# REJURAN DUAL EFFECT AMPOULE for skin with dark spots

**Lovi Fit: Average fit for skin with dark spots.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/sg/p/rejuran/dual-effect-ampoule/for/dark-spots

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Brand: [REJURAN](https://lovi.care/skincare/sg/brands/rejuran)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/sg/best/moisturizers)

This fit is calculated for the concerns frequently associated with dark spots: hyperpigmentation, sun spots, and uneven skin tone. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for skin with dark spots; other moisturizers fit it better.

## Why this fit

- This product offers moderate suitability for your normal skin, providing excellent hydration and soothing benefits through ingredients like Hyaluronic Acid and Aloe Barbadensis Leaf Juice, which are well-suited for maintaining skin balance.
- While it addresses general skincare needs effectively, it lacks sufficient concentrations of key ingredients like Arbutin and Niacinamide to specifically target your primary concern of pigmentation.
- The formulation is safe for your normal skin, as it contains soothing agents like Bisabolol and avoids harsh or irritating components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sg/p/rejuran/dual-effect-ampoule/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/sg/p/rejuran/dual-effect-ampoule/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/sg/p/rejuran/dual-effect-ampoule/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/sg/p/rejuran/dual-effect-ampoule/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/sg/p/rejuran/dual-effect-ampoule/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/sg/p/rejuran/dual-effect-ampoule/for/dark-spots): Average (this page)
- [Mature skin](https://lovi.care/skincare/sg/p/rejuran/dual-effect-ampoule/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/sg/p/rejuran/dual-effect-ampoule/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/sg/p/rejuran/dual-effect-ampoule/for/oily-acne-prone-skin): Average

## Key ingredients

Blackberry Leaf Extract, Glycyrrhiza Glabra Extract Licorice Extract, Calendula Officinalis Flower Extract

## What the research says

- A blackberry and dill extract combination synergistically increased skin elasticity and induced elastogenesis compared to each ingredient alone and placebo. ([International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/32583541/))
- Tropical highland blackberry juice reduced UVB-mediated DNA damage and increased apoptosis in human epidermal keratinocytes and a reconstituted skin equivalent model. ([Photochemistry and Photobiology, 2013](https://pubmed.ncbi.nlm.nih.gov/23711186/))
- Strawberry and blackberry crude extracts, anthocyanin-enriched fractions, and proanthocyanidin-enriched fractions demonstrated anti-inflammatory effects through ROS reduction, gene expression inhibition, and NO suppression, while anthocyanin fractions promoted fibroblast migration in vitro. ([Food Research International, 2019](https://pubmed.ncbi.nlm.nih.gov/31108769/))
- Combining 755 nm alexandrite laser with topical licorice gel significantly reduces terminal hair counts compared to alexandrite laser with placebo in women with idiopathic hirsutism. ([Evidence-based Complementary and Alternative Medicine, 2015](https://pubmed.ncbi.nlm.nih.gov/26273313/))
- Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo. ([Experimental Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25381913/))
- Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide. ([Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/))
- Topical application of Calendula officinalis extract cream significantly improved skin hydration and firmness (reflected in significant changes in R0 and R6 parameters) in 21 healthy human volunteers compared to a base cream. ([Acta Poloniae Pharmaceutica, 2011](https://pubmed.ncbi.nlm.nih.gov/21928714/))
- Treatment with standardized extract of Calendula officinalis L. led to a shorter epithelization time and faster healing speed compared to mineral oil in patients with acute skin loss wounds of the hand and fingers healing by secondary intention. ([Tissue Barriers, 2022](https://pubmed.ncbi.nlm.nih.gov/34674610/))
- Topical administration of Calendula provides weak evidence of effectiveness in acute and chronic wounds compared to standard treatments based on a narrative review of available trials. ([Wounds, 2008](https://pubmed.ncbi.nlm.nih.gov/25941793/))

## What reviewers say

This ampoule is widely praised for delivering the "glass skin" look, with users reporting immediate improvements in hydration, radiance, and skin texture. It is particularly favored by those with aging or damaged skin for its ability to smooth fine lines and repair the skin barrier using its signature salmon DNA (PDRN) formula, though its high price point is a common contention.

- Liked: Instant Glow (mostly mentioned)
- Disliked: High price point (mostly mentioned)
- Liked: Deep Hydration (often mentioned)
- Liked: Texture Smoothing (often mentioned)
- Disliked: Packaging issues (often mentioned)
- Liked: Fast Absorption (sometimes noted)
- Liked: Soothing & Repair (sometimes noted)
- Disliked: Breakouts/Irritation (rarely noted)
- Disliked: Heavy/Sticky finish (rarely noted)
- Disliked: Not hydrating enough (rarely noted)

## How to apply

- Could be used as part of your AM and PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply this moisturizer after your cleanser and toner, right before your morning SPF.
- Gently press a small amount of the moisturizer into your skin. Avoid rubbing it too hard so it absorbs nicely.
- For the best moisture, you can apply it when your skin is slightly damp. This helps your skin stay soft and happy.
- Remember to avoid the eye area when applying. Always do a patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Rejuran Dual Effect Ampoule work for skin with dark spots?

This product works moderately well for skin with dark spots, providing good hydration and soothing benefits while keeping irritation low. However, it lacks high enough amounts of ingredients like arbutin and niacinamide to specifically target dark spots. A product for this skin needs higher levels of targeted brightening ingredients along with soothing and hydrating components.

### Which ingredients make this serum a good fit for skin with dark spots?

This serum fits skin with dark spots because it contains Niacinamide and Arbutin, though it needs higher amounts of these key ingredients to truly fade dark spots. A top-rated product for this skin needs strong dark spot fighters alongside nourishing ingredients that keep skin soft and smooth.

### What does Blackberry Leaf Extract do for skin with dark spots?

Blackberry leaf extract helps fade dark spots by targeting excess skin pigment. This plant-based ingredient may improve uneven skin tone safely with a low risk of irritation.
Sources: [The Journal of Investigative Dermatology. Symposium Proceedings, 2008](https://pubmed.ncbi.nlm.nih.gov/18369335/)

### What does Licorice Extract do for skin with dark spots?

Licorice extract helps fade dark spots and even out skin tone by slowing down the melanin production that causes discoloration. It is also very safe and gentle, making it unlikely to irritate even sensitive skin while brightening your complexion.
Sources: [Journal of Ethnopharmacology, 2025](https://pubmed.ncbi.nlm.nih.gov/40350048/), [Pigment Cell Research, 1998](https://pubmed.ncbi.nlm.nih.gov/9870547/)

### Where does this serum go in a skincare routine for skin with dark spots?

This treatment goes in the evening routine after cleansing and toning, and before moisturizing. To better fade dark spots, this skin needs products with higher amounts of targeted brightening ingredients like arbutin and niacinamide.

### Can I use this serum with retinol, and in what order?

You can use this moisturizing treatment with retinol by applying it before your retinol to keep skin hydrated and calm. This type of product needs to include brightening ingredients like vitamin C or kojic acid to effectively help fade dark spots on this skin.

### How often should I use this serum?

You can use this serum in the evening as part of your routine for dark spots, and some types can also be used in the morning or twice a day. This product type helps keep skin hydrated and calm, but for dark spots it needs higher levels of ingredients like arbutin and niacinamide to specifically target pigmentation.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26151786/)

### Can this serum clog pores, cause breakouts or purging for skin with dark spots?

This serum is unlikely to cause breakouts or clogged pores for skin with dark spots because it contains gentle, soothing ingredients and avoids harsh components. Skin with dark spots needs a product that also features higher amounts of targeted brightening ingredients like arbutin and niacinamide to effectively fade discoloration.

### Can I use this serum around the eyes or on my body?

You can use this moisturizing treatment around the eyes and on the body because it has a very safe formula with soothing agents like Bisabolol, though it works better on other areas since skin thickness varies greatly across the body. To effectively care for the thin skin around the eyes or body skin, this type of product needs a gentle blend with ingredients like hyaluronic acid and botanical extracts that support delicate areas without irritation.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37896378/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for skin with dark spots

- [MISSHA Super Aqua Ultra Hyalron Ampoule](https://lovi.care/skincare/sg/p/missha/super-aqua-ultra-hyalron-ampoule/for/dark-spots) — Average fit — S$23.12 at YesStyle

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/sg/p/cerave/foaming-facial-cleanser/for/dark-spots) — Superior fit — S$30.40 at Amazon
- Hydrating Toner: [ma:nyo Bifida Biome Ampoule Toner](https://lovi.care/skincare/sg/p/ma-nyo/bifida-biome-ampoule-toner/for/dark-spots) — Superior fit — S$36.16 at Amazon
- SPF: [d'Alba UVessence Mild Waterfull Sun Cream SPF 50](https://lovi.care/skincare/sg/p/d-alba/uvessence-mild-waterfull-sun-cream-spf-50/for/dark-spots) — Superior fit — S$36.14 at Amazon

## Where to buy

No store in Singapore has a checked price for this product, so the page shows none.

## Ingredients

Blackberry Leaf Extract, Glycyrrhiza Glabra Extract Licorice Extract, Calendula Officinalis Flower Extract, Aloe Barbadensis Leaf Juice, Blueberry Fruit Extract, Morus Nigra Fruit Extract, Peg-6, Glycerin, Water, Hyaluronic Acid, Niacinamide, Dipropylene Glycol, Butylene Glycol, 1,2-Hexanediol, Carbomer, Gerotine Hydrolyzed Dna, Hydrolyzed Dna, Xanthan Gum, Polysorbate 20, Adenosine, Tocopheryl Acetate, Bisabolol, Arbutin, Ethylhexylglycerin, Caprylyl Glycol, Hexylene Glycol, Trehalose, Urea, Serine, Pentylene Glycol, Glyceryl Polyacrylate, Algin, Pullulan, Disodium Phosphate, Potassium Phosphate, Squalane, Hydrogenated Lecithin, Ceramide Np, Oleic Acid, Inulin Lauryl Carbamate, Cholesterol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/rejuran/dual-effect-ampoule/for/dark-spots
- United Kingdom: https://lovi.care/skincare/uk/p/rejuran/dual-effect-ampoule/for/dark-spots
- Ireland: https://lovi.care/skincare/ie/p/rejuran/dual-effect-ampoule/for/dark-spots
- Germany: https://lovi.care/skincare/de/p/rejuran/dual-effect-ampoule/for/dark-spots
- France: https://lovi.care/skincare/fr/p/rejuran/dual-effect-ampoule/for/dark-spots
- Italy: https://lovi.care/skincare/it/p/rejuran/dual-effect-ampoule/for/dark-spots
- Netherlands: https://lovi.care/skincare/nl/p/rejuran/dual-effect-ampoule/for/dark-spots
- Spain: https://lovi.care/skincare/es/p/rejuran/dual-effect-ampoule/for/dark-spots
- Canada: https://lovi.care/skincare/ca/p/rejuran/dual-effect-ampoule/for/dark-spots
- Australia: https://lovi.care/skincare/au/p/rejuran/dual-effect-ampoule/for/dark-spots
- Singapore: https://lovi.care/skincare/sg/p/rejuran/dual-effect-ampoule/for/dark-spots (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/p/rejuran/dual-effect-ampoule/for/dark-spots
- United Arab Emirates: https://lovi.care/skincare/ae/p/rejuran/dual-effect-ampoule/for/dark-spots