# Skinfix vs Sesderma

Page: https://lovi.care/skincare/uk/compare/skinfix-vs-sesderma

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

Skinfix and Sesderma are distinguished skincare brands rooted in clinical efficacy, with the Canadian line established in 2014 and the Spanish laboratory operating since 1989. Skinfix is beloved for its deeply nourishing moisturizers featuring rich, restorative ingredients, making it best suited for dry and sensitive skin, whereas Sesderma is beloved for its advanced [serums](https://lovi.care/skincare/uk/ingredients/serum) and botanical [extracts](https://lovi.care/skincare/uk/ingredients/extract) that best suit sensitive, hyperpigmented, and aging skin types. Both offer targeted solutions, such as the Barrier+ Triple Lipid-Peptide Cream for acne-prone skin from the former and the Azelac RU Serum for similar concerns from the latter, highlighting how they differ in product delivery while sharing a commitment to a balanced complexion.

Skinfix is a Canadian skincare brand founded in 2014 and owned by Skinfix Inc..

[beautymatter.com](https://beautymatter.com/articles/skinfix-lands-minority-investment-from-stride-consumer-partners) [cosmeticsbusiness.com](https://cosmeticsbusiness.com/skinfix-receives-investment-from-stride-consumer-partners--180630) [pitchbook.com](https://pitchbook.com/profiles/company/64084-06) [tracxn.com](https://tracxn.com/d/companies/skinfix/__rnqx6Hpl126uCbS_SdRXV6LT-3OGmp-eFlZic9k9aZ0)

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

[skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html)

This page compares some of the most popular Skinfix and Sesderma products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pgaa00a9fcf5).

### Popular Skinfix vs Sesderma products

#### Skinfix

- [Barrier+ Triple Lipid-Peptide Cream](https://lovi.care/skincare/uk/p/skinfix/barrier-triple-lipid-peptide-cream/for/dry-sensitive-skin) — High fit

#### Sesderma

- [Azelac RU Serum](https://lovi.care/skincare/uk/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit — [£26.27 at Amazon](https://www.amazon.co.uk/dp/B00987RKWW?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)

## Questions and answers

### Skinfix or Sesderma: which is better?

Skinfix is a better fit for dry sensitive skin, as Lovi rates its products High for that skin type, whereas Sesderma rates Low. Every product on this page from Skinfix lists no fragrance, while Sesderma includes fragrance.

### What is the difference between Skinfix and Sesderma?

Skinfix was founded in 2014 in Canada, whereas Sesderma was founded in 1989 in Spain. Lovi gives the products on this page for Skinfix a High fit for dry, sensitive, mature, and sensitive skin, while Sesderma earns a High fit for acne-prone skin and skin with dark spots. Additionally, every product on this page for Skinfix lists no fragrance, while Sesderma includes fragrance in its [serum](https://lovi.care/skincare/uk/ingredients/serum).

### Which is more affordable, Skinfix or Sesderma?

The provided page facts do not include pricing information, so it is not possible to determine whether Skinfix or Sesderma is more affordable based on this page.

### Which causes fewer breakouts, Skinfix or Sesderma?

Skinfix earns an Average fit from Lovi for oily acne-prone skin, while Sesderma receives a High fit for acne-prone skin because of its serum. Every product on the Skinfix page lists no fragrance, whereas the Sesderma serum contains fragrance.

### Which brand is older, Skinfix or Sesderma, and where were they founded?

Sesderma is the older brand, having been founded in Spain in 1989, while Skinfix was founded later in Canada in 2014.

### Do Skinfix products contain fragrance compared to Sesderma?

Skinfix products on this page list no fragrance in their ingredients, whereas the Sesderma product contains fragrance. Therefore, shoppers looking to avoid fragrance will find that Skinfix is the better option.

### Which brand offers a moisturizer versus a serum on this page?

Skinfix offers a moisturizer on this page, while Sesderma offers a serum. Lovi gives the Skinfix moisturizer a High fit for dry and sensitive skin, and the Sesderma serum a High fit for acne-prone skin and skin with dark spots.

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Panthenol · American Journal of Clinical Dermatology, 2002
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004
- [Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin](https://pubmed.ncbi.nlm.nih.gov/18492182/) Peptide complex · International Journal of Cosmetic Science, 2005
- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [Alteration of barrier properties, stratum corneum ceramides and microbiome composition in response to lotion application on cosmetic dry skin](https://pubmed.ncbi.nlm.nih.gov/35340018/) Ceramides · Scientific Reports, 2022
- [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021
- [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Panthenol · The Journal of Dermatological Treatment, 2017
- [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024
- [A randomized controlled trial to compare the effectiveness and safety of adsorbent lotion containing tapioca starch, spent grain wax, Butyrospermum parkii extract, argania spinosa kernel oil, aloe barbadensis, rosehip oil, and allantoin with a low-potency topical corticosteroid in the treatment of intertrigo](https://pubmed.ncbi.nlm.nih.gov/33811776/) Shea butter · Journal of Cosmetic Dermatology, 2022
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Panthenol · Journal of Cosmetic Dermatology, 2025
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024
- [Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/41134387/) Shea butter · Lasers in Medical Science, 2025

## The brands

- Canadian skincare: [Skinfix](https://lovi.care/skincare/uk/brands/skinfix)
- Spanish skincare: [Sesderma](https://lovi.care/skincare/uk/brands/sesderma)

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## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/skinfix-vs-sesderma
- United Kingdom: https://lovi.care/skincare/uk/compare/skinfix-vs-sesderma (this page)
- Ireland: https://lovi.care/skincare/ie/compare/skinfix-vs-sesderma
- Germany: https://lovi.care/skincare/de/compare/skinfix-vs-sesderma
- France: https://lovi.care/skincare/fr/compare/skinfix-vs-sesderma
- Italy: https://lovi.care/skincare/it/compare/skinfix-vs-sesderma
- Netherlands: https://lovi.care/skincare/nl/compare/skinfix-vs-sesderma
- Spain: https://lovi.care/skincare/es/compare/skinfix-vs-sesderma
- Canada: https://lovi.care/skincare/ca/compare/skinfix-vs-sesderma
- Australia: https://lovi.care/skincare/au/compare/skinfix-vs-sesderma
- Singapore: https://lovi.care/skincare/sg/compare/skinfix-vs-sesderma
- Saudi Arabia: https://lovi.care/skincare/sa/compare/skinfix-vs-sesderma
- United Arab Emirates: https://lovi.care/skincare/ae/compare/skinfix-vs-sesderma