# Paula's Choice Niacinamide 20% Treatment for dry sensitive skin

**Lovi Fit: High fit for dry sensitive skin.**
Dry Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/sg/p/paula-s-choice/niacinamide-20-treatment/for/dry-sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Brand: [Paula's Choice](https://lovi.care/skincare/sg/brands/paula-s-choice)
Category: [Serums and treatments](https://lovi.care/skincare/sg/best/serums)

This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for dry sensitive skin; a few serums fit it even better.

## Why this fit

- Offers excellent pore-clearing and skin-evening effects for your dry and sensitive skin, as niacinamide and acetyl glucosamine refine texture and reduce blemishes while supporting your skin barrier.
- Glycerin and panthenol provide essential humectant action and barrier repair, addressing your dry or flaky skin concerns.
- The formulation is safe for your dry and sensitive skin, with no harsh ingredients that could cause irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sg/p/paula-s-choice/niacinamide-20-treatment/for/oily-skin): Superior
- [Dry skin](https://lovi.care/skincare/sg/p/paula-s-choice/niacinamide-20-treatment/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/sg/p/paula-s-choice/niacinamide-20-treatment/for/combination-skin): Superior
- [Sensitive skin](https://lovi.care/skincare/sg/p/paula-s-choice/niacinamide-20-treatment/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/sg/p/paula-s-choice/niacinamide-20-treatment/for/acne-prone-skin): Superior
- [Skin with dark spots](https://lovi.care/skincare/sg/p/paula-s-choice/niacinamide-20-treatment/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/sg/p/paula-s-choice/niacinamide-20-treatment/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/sg/p/paula-s-choice/niacinamide-20-treatment/for/dry-sensitive-skin): High (this page)
- [Oily acne-prone skin](https://lovi.care/skincare/sg/p/paula-s-choice/niacinamide-20-treatment/for/oily-acne-prone-skin): High

## Key ingredients

Niacinamide, Acetyl Glucosamine, Ascorbyl Glucoside, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Portulaca Oleracea Extract Purslane Extract

## What the research says

- Topical 2% N-acetyl glucosamine reduced facial hyperpigmentation in an 8-week split-face clinical test, with an even greater effect observed when combined with 4% niacinamide. ([Journal of Cosmetic Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17348991/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- N-acetyl-glucosamine-loaded nanostructured lipid carriers successfully delivered the hydrophilic agent through the skin and reduced melanin distribution in healthy volunteers. ([Advanced Pharmaceutical Bulletin, 2016](https://pubmed.ncbi.nlm.nih.gov/28101465/))
- Topical cosmetic products containing hyaluronic acid, N-acetyl glucosamine, and gamma-amino butyric acid improved skin hydration by 24.28% to 33.60%, elasticity by 11.98%, and skin lightening by 5.26% over 2 months in 20 female participants. ([Journal of Cosmetic and Laser Therapy, 2019](https://pubmed.ncbi.nlm.nih.gov/30040516/))
- Liposomes containing N-acetyl glucosamine prepared using the fusion method significantly increased skin moisture content compared to empty liposomes in human volunteers over a 5-hour period. ([Journal of Cosmetic Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23725302/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Combining 755 nm alexandrite laser with topical licorice gel significantly reduces terminal hair counts compared to alexandrite laser with placebo in women with idiopathic hirsutism. ([Evidence-based Complementary and Alternative Medicine, 2015](https://pubmed.ncbi.nlm.nih.gov/26273313/))
- Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo. ([Experimental Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25381913/))
- Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide. ([Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/))
- Topical purslane at 5% and 10% concentrations achieved alleviation of symptoms and lesion remission comparable to topical 0.1% triamcinolone acetonide in 34 subjects with oral lichen planus over 90 days. ([BMC Oral Health, 2023](https://pubmed.ncbi.nlm.nih.gov/37726676/))
- Facial masks containing low-temperature extracted Portulaca oleracea protect sensitive skin from photothermal stimulation and improve skin barrier function during photorejuvenation. ([Cutaneous and Ocular Toxicology, 2025](https://pubmed.ncbi.nlm.nih.gov/41182319/))
- Portulaca oleracea extract ameliorated skin barrier damage and inflammation induced by combined exposure to glycolic acid and UVB in HaCaT cells. ([Cutaneous and Ocular Toxicology, 2022](https://pubmed.ncbi.nlm.nih.gov/35920724/))

## What reviewers say

Based on a very large amount of data, users with oily, combination, and aging skin frequently report significant improvements in skin texture and a visible reduction in the appearance of enlarged pores and "orange-peel" skin. Many praise its ability to smooth and brighten the complexion. A notable minority with sensitive skin experienced irritation, redness, or burning due to the high concentration of niacinamide.

- Liked: Minimizes enlarged pores (often mentioned)
- Liked: Smoother skin texture (often mentioned)
- Liked: Brightens skin tone (sometimes noted)
- Liked: Lightweight non-sticky texture (sometimes noted)
- Disliked: Causes skin irritation (sometimes noted)
- Disliked: Expensive price point (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: No visible results (rarely noted)

## How to apply

- Use this PM routine for your evening skincare. Start using the serum 3 times a week and increase to daily use if your skin feels comfortable.
- Apply the serum after cleansing and toner, but right before your moisturizer. This step locks in deep hydration for dry skin.
- Gently press 2-3 drops of the serum into your skin using your palms. Let it absorb completely for a minute ⏱ before applying your next product.
- Since your skin is sensitive, apply the serum on completely dry skin for better tolerance and less irritation.
- Avoid the sensitive eye area during application. Always do a patch test before your first use to ensure your skin reacts well.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Paula's Choice Niacinamide 20% Treatment a great fit for dry sensitive skin?

This treatment is a great fit because niacinamide and acetyl glucosamine smooth your skin texture and clear pores while keeping your barrier strong. Glycerin and panthenol add essential moisture to relieve dry and flaky patches safely without causing irritation.
Sources: [Journal of Cosmetic Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17348991/)

### Which ingredients make this treatment a good fit for dry sensitive skin?

This treatment is a great fit because niacinamide and acetyl glucosamine smooth your texture and even out your tone while supporting your skin barrier. Glycerin and panthenol also help relieve dry or flaky skin by keeping it hydrated and repairing the barrier safely without irritation.
Sources: [Journal of Cosmetic Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17348991/)

### What does Niacinamide do for dry sensitive skin?

Niacinamide helps dry sensitive skin by calming irritation and keeping moisture locked in so your face feels soft and smooth. It works to build up your skin barrier and calm redness while being very gentle and unlikely to cause irritation.
Sources: [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/), [International Journal of Pharmaceutics, 2013](https://pubmed.ncbi.nlm.nih.gov/23220080/)

### What does Acetyl Glucosamine do for dry sensitive skin?

Acetyl Glucosamine helps dry sensitive skin by boosting moisture and keeping it soft and smooth. It may also help calm the skin and fade dark spots while supporting hydration.
Sources: [Journal of Cosmetic and Laser Therapy, 2019](https://pubmed.ncbi.nlm.nih.gov/30040516/), [Journal of Cosmetic Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17348991/)

### Where does this treatment go in a skincare routine for dry sensitive skin?

This treatment goes in the evening routine for dry sensitive skin, placed after cleansing and a soothing toner and before your moisturizer. Using it at night helps keep things simple and adds extra safety around sun exposure.

### Can I use this treatment with retinol, and in what order?

You can use this treatment with retinol by applying the treatment first and following with your retinol, or by using them on alternating nights to help prevent any possible irritation. This helps smooth your skin texture while keeping your dry and sensitive skin calm and comfortable.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/)

### How often should I use this treatment?

You can use this treatment in the evening as part of your routine, or you may also use it in the morning or twice a day. It helps refine texture and reduce blemishes while supporting your skin barrier, with a safety profile suitable for dry and sensitive skin.
Sources: [Journal of Cosmetic Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17348991/)

### Can this treatment clog pores, cause breakouts or purging for dry sensitive skin?

This treatment is unlikely to clog pores or cause breakouts for dry sensitive skin because its ingredients help clear pores and smooth texture safely without harsh components. Reviewers rarely report breakouts, though some note mild irritation.
Sources: [Journal of Cosmetic Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17348991/)

### Is this treatment fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for dry sensitive skin

- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vitamin-c-serum/for/dry-sensitive-skin) — High fit — S$50.41 at Amazon
- [ma:nyo Bifida Biome Complex Ampoule](https://lovi.care/skincare/sg/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-sensitive-skin) — High fit — S$40.09 at Amazon
- [PCA Skin C&E Advanced with Hexylresorcinol and Silymarin](https://lovi.care/skincare/sg/p/pca-skin/c-and-e-advanced/for/dry-sensitive-skin) — High fit — S$192.38 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/sg/p/cerave/hydrating-facial-cleanser/for/dry-sensitive-skin) — Superior fit — S$25.06 at Amazon
- Soothing Toner: [Mario Badescu Facial Spray with Aloe, Chamomile and Lavender](https://lovi.care/skincare/sg/p/mario-badescu/facial-spray-with-aloe-chamomile-and-lavender/for/dry-sensitive-skin) — High fit — S$34.52 at Amazon
- Moisturizer with Sun Protection: [Dr.G Green Mild Up Sun+](https://lovi.care/skincare/sg/p/dr-g/green-mild-up-sun/for/dry-sensitive-skin) — Superior fit — S$59.06 at Amazon

## Where to buy

No store in Singapore has a checked price for this product, so the page shows none.

## Ingredients

Water, Niacinamide, Pentylene Glycol, Butylene Glycol, Glycerin, Acetyl Glucosamine, Ascorbyl Glucoside, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Spiraea Ulmaria Extract, Portulaca Oleracea Extract Purslane Extract, Camellia Japonica Flower Extract, Epigallocatechin Gallate, Boerhavia Diffusa Root Extract, Camellia Sinensis Leaf Extract, Allantoin, Lecithin, Pullulan, Panthenol, Silica, Xanthan Gum, Sclerotium Gum, Propanediol, Sodium Phytate, Phenoxyethanol, Ethylhexylglycerin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/paula-s-choice/niacinamide-20-treatment/for/dry-sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/paula-s-choice/niacinamide-20-treatment/for/dry-sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/paula-s-choice/niacinamide-20-treatment/for/dry-sensitive-skin
- Germany: https://lovi.care/skincare/de/p/paula-s-choice/niacinamide-20-treatment/for/dry-sensitive-skin
- France: https://lovi.care/skincare/fr/p/paula-s-choice/niacinamide-20-treatment/for/dry-sensitive-skin
- Italy: https://lovi.care/skincare/it/p/paula-s-choice/niacinamide-20-treatment/for/dry-sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/paula-s-choice/niacinamide-20-treatment/for/dry-sensitive-skin
- Spain: https://lovi.care/skincare/es/p/paula-s-choice/niacinamide-20-treatment/for/dry-sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/paula-s-choice/niacinamide-20-treatment/for/dry-sensitive-skin
- Australia: https://lovi.care/skincare/au/p/paula-s-choice/niacinamide-20-treatment/for/dry-sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/paula-s-choice/niacinamide-20-treatment/for/dry-sensitive-skin (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/p/paula-s-choice/niacinamide-20-treatment/for/dry-sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/paula-s-choice/niacinamide-20-treatment/for/dry-sensitive-skin