# VT Cosmetics PDRN Essence 100 for combination skin

**Lovi Fit: High fit for combination skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/sg/p/vt-cosmetics/pdrn-essence-100/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Brand: [VT Cosmetics](https://lovi.care/skincare/sg/brands/vt-cosmetics)
Category: [Serums and treatments](https://lovi.care/skincare/sg/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best serums for combination skin.

## Why this fit

- Offers excellent skin regeneration for your combination skin, as PDRN Polydeoxyribonucleotide and Sodium Hyaluronate improve elasticity and hydration while Niacinamide helps regulate sebum production to address oily shine.
- The inclusion of Panthenol and Allantoin further supports skin soothing and barrier function, making it a well-rounded choice for your skin type.
- The safety profile is excellent, with no harsh ingredients and a focus on soothing components suitable for combination skin.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sg/p/vt-cosmetics/pdrn-essence-100/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/sg/p/vt-cosmetics/pdrn-essence-100/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/sg/p/vt-cosmetics/pdrn-essence-100/for/combination-skin): High (this page)
- [Sensitive skin](https://lovi.care/skincare/sg/p/vt-cosmetics/pdrn-essence-100/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/sg/p/vt-cosmetics/pdrn-essence-100/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/sg/p/vt-cosmetics/pdrn-essence-100/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/sg/p/vt-cosmetics/pdrn-essence-100/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/sg/p/vt-cosmetics/pdrn-essence-100/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/sg/p/vt-cosmetics/pdrn-essence-100/for/oily-acne-prone-skin): High

## Key ingredients

Pdrn Polydeoxyribonucleotide, Sodium Hyaluronate, Niacinamide, Adenosine

## What the research says

- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- Topical application of Low-Peony PDRN enhanced barrier recovery and improved periorbital skin elasticity in human subjects. ([International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/))
- Polydeoxyribonucleotide promotes skin regeneration by increasing ERK phosphorylation, collagen accumulation, and cell proliferation and migration in fibroblasts while inhibiting ERK phosphorylation and inflammatory cytokine expression in keratinocytes. ([Molecular Medicine Reports, 2023](https://pubmed.ncbi.nlm.nih.gov/37350391/))
- A topical mixture of polydeoxyribonucleotide, vitamin C, and niacinamide delivered via a microneedling therapy system decreased skin pigmentation and increased skin elasticity by attenuating melanogenesis and the destruction of collagen and elastin fibers in a UV-B-radiated animal model. ([Molecules, 2022](https://pubmed.ncbi.nlm.nih.gov/35209068/))
- Plant-derived polydeoxyribonucleotide from Panax ginseng promoted skin wound healing and enhanced the skin barrier by stimulating keratinocyte and fibroblast proliferation in skin cells and an artificial skin model. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37959659/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))

## What reviewers say

Based on a very large amount of data, users with dry, sensitive, and combination skin highly praise this essence for its ability to deliver a glass skin finish and deep hydration without irritation. It is widely celebrated for restoring compromised barriers and plumping fine lines. A minority of users with oily skin find the texture too heavy or tacky.

- Liked: Hydration and glow (mostly mentioned)
- Liked: Soothing and repair (often mentioned)
- Liked: Fragrance-free (sometimes noted)
- Liked: Good texture (sometimes noted)
- Disliked: Sticky finish (sometimes noted)
- Liked: Nice packaging (rarely noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Expensive price (rarely noted)
- Disliked: Pump design (rarely noted)
- Disliked: Texture issues (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes VT COSMETICS PDRN Essence 100 a great fit for combination skin?

VT COSMETICS PDRN Essence 100 is a great fit for combination skin because PDRN Polydeoxyribonucleotide and Sodium Hyaluronate improve elasticity and hydration while Niacinamide helps control oily shine. Panthenol and Allantoin further calm your skin and support its barrier, making it a well-rounded choice with a very safe and gentle formula.
Sources: [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/), [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/)

### Which ingredients make this treatment a good fit for combination skin?

This treatment is a great fit for your combination skin because PDRN Polydeoxyribonucleotide and Sodium Hyaluronate improve elasticity and hydration while Niacinamide helps control oily shine. Panthenol and Allantoin also support soothing and barrier function to keep your skin balanced.
Sources: [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/), [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/)

### What does PDRN do for combination skin?

PDRN helps balance combination skin by supporting skin barrier recovery and keeping moisture steady across dry and oily areas. It may also improve skin elasticity and promote skin regeneration with a low likelihood of side effects.
Sources: [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/), [Regenerative Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32757710/)

### What does Hyaluronic Acid do for combination skin?

Hyaluronic acid is a great fit for combination skin because it quenches dry areas with a boost of hydration while keeping oily zones balanced. Regular use helps smooth out fine lines and makes your skin feel soft and plump without causing irritation.
Sources: [Dermatology and Therapy, 2021](https://pubmed.ncbi.nlm.nih.gov/34176098/), [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/)

### Where does this treatment go in a skincare routine for combination skin?

This treatment goes in your evening routine, applied after cleansing and toning and before your moisturizer. Putting it in the evening keeps things simple and provides extra safety around sun exposure, while soothing components and niacinamide help balance combination skin.

### Can I use this treatment with retinol, and in what order?

You can use this treatment with retinol by applying the treatment first in your evening routine, allowing it to absorb before applying your retinol. This approach helps support skin soothing and barrier function while managing potential dryness or irritation from the retinol.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/)

### How often should I use this treatment?

This treatment is a great fit for your combination skin and is used in the evening routine. It helps keep your skin soft and calm while supporting hydration and elasticity with very low risk of irritation.
Sources: [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/), [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/)

### Can this treatment clog pores, cause breakouts or purging for combination skin?

This treatment is unlikely to cause breakouts for combination skin, as it features a safe formula focused on soothing components with a low complaint rate for causing blemishes. Pdrn Polydeoxyribonucleotide and Sodium Hyaluronate help keep your skin smooth and balanced without heavy oils.
Sources: [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Is this treatment fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for combination skin

- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/sg/p/skin1004/probio-cica-intensive-ampoule/for/combination-skin) — High fit — S$28.55 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vitamin-c-serum/for/combination-skin) — High fit — S$50.41 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vita-c-serum/for/combination-skin) — High fit — S$50.41 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/sg/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — S$30.00 at Amazon
- Hydrating Toner: [Whamisa Organic Flowers Toner Deep Rich](https://lovi.care/skincare/sg/p/whamisa/organic-flowers-toner-deep-rich/for/combination-skin) — Superior fit — S$64.81 at Amazon
- SPF: [CeraVe AM Facial Moisturizing Lotion](https://lovi.care/skincare/sg/p/cerave/am-facial-moisturizing-lotion-spf-30/for/combination-skin) — Superior fit — S$28.72 at Amazon

## Where to buy

- Amazon.sg: S$45.93 (https://www.amazon.sg/dp/B0CRKPZ9PQ?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
Prices checked 4 Nov 2026.

## Ingredients

Water, Pdrn Polydeoxyribonucleotide, Sodium Hyaluronate, Glycerin, Butylene Glycol, Niacinamide, Panthenol, Allantoin, Adenosine, Betaine, Phenoxyethanol, Ethylhexylglycerin, Carbomer, Triethanolamine
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/vt-cosmetics/pdrn-essence-100/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/vt-cosmetics/pdrn-essence-100/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/vt-cosmetics/pdrn-essence-100/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/vt-cosmetics/pdrn-essence-100/for/combination-skin
- France: https://lovi.care/skincare/fr/p/vt-cosmetics/pdrn-essence-100/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/vt-cosmetics/pdrn-essence-100/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/vt-cosmetics/pdrn-essence-100/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/vt-cosmetics/pdrn-essence-100/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/vt-cosmetics/pdrn-essence-100/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/vt-cosmetics/pdrn-essence-100/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/vt-cosmetics/pdrn-essence-100/for/combination-skin (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/p/vt-cosmetics/pdrn-essence-100/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/vt-cosmetics/pdrn-essence-100/for/combination-skin