# Skin Nutrition Botanicals Niacinamide 5% + Squalane Serum for combination skin

**Lovi Fit: High fit for combination skin.**
Combination Skin Fit: Superior · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/sg/p/skin-nutrition-botanicals/niacinamide-5-squalane-serum/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Brand: [Skin Nutrition Botanicals](https://lovi.care/skincare/sg/brands/skin-nutrition-botanicals)
Category: [Serums and treatments](https://lovi.care/skincare/sg/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best serums for combination skin.

## Why this fit

- Excellent suitability for your combination skin is provided by zinc gluconate and squalane, which help regulate sebum production and offer emollient action, addressing your oily shine concerns.
- Kojic acid and niacinamide further enhance the brightening and pore-minimizing benefits, making this serum highly effective for your specific skin needs.
- The product is safe for your combination skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sg/p/skin-nutrition-botanicals/niacinamide-5-squalane-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/sg/p/skin-nutrition-botanicals/niacinamide-5-squalane-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/sg/p/skin-nutrition-botanicals/niacinamide-5-squalane-serum/for/combination-skin): High (this page)
- [Sensitive skin](https://lovi.care/skincare/sg/p/skin-nutrition-botanicals/niacinamide-5-squalane-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/sg/p/skin-nutrition-botanicals/niacinamide-5-squalane-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/sg/p/skin-nutrition-botanicals/niacinamide-5-squalane-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/sg/p/skin-nutrition-botanicals/niacinamide-5-squalane-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/sg/p/skin-nutrition-botanicals/niacinamide-5-squalane-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/sg/p/skin-nutrition-botanicals/niacinamide-5-squalane-serum/for/oily-acne-prone-skin): High

## Key ingredients

Niacinamide, Squalane, Kojic Acid, Zinc Gluconate, Panthenol

## What the research says

- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- A topical formulation containing kojic acid, emblica extract, and glycolic acid demonstrated efficacy parity compared with hydroquinone 4% in multiethnic participants with mild to moderate facial dyschromia. ([Cutis, 2010](https://pubmed.ncbi.nlm.nih.gov/21049734/))
- A nanoemulsion containing 1 mg/mL kojic dipalmitate and 5% rosehip oil demonstrated high incorporation efficiency, suitable physicochemical stability, antioxidant and depigmenting efficacy close to 1 mM ascorbic acid, and no cytotoxicity at concentrations from 0.06% to 1% in vitro. ([Pharmaceutics, 2023](https://pubmed.ncbi.nlm.nih.gov/36839792/))
- Topical application of iron chelators kojic acid and deferiprone significantly accelerated wound healing in rats compared to control groups, with deferiprone showing superior efficacy due to higher antioxidant and iron chelation abilities. ([International Wound Journal, 2013](https://pubmed.ncbi.nlm.nih.gov/22621771/))
- A dermocosmetic cream containing Punica granatum Pericarp extract, Salicylic acid, Niacinamide, Zinc gluconate, and Aqua Posae Filiformis significantly decreased inflammatory, non-inflammatory, and total lesion counts in subjects with mild to moderate acne compared to untreated hemi-faces after 15 days. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41487026/))
- Daily use of a deep cleansing gel containing salicylic acid 2%, zinc gluconate 0.2% and lipohydroxy acid 0.05% significantly reduced total lesion count by 56.3% after 84 days in 35 subjects with mild to moderate truncal acne. ([Clinical, Cosmetic and Investigational Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36698447/))
- Different strains of Propionibacterium acnes modulate cutaneous innate immunity with varying pro-inflammatory potentials, with P. acnes type III showing the highest and P. avidum the weakest, and zinc gluconate down-regulates the expression of most induced immune markers. ([Experimental Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23947673/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans. ([Arzneimittel-Forschung, 2000](https://pubmed.ncbi.nlm.nih.gov/10965426/))
- Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two. ([Auris, Nasus, Larynx, 2020](https://pubmed.ncbi.nlm.nih.gov/32067777/))

## What reviewers say

Some users with sensitive skin have reported mild irritation. There are also infrequent comments regarding the brand's lack of transparency and difficulty in finding the product.

- Liked: Affordable price (mostly mentioned)
- Liked: Hydrating and moisturizing (often mentioned)
- Disliked: Causes irritation (sometimes noted)
- Disliked: Hard to find (rarely noted)
- Disliked: Lacks transparency (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Skin Nutrition Botanicals Niacinamide 5% + Squalane Serum a great fit for combination skin?

Skin Nutrition Botanicals Niacinamide 5% + Squalane Serum is a great fit because zinc gluconate and squalane help control oily shine, while niacinamide and kojic acid brighten the skin and minimize pores. It is very safe for your skin with no harsh ingredients.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### Which ingredients make this serum a good fit for combination skin?

Zinc gluconate and squalane make this serum a great fit for your combination skin by helping control oily shine and keeping your skin soft. Niacinamide and kojic acid also help brighten your skin and tighten pores safely without irritation.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### What does Niacinamide do for combination skin?

Niacinamide helps balance oily areas by reducing excess shine and pore size while keeping dry patches hydrated and smooth. It also works to calm redness and even out skin tone, making it very suitable for combination skin.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### What does Squalane do for combination skin?

Squalane helps keep combination skin soft and smooth by locking in moisture without feeling heavy or greasy. It supports the skin barrier and provides lightweight hydration that works well for both dry and oily areas.
Sources: [Skin Health and Disease, 2024](https://pubmed.ncbi.nlm.nih.gov/39355739/), [Journal of Nanobiotechnology, 2025](https://pubmed.ncbi.nlm.nih.gov/40001122/)

### Where does this serum go in a skincare routine for combination skin?

This serum goes in the evening routine after cleansing and toning, followed by your moisturizer. Putting it in the evening keeps your routine simple and adds extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol, but it is best to apply retinol first and follow with this treatment to keep your skin calm and balanced. This product is safe for your combination skin, with no risks of irritation due to the absence of harsh ingredients.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/)

### How often should I use this serum?

This serum fits into your evening routine, where you can apply it once a day to help manage oily shine and brighten your skin. It is unlikely to cause irritation since it avoids harsh ingredients.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Can this serum clog pores, cause breakouts or purging for combination skin?

This serum is unlikely to clog pores or cause breakouts on combination skin, as it contains lightweight ingredients like squalane and zinc gluconate that help balance oily shine without heavy buildup. While some shoppers report mild irritation, the formula is generally well-tolerated and free of harsh ingredients that typically trigger purging.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for combination skin

- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/sg/p/skin1004/probio-cica-intensive-ampoule/for/combination-skin) — High fit — S$28.55 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vitamin-c-serum/for/combination-skin) — High fit — S$50.41 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vita-c-serum/for/combination-skin) — High fit — S$50.41 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/sg/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — S$30.00 at Amazon
- Hydrating Toner: [Whamisa Organic Flowers Toner Deep Rich](https://lovi.care/skincare/sg/p/whamisa/organic-flowers-toner-deep-rich/for/combination-skin) — Superior fit — S$64.81 at Amazon
- SPF: [CeraVe AM Facial Moisturizing Lotion](https://lovi.care/skincare/sg/p/cerave/am-facial-moisturizing-lotion-spf-30/for/combination-skin) — Superior fit — S$28.72 at Amazon

## Where to buy

No store in Singapore has a checked price for this product, so the page shows none.

## Ingredients

Glycerin, Rice Ferment Filtrate, Kojic Acid, Sucrose, Squalane, Saccharomyces Xylinum Black Tea Ferment, Panthenol, Zinc Gluconate, Hydrolyzed Jojoba Esters, Disodium Edta, Carbomer, Beta-Carotene, Lauryl Glucoside, Xanthan Gum, Phenoxyethanol, Ethylhexylglycerin, Sodium Dehydroacetate, Tocopherol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/skin-nutrition-botanicals/niacinamide-5-squalane-serum/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/skin-nutrition-botanicals/niacinamide-5-squalane-serum/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/skin-nutrition-botanicals/niacinamide-5-squalane-serum/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/skin-nutrition-botanicals/niacinamide-5-squalane-serum/for/combination-skin
- France: https://lovi.care/skincare/fr/p/skin-nutrition-botanicals/niacinamide-5-squalane-serum/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/skin-nutrition-botanicals/niacinamide-5-squalane-serum/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/skin-nutrition-botanicals/niacinamide-5-squalane-serum/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/skin-nutrition-botanicals/niacinamide-5-squalane-serum/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/skin-nutrition-botanicals/niacinamide-5-squalane-serum/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/skin-nutrition-botanicals/niacinamide-5-squalane-serum/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/skin-nutrition-botanicals/niacinamide-5-squalane-serum/for/combination-skin (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/p/skin-nutrition-botanicals/niacinamide-5-squalane-serum/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/skin-nutrition-botanicals/niacinamide-5-squalane-serum/for/combination-skin