THE HISTORY OF WHOO Cheongidan Hwahyun Gold Ampule for skin with dark spots

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Questions and answers

What the research says

• Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer.

  The British Journal of Dermatology, 2002

• Ginsenoside Rf inhibited Forskolin- or UV-stimulated melanogenesis, downregulating cellular tyrosinase activity and the expression of MITF, tyrosinase, and Tyrps in melanocytes and ex vivo human skin by mitigating PKA activity and CREB phosphorylation.

  Journal of Ginseng Research, 2021

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Enzyme-modified ginseng extract cream significantly reduced the global photo-damage score and various roughness measures including total roughness, smoothness depth, and arithmetic roughness average compared to placebo in 23 human subjects.

  Rejuvenation Research, 2015

• A red ginseng hydrogel formulation with 1,2-hexanediol promoted selective growth of Staphylococcus epidermidis and decreased Cutibacterium acnes in 20 female subjects.

  Journal of Ginseng Research, 2022

• A 1% fermented black ginseng cream significantly reduced eye wrinkles and brightened skin color in twenty-three human subjects compared to control cream and baseline.

  Journal of Toxicology and Environmental Health. Part A, 2020

• Partially purified paeoniflorin protected human keratinocytes and mouse skin from UV-induced DNA damage and reduced facial wrinkles in human volunteers.

  Journal of Cosmetic Science, 2006

• Paeonia suffruticosa callus extract downregulated inflammatory factors, alleviated DNA damage, and increased total collagen content in in vitro and in vivo evaluations.

  International Journal of Cosmetic Science, 2025

• Topical application of Paeonia lactiflora root extract and paeoniflorin significantly decreases melanin content by 23% to 30% in reconstructed pigmented human epidermis compared to vehicle control.

  International Journal of Cosmetic Science, 2016

• Topical green tea and green tea plus lotus multiple emulsions reduced casual sebum secretions compared to placebo in healthy adults, with the combined treatment producing significantly greater reductions than green tea alone over a 60-day period.

  Hippokratia, 2013

• Combined topical application of lotus and green tea improved facial skin surface parameters including roughness, scaliness, smoothness, and wrinkling in healthy Asian men compared to single treatments and placebo.

  Rejuvenation Research, 2013

• Cosmetics containing lotus-derived callus extract showed a significant skin-whitening effect in 21 volunteers.

  Plants, 2023

• Topically delivered gold-coated silica microparticles combined with laser pulses reduced inflammatory lesions compared with sham treatments in patients with moderate-to-severe facial acne.

  The Journal of Investigative Dermatology, 2015

• Laser-activated gold microparticles combined with topical retinoids reduced inflammatory lesion counts by 68% at month 12 in 52 patients with mild-to-moderate inflammatory facial acne.

  Journal of Drugs in Dermatology, 2023

• Combined treatment with a micro-diamond and micro-gold topical serum and a 1064 nm picosecond Nd:YAG laser produced moderate clinical improvement and high participant satisfaction in 40% of participants for facial skin rejuvenation with minimal side effects.

  Dermatologic Therapy, 2022

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

Ingredients

Panax Ginseng Extract, Nelumbo Nucifera Flower Extract, Gold, Angelica Archangelica Root Extract, Rehmannia Root Extract, Paeonia Albiflora Root Extract, Licorice Root Extract, Honey, Adenosine, Niacinamide, Squalane, Sodium Hyaluronate, Glycerin, Butylene Glycol, Water

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.