# ROUND LAB Pine Calming Cica Ampoule for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: Excellent.

Page: https://lovi.care/skincare/sg/p/round-lab/pine-calming-cica-ampoule/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Brand: [ROUND LAB](https://lovi.care/skincare/sg/brands/round-lab)
Category: [Serums and treatments](https://lovi.care/skincare/sg/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best serums for mature skin.

## Why this fit

- Suitable for normal skin due to the humectant action of Sodium Hyaluronate and Hydrolyzed Hyaluronic Acid, which provide hydration, but it lacks specialized ingredients to effectively target wrinkles and fine lines.
- The formula contains Asiaticoside, Asiatic Acid, and Madecassoside to offer moderate skin calming and soothing benefits, which are generally supportive for normal skin.
- The safety profile is excellent, with no risks of irritation for your normal skin due to the absence of harsh ingredients and the presence of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sg/p/round-lab/pine-calming-cica-ampoule/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/sg/p/round-lab/pine-calming-cica-ampoule/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/sg/p/round-lab/pine-calming-cica-ampoule/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/sg/p/round-lab/pine-calming-cica-ampoule/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/sg/p/round-lab/pine-calming-cica-ampoule/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/sg/p/round-lab/pine-calming-cica-ampoule/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/sg/p/round-lab/pine-calming-cica-ampoule/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/sg/p/round-lab/pine-calming-cica-ampoule/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/sg/p/round-lab/pine-calming-cica-ampoule/for/oily-acne-prone-skin): High

## Key ingredients

Pine Extract, Centella Asiatica Extract, Sodium Hyaluronate, Glycerin, Madecassoside

## What the research says

- Profhilo treatment led to significant improvements in superficial skin hydration and transepidermal water loss over time in Chinese females, while demonstrating good product tolerability. ([Aesthetic Plastic Surgery, 2026](https://pubmed.ncbi.nlm.nih.gov/40921777/))
- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- A topical antioxidant serum significantly reduced air pollution-induced skin pigmentation and proinflammatory gene expression ex vivo, and improved skin aging signs in 40 healthy adult females after 90 days of daily use. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35150043/))
- A xanthan gum and alginate-based bioadhesive film loaded with pycnogenol provides sustained drug release within 24 hours, achieves a safe maximum concentration of ~ 0.2 mg/mL for keratinocytes, and absorbs simulated wound fluid, demonstrating suitability for topical wound treatment. ([Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33802607/))
- Topical treatment with Pinus brutia bark extract cream significantly accelerated incision wound healing in albino rats, demonstrating a 35% decrease in MDA and a 46.8% increase in SOD activity compared to the control group. ([Die Pharmazie, 2013](https://pubmed.ncbi.nlm.nih.gov/23444785/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))

## What reviewers say

Based on a very large amount of data, this ampoule is highly recommended for those with sensitive, oily, and acne-prone skin due to its fast-absorbing, watery texture that effectively calms redness and inflammation without causing breakouts. Users appreciate its gentle formulation and ability to refine skin texture. However, individuals with dry skin may find it insufficient on its own and need to layer with a richer moisturizer.

- Liked: Soothing and calming (mostly mentioned)
- Liked: Lightweight absorption (often mentioned)
- Liked: Non-irritating formula (often mentioned)
- Liked: Gentle texture improvement (sometimes noted)
- Disliked: Insufficient for dry skin (sometimes noted)
- Disliked: Small volume/price (sometimes noted)
- Disliked: Breakouts/reactions (rarely noted)
- Disliked: Sticky finish (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes ROUND LAB Pine Calming Cica Ampoule a great fit for mature skin?

This product is a great fit because it contains sodium hyaluronate and glycerin to help keep dry and mature skin hydrated and soft. It also includes soothing centella asiatica extracts like madecassoside to calm the skin with a very low risk of irritation.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for mature skin?

Sodium Hyaluronate and hydrolyzed hyaluronic acid help keep mature skin hydrated, while Centella Asiatica extract and madecassoside help calm and soothe it. It is very unlikely to cause any irritation.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Pine Extract do for mature skin?

Pine extract helps keep mature skin firm and soft by supporting moisture and natural collagen while fading dark spots. Studies show it improves skin elasticity and hydration, making it a useful addition to routines targeting aging signs.
Sources: [Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35150043/), [Skin Pharmacology and Physiology, 2016](https://pubmed.ncbi.nlm.nih.gov/26492562/)

### What does Centella Asiatica Extract do for mature skin?

Centella Asiatica Extract helps mature skin by improving moisture, reducing moisture loss, and supporting collagen production to keep skin firm and smooth. It also provides antioxidant and calming benefits that help protect against everyday stress and visible signs of aging.
Sources: [Scientific Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34188145/), [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516082/)

### Where does this serum go in a skincare routine for mature skin?

This treatment goes in the evening routine after your cleansing toner and before your moisturizer. Putting it in the evening helps keep things simple and adds extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to calm your skin and provide hydration, followed by your retinol product. This product is unlikely to cause irritation thanks to its soothing ingredients, making it a gentle pairing for a retinol routine.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### How often should I use this serum?

You can use this treatment in your evening routine. It has a great safety profile and is unlikely to cause irritation for your mature skin.

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to cause breakouts or reactions for mature skin, as it has a very safe formula with soothing ingredients and no harsh irritants. Reviewers rarely mention breakouts, and the gentle calming components help keep skin comfortable.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — S$50.41 at Amazon
- [PCA Skin C&E Strength Max](https://lovi.care/skincare/sg/p/pca-skin/c-and-e-strength-max/for/mature-skin) — High fit — S$179.75 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vitamin-c-serum/for/mature-skin) — High fit — S$50.41 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/sg/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — S$30.00 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/sg/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — S$41.07 at Amazon
- SPF: [ISDIN Eryfotona Actinica SPF 50+](https://lovi.care/skincare/sg/p/isdin/eryfotona-actinica-spf-50/for/mature-skin) — Superior fit — S$110.01 at Amazon

## Where to buy

No store in Singapore has a checked price for this product, so the page shows none.

## Ingredients

Butylene Glycol, Dipropylene Glycol, Glycereth-26, Glycerin, 2-Hexanediol, Propanediol, Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid, Ethylhexyl Glycerin, Water, Glycoprotein, Indo Mulberry Leaf Extract, Yellow Lotus Root Extract, Indo Mulberry Flower Extract, Hydroxyacetophenone, Asiaticoside, Asiatic Acid, Madecassoside, Madecasic Acid, Sodium Citrate, Capryloyl Salicylic Acid, Disodium Edta, Xanthan Gum, Carbomer, Tromethamine, Citric Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/round-lab/pine-calming-cica-ampoule/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/round-lab/pine-calming-cica-ampoule/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/round-lab/pine-calming-cica-ampoule/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/round-lab/pine-calming-cica-ampoule/for/mature-skin
- France: https://lovi.care/skincare/fr/p/round-lab/pine-calming-cica-ampoule/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/round-lab/pine-calming-cica-ampoule/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/round-lab/pine-calming-cica-ampoule/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/round-lab/pine-calming-cica-ampoule/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/round-lab/pine-calming-cica-ampoule/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/round-lab/pine-calming-cica-ampoule/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/round-lab/pine-calming-cica-ampoule/for/mature-skin (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/p/round-lab/pine-calming-cica-ampoule/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/round-lab/pine-calming-cica-ampoule/for/mature-skin