# SENTÉ Bio Complete Serum for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/sg/p/sente/bio-complete-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Brand: [SENTÉ](https://lovi.care/skincare/sg/brands/sente)
Category: [Serums and treatments](https://lovi.care/skincare/sg/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other serums fit it better.

## Why this fit

- Offers moderate benefits for minimizing fine lines and wrinkles due to the presence of retinol and myristoyl pentapeptide-17, which are supportive for your normal skin. Glycerin and allantoin provide general hydration and soothing effects, complementing the retinoid action.
- The formulation is highly suitable for normal skin, with sodium hyaluronate offering humectant action to enhance the retinoid benefits.
- The safety profile is excellent, with no risks of irritation for your normal skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sg/p/sente/bio-complete-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/sg/p/sente/bio-complete-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/sg/p/sente/bio-complete-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/sg/p/sente/bio-complete-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/sg/p/sente/bio-complete-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/sg/p/sente/bio-complete-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/sg/p/sente/bio-complete-serum/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/sg/p/sente/bio-complete-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/sg/p/sente/bio-complete-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Sodium Hyaluronate, Retinol, Glycosaminoglycans, Heparan Sulfate, Niacinamide

## What the research says

- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle. ([Archives of Dermatological Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28247017/))
- Topical treatment with sphingolipids and glycosaminoglycans attenuated clinical worsening and reduced CADESI and PVAS scores compared to the untreated control group in house dust mite-allergic beagle dogs. ([BMC Veterinary Research, 2020](https://pubmed.ncbi.nlm.nih.gov/32197613/))
- Glycosaminoglycans restored type I collagen synthesis, reduced matrix metalloproteinase-1 levels, upregulated tissue inhibitor of metalloproteinase-1, and attenuated apoptosis in tumor necrosis factor-alpha-stimulated human dermal fibroblasts by inhibiting extracellular signal-regulated kinase/activator protein-1 signaling. ([International Journal of Molecular Medicine, 2018](https://pubmed.ncbi.nlm.nih.gov/29436595/))
- Fraction 3 of glycosaminoglycans from Liparis tessellatus eggs showed 20.1% tyrosinase inhibition at 50mg/mL and effective skin regeneration activities at 200mg/mL against skin fibroblast CCD-986sk cell lines. ([International Journal of Biological Macromolecules, 2017](https://pubmed.ncbi.nlm.nih.gov/28917941/))
- A topical eye cream containing low molecular weight heparan sulfate and naturally derived extracts improved periorbital hyperpigmentation, fine and coarse wrinkles, puffiness, and dark circles in 15 subjects over 12 weeks. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30636356/))
- Topical low molecular weight heparan sulfate improved periorbital discoloration and wrinkles starting at week two with continuous improvement up to week 12. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32562303/))
- Topical low molecular weight heparan sulfate improved skin hydration, firmness, elasticity, barrier function, and fine lines and wrinkles in 15 patients over 8 weeks. ([Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26151781/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))

## What reviewers say

Based on limited data, this serum is highly praised for its anti-aging effects, improving skin texture and firmness while reducing fine lines. Some users experienced a greasy feel or slow results, and a negligible number mentioned the presence of fragrance.

- Liked: Gentle formula (mostly mentioned)
- Liked: Improves texture (often mentioned)
- Liked: Anti-aging benefits (sometimes noted)
- Liked: Hydrating (sometimes noted)
- Disliked: Contains fragrance (rarely noted)
- Disliked: Greasy feel (rarely noted)
- Disliked: Slow results (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does SENTÉ Bio Complete Serum work for mature skin?

SENTÉ Bio Complete Serum works moderately well for mature skin, offering helpful ingredients like retinol and peptides that help soften fine lines and wrinkles. Mature skin needs treatments of this type that are exceptionally safe, exceptionally effective against wrinkles, rich in antioxidants and skin-repairing ingredients, and highly suitable for maintaining skin health and elasticity without irritation.

### Which ingredients make this serum a good fit for mature skin?

This serum fits mature skin because it contains retinol and myristoyl pentapeptide-17 to help smooth fine lines, along with sodium hyaluronate and glycerin for hydration. A treatment for mature skin needs powerful anti-aging ingredients, rich hydrators, and skin-repairing components like peptides and antioxidants to deliver optimal results against wrinkles.
Sources: [International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/)

### What does Hyaluronic Acid do for mature skin?

Hyaluronic acid helps mature skin by deeply boosting moisture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Regular use keeps the skin looking plump and soft while supporting overall firmness and hydration.
Sources: [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/), [Skin Research and Technology, 2024](https://pubmed.ncbi.nlm.nih.gov/38591218/)

### What does Retinol do for mature skin?

Retinol helps smooth out fine lines and wrinkles while improving overall skin thickness and firmness over time. It may also cause temporary dryness, scaling, or stinging as your skin gets used to it.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### Where does it go in a skincare routine for mature skin?

This treatment goes in the evening routine after cleansing and toning, and before moisturizing. A product of this type for mature skin also needs firming peptides, nourishing antioxidants, and deep hydrators to smooth fine lines and improve elasticity.

### Can I use this serum with glycolic acid, and in what order?

You can use this serum with glycolic acid, but it is best to apply them on alternate nights to lower the chance of irritation on mature skin. Using strong exfoliating acids alongside retinoids may cause dryness and redness, so mature skin benefits from pairing retinoids with hydrating ingredients like sodium hyaluronate and soothing components like allantoin to maintain comfort.

### How often should I use it?

You can use this treatment in the evening as part of your routine. To get better results for mature skin, a product of this type needs extra firming peptides, nourishing plant oils, and deep moisture-binding ingredients.

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to cause breakouts or clog pores, and the safety profile is excellent with no harsh ingredients that typically irritate mature skin. To care for mature skin best, this type of product needs ingredients like retinol and hyaluronic acid to help smooth fine lines and keep the skin feeling soft and smooth.
Sources: [International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/)

### Is it fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — S$50.41 at Amazon
- [PCA Skin C&E Strength Max](https://lovi.care/skincare/sg/p/pca-skin/c-and-e-strength-max/for/mature-skin) — High fit — S$179.75 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vitamin-c-serum/for/mature-skin) — High fit — S$50.41 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/sg/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — S$30.00 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/sg/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — S$41.07 at Amazon
- SPF: [ISDIN Eryfotona Actinica SPF 50+](https://lovi.care/skincare/sg/p/isdin/eryfotona-actinica-spf-50/for/mature-skin) — Superior fit — S$110.01 at Amazon

## Where to buy

No store in Singapore has a checked price for this product, so the page shows none.

## Ingredients

Water, Butylene Glycol, Dipropylene Glycol, Cyclopentasiloxane, Peg-12 Dimethicone Crosspolymer, Dimethicone Crosspolymer, Dimethicone Vinyl Dimethicone Crosspolymer, Dimethiconol, Dimethicone, Laureth-23, Laureth-4, Glycerin, Heparan Sulfate, Pentylene Glycol, Retinyl Safflowerate, Retinol, Lysophosphatidic Acid, Myristoyl Nonapeptide-3, Myristoyl Pentapeptide-17, Ethyl Safflowerate, Ethyl Flaxseedate, Dipalmitoyl Hydroxyproline, Allantoin, Panthenol, Sodium Hyaluronate, Sodium Ascorbyl Phosphate, Alanine, Arginine Hcl, Asparagine, Aspartic Acid, Cystine, Glutamic Acid, Glutamine, Histidine Hcl, Isoleucine, Leucine, Lysine Hcl, Acetyl Methionine, Phenylalanine, Proline, Serine, Threonine, Tryptophan, Tyrosine, Valine, Calcium Pantothenate, Folic Acid, Inositol, Niacinamide, Pyridoxal Hcl, Riboflavin, Thiamine Hcl, Calcium Chloride, Magnesium Sulfate, Potassium Chloride, Sodium Chloride, Sodium Phosphate, Beta-Carotene, Polysorbate 80, Polyaminopropyl Biguanide, Tromethamine
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/sente/bio-complete-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/sente/bio-complete-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/sente/bio-complete-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/sente/bio-complete-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/sente/bio-complete-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/sente/bio-complete-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/sente/bio-complete-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/sente/bio-complete-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/sente/bio-complete-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/sente/bio-complete-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/sente/bio-complete-serum/for/mature-skin (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/p/sente/bio-complete-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/sente/bio-complete-serum/for/mature-skin