# SKIN1004 Madagascar Centella Hyalu-Cica First Ampoule for sensitive skin

**Lovi Fit: Superior fit for sensitive skin.**
Normal Skin Fit: Superior · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/sg/p/skin1004/madagascar-centella-hyalu-cica-first-ampoule/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Brand: [SKIN1004](https://lovi.care/skincare/sg/brands/skin1004)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/sg/best/moisturizers)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best moisturizers for sensitive skin.

## Why this fit

- Excellent suitability for your normal skin and effective for redness and irritation due to high concentrations of Centella Asiatica Extract and Sodium Hyaluronate, which hydrate and soothe your skin.
- Niacinamide further supports inflammation reduction, complementing the barrier repair and humectant actions for overall skin health.
- The product is safe for your sensitive skin, containing no harsh or prohibited ingredients that could cause irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sg/p/skin1004/madagascar-centella-hyalu-cica-first-ampoule/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/sg/p/skin1004/madagascar-centella-hyalu-cica-first-ampoule/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/sg/p/skin1004/madagascar-centella-hyalu-cica-first-ampoule/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/sg/p/skin1004/madagascar-centella-hyalu-cica-first-ampoule/for/sensitive-skin): Superior (this page)
- [Acne-prone skin](https://lovi.care/skincare/sg/p/skin1004/madagascar-centella-hyalu-cica-first-ampoule/for/acne-prone-skin): Superior
- [Skin with dark spots](https://lovi.care/skincare/sg/p/skin1004/madagascar-centella-hyalu-cica-first-ampoule/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/sg/p/skin1004/madagascar-centella-hyalu-cica-first-ampoule/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/sg/p/skin1004/madagascar-centella-hyalu-cica-first-ampoule/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/sg/p/skin1004/madagascar-centella-hyalu-cica-first-ampoule/for/oily-acne-prone-skin): High

## Key ingredients

Centella Asiatica, Sodium Hyaluronate, Niacinamide, Glycerin, Curcuma Longa Extract

## What the research says

- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Topical application of curcumin or turmeric treats various skin conditions by leveraging antioxidant, anti-inflammatory, and antimicrobial properties. ([Skin Pharmacology and Physiology, 2023](https://pubmed.ncbi.nlm.nih.gov/38008088/))
- Topical formulations of curcumin target oxidative damage and inflammation to improve wound healing in animal models. ([Drug Discovery Today, 2017](https://pubmed.ncbi.nlm.nih.gov/28711364/))
- A curcumin-loaded spanlastic anti-aging gel utilizing formula F5 incorporated into 2% HPMC E50 demonstrated sustained release action, compatibility, and the ability to penetrate skin layers to a depth of about 112.5 um without signs of irritation. ([Saudi Pharmaceutical Journal, 2024](https://pubmed.ncbi.nlm.nih.gov/38178851/))

## What reviewers say

Based on a very large amount of data, this ampoule is widely praised as a holy grail for oily, combination, and sensitive skin types due to its incredibly lightweight, water-like texture that deeply hydrates without clogging pores. While it excels at soothing redness and prepping the skin for makeup, users with very dry skin often find it insufficient as a standalone moisturizer, particularly during colder months.

- Liked: Lightweight hydration (mostly mentioned)
- Liked: Rapid absorption (mostly mentioned)
- Liked: Soothing and calming (often mentioned)
- Liked: Makeup compatibility (sometimes noted)
- Liked: Value for money (sometimes noted)
- Disliked: Insufficient for dry (sometimes noted)
- Disliked: Breakouts rare (rarely noted)
- Disliked: Lack of wow (rarely noted)
- Disliked: Runny texture (rarely noted)

## How to apply

- Use this soothing AM and PM routine every day to keep your normal skin calm. Always remember to apply SPF in the morning after your moisturizer.
- Apply your moisturizer after your toner in the morning, and after your serum in the evening. This step locks in hydration and protects your skin.
- Gently press a small amount of the moisturizer evenly across your face. Avoid rubbing to keep your sensitive skin happy and calm.
- You can apply this gentle formula on dry or slightly damp skin for the best comfort. It works wonderfully on clean skin to soothe redness and irritation.
- Do a patch test before your very first use to check your skin's reaction. Avoid getting the product directly into your eyes .
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes SKIN1004 Hyalu-Cica First Ampoule one of the best fits for sensitive skin?

This product is an exceptional fit because it combines soothing centella asiatica and hydrating hyaluronic acid to calm redness and irritation. It also includes niacinamide to support barrier repair and keep sensitive skin feeling comfortable and calm.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for sensitive skin?

Centella Asiatica and sodium hyaluronate make this serum a great fit because they hydrate and calm sensitive skin, while niacinamide helps reduce redness and irritation. This formula is very safe for your skin type, as it contains no harsh ingredients that may trigger a flare-up.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Centella Asiatica do for sensitive skin?

Centella asiatica helps calm sensitive skin and keeps it feeling soft by soothing irritation and supporting the skin barrier. It is unlikely to cause trouble and may help reduce redness and discomfort over a few weeks of regular use.
Sources: [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40682399/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### What does Hyaluronic Acid do for sensitive skin?

Hyaluronic acid helps calm and hydrate sensitive skin while supporting the skin barrier to keep it soft and comfortable. Clinical studies show it improves surface moisture and reduces dryness, roughness, and redness without irritation.
Sources: [Journal of Drugs in Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41037531/), [Journal of Cosmetic Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29356277/)

### Where does this serum go in a skincare routine for sensitive skin?

This treatment goes in the evening routine after your soothing toner and before your moisturizer. Putting it in the evening keeps things simple and gives you extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this treatment alongside retinol by applying it right before your retinol to keep your skin calm and hydrated. Barrier-improving and soothing ingredients help reduce the dryness and irritation that often come with retinol use.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### How often should I use this serum?

You can use this serum in your evening routine, and some people also use it in the morning or twice a day. It is safe for sensitive skin and helps keep your skin calm and hydrated without causing irritation.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### Can this serum clog pores, cause breakouts or purging for sensitive skin?

This product is unlikely to clog pores or cause breakouts on sensitive skin because it is free of harsh ingredients and uses soothing components like Centella Asiatica that help calm irritation.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### Can I use this serum around the eyes or on my body?

You can safely apply this moisturizing treatment to the thin skin around your eyes and on your body because it has a very gentle formula without harsh ingredients. Its soothing and hydrating ingredients help calm redness and keep sensitive skin comfortable everywhere.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for sensitive skin

- [Revision Skincare Hydrating Serum](https://lovi.care/skincare/sg/p/revision-skincare/hydrating-serum/for/sensitive-skin) — High fit — S$127.77 at Amazon
- [Elizavecca Witch Piggy Hell Pore Control Hyaluronic Acid 97%](https://lovi.care/skincare/sg/p/elizavecca/witch-piggy-hell-pore-control-hyaluronic-acid-97/for/sensitive-skin) — High fit — S$18.65 at Amazon
- [innisfree Green Tea Seed Hyaluronic Acid Hydrating Serum](https://lovi.care/skincare/sg/p/innisfree/green-tea-seed-hyaluronic-acid-hydrating-serum/for/sensitive-skin) — High fit — S$35.27 at YesStyle

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/sg/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — S$30.00 at Amazon
- Soothing Toner: [One Thing Centella Asiatica Extract Toner](https://lovi.care/skincare/sg/p/one-thing/centella-asiatica-extract-toner/for/sensitive-skin) — Superior fit — S$30.07 at Amazon
- Moisturizer with Sun Protection: [ISDIN Eryfotona Actinica SPF 50+](https://lovi.care/skincare/sg/p/isdin/eryfotona-actinica-spf-50/for/sensitive-skin) — Superior fit — S$110.01 at Amazon

## Where to buy

- YesStyle: S$19.26 (https://www.yesstyle.com/en/skin1004-madagascar-centella-hyalu-cica-first-ampoule-jumbo-100ml/info.html/pid.1113064819?curr=SGD&rco=SG)
Prices checked 13 Oct 2026.

## Ingredients

Centella Asiatica Extract, Butylene Glycol, Niacinamide, 1,2-Hexanediol, Water, Hydroxyacetophenone, Carbomer, Glycereth-25 Pca Isostearate, Ethylhexylglycerin, Tromethamine, Sodium Hyaluronate, Betula Platyphylla Japonica Juice, Melia Azadirachta Leaf Extract, Melia Azadirachta Flower Extract, Propanediol, Musa Sapientum Flower Extract, Coccinia Indica Fruit Extract, Rosa Damascena Flower Water, Pyrus Communis Fruit Extract, Prunus Domestica Fruit Extract, Aloe Barbadensis Flower Extract, Cucumis Melo Fruit Extract, Solanum Melongena Fruit Extract, Hedera Helix Stem Extract Leaf, Ocimum Sanctum Leaf Extract, Glycerin, Anastatica Hierochuntica Extract, Corallina Officinalis Extract, Curcuma Longa Root Extract, Hydrolyzed Hyaluronic Acid, Portulaca Oleracea Extract, Artemisia Princeps Extract, Rhodiola Rosea Root Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/skin1004/madagascar-centella-hyalu-cica-first-ampoule/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/skin1004/madagascar-centella-hyalu-cica-first-ampoule/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/skin1004/madagascar-centella-hyalu-cica-first-ampoule/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/skin1004/madagascar-centella-hyalu-cica-first-ampoule/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/skin1004/madagascar-centella-hyalu-cica-first-ampoule/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/skin1004/madagascar-centella-hyalu-cica-first-ampoule/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/skin1004/madagascar-centella-hyalu-cica-first-ampoule/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/skin1004/madagascar-centella-hyalu-cica-first-ampoule/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/skin1004/madagascar-centella-hyalu-cica-first-ampoule/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/skin1004/madagascar-centella-hyalu-cica-first-ampoule/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/skin1004/madagascar-centella-hyalu-cica-first-ampoule/for/sensitive-skin (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/p/skin1004/madagascar-centella-hyalu-cica-first-ampoule/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/skin1004/madagascar-centella-hyalu-cica-first-ampoule/for/sensitive-skin