# ISDIN vs Grown Alchemist

Page: https://lovi.care/skincare/uk/compare/isdin-vs-grown-alchemist

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

ISDIN and Grown Alchemist are distinct skincare brands offering expert preparations that consistently support daily skin health and comfort. The Spanish company, founded in 1975 and owned by Puig, is beloved for sophisticated moisturizers, advanced sunscreens, targeted [serums](https://lovi.care/skincare/uk/ingredients/serum), and soothing eye products driven by meticulously crafted formulas, while the second brand is loved for its cleansers, serums, and other formulas. Both suit sensitive skin and dry skin best, providing gentle and nourishing care, though Grown Alchemist also suits combination skin. They differ in their standout solutions, with ISDIN offering Fusion [Water](https://lovi.care/skincare/uk/ingredients/water) for acne-prone skin, Eryfotona Actinica for skin with dark spots, and K-Ox Eyes for mature skin, whereas the other brand features the Hydra-Restore Cream Cleanser, Instant Smoothing Serum, and Gentle Gel Facial Cleanser for those respective concerns.

ISDIN is a Spanish skincare brand founded in 1975 and owned by Puig.

[puig.com](https://www.puig.com/en/newsroom/new-chapter-for-Isdin-Puig-to-assume-full-ownership/) [beautymatter.com](https://beautymatter.com/articles/puig-to-take-full-ownership-of-isdin-in-1-39-billion-deal) [uploads.puig.com](https://uploads.puig.com/uploads/Puig_NP_Sept_14_EN_fc21e2f47a.pdf)

This page compares some of the most popular ISDIN and Grown Alchemist products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pgcf8cb25c89).

### Popular ISDIN vs Grown Alchemist products

#### ISDIN

- [Eryfotona Actinica](https://lovi.care/skincare/uk/p/isdin/eryfotona-actinica/for/mature-skin) — Superior fit — [£29.20 at Amazon](https://www.amazon.co.uk/dp/B00D3HXWCK?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- [Fusion Water](https://lovi.care/skincare/uk/p/isdin/fusion-water/for/dry-sensitive-skin) — Superior fit — [£23.49 at Amazon](https://www.amazon.co.uk/dp/B00Z72U6JQ?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- [K-Ox Eyes](https://lovi.care/skincare/uk/p/isdin/k-ox-eyes/for/dry-skin) — High fit
- [Hyaluronic Concentrate](https://lovi.care/skincare/uk/p/isdin/hyaluronic-concentrate/for/sensitive-skin) — High fit
- [Hyaluronic Moisture](https://lovi.care/skincare/uk/p/isdin/hyaluronic-moisture/for/dry-sensitive-skin) — Average fit
- [Flavo-C Serum](https://lovi.care/skincare/uk/p/isdin/flavo-c-serum/for/sensitive-skin) — High fit — [£38.90 at Amazon](https://www.amazon.co.uk/dp/B01BMLQ086?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- [Uradin Lotion 10](https://lovi.care/skincare/uk/p/isdin/uradin-lotion-10/for/dry-skin) — High fit
- [Retinal Intense Serum](https://lovi.care/skincare/uk/p/isdin/retinal-intense-serum/for/acne-prone-skin) — High fit — [£71.32 at Amazon](https://www.amazon.co.uk/dp/B0BD9DK6SC?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)

#### Grown Alchemist

- [Gentle Gel Facial Cleanser](https://lovi.care/skincare/uk/p/grown-alchemist/gentle-gel-facial-cleanser/for/dry-sensitive-skin) — Average fit
- [Hydra-Restore Cream Cleanser](https://lovi.care/skincare/uk/p/grown-alchemist/hydra-restore-cream-cleanser/for/sensitive-skin) — High fit — [£37.00 at Amazon](https://www.amazon.co.uk/dp/B00G3J8ISI?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- [Instant Smoothing Serum](https://lovi.care/skincare/uk/p/grown-alchemist/instant-smoothing-serum/for/dry-sensitive-skin) — Average fit

## People Say

ISDIN

Grown Alchemist

- Texture and finish Mostly Mentioned Mostly Mentioned “absorbs instantly — ISDIN Eryfotona Actinica” “ultra-light fluid product, which makes it super easy to apply — ISDIN Fusion Water” “Lightweight formula absorbs fast — ISDIN Hyaluronic Concentrate” “silkiest cleanser — Grown Alchemist Hydra-Restore Cream Cleanser”
- Sensitivity and gentleness Often Mentioned Mostly Mentioned “Sensitive/reactive skin tolerates — ISDIN Hyaluronic Moisture” “no excessive exfoliation — ISDIN Retinal Intense Serum” “Perfect for sensitive skin — Grown Alchemist Gentle Gel Facial Cleanser” “calms my skin down — Grown Alchemist Hydra-Restore Cream Cleanser”
- Hydration and plumping Often Mentioned Mostly Mentioned “Skin version of chugging water — Grown Alchemist Instant Smoothing Serum” “doesn't strip at all — Grown Alchemist Hydra-Restore Cream Cleanser” “Improved moisture and texture — ISDIN Hyaluronic Moisture”
- Cleansing experience Not noted Mostly Mentioned “Doesn't dry out my skin — Grown Alchemist Gentle Gel Facial Cleanser” “Gets everything nice and clean — Grown Alchemist Gentle Gel Facial Cleanser” “smell is divine — Grown Alchemist Hydra-Restore Cream Cleanser”
- Skin renewal and tone Sometimes Noted Sometimes Noted “My hyperpigmentation has lightened and skin looks more even, even shines more. — ISDIN Flavo-C Serum” “I am more on a dehydrated side and this helps me look hydrated and smooth. — ISDIN Flavo-C Serum” “Smooths out fine lines — Grown Alchemist Instant Smoothing Serum”
- Scent and appeal Rarely Noted Often Mentioned “Smells amazing — Grown Alchemist Gentle Gel Facial Cleanser” “Smells absolutely amazing — ISDIN Hyaluronic Concentrate”
- Price and value Often Mentioned Often Mentioned “very expensive — ISDIN Eryfotona Actinica” “My only wish is that ISDIN would make this product in a bigger size bottle. — ISDIN Fusion Water” “expensive for what it is — Grown Alchemist Hydra-Restore Cream Cleanser” “A bit pricey — Grown Alchemist Instant Smoothing Serum”
- Fragrance and scent Often Mentioned Often Mentioned “smell is overpowering — ISDIN Eryfotona Actinica” “lingering headache inducing effect — ISDIN K-Ox Eyes” “Too perfumy notes — Grown Alchemist Gentle Gel Facial Cleanser” “smells medicinal — Grown Alchemist Hydra-Restore Cream Cleanser”
- Packaging and dispensing Rarely Noted Often Mentioned “Pump stopped working — ISDIN Hyaluronic Concentrate” “I like the actual product, but the packaging is awful, I've already lost three bottles the applicator pops off. — ISDIN Flavo-C Serum” “tube cracks easily — Grown Alchemist Hydra-Restore Cream Cleanser”

## Questions and answers

### ISDIN or Grown Alchemist: which is better?

ISDIN and Grown Alchemist both perform well depending on your skin goals, with ISDIN standing out for its ultralight sunscreens and Grown Alchemist doing better for gentle cleansing and hydration. The products on this page from ISDIN are well-suited for sensitive, dry, and acne-prone skin types.

### What is the difference between ISDIN and Grown Alchemist?

ISDIN features ultralight sunscreens and a high price point, while Grown Alchemist offers hydrating and gentle cleansers that reviewers praise despite some packaging issues.

### Which is more affordable, ISDIN or Grown Alchemist?

When it comes to affordability, reviewers of ISDIN often note its high price point. Lovi rates price and value equally for both ISDIN and Grown Alchemist across the products on this page.

### Which causes fewer breakouts, ISDIN or Grown Alchemist?

When it comes to acne-prone skin, the products on this page from ISDIN fit acne-prone skin best, whereas Grown Alchemist's cleansers and [serums](https://lovi.care/skincare/uk/ingredients/serum) mostly have an average fit for it.

### Which brand was founded earlier, ISDIN or Grown Alchemist?

ISDIN was founded earlier in 1975 in Spain, whereas Grown Alchemist was founded later in 2008.

### How many ISDIN products on the page list no fragrance compared to Grown Alchemist?

For the products on this page, 3 of 8 ISDIN products list no fragrance compared to every Grown Alchemist product.

### What are the skin types that ISDIN fits best according to its brand-focused routines?

According to its brand-focused routines, ISDIN fits sensitive skin, dry skin, and acne-prone skin best.

## Research behind their key ingredients

- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Skin delivery of epigallocatechin-3-gallate (EGCG) and hyaluronic acid loaded nano-transfersomes for antioxidant and anti-aging effects in UV radiation induced skin damage](https://pubmed.ncbi.nlm.nih.gov/28155509/) Antioxidants · Drug Delivery, 2017
- [Final report on the safety assessment of Benzyl Alcohol, Benzoic Acid, and Sodium Benzoate](https://pubmed.ncbi.nlm.nih.gov/11766131/) Benzyl alcohol · International Journal of Toxicology, 2001
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Sodium hyaluronate molecule · Dermatologic Therapy, 2022
- [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Panthenol · American Journal of Clinical Dermatology, 2002
- [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Ascorbic acid, Tocopherol · Journal of Cosmetic Dermatology, 2020
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Bakuchiol · The British Journal of Dermatology, 2019
- [Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations](https://pubmed.ncbi.nlm.nih.gov/30588129/) Aloe barbadensis leaf extract · Clinical Pharmacology, 2018
- [Antiaging efficacy of melatonin-based day and night creams: a randomized, split-face, assessor-blinded proof-of-concept trial](https://pubmed.ncbi.nlm.nih.gov/29416368/) Melatonin · Clinical, Cosmetic and Investigational Dermatology, 2018
- [Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation](https://pubmed.ncbi.nlm.nih.gov/32052907/) Ascorbic acid · Journal of Cosmetic Dermatology, 2020
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Panthenol · The Journal of Dermatological Treatment, 2017
- [Stable Ozonides with Vitamin E Acetate versus Corticosteroid in the Treatment of Lichen Sclerosus in Foreskin: Evaluation of Effects on Inflammation](https://pubmed.ncbi.nlm.nih.gov/30991399/) Tocopheryl acetate · Urologia Internationalis, 2019
- [A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population](https://pubmed.ncbi.nlm.nih.gov/33150170/) Salicylic acid · BioMed Research International, 2020
- [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024
- [Efficacy of olive leaf extract-containing cream for facial rejuvenation: A pilot study](https://pubmed.ncbi.nlm.nih.gov/32333467/) Olive leaf extract · Journal of Cosmetic Dermatology, 2020
- [Biomimetic hyaluronic acid-stabilized zinc oxide nanoparticles in acne treatment: A preclinical and clinical approach](https://pubmed.ncbi.nlm.nih.gov/40254135/) Zinc oxide · Journal of Controlled Release, 2025
- [Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study](https://pubmed.ncbi.nlm.nih.gov/37941097/) Salicylic acid · Journal of Cosmetic Dermatology, 2024
- [Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications](https://pubmed.ncbi.nlm.nih.gov/25817264/) Palmitoyl tripeptide-1, Palmitoyl tetrapeptide-7 · Journal of Cosmetic Dermatology, 2015
- [A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide](https://pubmed.ncbi.nlm.nih.gov/38051857/) Salicylic acid · Journal of Drugs in Dermatology, 2023
- [Botulinum toxin injection as a single or combined treatment with non-cross-linked high molecular weight and low molecular weight hyaluronic acid gel for neck rejuvenation: A randomized clinical trial](https://pubmed.ncbi.nlm.nih.gov/35775872/) Hydrolyzed hyaluronic acid · Dermatologic Therapy, 2022
- [A Rose Extract Protects the Skin against Stress Mediators: A Potential Role of Olfactory Receptors](https://pubmed.ncbi.nlm.nih.gov/33081083/) Rose bud · Molecules, 2020
- [Is benzyl alcohol a significant contact sensitizer?](https://pubmed.ncbi.nlm.nih.gov/35080274/) Benzyl alcohol · Journal of the European Academy of Dermatology and Venereology, 2022
- [Effect of a botanical cleansing lotion on skin sebum and erythema of the face: A randomized controlled blinded half-side comparison](https://pubmed.ncbi.nlm.nih.gov/30022595/) Willow bark extract · Journal of Cosmetic Dermatology, 2019
- [Anti-Inflammatory Effect of a Novel Topical Herbal Composition (VEL-091604) Consisting of Gentian Root, Licorice Root and Willow Bark Extract](https://pubmed.ncbi.nlm.nih.gov/30690691/) Willow bark extract · Planta Medica, 2019
- [Noninvasive evaluation of the influence of aucubin-containing cosmetic macroemulsion on selected skin parameters](https://pubmed.ncbi.nlm.nih.gov/32750209/) Plantago extract · Journal of Cosmetic Dermatology, 2021
- [Comparison of methods for assessing photoprotection against ultraviolet A in vivo](https://pubmed.ncbi.nlm.nih.gov/3819071/) Butyl methoxydibenzoylmethane · Journal of the American Academy of Dermatology, 1987
- [Using ordered mesoporous silica SBA-15 to limit cutaneous penetration and transdermal permeation of organic UV filters](https://pubmed.ncbi.nlm.nih.gov/31437563/) Butyl methoxydibenzoylmethane · International Journal of Pharmaceutics, 2019
- [Topical Zinc Oxide Nanoparticle Formulations for Acne Vulgaris: A Systematic Review of Pre-Clinical and Early-Phase Clinical Evidence](https://pubmed.ncbi.nlm.nih.gov/41007718/) Zinc oxide · Biomedicines, 2025
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Enhancing Photoprotection and Mitigating Ex Vivo Stratum Corneum Oxidative Stress: A Multifunctional Strategy Combining Rosmarinic Acid with UVB Filters](https://pubmed.ncbi.nlm.nih.gov/40227214/) Octocrylene · Antioxidants, 2025
- [Rosa gallica and its active compound, cyanidin-3,5-O-diglucoside, improve skin hydration via the GLK signaling pathway](https://pubmed.ncbi.nlm.nih.gov/36573713/) Rose bud · BioFactors, 2023
- [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Panthenol · Journal of Cosmetic Dermatology, 2025
- [TiO2-embedded mesoporous silica with lower porosity is beneficial to adsorb the pollutants and retard UV filter absorption: A possible application for outdoor skin protection](https://pubmed.ncbi.nlm.nih.gov/36455708/) Butyl methoxydibenzoylmethane · European Journal of Pharmaceutical Sciences, 2023
- [Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study](https://pubmed.ncbi.nlm.nih.gov/40921777/) Hydrolyzed hyaluronic acid · Aesthetic Plastic Surgery, 2026
- [Ginkgo biloba leaves extract's cosmeceutical evaluation: a preliminary assessments on human volunteers towards achieving improved skin condition and rejuvenation](https://pubmed.ncbi.nlm.nih.gov/37074796/) Ginkgo biloba leaf extract · Drug Development and Industrial Pharmacy, 2023
- [Clinical efficacy of herbal extract cream on the skin hydration, elasticity, thickness, and dermis density for aged skin: A randomized controlled double-blind study](https://pubmed.ncbi.nlm.nih.gov/30636339/) Botanical extracts · Journal of Cosmetic Dermatology, 2019
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Nanocomplex of quaternized cyclodextrin grafted chitosan and hyaluronic acid for a skin delivery](https://pubmed.ncbi.nlm.nih.gov/36279763/) Hydrolyzed hyaluronic acid · Colloids and Surfaces. B, Biointerfaces, 2022
- [Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/37109405/) Caprylic capric triglyceride · Life, 2023
- [Influence of the emulsifier on nanostructure and clinical application of liquid crystalline emulsions](https://pubmed.ncbi.nlm.nih.gov/36918671/) Camellia seed oil · Scientific Reports, 2023
- [Development and efficacy assessments of tea seed oil makeup remover](https://pubmed.ncbi.nlm.nih.gov/27988044/) Camellia seed oil · Annales Pharmaceutiques Francaises, 2017
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [Facial disbiosis and UV filters](https://pubmed.ncbi.nlm.nih.gov/39499337/) Ethylhexyl salicylate · Archives of Dermatological Research, 2024
- [The clinical efficacy of a new emulsion for acne and conspicuous facial pore amelioration](https://pubmed.ncbi.nlm.nih.gov/38140770/) Lens esculenta seed extract · Journal of Cosmetic Dermatology, 2024
- [Effects of fermented tea seed oil on the skin lipid barrier and microbiome of sensitive skin](https://pubmed.ncbi.nlm.nih.gov/41319188/) Camellia seed oil · International Journal of Cosmetic Science, 2026
- [Retrospective Review of Dermal Safety Studies of Organic Sunscreens](https://pubmed.ncbi.nlm.nih.gov/40911743/) Ethylhexyl salicylate · Journal of Drugs in Dermatology, 2025
- [Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism](https://pubmed.ncbi.nlm.nih.gov/41527525/) Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2026
- [Mechanistic understanding and peptide ingredient screening for type III collagen via biological knowledge graph and molecular docking](https://pubmed.ncbi.nlm.nih.gov/42683869/) Palmitoyl tripeptide-1, Palmitoyl tetrapeptide-7 · International Journal of Cosmetic Science, 2026
- [Prospective, Randomized, Double-Blind Assessment of Supramolecular Bakuchiol and Terminalia Chebula Extract for Facial Photoaging in Chinese Sensitive Skin Population](https://pubmed.ncbi.nlm.nih.gov/41424674/) Bakuchiol · Health Science Reports, 2025

## The brands

- Spanish skincare: [ISDIN](https://lovi.care/skincare/uk/brands/isdin)
- Skincare: [Grown Alchemist](https://lovi.care/skincare/uk/brands/grown-alchemist)

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## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

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