Peter Thomas Roth FIRMx Peeling Gel for skin with dark spots

How to apply

Questions and answers

What the research says

• Bacterial cellulose membranes with and without glycerin showed good skin compatibility and no barrier disruption in human subjects compared to a negative control, with glycerin-containing membranes additionally providing a statistically significant skin moisturizing effect (p=0.044).

  European Journal of Pharmaceutics and Biopharmaceutics, 2014

• Oral bromelain slightly reduced pain compared to controls (mean difference -0.27) and topical bromelain reduced time to complete debridement by 6.89 days, with no major health risks reported.

  Nutrition and Health, 2023

• An upcycled pineapple leaf fibre crosspolymer forms a physical barrier that protects against environmental aggressors while providing antioxidant, anti-inflammatory, antipollution, UV protection, hydration, and hair benefits.

  International Journal of Cosmetic Science, 2026

• A coaxial electrospun core-shell nanofiber scaffold delivering bromelain and salvianolic acid B demonstrated sustained drug release, in vitro endothelial cell migration, increased capillary formation in an in ovo assay, and in vivo efficacy for skin regeneration and wound healing.

  Biomedical Materials, 2017

• Exposure to a Kiperin Bromelain & Papain complex at 2.5 µg/mL increased cell viability, altered wound closure, decreased inflammation-related gene expression, and increased skin barrier/keratinization gene expression in CCD-18Co colon fibroblasts, HME-1 mammary epithelial cells, and HaCaT keratinocytes.

  Scientific Reports, 2026

• Nanofibrillar cellulose dressing provides efficient wound healing comparable to polylactide-based copolymer dressings at skin graft donor sites in 24 patients, with significant improvements in observer scar thickness and vascularity and skin elasticity.

  Advances in Wound Care, 2020

• AgNP-BC exhibited over 99% reduction in Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa with no cytotoxicity, allowing epidermal cell attachment and growth compared to unmodified bacterial cellulose.

  Carbohydrate Polymers, 2014

• Cellulose acetate and soy protein hydrolysate nanofibrous dressings promote fibroblast proliferation in vitro and accelerate wound healing with reduced scar formation in vivo.

  Advanced Healthcare Materials, 2018

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

  Journal of Cosmetic Dermatology, 2020

• Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

  International Journal of Cosmetic Science, 2001

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Enzymatic exfoliation using the keratinase HT1 efficiently decomposed human skin keratin and exfoliated the outermost stratum corneum with less abrasiveness and no damage to the epidermal layer compared with chemical exfoliation.

  Enzyme and Microbial Technology, 2025

Ingredients

Water, Peg-32, Cellulose, Butylene Glycol, Bergamot Fruit Water, Sorbitol, R-Bacillus Licheniformis Keratinase, Pineapple Fruit Extract, Lactobacillus Punica Granatum Extract Fruit Ferment, Leuconostoc Radish Root Ferment Filtrate, Sodium Hyaluronate, Glycerin, Sodium Hydroxide, Citric Acid, Tetrasodium Edta, Algin, Carbomer, Tromethamine, Isopropyl Myristate, Sodium Chloride, Calcium Chloride, Potassium Sorbate, Sodium Benzoate, Mica, Phenoxyethanol

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.