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Glycolic acid and hexapeptide

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Glycolic acid and hexapeptide: keep them apart

Keep them apart

Use them at different times of day, applying glycolic acid in the morning and hexapeptide at night, because acid ruins peptide strength. Glycolic acid breaks down hexapeptide bonds so the peptide stops working effectively on your skin. You can use an acid with a gentler strength or separate them into different routines.

Glycolic acid products

Hexapeptide products

Questions and answers

Can you use glycolic acid and hexapeptide together?

Keep glycolic acid and hexapeptide apart by using them in separate routines, such as morning and evening, because the low pH of glycolic acid may destabilize the peptide bonds and reduce their effectiveness.

Which goes first, glycolic acid or hexapeptide?

Keep glycolic acid and hexapeptide apart by using them in separate steps or routines, such as applying one in the morning and the other at night. Mixing them in the same routine may destabilize the peptide and reduce its effectiveness due to the low pH of the acid.

Are glycolic acid and hexapeptide good for sensitive skin?

Glycolic acid and hexapeptide should be kept apart in your routine because the low pH of glycolic acid may destabilize peptide bonds and reduce their effectiveness. Sensitive skin types should especially avoid combining them in the same routine, using them in separate steps or routines instead.

Research on glycolic acid and hexapeptide

Behind this pairing advice

Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sof铆a Perea P茅rez, MD, MSc

    Dr. Sof铆a Perea P茅rez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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