# SkinMedica TNS Advanced+ Serum for sensitive skin

**Lovi Fit: Average fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/sg/p/skinmedica/tns-advanced-serum/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Brand: [SkinMedica](https://lovi.care/skincare/sg/brands/skinmedica)
Category: [Serums and treatments](https://lovi.care/skincare/sg/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for sensitive skin; other serums fit it better.

## Why this fit

- Offers moderate benefits for your normal skin, as Human Fibroblast Conditioned Media and Whey Protein support collagen stimulation and barrier repair, while Glycerin and Saccharide Isomerate provide essential hydration beneficial for redness and irritation.
- The presence of Trifluoroacetyl Tripeptide-2 and Vitis Vinifera Flower Cell Extract further aids in skin rejuvenation and texture improvement, complementing the overall soothing effects.
- The product is safe for your sensitive skin, with no harsh or prohibited ingredients identified that would cause irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sg/p/skinmedica/tns-advanced-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/sg/p/skinmedica/tns-advanced-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/sg/p/skinmedica/tns-advanced-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/sg/p/skinmedica/tns-advanced-serum/for/sensitive-skin): Average (this page)
- [Acne-prone skin](https://lovi.care/skincare/sg/p/skinmedica/tns-advanced-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/sg/p/skinmedica/tns-advanced-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/sg/p/skinmedica/tns-advanced-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/sg/p/skinmedica/tns-advanced-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/sg/p/skinmedica/tns-advanced-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Human Fibroblast Conditioned Media, Collagen Peptides, Trifluoroacetyl Tripeptide-2, Glycerin, Vitis Vinifera Flower Cell Extract Grape Flower Cell Extract

## What the research says

- A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events. ([Lasers in Medical Science, 2025](https://pubmed.ncbi.nlm.nih.gov/41134387/))
- A novel moisturizer containing saccharide isomerate accelerates skin barrier recovery, improves hydration, reduces erythema, and alleviates discomfort compared to a control moisturizer following intense pulsed light treatment in subjects with skin aging. ([The Journal of Dermatological Treatment, 2025](https://pubmed.ncbi.nlm.nih.gov/41211697/))
- Grape-derived exosome-like nanoparticles significantly reduce ultraviolet light damage and promote skin repair and regeneration in photoaged skin by modulating epithelial cell proliferation and differentiation. ([Journal of Food Science, 2025](https://pubmed.ncbi.nlm.nih.gov/40504599/))
- Pre-treatment with Vitis vinifera L. water extract (100 ΓΙg/mL) demonstrated antioxidant and scavenger activity against UV-A radiation and exerted an anti-mutagenic effect by maintaining apoptosis in UV-A and UV-B irradiated human keratinocytes (HaCaT). ([Journal of Photochemistry and Photobiology. B, Biology, 2020](https://pubmed.ncbi.nlm.nih.gov/32028189/))
- A liquid formulation containing hydrolyzed collagen demonstrated structural stability, peptide mass distribution between 0.5 and 19.5 kDa, and faded forehead wrinkles in five volunteers while proving to be non-irritating and hypoallergenic. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/32390321/))
- Exposure to collagen peptides increased the expression of COL1A1, ELN, and VCAN genes and collagen protein levels in cultured human dermal fibroblasts compared to untreated controls. ([Frontiers in Medicine, 2024](https://pubmed.ncbi.nlm.nih.gov/38751975/))
- Salmo salar and Tilapia nilotica skin collagen peptides accelerate wound healing in a rat murine wound model by reducing proinflammatory cytokines, upregulating BD14, NOD2, IL-10, VEGF, and beta-FGF, and favorably altering wound microflora colonization compared to untreated controls. ([Journal of Agricultural and Food Chemistry, 2020](https://pubmed.ncbi.nlm.nih.gov/31967468/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))

## What reviewers say

Based on a very large amount of data, this serum is highly praised for its potent anti-aging benefits, specifically targeting coarse wrinkles, fine lines, and sagging skin to produce a firmer, more radiant complexion. Users frequently report visible improvements in skin texture and elasticity. However, the product's high price tag and recurring issues with its dual-chamber pump packaging are common points of frustration.

- Liked: Improves fine lines (mostly mentioned)
- Disliked: Very expensive price (mostly mentioned)
- Liked: Firms sagging skin (often mentioned)
- Liked: Smoothes skin texture (often mentioned)
- Disliked: Faulty pump dispenser (often mentioned)
- Liked: Safe for sensitive skin (sometimes noted)
- Disliked: Uneven product dispensing (sometimes noted)

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does SkinMedica TNS Advanced+ work for sensitive skin?

SkinMedica TNS Advanced+ Serum works decently for sensitive skin, offering moderate hydration and support for redness and irritation without causing adverse reactions. Treatments that fit sensitive skin better need calming ingredients like niacinamide and snail secretion filtrate to soothe the skin while keeping it comfortable.
Sources: [Lasers in Medical Science, 2025](https://pubmed.ncbi.nlm.nih.gov/41134387/), [The Journal of Dermatological Treatment, 2025](https://pubmed.ncbi.nlm.nih.gov/41211697/)

### Which ingredients make this serum a good fit for sensitive skin?

Glycerin and saccharide isomerate make this serum a good fit for sensitive skin because they provide essential hydration that helps calm redness and irritation, while supporting skin barrier recovery. To fit sensitive skin even better, a treatment of this type needs soothing ingredients like niacinamide and snail secretion filtrate to further calm irritation and support overall skin health.
Sources: [Lasers in Medical Science, 2025](https://pubmed.ncbi.nlm.nih.gov/41134387/), [The Journal of Dermatological Treatment, 2025](https://pubmed.ncbi.nlm.nih.gov/41211697/)

### What does Human Fibroblast Conditioned Media do for sensitive skin?

Human Fibroblast Conditioned Media helps support skin repair and encourages a calm, smooth feel on sensitive skin. It is unlikely to cause irritation, and studies suggest it aids in cell renewal and overall recovery.
Sources: [BioMed Research International, 2021](https://pubmed.ncbi.nlm.nih.gov/33937411/), [Regenerative Medicine, 2026](https://pubmed.ncbi.nlm.nih.gov/41784011/)

### What do Collagen Peptides do for sensitive skin?

Collagen peptides help improve hydration, elasticity, and barrier strength for sensitive skin. They may also support a calm, smooth feel by keeping the skin well-moisturized and reducing dryness.
Sources: [Skin Pharmacology and Physiology, 2021](https://pubmed.ncbi.nlm.nih.gov/33774639/), [Journal of Medicinal Food, 2022](https://pubmed.ncbi.nlm.nih.gov/36516059/)

### Where does this serum go in a skincare routine for sensitive skin?

This treatment serum goes in your evening routine after your soothing toner and before your moisturizer. Sensitive skin needs a product of this type that also includes soothing ingredients and gentle hydrators to calm redness and irritation.

### Can I use this serum with retinol, and in what order?

You can use this treatment with retinol by applying the retinol first at night, followed by this serum, to help keep sensitive skin calm and hydrated. This combination is generally well tolerated, though sensitive skin needs a product containing soothing ingredients like glycerin and calming plant extracts to keep the skin comfortable.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/)

### How often should I use this serum?

You can use this serum in your evening routine. A product of this type for sensitive skin needs soothing ingredients like glycerin and barrier-supporting peptides to provide hydration and calm redness without irritation.

### Can this serum clog pores, cause breakouts or purging for sensitive skin?

This serum is unlikely to clog pores or cause breakouts for sensitive skin, as it contains no harsh ingredients that typically trigger irritation. To work best for sensitive skin, this type of product needs soothing ingredients like glycerin and calming plant extracts to keep skin smooth and comfortable without heavy oils.
Sources: [Lasers in Medical Science, 2025](https://pubmed.ncbi.nlm.nih.gov/41134387/), [The Journal of Dermatological Treatment, 2025](https://pubmed.ncbi.nlm.nih.gov/41211697/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for sensitive skin

- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vitamin-c-serum/for/sensitive-skin) — High fit — S$50.41 at Amazon
- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/sg/p/skin1004/probio-cica-intensive-ampoule/for/sensitive-skin) — High fit — S$28.55 at Amazon
- [PCA Skin C&E Advanced with Hexylresorcinol and Silymarin](https://lovi.care/skincare/sg/p/pca-skin/c-and-e-advanced/for/sensitive-skin) — Average fit — S$192.38 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/sg/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — S$30.00 at Amazon
- Soothing Toner: [One Thing Centella Asiatica Extract Toner](https://lovi.care/skincare/sg/p/one-thing/centella-asiatica-extract-toner/for/sensitive-skin) — Superior fit — S$30.07 at Amazon
- Moisturizer with Sun Protection: [ISDIN Eryfotona Actinica SPF 50+](https://lovi.care/skincare/sg/p/isdin/eryfotona-actinica-spf-50/for/sensitive-skin) — Superior fit — S$110.01 at Amazon

## Where to buy

- Amazon.sg: S$451.54 (https://www.amazon.sg/dp/B07SCJ445R?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
Prices checked 3 Nov 2026.

## Ingredients

Water, Pentylene Glycol, Human Fibroblast Conditioned Media, Glycereth-7 Triacetate, Shea Ethyl Esters Butter, Glycerin, Ethoxydiglycol, Lactococcus Lysate Ferment, Whey Protein, Chlorella Vulgaris Extract, Saccharide Isomerate, Trifluoroacetyl Tripeptide-2, Dimer Tripeptide-43, Hydrolyzed Linseed Extract, Vitis Vinifera Flower Cell Extract Grape Flower Cell Extract, Pyrus Malus Fruit Extract, Hydroxyacetophenone, Tocopheryl Acetate, Propanediol, Xanthan Gum, Polyacrylate Crosspolymer-6, Polyacrylate-13, Polyisobutene, Sclerotium Gum, Peg-12 Dimethicone, Lecithin, Pullulan, Butylene Glycol, Sodium Citrate, Polysorbate 20, Aminomethyl Propanol, Dextran, Disodium Edta, Phenoxyethanol, Ethylhexylglycerin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/skinmedica/tns-advanced-serum/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/skinmedica/tns-advanced-serum/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/skinmedica/tns-advanced-serum/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/skinmedica/tns-advanced-serum/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/skinmedica/tns-advanced-serum/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/skinmedica/tns-advanced-serum/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/skinmedica/tns-advanced-serum/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/skinmedica/tns-advanced-serum/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/skinmedica/tns-advanced-serum/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/skinmedica/tns-advanced-serum/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/skinmedica/tns-advanced-serum/for/sensitive-skin (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/p/skinmedica/tns-advanced-serum/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/skinmedica/tns-advanced-serum/for/sensitive-skin