# Sesderma vs Mesoestetic

Page: https://lovi.care/skincare/uk/compare/sesderma-vs-mesoestetic

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

Sesderma and Mesoestetic are celebrated Spanish skincare brands established in the nineteen-eighties that offer advanced [serums](https://lovi.care/skincare/uk/ingredients/serum) and meticulously engineered formulas to elevate daily routines. Sesderma is beloved for its botanical [extracts](https://lovi.care/skincare/uk/ingredients/extract) and active compounds that suit sensitive, hyperpigmented, and aging skin types best, featuring standout solutions like the Azelac RU Serum for acne-prone skin. Mesoestetic is prized for its gentle yet rigorous composition that best suits mature, sensitive, and uneven skin, featuring precise treatments like the Cosmelan 2 for blemishes. While both refine skin texture and promote a radiant complexion, they differ through their distinct heritage and specific active formulations.

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

[skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html)

Mesoestetic is a Spanish skincare brand founded in 1984 and owned by Mesoestetic Pharma Group, S.L..

[mesoestetic.com](https://www.mesoestetic.com/about-us) [tracxn.com](https://tracxn.com/d/companies/mesoestetic/__1eAnF7uALQzHII_So8HqZbHfSUJuilusj9hTisrG0tk)

This page compares some of the most popular Sesderma and Mesoestetic products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg4d6ed0b2f3).

### Popular Sesderma vs Mesoestetic products

#### Sesderma

- [Azelac RU Serum](https://lovi.care/skincare/uk/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit — [£26.27 at Amazon](https://www.amazon.co.uk/dp/B00987RKWW?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)

#### Mesoestetic

- [Cosmelan 2](https://lovi.care/skincare/uk/p/mesoestetic/cosmelan-2/for/acne-prone-skin) — Average fit

### Sesderma vs Mesoestetic [serums](https://lovi.care/skincare/uk/ingredients/serum) and treatments

#### Sesderma

- [Azelac RU Serum](https://lovi.care/skincare/uk/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit — [£26.27 at Amazon](https://www.amazon.co.uk/dp/B00987RKWW?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)

#### Mesoestetic

- [Cosmelan 2](https://lovi.care/skincare/uk/p/mesoestetic/cosmelan-2/for/acne-prone-skin) — Average fit

## Questions and answers

### Sesderma or Mesoestetic: which is better?

For skin with dark spots, Lovi gives Sesderma's Azelac RU [Serum](https://lovi.care/skincare/uk/ingredients/serum) a High fit and Mesoestetic's Cosmelan 2 an Average fit. [Azelaic acid](https://lovi.care/skincare/uk/ingredients/azelaic-acid) helps reduce acne vulgaris. [Niacinamide](https://lovi.care/skincare/uk/ingredients/niacinamide) helps reduce cutaneous pigmentation.

[Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/) [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### What is the difference between Sesderma and Mesoestetic?

For skin with dark spots, the products on this page by Sesderma achieve a High Lovi fit level, whereas Mesoestetic achieves an Average fit level. Sesderma's Azelac RU Serum on this page lists fragrance in its ingredients, while Mesoestetic's product lists no fragrance.

### Which is more affordable, Sesderma or Mesoestetic?

Neither Sesderma nor Mesoestetic is described on this page regarding affordability, as pricing information is not provided for either brand.

### Which causes fewer breakouts, Sesderma or Mesoestetic?

For acne-prone skin, Lovi rates Sesderma's Azelac RU Serum as High, while Mesoestetic's Cosmelan 2 has an Average fit. Azelaic acid helps manage acne vulgaris.

[Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/)

### When were Sesderma and Mesoestetic each founded and in which country?

Sesderma was founded in 1989 in Spain, and Mesoestetic was founded in 1984 also in Spain.

### Which brand has fragrance listed in its products on this page?

Sesderma has fragrance listed in its products on this page, as its Azelac RU Serum contains fragrance, whereas Mesoestetic lists no fragrance in the ingredients of its products on this page.

### How does the Lovi fit level for dark spots compare between Sesderma's Azelac RU Serum and Mesoestetic's Cosmelan 2?

For skin with dark spots, Sesderma's Azelac RU Serum achieves a High Lovi fit level, whereas Mesoestetic's Cosmelan 2 has an Average fit level.

[The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/) [Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/)

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004
- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations](https://pubmed.ncbi.nlm.nih.gov/30588129/) Aloe barbadensis leaf juice · Clinical Pharmacology, 2018
- [Tailoring of Retinyl Palmitate-Based Ethosomal Hydrogel as a Novel Nanoplatform for Acne Vulgaris Management: Fabrication, Optimization, and Clinical Evaluation Employing a Split-Face Comparative Study](https://pubmed.ncbi.nlm.nih.gov/34211271/) Retinyl palmitate · International Journal of Nanomedicine, 2021
- [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021
- [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population](https://pubmed.ncbi.nlm.nih.gov/33150170/) Salicylic acid · BioMed Research International, 2020
- [Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study](https://pubmed.ncbi.nlm.nih.gov/37941097/) Salicylic acid · Journal of Cosmetic Dermatology, 2024
- [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024
- [A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide](https://pubmed.ncbi.nlm.nih.gov/38051857/) Salicylic acid · Journal of Drugs in Dermatology, 2023
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024

## The brands

- Spanish skincare: [Sesderma](https://lovi.care/skincare/uk/brands/sesderma)
- Spanish skincare: [Mesoestetic](https://lovi.care/skincare/uk/brands/mesoestetic)

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## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/sesderma-vs-mesoestetic
- United Kingdom: https://lovi.care/skincare/uk/compare/sesderma-vs-mesoestetic (this page)
- Ireland: https://lovi.care/skincare/ie/compare/sesderma-vs-mesoestetic
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