SkinMedica TNS Advanced+ Serum for sensitive skin
Human Fibroblast Conditioned Media
Collagen Peptides
Trifluoroacetyl Tripeptide-2
Glycerin
Vitis Vinifera Flower Cell Extract Grape Flower Cell Extract
Average
- HighNormal Skin Fit
- AverageEffectiveness
- HighSafety
Works for sensitive skin; other serums fit it better.
This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate benefits for your normal skin, as Human Fibroblast Conditioned Media and Whey Protein support collagen stimulation and barrier repair, while Glycerin and Saccharide Isomerate provide essential hydration beneficial for redness and irritation.
- The presence of Trifluoroacetyl Tripeptide-2 and Vitis Vinifera Flower Cell Extract further aids in skin rejuvenation and texture improvement, complementing the overall soothing effects.
- The product is safe for your sensitive skin, with no harsh or prohibited ingredients identified that would cause irritation.
How to apply
- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
People Say
★4.5Overall rating based on 5.2k+ reviewsBased on a very large amount of data, this serum is highly praised for its potent anti-aging benefits, specifically targeting coarse wrinkles, fine lines, and sagging skin to produce a firmer, more radiant complexion. Users frequently report visible improvements in skin texture and elasticity. However, the product's high price tag and recurring issues with its dual-chamber pump packaging are common points of frustration.
Highlights
Improves fine lines Mostly Mentioned
- “can make the world of difference in your fine lines and wrinkles”
- “deeper lines around my mouth lessened significantly”
- “notice an improvement in fines lines”
- “creases in my forehead became more shallow”
Very expensive price Mostly Mentioned
- “The price tag is steep”
- “Expensive but fast results!”
- “The price is ridiculous”
- “A lot of money for a flawed product”
Firms sagging skin Often Mentioned
- “my skin had much more elasticity”
- “feels firmer, stays well hydrated”
- “preventing/restoring sagging skin”
- “plumps and firms with zero irritation”
Smoothes skin texture Often Mentioned
- “My skin looks smoother”
- “enhanced skin texture and tone”
- “overall glow to my skin”
- “visibly softer skin and improved texture”
Faulty pump dispenser Often Mentioned
- “One of the pumps failed on me”
- “The pumps did not work properly”
- “faulty pump & other issues”
- “dual pump failure issue”
Safe for sensitive skin Sometimes Noted
- “anti aging treatment that works for sensitive skin”
- “enhanced my skin without causing irritation”
- “plumps and firms with zero irritation”
- “Safe for sensitive skin”
Uneven product dispensing Sometimes Noted
- “serum ran out before the cream that you mix it with”
- “never know whether I'm getting enough from each side”
- “only have the clear serum but not the white one coming out”
- “They didn't dispense evenly”
Sources: lovi.care, dermapproved.com, lovelyskin.com, ellemesmedspa.com, walmart.com, theskinspot.com, and more
Questions and answers
How well does SkinMedica TNS Advanced+ work for sensitive skin?
SkinMedica TNS Advanced+ Serum works decently for sensitive skin, offering moderate hydration and support for redness and irritation without causing adverse reactions. Treatments that fit sensitive skin better need calming ingredients like niacinamide and snail secretion filtrate to soothe the skin while keeping it comfortable.
Lasers in Medical Science, 2025The Journal of Dermatological Treatment, 2025
Which ingredients make this serum a good fit for sensitive skin?
Glycerin and saccharide isomerate make this serum a good fit for sensitive skin because they provide essential hydration that helps calm redness and irritation, while supporting skin barrier recovery. To fit sensitive skin even better, a treatment of this type needs soothing ingredients like niacinamide and snail secretion filtrate to further calm irritation and support overall skin health.
Lasers in Medical Science, 2025The Journal of Dermatological Treatment, 2025
What does Human Fibroblast Conditioned Media do for sensitive skin?
Human Fibroblast Conditioned Media helps support skin repair and encourages a calm, smooth feel on sensitive skin. It is unlikely to cause irritation, and studies suggest it aids in cell renewal and overall recovery.
BioMed Research International, 2021Regenerative Medicine, 2026
What do Collagen Peptides do for sensitive skin?
Collagen peptides help improve hydration, elasticity, and barrier strength for sensitive skin. They may also support a calm, smooth feel by keeping the skin well-moisturized and reducing dryness.
Skin Pharmacology and Physiology, 2021Journal of Medicinal Food, 2022
Where does this serum go in a skincare routine for sensitive skin?
This treatment serum goes in your evening routine after your soothing toner and before your moisturizer. Sensitive skin needs a product of this type that also includes soothing ingredients and gentle hydrators to calm redness and irritation.
Can I use this serum with retinol, and in what order?
You can use this treatment with retinol by applying the retinol first at night, followed by this serum, to help keep sensitive skin calm and hydrated. This combination is generally well tolerated, though sensitive skin needs a product containing soothing ingredients like glycerin and calming plant extracts to keep the skin comfortable.
How often should I use this serum?
You can use this serum in your evening routine. A product of this type for sensitive skin needs soothing ingredients like glycerin and barrier-supporting peptides to provide hydration and calm redness without irritation.
Can this serum clog pores, cause breakouts or purging for sensitive skin?
This serum is unlikely to clog pores or cause breakouts for sensitive skin, as it contains no harsh ingredients that typically trigger irritation. To work best for sensitive skin, this type of product needs soothing ingredients like glycerin and calming plant extracts to keep skin smooth and comfortable without heavy oils.
Lasers in Medical Science, 2025The Journal of Dermatological Treatment, 2025
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events.
Lasers in Medical Science, 2025A novel moisturizer containing saccharide isomerate accelerates skin barrier recovery, improves hydration, reduces erythema, and alleviates discomfort compared to a control moisturizer following intense pulsed light treatment in subjects with skin aging.
The Journal of Dermatological Treatment, 2025Grape-derived exosome-like nanoparticles significantly reduce ultraviolet light damage and promote skin repair and regeneration in photoaged skin by modulating epithelial cell proliferation and differentiation.
Journal of Food Science, 2025Pre-treatment with Vitis vinifera L. water extract (100 ΓΙg/mL) demonstrated antioxidant and scavenger activity against UV-A radiation and exerted an anti-mutagenic effect by maintaining apoptosis in UV-A and UV-B irradiated human keratinocytes (HaCaT).
Journal of Photochemistry and Photobiology. B, Biology, 2020A liquid formulation containing hydrolyzed collagen demonstrated structural stability, peptide mass distribution between 0.5 and 19.5 kDa, and faded forehead wrinkles in five volunteers while proving to be non-irritating and hypoallergenic.
Journal of Cosmetic Dermatology, 2021Exposure to collagen peptides increased the expression of COL1A1, ELN, and VCAN genes and collagen protein levels in cultured human dermal fibroblasts compared to untreated controls.
Frontiers in Medicine, 2024Salmo salar and Tilapia nilotica skin collagen peptides accelerate wound healing in a rat murine wound model by reducing proinflammatory cytokines, upregulating BD14, NOD2, IL-10, VEGF, and beta-FGF, and favorably altering wound microflora colonization compared to untreated controls.
Journal of Agricultural and Food Chemistry, 2020A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.
Journal of Cosmetic Dermatology, 2020Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.
International Journal of Cosmetic Science, 2001
Ingredients
Water, Pentylene Glycol, Human Fibroblast Conditioned Media, Glycereth-7 Triacetate, Shea Ethyl Esters Butter, Glycerin, Ethoxydiglycol, Lactococcus Lysate Ferment, Whey Protein, Chlorella Vulgaris Extract, Saccharide Isomerate, Trifluoroacetyl Tripeptide-2, Dimer Tripeptide-43, Hydrolyzed Linseed Extract, Vitis Vinifera Flower Cell Extract Grape Flower Cell Extract, Pyrus Malus Fruit Extract, Hydroxyacetophenone, Tocopheryl Acetate, Propanediol, Xanthan Gum, Polyacrylate Crosspolymer-6, Polyacrylate-13, Polyisobutene, Sclerotium Gum, Peg-12 Dimethicone, Lecithin, Pullulan, Butylene Glycol, Sodium Citrate, Polysorbate 20, Aminomethyl Propanol, Dextran, Disodium Edta, Phenoxyethanol, Ethylhexylglycerin
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
Scan your face, then any product: Lovi shows how well it fits you and what fits even better.