# SkinCeuticals P-TOX for dry sensitive skin

**Lovi Fit: High fit for dry sensitive skin.**
Dry Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/sg/p/skinceuticals/p-tox/for/dry-sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Brand: [SkinCeuticals](https://lovi.care/skincare/sg/brands/skinceuticals)
Category: [Serums and treatments](https://lovi.care/skincare/sg/best/serums)

This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for dry sensitive skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your dry and sensitive skin, the Advanced Peptide Complex and Hexapeptide work to stimulate collagen and repair your skin barrier, while PHA and Niacinamide offer gentle exfoliation and hydration.
- Laminaria Digitata Extract further supports skin hydration and barrier function, complementing the plumping and firming effects from the peptide blend.
- The formulation is safe for your skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sg/p/skinceuticals/p-tox/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/sg/p/skinceuticals/p-tox/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/sg/p/skinceuticals/p-tox/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/sg/p/skinceuticals/p-tox/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/sg/p/skinceuticals/p-tox/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/sg/p/skinceuticals/p-tox/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/sg/p/skinceuticals/p-tox/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/sg/p/skinceuticals/p-tox/for/dry-sensitive-skin): High (this page)
- [Oily acne-prone skin](https://lovi.care/skincare/sg/p/skinceuticals/p-tox/for/oily-acne-prone-skin): High

## Key ingredients

Advanced Peptide Complex, Hexapeptide, Niacinamide, Laminaria Digitata Extract

## What the research says

- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- A peptide complex stimulated basement membrane protein expressions and significantly improved skin wrinkles at all five measured sites after two weeks in 22 healthy Asian female volunteers older than 40 years. ([International Journal of Molecular Sciences, 2019](https://pubmed.ncbi.nlm.nih.gov/31861912/))
- A novel anti-aging serum containing acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate, gluconolactone, niacinamide, and laminaria extract significantly increased anti-aging biomarkers and improved static and dynamic wrinkles as well as skin quality in clinical studies. ([International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/41668671/))
- Postresurfacing use of a tripeptide/hexapeptide system improved healing, reduced erythema, exudation, tenderness, and burning/stinging, and increased subject satisfaction compared to a bland ointment and cream in 14 female subjects following facial laser resurfacing. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28371204/))
- Adding a tripeptide/hexapeptide anhydrous gel pre- and post-procedure to a topical body treatment significantly reduced patient-reported scores of skin edema, induration, and subcutaneous fibrous banding compared to the body treatment alone in 10 female patients undergoing neck and body contouring procedures. ([Aesthetic Surgery Journal. Open Forum, 2021](https://pubmed.ncbi.nlm.nih.gov/33791673/))
- Topical tripeptide/hexapeptide formulations (RSN and TFB) applied around medial thigh liposuction accelerated healing, reduced induration, edema, and fluid infiltration, and improved extracellular matrix remodeling compared to a bland moisturizer. ([Aesthetic Surgery Journal. Open Forum, 2021](https://pubmed.ncbi.nlm.nih.gov/33791675/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- A skincare regimen containing Macrocystis pyrifera ferment consisting of a cleansing foam, a serum, and a moisturizer decreases the visible effects of inflammation and aging while promoting healing and improving patient satisfaction. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38922798/))
- Macrocystis pyrifera ferment-containing creams decrease visible inflammation and signs of aging while enhancing barrier resilience and recovery. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/38041526/))
- Aqueous extracts from Macrocystis pyrifera and Durvillaea antarctica exhibited antiviral activity against acyclovir-sensitive and acyclovir-resistant HSV-1 and HSV-2, and topical formulations significantly reduced the severity and duration of HSV-1 skin lesions in an animal model compared to mock treatment and acyclovir. ([Frontiers in Microbiology, 2020](https://pubmed.ncbi.nlm.nih.gov/33013743/))

## What reviewers say

Based on a very large amount of data, this anti-aging peptide serum and cream duo is highly rated for targeting expression lines, deep-set wrinkles, and uneven skin texture. Users frequently report achieving a radiant, smooth, and hydrated complexion. Some users note that it may take time to see results on deeper wrinkles, and a few experienced breakouts. The high price point is also a common consideration.

- Liked: Smoother skin (mostly mentioned)
- Liked: Hydrating and light (often mentioned)
- Liked: Reduces lines (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Complements Botox (sometimes noted)
- Disliked: Slow results (sometimes noted)
- Disliked: Causes breakouts (rarely noted)

## How to apply

- Use this PM routine for your evening skincare. Start using the serum 3 times a week and increase to daily use if your skin feels comfortable.
- Apply the serum after cleansing and toner, but right before your moisturizer. This step locks in deep hydration for dry skin.
- Gently press 2-3 drops of the serum into your skin using your palms. Let it absorb completely for a minute ⏱ before applying your next product.
- Since your skin is sensitive, apply the serum on completely dry skin for better tolerance and less irritation.
- Avoid the sensitive eye area during application. Always do a patch test before your first use to ensure your skin reacts well.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes SkinCeuticals P-Tox a great fit for dry sensitive skin?

SkinCeuticals P-TOX is a great fit because its Advanced Peptide Complex and hexapeptide help repair your skin barrier, while PHA and niacinamide provide gentle hydration and smoothing without irritation. Laminaria Digitata Extract further supports moisture levels, keeping your dry skin soft and comfortable.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/)

### Which ingredients make this treatment a good fit for dry sensitive skin?

Advanced Peptide Complex and Hexapeptide make this treatment a great fit by repairing your skin barrier, while PHA and Niacinamide provide gentle hydration and smoothing benefits. Laminaria Digitata Extract also supports your skin's moisture barrier without causing irritation.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [International Journal of Molecular Sciences, 2019](https://pubmed.ncbi.nlm.nih.gov/31861912/)

### What does Peptide Complex do for dry sensitive skin?

A peptide complex helps smooth wrinkles and improve firmness, but for dry sensitive skin, it also needs soothing ingredients like ceramides and centella asiatica to calm irritation and repair the moisture barrier.
Sources: [International Journal of Molecular Sciences, 2019](https://pubmed.ncbi.nlm.nih.gov/31861912/), [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40682399/)

### What does Hexapeptide do for dry sensitive skin?

Hexapeptide helps smooth out wrinkles and keeps dry skin hydrated, though its low penetration can limit how well it works on its own. For dry sensitive skin, a product of this type needs extra soothing and deeply moisturizing ingredients to properly calm and nourish the skin.
Sources: [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/40565185/), [Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/)

### Where does this treatment go in a skincare routine for dry sensitive skin?

This treatment goes in your evening routine, applied after your soothing toner and before your moisturizer. Putting it at night helps keep things simple and safe around sun exposure, while peptides and niacinamide work to gently hydrate and repair your skin.

### Can I use this treatment with retinol, and in what order?

You can use this treatment alongside a retinol, applying the treatment in your evening routine after your soothing toner and before your moisturizer. Because your skin is dry and sensitive, this peptide-packed formula helps repair your skin barrier and provides hydration while minimizing risks of irritation.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/)

### How often should I use this treatment?

This treatment is used in the evening as part of your routine. You can safely apply it every evening since it has a very low likelihood of causing irritation.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/)

### Can this treatment clog pores, cause breakouts or purging for dry sensitive skin?

This treatment is unlikely to cause breakouts for dry sensitive skin since causes breakouts is a low complaint among reviewers and the formula contains gentle, hydrating ingredients. It is formulated without harsh ingredients to keep your skin calm and smooth.

## Alternatives for dry sensitive skin

- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vitamin-c-serum/for/dry-sensitive-skin) — High fit — S$50.41 at Amazon
- [ma:nyo Bifida Biome Complex Ampoule](https://lovi.care/skincare/sg/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-sensitive-skin) — High fit — S$40.09 at Amazon
- [PCA Skin C&E Advanced with Hexylresorcinol and Silymarin](https://lovi.care/skincare/sg/p/pca-skin/c-and-e-advanced/for/dry-sensitive-skin) — High fit — S$192.38 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/sg/p/cerave/hydrating-facial-cleanser/for/dry-sensitive-skin) — Superior fit — S$25.06 at Amazon
- Soothing Toner: [Mario Badescu Facial Spray with Aloe, Chamomile and Lavender](https://lovi.care/skincare/sg/p/mario-badescu/facial-spray-with-aloe-chamomile-and-lavender/for/dry-sensitive-skin) — High fit — S$34.52 at Amazon
- Moisturizer with Sun Protection: [Dr.G Green Mild Up Sun+](https://lovi.care/skincare/sg/p/dr-g/green-mild-up-sun/for/dry-sensitive-skin) — Superior fit — S$59.06 at Amazon

## Where to buy

No store in Singapore has a checked price for this product, so the page shows none.

## Ingredients

Advanced Peptide Complex, Hexapeptide, Dipeptide, Pha, Niacinamide, Laminaria Digitata Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/skinceuticals/p-tox/for/dry-sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/skinceuticals/p-tox/for/dry-sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/skinceuticals/p-tox/for/dry-sensitive-skin
- Germany: https://lovi.care/skincare/de/p/skinceuticals/p-tox/for/dry-sensitive-skin
- France: https://lovi.care/skincare/fr/p/skinceuticals/p-tox/for/dry-sensitive-skin
- Italy: https://lovi.care/skincare/it/p/skinceuticals/p-tox/for/dry-sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/skinceuticals/p-tox/for/dry-sensitive-skin
- Spain: https://lovi.care/skincare/es/p/skinceuticals/p-tox/for/dry-sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/skinceuticals/p-tox/for/dry-sensitive-skin
- Australia: https://lovi.care/skincare/au/p/skinceuticals/p-tox/for/dry-sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/skinceuticals/p-tox/for/dry-sensitive-skin (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/p/skinceuticals/p-tox/for/dry-sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/skinceuticals/p-tox/for/dry-sensitive-skin