-hexapeptide-9)
- Keep them apart: [Vitamin A and palmitoyl pentapeptide-4](https://lovi.care/skincare/uk/ingredients/vitamin-a-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Vitamin A and palmitoyl tripeptide-1](https://lovi.care/skincare/uk/ingredients/vitamin-a-and-palmitoyl-tripeptide-1)
- Keep them apart: [Vitamin A and peptide-rich plasma](https://lovi.care/skincare/uk/ingredients/vitamin-a-and-peptide-rich-plasma)
- Keep them apart: [Vitamin A and triple peptide blend](https://lovi.care/skincare/uk/ingredients/vitamin-a-and-triple-peptide-blend)
- Work well together: [Hexapeptide and liposome](https://lovi.care/skincare/uk/ingredients/hexapeptide-and-liposome)
- Work well together: [Hexapeptide and microcapsule](https://lovi.care/skincare/uk/ingredients/hexapeptide-and-microcapsule)
- Depends on the strength: [Vitamin C and hexapeptide](https://lovi.care/skincare/uk/ingredients/vitamin-c-and-hexapeptide)
- Depends on the strength: [Niacinamide and vitamin A](https://lovi.care/skincare/uk/ingredients/niacinamide-and-vitamin-a)
- Work well together: [Hexapeptide and betaine](https://lovi.care/skincare/uk/ingredients/hexapeptide-and-betaine)
- Work well together: [Glycerin and hexapeptide](https://lovi.care/skincare/uk/ingredients/glycerin-and-hexapeptide)
- Work well together: [Hexapeptide and hyaluronic acid](https://lovi.care/skincare/uk/ingredients/hexapeptide-and-hyaluronic-acid)
- Depends on the strength: [Niacinamide and hexapeptide](https://lovi.care/skincare/uk/ingredients/niacinamide-and-hexapeptide)
- Work well together: [Panthenol and hexapeptide](https://lovi.care/skincare/uk/ingredients/panthenol-and-hexapeptide)
- Work well together: [Bakuchiol and hexapeptide](https://lovi.care/skincare/uk/ingredients/bakuchiol-and-hexapeptide)
- Work well together: [Hexapeptide and arginine](https://lovi.care/skincare/uk/ingredients/hexapeptide-and-arginine)
- Work well together: [Hexapeptide and GABA](https://lovi.care/skincare/uk/ingredients/hexapeptide-and-gaba)
- Work well together: [Hexapeptide and silk amino acids](https://lovi.care/skincare/uk/ingredients/hexapeptide-and-silk-amino-acids)
- Work well together: [Hexapeptide and taurine](https://lovi.care/skincare/uk/ingredients/hexapeptide-and-taurine)
- Work well together: [Hexapeptide and theanine](https://lovi.care/skincare/uk/ingredients/hexapeptide-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and hexapeptide](https://lovi.care/skincare/uk/ingredients/aha-blend-glycolic-and-citric-acids-and-hexapeptide)
- Keep them apart: [Hexapeptide and citric acid](https://lovi.care/skincare/uk/ingredients/hexapeptide-and-citric-acid)
- Keep them apart: [Glycolic acid and hexapeptide](https://lovi.care/skincare/uk/ingredients/glycolic-acid-and-hexapeptide)
- Keep them apart: [Hexapeptide and lactic acid](https://lovi.care/skincare/uk/ingredients/hexapeptide-and-lactic-acid)
- Keep them apart: [Hexapeptide and mandelic acid](https://lovi.care/skincare/uk/ingredients/hexapeptide-and-mandelic-acid)
- Work well together: [Coenzyme Q10 and hexapeptide](https://lovi.care/skincare/uk/ingredients/coenzyme-q10-and-hexapeptide)
- Work well together: [Green tea and hexapeptide](https://lovi.care/skincare/uk/ingredients/green-tea-and-hexapeptide)
- Work well together: [Vitamin E and hexapeptide](https://lovi.care/skincare/uk/ingredients/vitamin-e-and-hexapeptide)
- Work well together: [Hexapeptide and beta-sitosterol](https://lovi.care/skincare/uk/ingredients/hexapeptide-and-beta-sitosterol)
- Work well together: [Ceramide-building complex and hexapeptide](https://lovi.care/skincare/uk/ingredients/ceramide-building-complex-and-hexapeptide)
- Work well together: [Hexapeptide and cholesterol](https://lovi.care/skincare/uk/ingredients/hexapeptide-and-cholesterol)
- Work well together: [Hexapeptide and phytosphingosine](https://lovi.care/skincare/uk/ingredients/hexapeptide-and-phytosphingosine)
- Work well together: [Hexapeptide and phytosterol](https://lovi.care/skincare/uk/ingredients/hexapeptide-and-phytosterol)
- Work well together: [Hexapeptide and squalene](https://lovi.care/skincare/uk/ingredients/hexapeptide-and-squalene)
- Work well together: [Hexapeptide and tri-ceramide complex](https://lovi.care/skincare/uk/ingredients/hexapeptide-and-tri-ceramide-complex)
- Keep them apart: [Salicylic acid and hexapeptide](https://lovi.care/skincare/uk/ingredients/salicylic-acid-and-hexapeptide)
- Keep them apart: [Hexapeptide and baking soda](https://lovi.care/skincare/uk/ingredients/hexapeptide-and-baking-soda)
- Keep them apart: [Hexapeptide and bleach](https://lovi.care/skincare/uk/ingredients/hexapeptide-and-bleach)
- Keep them apart: [Hexapeptide and potassium hydroxide](https://lovi.care/skincare/uk/ingredients/hexapeptide-and-potassium-hydroxide)
- Keep them apart: [Hexapeptide and behenyl alcohol](https://lovi.care/skincare/uk/ingredients/hexapeptide-and-behenyl-alcohol)
- Keep them apart: [Hexapeptide and isopropyl alcohol](https://lovi.care/skincare/uk/ingredients/hexapeptide-and-isopropyl-alcohol)
- Keep them apart: [Hexapeptide and polyvinyl alcohol](https://lovi.care/skincare/uk/ingredients/hexapeptide-and-polyvinyl-alcohol)
- Keep them apart: [Hexapeptide and copper](https://lovi.care/skincare/uk/ingredients/hexapeptide-and-copper)
- Keep them apart: [Hexapeptide and magnesium](https://lovi.care/skincare/uk/ingredients/hexapeptide-and-magnesium)
- Keep them apart: [Hexapeptide and zinc](https://lovi.care/skincare/uk/ingredients/hexapeptide-and-zinc)
- Keep them apart: [Hexapeptide and zinc sulfate](https://lovi.care/skincare/uk/ingredients/hexapeptide-and-zinc-sulfate)
- Keep them apart: [Benzoyl peroxide and hexapeptide](https://lovi.care/skincare/uk/ingredients/benzoyl-peroxide-and-hexapeptide)
- Keep them apart: [Azelaic acid and hexapeptide](https://lovi.care/skincare/uk/ingredients/azelaic-acid-and-hexapeptide)
- Keep them apart: [Hexapeptide and protease](https://lovi.care/skincare/uk/ingredients/hexapeptide-and-protease)
- Keep them apart: [Hexapeptide and superoxide dismutase](https://lovi.care/skincare/uk/ingredients/hexapeptide-and-superoxide-dismutase)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/hexapeptide-and-vitamin-a
- United Kingdom: https://lovi.care/skincare/uk/ingredients/hexapeptide-and-vitamin-a (this page)
- Ireland: https://lovi.care/skincare/ie/ingredients/hexapeptide-and-vitamin-a
- Germany: https://lovi.care/skincare/de/ingredients/hexapeptide-and-vitamin-a
- France: https://lovi.care/skincare/fr/ingredients/hexapeptide-and-vitamin-a
- Italy: https://lovi.care/skincare/it/ingredients/hexapeptide-and-vitamin-a
- Netherlands: https://lovi.care/skincare/nl/ingredients/hexapeptide-and-vitamin-a
- Spain: https://lovi.care/skincare/es/ingredients/hexapeptide-and-vitamin-a
- Canada: https://lovi.care/skincare/ca/ingredients/hexapeptide-and-vitamin-a
- Australia: https://lovi.care/skincare/au/ingredients/hexapeptide-and-vitamin-a
- Singapore: https://lovi.care/skincare/sg/ingredients/hexapeptide-and-vitamin-a
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/hexapeptide-and-vitamin-a
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/hexapeptide-and-vitamin-a