# Perricone MD Vitamin C Ester Brightening Serum for sensitive skin

**Lovi Fit: Average fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/sg/p/perricone-md/vitamin-c-ester-brightening-serum/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Brand: [Perricone MD](https://lovi.care/skincare/sg/brands/perricone-md)
Category: [Serums and treatments](https://lovi.care/skincare/sg/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for sensitive skin; other serums fit it better.

## Why this fit

- Offers moderate brightening for your normal skin due to Tetrahexyldecyl Ascorbate and Ferulic Acid, which help even skin tone and provide antioxidant activity. Sodium Hyaluronate and Beta-Glucan offer supportive hydration and soothing benefits for your redness and irritation.
- Tocotrienols further enhance antioxidant protection, supporting overall skin health for your normal skin type.
- The formulation is safe for your sensitive skin, as it lacks harsh ingredients and carries no risk of irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sg/p/perricone-md/vitamin-c-ester-brightening-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/sg/p/perricone-md/vitamin-c-ester-brightening-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/sg/p/perricone-md/vitamin-c-ester-brightening-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/sg/p/perricone-md/vitamin-c-ester-brightening-serum/for/sensitive-skin): Average (this page)
- [Acne-prone skin](https://lovi.care/skincare/sg/p/perricone-md/vitamin-c-ester-brightening-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/sg/p/perricone-md/vitamin-c-ester-brightening-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/sg/p/perricone-md/vitamin-c-ester-brightening-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/sg/p/perricone-md/vitamin-c-ester-brightening-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/sg/p/perricone-md/vitamin-c-ester-brightening-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Ascorbic Acid Ester, Squalane, Ferulic Acid, Rosemary Leaf Extract, Sodium Hyaluronate

## What the research says

- A 3-in-1 anti-aging topical night serum-in-oil applied once daily decreased wrinkles by 11%, increased skin firmness by 8%, reduced redness by 70%, and improved overall skin quality and complexion in 103 female subjects over 28 to 84 days compared to baseline. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30924254/))
- Topical application of a tocopherols and tocotrienols formulation significantly reduced photo-induced skin reactions compared to simple vehicle and vitamin A in patients with photosensitivity. ([Journal of the European Academy of Dermatology and Venereology, 2012](https://pubmed.ncbi.nlm.nih.gov/21917024/))
- A multiple W/O/W emulsion containing Rosmarinus officinalis L., Avena sativa L., and Linum usitatissimum L. extracts showed no irritant, phototoxic, inflammatory, or allergenic potential in human skin models and patch tests, establishing its safety as a cosmetic base. ([Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/34065623/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Treatment with 14% ferulic acid and 12% l-ascorbic acid significantly reduced pigmentation and erythema while improving hydration and elasticity in 20 women with photoaged skin, with neither acid proving definitively more effective overall though ascorbic acid showed slightly greater skin lightening. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/34877760/))
- Combining fractional microneedle radiofrequency with a topical antioxidant serum significantly reduced wrinkle severity by 29.9% versus 18.0%, increased elasticity by 12.9% versus 2.3%, and improved aesthetic outcomes in 31 participants compared to radiofrequency and placebo. ([The Journal of Dermatological Treatment, 2025](https://pubmed.ncbi.nlm.nih.gov/40464749/))
- Pretreatment with a topical antioxidant mixture of vitamin C, ferulic acid, and phloretin attenuated ultraviolet-induced sunburn cell formation, thymine dimer formation, matrix metalloproteinase-9 expression, p53 protein expression, and the suppression of CD1a-expressing Langerhans cells in human skin compared to vehicle control. ([Journal of Cosmetic Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19146606/))
- Topical application of rosemary essential oil-loaded lipid nanoparticles in gel vehicles significantly increased skin hydration compared to gels containing free oil, and increased elasticity to a lesser extent, in ten healthy volunteers. ([Pharmaceutics, 2017](https://pubmed.ncbi.nlm.nih.gov/29065483/))
- Topical application of a cream containing the NHE1 activator rosmarinic acid decreased skin surface pH and transepidermal water loss while increasing skin hydration in 50-60-year-old adult females compared to vehicle cream and no treatment. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35409270/))
- An alcoholic extract of rosemary leaves, Rosm1, demonstrates strong antioxidant activity and inhibits oxidative alterations to skin surface lipids when evaluated in vitro and in vivo. ([International Journal of Tissue Reactions, 2000](https://pubmed.ncbi.nlm.nih.gov/10937349/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))

## What reviewers say

Users consistently report that the serum effectively brightens the complexion and smooths skin texture, often delivering a noticeable "glow" and reducing the appearance of dark spots. While the lightweight, citrus-scented formula is praised for quick absorption, some users with sensitive or dry skin experienced irritation and found it necessary to layer a heavy moisturizer on top.

- Liked: Brightens and glows (often mentioned)
- Liked: Smooths texture (often mentioned)
- Liked: Fades dark spots (sometimes noted)
- Liked: Lightweight absorption (sometimes noted)
- Liked: Pleasant scent (sometimes noted)
- Disliked: Drying formula (sometimes noted)
- Disliked: High price (sometimes noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Scent dislike (rarely noted)
- Disliked: Skin irritation (rarely noted)

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Perricone MD Vitamin C Ester Brightening Serum work for sensitive skin?

Perricone MD Vitamin C Ester Brightening Serum is an average fit for sensitive skin, as it provides moderate brightening and hydration while being safe from harsh ingredients. However, to work best for sensitive skin, this type of product needs soothing and calming ingredients like niacinamide and snail secretion filtrate to better manage redness and irritation without adverse effects.
Sources: [Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/34065623/), [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30924254/)

### Which ingredients make this serum a good fit for sensitive skin?

Sodium hyaluronate, beta-glucan, and squalane help make this serum a good fit for sensitive skin by offering supportive hydration and soothing benefits for redness and irritation without carrying any risk of irritation. To work best for sensitive skin, a product of this type needs soothing ingredients like niacinamide and snail secretion filtrate to actively calm redness while maintaining high compatibility.

### What does Ascorbic Acid do for sensitive skin?

Ascorbic Acid helps improve skin elasticity and calms redness in reactive and sensitive skin when used properly. Studies show it is generally well-tolerated and provides safe anti-aging benefits for delicate skin types.
Sources: [Antioxidants, 2024](https://pubmed.ncbi.nlm.nih.gov/38397772/)

### What does Squalane do for sensitive skin?

Squalane helps calm sensitive skin by defending against everyday irritation and keeping it smooth and soft. It is unlikely to cause irritation and supports your skin barrier so it stays comfortable and hydrated.
Sources: [International Journal of Molecular Sciences, 2017](https://pubmed.ncbi.nlm.nih.gov/29280987/)

### Where does this serum go in a skincare routine for sensitive skin?

This treatment goes in the evening routine after your soothing toner and before your moisturizer. It is safe for sensitive skin, but this skin type often needs a product featuring soothing hydrators like sodium hyaluronate and beta-glucan to keep redness and irritation completely calm.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying your retinol in your nighttime routine and using this treatment in the morning, or by alternating the nights you use them. This approach helps prevent excessive dryness and irritation while still giving you the brightening and smoothing benefits.

### How often should I use this serum?

You can use this treatment in the evening, applying it after your cleansing and toning steps. This serum for sensitive skin needs soothing ingredients like sodium hyaluronate and beta-glucan to keep skin calm while brightening it.
Sources: [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30924254/)

### Can this serum clog pores, cause breakouts or purging for sensitive skin?

This serum is unlikely to clog pores or cause breakouts for sensitive skin, as it has a safe profile and lacks harsh ingredients. However, a product of this type needs soothing ingredients like beta-glucan and squalane, along with gentle hydrators, to keep sensitive skin calm and comfortable.
Sources: [Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/34065623/)

### Is this serum fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (benzyl alcohol, parfum, limonene, linalool, citral, and citronellol). Behenyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for sensitive skin

- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vitamin-c-serum/for/sensitive-skin) — High fit — S$50.41 at Amazon
- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/sg/p/skin1004/probio-cica-intensive-ampoule/for/sensitive-skin) — High fit — S$28.55 at Amazon
- [PCA Skin C&E Advanced with Hexylresorcinol and Silymarin](https://lovi.care/skincare/sg/p/pca-skin/c-and-e-advanced/for/sensitive-skin) — Average fit — S$192.38 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/sg/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — S$30.00 at Amazon
- Soothing Toner: [One Thing Centella Asiatica Extract Toner](https://lovi.care/skincare/sg/p/one-thing/centella-asiatica-extract-toner/for/sensitive-skin) — Superior fit — S$30.07 at Amazon
- Moisturizer with Sun Protection: [ISDIN Eryfotona Actinica SPF 50+](https://lovi.care/skincare/sg/p/isdin/eryfotona-actinica-spf-50/for/sensitive-skin) — Superior fit — S$110.01 at Amazon

## Where to buy

No store in Singapore has a checked price for this product, so the page shows none.

## Ingredients

Water, Tetrahexyldecyl Ascorbate, Caprylyl Methicone, Hydrogenated Lecithin, Behenyl Alcohol, Benzyl Alcohol, Squalane, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Ferulic Acid, Jojoba Seed Oil, Sodium Hyaluronate, Polysorbate 20, Xanthan Gum, Beta-Glucan, Parfum, Sorbitol, Limonene, Stearyl Glycyrrhetinate, Disodium Edta, Palm Oil, Tocotrienols, Linalool, Tocopherol, Citral, Citronellol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/perricone-md/vitamin-c-ester-brightening-serum/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/perricone-md/vitamin-c-ester-brightening-serum/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/perricone-md/vitamin-c-ester-brightening-serum/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/perricone-md/vitamin-c-ester-brightening-serum/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/perricone-md/vitamin-c-ester-brightening-serum/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/perricone-md/vitamin-c-ester-brightening-serum/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/perricone-md/vitamin-c-ester-brightening-serum/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/perricone-md/vitamin-c-ester-brightening-serum/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/perricone-md/vitamin-c-ester-brightening-serum/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/perricone-md/vitamin-c-ester-brightening-serum/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/perricone-md/vitamin-c-ester-brightening-serum/for/sensitive-skin (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/p/perricone-md/vitamin-c-ester-brightening-serum/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/perricone-md/vitamin-c-ester-brightening-serum/for/sensitive-skin