# Shiseido Vital Perfection Intensive WrinkleSpot Treatment for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/sg/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Brand: [Shiseido](https://lovi.care/skincare/sg/brands/shiseido)
Category: [Serums and treatments](https://lovi.care/skincare/sg/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best serums for mature skin.

## Why this fit

- Offers high suitability for your normal skin, as retinol and retinyl acetate promote skin renewal for wrinkles and fine lines, while tocopheryl acetate provides antioxidant benefits.
- The inclusion of potassium methoxysalicylate further aids in skin renewal and texture improvement.
- The product is safe for your normal skin, with no risks of irritation due to the absence of harsh ingredients and the presence of soothing components like Rosa Damascena Flower Water and Lavandula Angustifolia Oil.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sg/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/sg/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/sg/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/sg/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/sg/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/sg/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/sg/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/sg/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/sg/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/oily-acne-prone-skin): Average

## Key ingredients

Retinol, 4msk, Kurenai-Trulift Complex, Reneura Technology, Glycyrrhiza Glabra Root Extract Licorice Root Extract

## What the research says

- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Potassium 4-methoxysalicylate (4MSK) suppresses melanin content, promotes keratinocyte differentiation, increases skin lightness in pigmented and non-pigmented cheek areas, and reduces the desquamation area ratio. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40071590/))
- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle. ([Archives of Dermatological Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28247017/))
- An in situ hydrated ionic liquid-like state strategy using potassium 4-methoxysalicylate and arginine hydrochloride increased human skin permeation to 237% of control and reduced melanin content by 33% in a reconstructed human epidermis model. ([International Journal of Pharmaceutics, 2026](https://pubmed.ncbi.nlm.nih.gov/42822711/))
- Plant extracts from Gomphrena globasa L., Clitoria ternatea L., Carthamus tinctorius L., Punica granatum L., and Papaver rhoeas L. demonstrated no cytotoxicity, high antioxidant potential, strong collagenase inhibition, moderate elastase inhibition, effective skin hydration, and varying suitability as stable cosmetic dyes when tested on keratinocyte and fibroblast cell lines and incorporated into face cream formulations. ([Molecules, 2021](https://pubmed.ncbi.nlm.nih.gov/34068613/))
- Water extracts of Papaver rhoeas L., Punica granatum L., Clitoria ternatea L., Carthamus tinctorius L., and Gomphrena globosa L. showed no cytotoxicity on skin cells while exhibiting antioxidant, anti-inflammatory, and enzyme-inhibiting properties, with P. rhoeas, C. ternatea, and C. tinctorius demonstrating strong permanent coloring ability in cosmetic products. ([Molecules, 2022](https://pubmed.ncbi.nlm.nih.gov/35164187/))
- Combining 755 nm alexandrite laser with topical licorice gel significantly reduces terminal hair counts compared to alexandrite laser with placebo in women with idiopathic hirsutism. ([Evidence-based Complementary and Alternative Medicine, 2015](https://pubmed.ncbi.nlm.nih.gov/26273313/))
- Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo. ([Experimental Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25381913/))
- Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide. ([Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/))

## What reviewers say

Based on a very large amount of data, users with mature or aging skin frequently report that this treatment visibly softens deep wrinkles and fades dark spots. Many users also note improvements in skin firmness and appreciate the effective targeted application. Some users with sensitive skin experience dryness or irritation, and a low number find the texture heavy or the product ineffective for their needs.

- Liked: Reduces wrinkles (mostly mentioned)
- Liked: Fades dark spots (often mentioned)
- Liked: Improves firmness (sometimes noted)
- Liked: Targeted application (sometimes noted)
- Disliked: Causes dryness (sometimes noted)
- Disliked: High price (sometimes noted)
- Disliked: Irritates skin (sometimes noted)
- Disliked: Heavy texture (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Vital Perfection Intensive WrinkleSpot Treatment a great fit for mature skin?

Shiseido Vital Perfection Intensive WrinkleSpot Treatment is a great fit for mature skin because retinol and retinyl acetate help renew skin and smooth out fine lines, while potassium methoxysalicylate improves texture. It also delivers antioxidant benefits and keeps skin calm and comfortable.

### Which ingredients make this treatment a good fit for mature skin?

This treatment is a great fit for mature skin because retinol and retinyl acetate help renew the skin to smooth out wrinkles and fine lines, while potassium methoxysalicylate improves texture. Additionally, tocopheryl acetate offers antioxidant benefits, and soothing ingredients like rose water and lavender oil keep the skin calm.
Sources: [International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/)

### What does Retinol do for mature skin?

Retinol helps smooth out fine lines and wrinkles while improving overall skin thickness and firmness over time. It may also cause temporary dryness, scaling, or stinging as your skin gets used to it.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### What does 4-Methoxy potassium salicylate do for mature skin?

4-Methoxy potassium salicylate helps brighten dark spots and smooth out the texture of mature skin. With regular use, it helps even out skin tone and gives your face a fresher, clearer look.

### Where does this treatment go in a skincare routine for mature skin?

This treatment goes in the evening routine after cleansing and before moisturizing, which keeps application simple and safer around sun exposure.

### Can I use this treatment with vitamin C, and in what order?

You can use this treatment with vitamin C by applying vitamin C in your morning routine and this treatment at night, as separating them helps prevent skin irritation. Using them at different times of day allows both ingredients to work effectively on your mature skin.

### How often should I use this treatment?

This treatment is best used in the evening as part of your routine. Applying it then helps renew mature skin and smooth out lines while avoiding extra sun sensitivity.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/)

### Can this treatment clog pores, cause breakouts or purging for mature skin?

This treatment is unlikely to clog pores, but the retinol inside may cause mild purging as it helps renew mature skin and smooth out fine lines. Some reviewers do mention experiencing dryness or irritation, so you may want to start using it slowly.

### Is this treatment fragrance-free and alcohol-free?

It contains fragrance (parfum, limonene, hexyl cinnamal, linalool, and citronellol) and drying alcohol (alcohol).

## Alternatives for mature skin

- [Drunk Elephant A-Passioni Retinol Cream](https://lovi.care/skincare/sg/p/drunk-elephant/a-passioni-retinol-cream/for/mature-skin) — High fit — S$110.11 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — S$50.41 at Amazon
- [PCA Skin C&E Strength Max](https://lovi.care/skincare/sg/p/pca-skin/c-and-e-strength-max/for/mature-skin) — High fit — S$179.75 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/sg/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — S$30.00 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/sg/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — S$41.07 at Amazon
- SPF: [ISDIN Eryfotona Actinica SPF 50+](https://lovi.care/skincare/sg/p/isdin/eryfotona-actinica-spf-50/for/mature-skin) — Superior fit — S$110.01 at Amazon

## Where to buy

No store in Singapore has a checked price for this product, so the page shows none.

## Ingredients

Water, Pentaerythrityl Tetraethylhexanoate, Dipropylene Glycol, Hydrogenated Polydecene, Glycerin, Betaine, Behenyl Alcohol, Dimethicone, Potassium Methoxysalicylate, Petrolatum, Hydrogenated Palm Oil, Stearyl Alcohol, Maltitol, Beheneth-20, Palm Kernel Oil, Phenoxyethanol, Butylene Glycol, Palm Oil, Carnauba Wax Cera Copernicia Cerifera Cire De Carnauba Wax Cera, Hydrogenated Polyisobutene, Polyvinyl Alcohol, Microcrystalline Wax Cera Microcristallina Cire Microcristalline Wax Cera, Parfum, Carbomer, Tocopheryl Acetate, Rosa Damascena Flower Water, Xanthan Gum, Bht, Retinol, Polysorbate 20, Alcohol, Caffeine, Potassium Hydroxide, Lavandula Angustifolia Oil Lavender Oil, Trisodium Edta, Ppg-3 Dipivalate, Limonene, Tocopherol, Hexyl Cinnamal, Linalool, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Citronellol, Angelica Acutiloba Root Extract, Angelica Keiskei Stem Extract Leaf, Olea Europaea Leaf Extract Olive Leaf Extract, Sanguisorba Officinalis Root Extract, Lamium Album Stem Extract Flower Leaf, Camellia Sinensis Leaf Extract, Inositol, Carthamus Tinctorius Flower Extract, Pinus Sylvestris Cone Extract, Ziziphus Jujuba Fruit Extract, Retinyl Acetate, Helianthus Annuus Seed Oil Sunflower Seed Oil, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Cellulose, Beta-Carotene, Cinnamomum Cassia Bark Extract, Citric Acid, Bupleurum Falcatum Root Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/mature-skin
- France: https://lovi.care/skincare/fr/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/mature-skin (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/mature-skin