Perricone MD High Potency Hyaluronic Intensive Hydrating Serum for combination skin
Sodium Hyaluronate
Niacinamide
Squalane
Ceramide Np
Acetyl Glucosamine
High
- HighCombination Skin Fit
- HighEffectiveness
- ExcellentSafety
One of the best moisturizers for combination skin.
This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Highly suitable for your combination skin, this serum effectively addresses oily shine with niacinamide for seboregulation and provides deep hydration through sodium hyaluronate crosspolymer and sodium hyaluronate.
- The formula's excellent moisturizing capabilities are further enhanced by glycerin, ensuring your skin remains comfortably hydrated without feeling heavy.
- This product is safe for your skin, containing no harsh ingredients and including soothing components like niacinamide and glycerin.
How to apply
- Use this moisturizer in your AM and PM routine every day to control shine. Always pair with SPF in the morning.
- Apply this moisturizer after your cleanser and toner, right before your morning SPF.
- Gently press a small amount of the moisturizer into your skin and avoid harsh rubbing. Let it ⏳absorb for a minute.
- Apply the moisturizer on slightly damp skin to help it lock in moisture better. This keeps your combination skin balanced.
- Avoid the eye area when applying the moisturizer. Do a patch test before your first use.
People Say
★4.8Overall rating based on 1000+ reviewsUsers consistently praise this serum for its ability to deliver immediate and deep hydration, often noting that it visibly plumps fine lines and leaves skin feeling exceptionally soft and smooth. While the vast majority find the texture elegant and fast-absorbing, a small minority of users find it slightly sticky or heavy compared to more watery serums.
Highlights
Deep hydration Mostly Mentioned
- “Immediate deep hydration”
- “quench dehydrated skin”
- “endlessly hydrated”
- “replenish moisture”
Fast absorbing Often Mentioned
- “Absorbs quickly”
- “sinks in beautifully”
- “non-greasy”
- “no residue”
Plumps fine lines Often Mentioned
- “Plumps wrinkles”
- “softened fine lines”
- “visibly plump”
- “diminish look of lines”
Smooths texture Often Mentioned
- “Skin feels softer”
- “smooth complexion”
- “supple feeling”
- “satin veil”
High price point Often Mentioned
- “Pricey”
- “expensive”
- “splurge”
- “investment”
Gentle on skin Sometimes Noted
- “Lovely on sensitive skin”
- “very healing”
- “no irritation”
- “soothing”
Heavy texture Rarely Noted
- “Not water-like”
- “silicone feel”
- “thicker than expected”
- “too rich”
Packaging issues Rarely Noted
- “Pump broke”
- “hard to dispense”
- “bottle design”
- “product left at bottom”
Scent Rarely Noted
- “Clinical smell”
- “unpleasant scent”
- “strong odor”
- “chemical smell”
Sticky feel Rarely Noted
- “Little sticky”
- “tacky finish”
- “sticky residue”
- “feels heavy”
Sources: lovi.care, perriconemd.com, dermstore.com, lookfantastic.com, ulta.com, lovelyskin.com, and more
Questions and answers
What makes Perricone MD High Potency Hyaluronic Intensive Hydrating Serum a great fit for combination skin?
This serum is a great fit for your combination skin because it helps control oily shine while keeping your skin deeply hydrated without feeling heavy. It is very safe for your skin, containing no harsh ingredients and including soothing components that keep your skin comfortable.
Which ingredients make this serum a good fit for combination skin?
This serum is a great fit for your combination skin because niacinamide helps balance oily shine while sodium hyaluronate and glycerin provide deep hydration without feeling heavy. It is very safe and gentle, keeping your skin comfortably moisturized.
Clinical, Cosmetic and Investigational Dermatology, 2017The British Journal of Dermatology, 2002
What does Hyaluronic Acid do for combination skin?
Hyaluronic acid is a great fit for combination skin because it quenches dry areas with a boost of hydration while keeping oily zones balanced. Regular use helps smooth out fine lines and makes your skin feel soft and plump without causing irritation.
Dermatology and Therapy, 2021Journal of Drugs in Dermatology, 2011
What does Niacinamide do for combination skin?
Niacinamide helps balance oily areas by reducing excess shine and pore size while keeping dry patches hydrated and smooth. It also works to calm redness and even out skin tone, making it very suitable for combination skin.
Where does it go in a skincare routine for combination skin?
This treatment goes in the evening routine after cleansing and toning, and before moisturizing. Putting it in the evening helps keep things simple and adds extra safety around sun exposure.
Can I use this serum with retinol, and in what order?
You can use this serum with retinol by applying the serum first to keep your skin comfortably hydrated and calm while it adjusts to the retinoid. Using a gentle, barrier-supporting moisturizer helps reduce potential irritation like dryness and flaking.
How often should I use it?
You can use this serum in your evening routine for simplicity and extra safety around sun exposure. It safely gives your combination skin deep hydration without feeling heavy while helping manage oily shine.
Health Science Reports, 2021Clinical, Cosmetic and Investigational Dermatology, 2017
Can this serum clog pores, cause breakouts or purging for combination skin?
This serum is a great fit for combination skin because it helps control oily shine while providing deep hydration without feeling heavy. It is very unlikely to clog pores or cause breakouts, as its formula contains soothing and gentle ingredients.
Can I use it around the eyes or on my body?
You can use this serum around the eyes, where the skin is particularly thin, as it provides deep hydration and soothing benefits without feeling heavy. However, applying it to the entire body is usually unnecessary and impractical due to the product size and targeted facial formulation.
Surgical and Radiologic Anatomy, 2002Clinical, Cosmetic and Investigational Dermatology, 2017
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone.
Dermatologic Therapy, 2022A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer.
The British Journal of Dermatology, 2002Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.
Journal of Drugs in Dermatology, 2011Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.
Clinical Oral Investigations, 2022Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.
BMC Oral Health, 2019Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.
Molecules, 2025Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.
Antioxidants, 2025Topical 2% N-acetyl glucosamine reduced facial hyperpigmentation in an 8-week split-face clinical test, with an even greater effect observed when combined with 4% niacinamide.
Journal of Cosmetic Dermatology, 2007N-acetyl-glucosamine-loaded nanostructured lipid carriers successfully delivered the hydrophilic agent through the skin and reduced melanin distribution in healthy volunteers.
Advanced Pharmaceutical Bulletin, 2016Topical cosmetic products containing hyaluronic acid, N-acetyl glucosamine, and gamma-amino butyric acid improved skin hydration by 24.28% to 33.60%, elasticity by 11.98%, and skin lightening by 5.26% over 2 months in 20 female participants.
Journal of Cosmetic and Laser Therapy, 2019
Ingredients
Water, Dimethicone, Butylene Glycol, Niacinamide, Acetyl Glucosamine, Squalane, Sodium Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Polysilicone-11, Cetearyl Olivate, Hdi Trimethylol Hexyllactone Crosspolymer, Polyisobutene, Sorbitan Olivate, Dimethyl Isosorbide, Polysorbate 20, 1,2-Hexanediol, Caprylyl Glycol, Dimethyl Mea, Hydroxyacetophenone, Citric Acid, Ceramide Np, Caprylyl Capryl Glucoside, Sorbitan Oleate, Sodium Gluconate, Spermidine, Silica, Sodium Acetylated Hyaluronate, Sodium Hyaluronate, Phenoxyethanol, Phytosphingosine, Sodium Hyaluronate Crosspolymer, Ethylhexylglycerin, Acetyl Tetrapeptide-11, Acetyl Tetrapeptide-9, Glycerin, Disodium Acetyl Glucosamine Phosphate, Sodium Glucuronate, Magnesium Sulfate
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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