# Paula's Choice Niacinamide 20% Treatment for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: Superior · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/sg/p/paula-s-choice/niacinamide-20-treatment/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Brand: [Paula's Choice](https://lovi.care/skincare/sg/brands/paula-s-choice)
Category: [Serums and treatments](https://lovi.care/skincare/sg/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best serums for mature skin.

## Why this fit

- Excellent suitability for your normal skin, as the high concentration of niacinamide and panthenol work to regulate sebum and repair your skin barrier, while acetyl glucosamine smooths texture.
- The formula also addresses your concerns about wrinkles and fine lines with niacinamide and ascorbyl glucoside, which promote collagen synthesis and provide antioxidant protection.
- The product is safe for your skin due to the absence of harsh ingredients and the inclusion of soothing components like niacinamide and glycerin.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sg/p/paula-s-choice/niacinamide-20-treatment/for/oily-skin): Superior
- [Dry skin](https://lovi.care/skincare/sg/p/paula-s-choice/niacinamide-20-treatment/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/sg/p/paula-s-choice/niacinamide-20-treatment/for/combination-skin): Superior
- [Sensitive skin](https://lovi.care/skincare/sg/p/paula-s-choice/niacinamide-20-treatment/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/sg/p/paula-s-choice/niacinamide-20-treatment/for/acne-prone-skin): Superior
- [Skin with dark spots](https://lovi.care/skincare/sg/p/paula-s-choice/niacinamide-20-treatment/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/sg/p/paula-s-choice/niacinamide-20-treatment/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/sg/p/paula-s-choice/niacinamide-20-treatment/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/sg/p/paula-s-choice/niacinamide-20-treatment/for/oily-acne-prone-skin): High

## Key ingredients

Niacinamide, Acetyl Glucosamine, Ascorbyl Glucoside, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Portulaca Oleracea Extract Purslane Extract

## What the research says

- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline. ([Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/))
- Topical 2% N-acetyl glucosamine reduced facial hyperpigmentation in an 8-week split-face clinical test, with an even greater effect observed when combined with 4% niacinamide. ([Journal of Cosmetic Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17348991/))
- N-acetyl-glucosamine-loaded nanostructured lipid carriers successfully delivered the hydrophilic agent through the skin and reduced melanin distribution in healthy volunteers. ([Advanced Pharmaceutical Bulletin, 2016](https://pubmed.ncbi.nlm.nih.gov/28101465/))
- Topical cosmetic products containing hyaluronic acid, N-acetyl glucosamine, and gamma-amino butyric acid improved skin hydration by 24.28% to 33.60%, elasticity by 11.98%, and skin lightening by 5.26% over 2 months in 20 female participants. ([Journal of Cosmetic and Laser Therapy, 2019](https://pubmed.ncbi.nlm.nih.gov/30040516/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Combining 755 nm alexandrite laser with topical licorice gel significantly reduces terminal hair counts compared to alexandrite laser with placebo in women with idiopathic hirsutism. ([Evidence-based Complementary and Alternative Medicine, 2015](https://pubmed.ncbi.nlm.nih.gov/26273313/))
- Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo. ([Experimental Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25381913/))
- Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide. ([Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/))
- Topical purslane at 5% and 10% concentrations achieved alleviation of symptoms and lesion remission comparable to topical 0.1% triamcinolone acetonide in 34 subjects with oral lichen planus over 90 days. ([BMC Oral Health, 2023](https://pubmed.ncbi.nlm.nih.gov/37726676/))
- Facial masks containing low-temperature extracted Portulaca oleracea protect sensitive skin from photothermal stimulation and improve skin barrier function during photorejuvenation. ([Cutaneous and Ocular Toxicology, 2025](https://pubmed.ncbi.nlm.nih.gov/41182319/))
- Portulaca oleracea extract ameliorated skin barrier damage and inflammation induced by combined exposure to glycolic acid and UVB in HaCaT cells. ([Cutaneous and Ocular Toxicology, 2022](https://pubmed.ncbi.nlm.nih.gov/35920724/))

## What reviewers say

Based on a very large amount of data, users with oily, combination, and aging skin frequently report significant improvements in skin texture and a visible reduction in the appearance of enlarged pores and "orange-peel" skin. Many praise its ability to smooth and brighten the complexion. A notable minority with sensitive skin experienced irritation, redness, or burning due to the high concentration of niacinamide.

- Liked: Minimizes enlarged pores (often mentioned)
- Liked: Smoother skin texture (often mentioned)
- Liked: Brightens skin tone (sometimes noted)
- Liked: Lightweight non-sticky texture (sometimes noted)
- Disliked: Causes skin irritation (sometimes noted)
- Disliked: Expensive price point (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: No visible results (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Paula's Choice 20% Niacinamide Treatment a great fit for mature skin?

Paula's Choice 20% Niacinamide Treatment is a great fit for mature skin because its high concentration of niacinamide and panthenol helps repair your skin barrier and regulate sebum, while acetyl glucosamine smooths texture. Additionally, niacinamide and ascorbyl glucoside promote collagen synthesis to help address wrinkles and fine lines, and soothing components like glycerin keep the formula safe and gentle.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this treatment a good fit for mature skin?

This treatment is a great fit for mature skin because niacinamide and ascorbyl glucoside promote collagen synthesis to help smooth fine lines and wrinkles. Additionally, niacinamide and panthenol work to repair your skin barrier, while acetyl glucosamine helps make your skin smooth.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/)

### What does Niacinamide do for mature skin?

Niacinamide helps mature skin by smoothing out fine lines and wrinkles, reducing dark spots, and improving overall skin elasticity. It is also very well tolerated and supports a strong skin barrier to keep skin looking healthy.
Sources: [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### What does Acetyl Glucosamine do for mature skin?

Acetyl Glucosamine helps keep mature skin looking smooth and bright while improving hydration and firmness. It may also help reduce dark spots and signs of aging on the face and neck.
Sources: [The British Journal of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/19845667/), [Journal of Cosmetic Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17348991/)

### Where does this treatment go in a skincare routine for mature skin?

This treatment goes in the evening routine after your cleansing toner and before your moisturizer. Placing active serums at night provides extra safety around sun exposure and keeps your daily steps simple.

### Can I use this treatment with retinol, and in what order?

This treatment can be used with retinol, applying the treatment first and following with your retinol product, or using them on alternate nights to keep your skin calm and comfortable.

### How often should I use this treatment?

This treatment is used in the evening as part of your routine. It is a great fit for mature skin because its ingredients help smooth texture, support collagen, and keep your skin barrier healthy.

### Can this treatment clog pores, cause breakouts or purging for mature skin?

This treatment is unlikely to cause breakouts for mature skin because it has a very low risk of breakouts according to reviews and features soothing components like niacinamide and glycerin. It also helps repair your skin barrier and regulate sebum, making it a great fit for your normal mature skin.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this treatment fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Drunk Elephant A-Passioni Retinol Cream](https://lovi.care/skincare/sg/p/drunk-elephant/a-passioni-retinol-cream/for/mature-skin) — High fit — S$110.11 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — S$50.41 at Amazon
- [PCA Skin C&E Strength Max](https://lovi.care/skincare/sg/p/pca-skin/c-and-e-strength-max/for/mature-skin) — High fit — S$179.75 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/sg/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — S$30.00 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/sg/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — S$41.07 at Amazon
- SPF: [ISDIN Eryfotona Actinica SPF 50+](https://lovi.care/skincare/sg/p/isdin/eryfotona-actinica-spf-50/for/mature-skin) — Superior fit — S$110.01 at Amazon

## Where to buy

No store in Singapore has a checked price for this product, so the page shows none.

## Ingredients

Water, Niacinamide, Pentylene Glycol, Butylene Glycol, Glycerin, Acetyl Glucosamine, Ascorbyl Glucoside, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Spiraea Ulmaria Extract, Portulaca Oleracea Extract Purslane Extract, Camellia Japonica Flower Extract, Epigallocatechin Gallate, Boerhavia Diffusa Root Extract, Camellia Sinensis Leaf Extract, Allantoin, Lecithin, Pullulan, Panthenol, Silica, Xanthan Gum, Sclerotium Gum, Propanediol, Sodium Phytate, Phenoxyethanol, Ethylhexylglycerin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/paula-s-choice/niacinamide-20-treatment/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/paula-s-choice/niacinamide-20-treatment/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/paula-s-choice/niacinamide-20-treatment/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/paula-s-choice/niacinamide-20-treatment/for/mature-skin
- France: https://lovi.care/skincare/fr/p/paula-s-choice/niacinamide-20-treatment/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/paula-s-choice/niacinamide-20-treatment/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/paula-s-choice/niacinamide-20-treatment/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/paula-s-choice/niacinamide-20-treatment/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/paula-s-choice/niacinamide-20-treatment/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/paula-s-choice/niacinamide-20-treatment/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/paula-s-choice/niacinamide-20-treatment/for/mature-skin (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/p/paula-s-choice/niacinamide-20-treatment/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/paula-s-choice/niacinamide-20-treatment/for/mature-skin