# Perricone MD Vitamin C Ester Brightening Serum for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/sg/p/perricone-md/vitamin-c-ester-brightening-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Brand: [Perricone MD](https://lovi.care/skincare/sg/brands/perricone-md)
Category: [Serums and treatments](https://lovi.care/skincare/sg/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best serums for mature skin.

## Why this fit

- Highly suitable for your normal skin, this serum effectively targets wrinkles and fine lines with tetrahexyldecyl ascorbate and tocotrienols, which boost collagen production and provide antioxidant protection.
- Ferulic acid and vitamin C ester further enhance skin tone and brightness, complementing your skin's natural radiance.
- The formula is safe for your skin, containing no harsh ingredients and posing no irritation risks.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sg/p/perricone-md/vitamin-c-ester-brightening-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/sg/p/perricone-md/vitamin-c-ester-brightening-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/sg/p/perricone-md/vitamin-c-ester-brightening-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/sg/p/perricone-md/vitamin-c-ester-brightening-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/sg/p/perricone-md/vitamin-c-ester-brightening-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/sg/p/perricone-md/vitamin-c-ester-brightening-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/sg/p/perricone-md/vitamin-c-ester-brightening-serum/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/sg/p/perricone-md/vitamin-c-ester-brightening-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/sg/p/perricone-md/vitamin-c-ester-brightening-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Ascorbic Acid Ester, Squalane, Ferulic Acid, Rosemary Leaf Extract, Sodium Hyaluronate

## What the research says

- A 3-in-1 anti-aging topical night serum-in-oil applied once daily decreased wrinkles by 11%, increased skin firmness by 8%, reduced redness by 70%, and improved overall skin quality and complexion in 103 female subjects over 28 to 84 days compared to baseline. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30924254/))
- A multiple W/O/W emulsion containing Rosmarinus officinalis L., Avena sativa L., and Linum usitatissimum L. extracts showed no irritant, phototoxic, inflammatory, or allergenic potential in human skin models and patch tests, establishing its safety as a cosmetic base. ([Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/34065623/))
- Combining fractional microneedle radiofrequency with a topical antioxidant serum significantly reduced wrinkle severity by 29.9% versus 18.0%, increased elasticity by 12.9% versus 2.3%, and improved aesthetic outcomes in 31 participants compared to radiofrequency and placebo. ([The Journal of Dermatological Treatment, 2025](https://pubmed.ncbi.nlm.nih.gov/40464749/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Treatment with 14% ferulic acid and 12% l-ascorbic acid significantly reduced pigmentation and erythema while improving hydration and elasticity in 20 women with photoaged skin, with neither acid proving definitively more effective overall though ascorbic acid showed slightly greater skin lightening. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/34877760/))
- Pretreatment with a topical antioxidant mixture of vitamin C, ferulic acid, and phloretin attenuated ultraviolet-induced sunburn cell formation, thymine dimer formation, matrix metalloproteinase-9 expression, p53 protein expression, and the suppression of CD1a-expressing Langerhans cells in human skin compared to vehicle control. ([Journal of Cosmetic Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19146606/))
- Topical ferulic acid-containing formulations effectively reduce skin erythema, hyperpigmentation, and signs of aging in adults compared to baseline or alternative conditions. ([The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40538529/))
- Topical application of rosemary essential oil-loaded lipid nanoparticles in gel vehicles significantly increased skin hydration compared to gels containing free oil, and increased elasticity to a lesser extent, in ten healthy volunteers. ([Pharmaceutics, 2017](https://pubmed.ncbi.nlm.nih.gov/29065483/))
- Topical application of a cream containing the NHE1 activator rosmarinic acid decreased skin surface pH and transepidermal water loss while increasing skin hydration in 50-60-year-old adult females compared to vehicle cream and no treatment. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35409270/))
- An alcoholic extract of rosemary leaves, Rosm1, demonstrates strong antioxidant activity and inhibits oxidative alterations to skin surface lipids when evaluated in vitro and in vivo. ([International Journal of Tissue Reactions, 2000](https://pubmed.ncbi.nlm.nih.gov/10937349/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))

## What reviewers say

Users consistently report that the serum effectively brightens the complexion and smooths skin texture, often delivering a noticeable "glow" and reducing the appearance of dark spots. While the lightweight, citrus-scented formula is praised for quick absorption, some users with sensitive or dry skin experienced irritation and found it necessary to layer a heavy moisturizer on top.

- Liked: Brightens and glows (often mentioned)
- Liked: Smooths texture (often mentioned)
- Liked: Fades dark spots (sometimes noted)
- Liked: Lightweight absorption (sometimes noted)
- Liked: Pleasant scent (sometimes noted)
- Disliked: Drying formula (sometimes noted)
- Disliked: High price (sometimes noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Scent dislike (rarely noted)
- Disliked: Skin irritation (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Perricone MD Vitamin C Ester Brightening Serum a great fit for mature skin?

This serum is a great fit because it targets wrinkles and fine lines while improving skin tone and brightness. Tetrahexyldecyl ascorbate and tocotrienols help boost collagen and provide antioxidant protection, while ferulic acid and vitamin C ester enhance natural radiance with a low risk of irritation.
Sources: [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30924254/)

### Which ingredients make this serum a good fit for mature skin?

This serum is a great fit for mature skin because it contains tetrahexyldecyl ascorbate and tocotrienols, which help boost collagen production and smooth out wrinkles and fine lines. Ferulic acid and vitamin C ester also work together to brighten your skin tone and enhance your natural glow.
Sources: [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30924254/)

### What does Ascorbic Acid do for mature skin?

Ascorbic acid helps make mature skin look smoother and firmer while reducing fine lines and wrinkles. It supports collagen building and helps protect against daily skin damage.
Sources: [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/32383548/), [Archives of Otolaryngology--head & Neck Surgery, 1999](https://pubmed.ncbi.nlm.nih.gov/10522500/)

### What does Squalane do for mature skin?

Squalane helps keep mature skin feeling soft and smooth by boosting moisture and protecting the skin barrier. It also provides antioxidant support that helps improve the look of fine lines and wrinkles over time.
Sources: [Journal of Nanobiotechnology, 2025](https://pubmed.ncbi.nlm.nih.gov/40001122/), [Journal of Nanoscience and Nanotechnology, 2010](https://pubmed.ncbi.nlm.nih.gov/21137794/)

### Where does this serum go in a skincare routine for mature skin?

This treatment serum goes in your evening routine after your cleansing toner and before your moisturizer. Putting it in the evening helps keep your skin safe around sun exposure, and you may also use it in the morning or twice a day.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying your retinol product first and following with this treatment serum afterwards. This helps smooth fine lines while minimizing the likelihood of any irritation on mature skin.
Sources: [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30924254/)

### How often should I use this serum?

This serum is used in the evening as part of your routine. It has a great fit for mature skin, helping smooth wrinkles and brighten your skin tone safely.
Sources: [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30924254/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores or cause breakouts for mature skin, as it has a safe formula with no harsh ingredients and poses very low irritation risks. It helps smooth lines and brighten your complexion while keeping your skin calm and comfortable.
Sources: [Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/34065623/)

### Is this serum fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (benzyl alcohol, parfum, limonene, linalool, citral, and citronellol). Behenyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for mature skin

- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — S$50.41 at Amazon
- [PCA Skin C&E Strength Max](https://lovi.care/skincare/sg/p/pca-skin/c-and-e-strength-max/for/mature-skin) — High fit — S$179.75 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vitamin-c-serum/for/mature-skin) — High fit — S$50.41 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/sg/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — S$30.00 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/sg/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — S$41.07 at Amazon
- SPF: [ISDIN Eryfotona Actinica SPF 50+](https://lovi.care/skincare/sg/p/isdin/eryfotona-actinica-spf-50/for/mature-skin) — Superior fit — S$110.01 at Amazon

## Where to buy

No store in Singapore has a checked price for this product, so the page shows none.

## Ingredients

Water, Tetrahexyldecyl Ascorbate, Caprylyl Methicone, Hydrogenated Lecithin, Behenyl Alcohol, Benzyl Alcohol, Squalane, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Ferulic Acid, Jojoba Seed Oil, Sodium Hyaluronate, Polysorbate 20, Xanthan Gum, Beta-Glucan, Parfum, Sorbitol, Limonene, Stearyl Glycyrrhetinate, Disodium Edta, Palm Oil, Tocotrienols, Linalool, Tocopherol, Citral, Citronellol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

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- United States: https://lovi.care/skincare/p/perricone-md/vitamin-c-ester-brightening-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/perricone-md/vitamin-c-ester-brightening-serum/for/mature-skin
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