# Sesderma vs Sebamed

Page: https://lovi.care/skincare/uk/compare/sesderma-vs-sebamed

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

Sesderma and Sebamed are well-regarded European skincare lines offering specialized solutions for various complexions. The Spanish brand relies on botanical [extracts](https://lovi.care/skincare/uk/ingredients/extract) and active compounds within advanced [serums](https://lovi.care/skincare/uk/ingredients/serum) to suit sensitive, hyperpigmented, and aging skin. Meanwhile, the German brand focuses on barrier health through thoughtful moisturizers and gentle cleansers that suit sensitive, reactive, and problematic skin. Ultimately, the two differ in their core formulations, as the former utilizes meticulously engineered formulas while the latter maintains a skin-neutral pH.

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

[skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html)

Sebamed is a German skincare brand founded in 1967 and owned by Sebapharma GmbH & Co. KG.

[sebamed.ae](https://sebamed.ae/en/article/2/Sebapharma) [sebamed.com](https://sebamed.com/en/info/company/about-us/) [en.wikipedia.org](https://en.wikipedia.org/wiki/Sebamed) [de.wikipedia.org](https://de.wikipedia.org/wiki/Sebamed)

This page compares some of the most popular Sesderma and Sebamed products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg624a5abfaf).

### Popular Sesderma vs Sebamed products

#### Sesderma

- [Azelac RU Serum](https://lovi.care/skincare/uk/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit — [£26.27 at Amazon](https://www.amazon.co.uk/dp/B00987RKWW?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)

#### Sebamed

- [Clear Face Care Gel](https://lovi.care/skincare/uk/p/sebamed/clear-face-care-gel/for/oily-acne-prone-skin) — High fit — [£8.35 at Amazon](https://www.amazon.co.uk/dp/B003NTJJR0?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- [Facial Cleanser](https://lovi.care/skincare/uk/p/sebamed/facial-cleanser/for/combination-skin) — High fit

## Questions and answers

### Sesderma or Sebamed: which is better?

Both brands offer solid options, but Sebamed is better for fragrance-sensitive shoppers because the products on this page list no fragrance. Sesderma's Azelac RU [Serum](https://lovi.care/skincare/uk/ingredients/serum) holds a High fit for acne-prone skin and skin with dark spots, though it contains fragrance.

[Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/)

### What is the difference between Sesderma and Sebamed?

Sebamed offers fragrance-free formulas with products on this page reaching a High Lovi fit for oily and acne-prone skin, whereas Sesderma includes fragrance in its Azelac RU Serum which achieves a High fit for acne-prone, dark spots, and combination skin.

### Which is more affordable, Sesderma or Sebamed?

I am sorry, but the provided page facts and studies do not contain information about the pricing or affordability of Sesderma and Sebamed products.

### Which causes fewer breakouts, Sesderma or Sebamed?

Sebamed's products on this page have a High Lovi fit for oily acne-prone skin, whereas Sesderma's Azelac RU Serum has an Average fit for that skin type. Sebamed also has no fragrance across its products on this page, which helps prevent irritation.

### Which brand is older and where was each founded?

Sebamed is older, having been founded in Germany in 1967, whereas Sesderma was founded in Spain in 1989.

### Do Sesderma and Sebamed products contain fragrance?

Sebamed products on this page list no fragrance in their ingredients, whereas the Sesderma product contains fragrance. Azelac RU Serum by Sesderma includes fragrance.

### Which skin types are best suited for the Azelac RU Serum by Sesderma?

For acne-prone skin, skin with dark spots, and combination skin, the Azelac RU Serum by Sesderma achieves a High fit level on Lovi. For oily skin, oily acne-prone skin, sensitive skin, and mature skin, it earns an Average fit level.

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Sodium hyaluronate · Dermatologic Therapy, 2022
- [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Panthenol · American Journal of Clinical Dermatology, 2002
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004
- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [The effects of a topical gel containing chitosan, 0,2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower third molar extraction](https://pubmed.ncbi.nlm.nih.gov/27475700/) Allantoin · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016
- [Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations](https://pubmed.ncbi.nlm.nih.gov/30588129/) Aloe barbadensis leaf juice · Clinical Pharmacology, 2018
- [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021
- [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Panthenol · The Journal of Dermatological Treatment, 2017
- [Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial](https://pubmed.ncbi.nlm.nih.gov/32683390/) Allantoin · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020
- [High molecular compounds (polysaccharides and proanthocyanidins) from Hamamelis virginiana bark: influence on human skin keratinocyte proliferation and differentiation and influence on irritated skin](https://pubmed.ncbi.nlm.nih.gov/11684194/) Witch hazel bark extract · Phytochemistry, 2001
- [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024
- [Effect of seasonal and geographical differences on skin and effect of treatment with an osmoprotectant: Sorbitol](https://pubmed.ncbi.nlm.nih.gov/23752031/) Sorbitol · Journal of Cosmetic Science, 2013
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Panthenol · Journal of Cosmetic Dermatology, 2025
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024

## The brands

- Spanish skincare: [Sesderma](https://lovi.care/skincare/uk/brands/sesderma)
- German skincare: [Sebamed](https://lovi.care/skincare/uk/brands/sebamed)

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- [La Roche-Posay vs Sebamed](https://lovi.care/skincare/uk/compare/la-roche-posay-vs-sebamed)
- [Dr. Althea vs Sesderma](https://lovi.care/skincare/uk/compare/dr-althea-vs-sesderma)
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## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/sesderma-vs-sebamed
- United Kingdom: https://lovi.care/skincare/uk/compare/sesderma-vs-sebamed (this page)
- Ireland: https://lovi.care/skincare/ie/compare/sesderma-vs-sebamed
- Germany: https://lovi.care/skincare/de/compare/sesderma-vs-sebamed
- France: https://lovi.care/skincare/fr/compare/sesderma-vs-sebamed
- Italy: https://lovi.care/skincare/it/compare/sesderma-vs-sebamed
- Netherlands: https://lovi.care/skincare/nl/compare/sesderma-vs-sebamed
- Spain: https://lovi.care/skincare/es/compare/sesderma-vs-sebamed
- Canada: https://lovi.care/skincare/ca/compare/sesderma-vs-sebamed
- Australia: https://lovi.care/skincare/au/compare/sesderma-vs-sebamed
- Singapore: https://lovi.care/skincare/sg/compare/sesderma-vs-sebamed
- Saudi Arabia: https://lovi.care/skincare/sa/compare/sesderma-vs-sebamed
- United Arab Emirates: https://lovi.care/skincare/ae/compare/sesderma-vs-sebamed