# Paula's Choice 25% Vitamin C + Glutathione Clinical Serum for dry skin

**Lovi Fit: Average fit for dry skin.**
Dry Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/sg/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/dry-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Brand: [Paula's Choice](https://lovi.care/skincare/sg/brands/paula-s-choice)
Category: [Serums and treatments](https://lovi.care/skincare/sg/best/serums)

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for dry skin; other serums fit it better.

## Why this fit

- Offers moderate brightening and evening of skin tone due to the presence of tetrahexyldecyl ascorbate and glutathione, which are beneficial for your dry skin by improving barrier function. Ascorbic acid and sodium hyaluronate further support hydration and skin barrier health, addressing your dry or flaky skin concerns.
- The formula is highly suitable for dry skin, with glycerin and sodium hyaluronate providing humectant action, while trehalose and urea enhance hydration.
- The safety profile is excellent, with no risks of irritation for your dry skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sg/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/sg/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/dry-skin): Average (this page)
- [Combination skin](https://lovi.care/skincare/sg/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/sg/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/sg/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/sg/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/sg/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/sg/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/sg/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Ascorbic Acid, Glutathione, Ergothioneine, Ascorbyl Glucoside, Tocopherol

## What the research says

- Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/))
- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls. ([Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/))
- Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity. ([The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/))
- RayGel reduced skin reaction severity with a lower average score of 93.7 compared to 123.3 for the placebo group in patients undergoing whole breast external-beam irradiation. ([American Journal of Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/15862509/))
- A targeted skincare regimen containing active ingredients such as rhodophyceae extract, ergothioneine, and L-carnosine significantly reduced transepidermal water loss by 24.09%, improved skin elasticity, and decreased redness, dryness, and desquamation in thirty-five female Chinese participants over 4 weeks following advanced optimal pulse technology treatment. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/40497421/))
- A triple combination of ergothioneine, collagen peptides, and sodium hyaluronate attenuated UV-induced skin damage ex vivo and improved facial skin hydration, elasticity, barrier function, and wrinkles in Chinese women. ([Frontiers in Nutrition, 2026](https://pubmed.ncbi.nlm.nih.gov/42698538/))
- Ergothioneine at nanomolar concentrations ameliorated UVA-induced skin damage, reactive oxygen species, and apoptosis in human keratinocyte-derived HaCaT cells by upregulating Nrf2/ARE-mediated antioxidant genes. ([Free Radical Biology & Medicine, 2015](https://pubmed.ncbi.nlm.nih.gov/26021820/))
- Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40642809/))
- Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate. ([Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/))
- Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590207/))

## What reviewers say

Many reviewers report a noticeable glow, improved skin bounce, and the fading of stubborn sun spots and post-inflammatory hyperpigmentation after consistent use.

- Liked: Gentle & non-irritating (mostly mentioned)
- Liked: Effective brightening (often mentioned)
- Liked: Elegant texture (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Pleasant scent (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Heavy for oily (rarely noted)

## How to apply

- Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
- Place the serum after cleansing and toner, but right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on slightly damp skin to help lock in extra moisture.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Paula's Choice 25% Vitamin C + Glutathione Clinical Serum work for dry skin?

This product works for your dry skin, though other products fit it better. It helps improve moisture, smoothness, and skin tone, and is unlikely to cause irritation. A product of this type needs rich hydrating and soothing ingredients, such as ceramides, niacinamide, peptides, or propolis, along with nourishing antioxidants to give dry skin the best care.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/)

### Which ingredients make this serum a good fit for dry skin?

Ascorbic acid, glutathione, tetrahexyldecyl ascorbate, glycerin, and sodium hyaluronate help brighten skin, support the moisture barrier, and improve dry or flaky skin. To fit dry skin even better, this type of product needs soothing ingredients, ceramides, niacinamide, or peptides that provide deep hydration and skin-repairing benefits without irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/)

### What does Vitamin C do for dry skin?

Vitamin C helps dry skin by boosting moisture and keeping the surface smooth and soft. It may also improve skin hydration and support the outer protective barrier over time.
Sources: [Skin Research and Technology, 2008](https://pubmed.ncbi.nlm.nih.gov/19159387/), [Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/)

### What does Glutathione do for dry skin?

Glutathione helps dry skin by improving moisture levels and smoothness while keeping the skin barrier strong against daily stress. Topical application of glutathione may also reduce water loss through the skin, helping your face feel softer and more hydrated.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/), [The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/)

### Where does this serum go in a skincare routine for dry skin?

This serum goes in the evening routine after cleansing and before moisturizing, though products of this type for dry skin generally need extra rich hydrators, soothing oils, and moisture-locking ingredients to keep flaky areas soft and comfortable.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying this treatment first and following with your retinol, or alternating nights to keep your dry skin calm. A product for this skin needs rich hydrating ingredients like glycerin and sodium hyaluronate to lock in moisture and prevent flaking.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/)

### How often should I use this serum?

This serum works well in your evening routine, and a product of this type for dry skin needs deep moisturizers like glycerin and sodium hyaluronate to keep skin soft.

### Can this serum clog pores, cause breakouts or purging for dry skin?

This serum is unlikely to cause breakouts for dry skin since reviews rarely mention clogged pores and the formula has a very safe profile. However, because dry skin needs extra moisture and rich barrier-supporting ingredients to feel completely smooth and soft, this treatment works best when paired with a deeply nourishing cream.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/), [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for dry skin

- [ma:nyo Bifida Biome Complex Ampoule](https://lovi.care/skincare/sg/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-skin) — Superior fit — S$40.09 at Amazon
- [SKIN1004 Madagascar Centella Tone Brightening Capsule Ampoule](https://lovi.care/skincare/sg/p/skin1004/madagascar-centella-tone-brightening-capsule-ampoule/for/dry-skin) — Superior fit — S$54.11 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vitamin-c-serum/for/dry-skin) — Superior fit — S$50.41 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/sg/p/cerave/hydrating-facial-cleanser/for/dry-skin) — Superior fit — S$25.06 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/sg/p/cosrx/propolis-synergy-toner/for/dry-skin) — Superior fit — S$41.07 at Amazon
- Moisturizer: [d'Alba First Spray Serum](https://lovi.care/skincare/sg/p/d-alba/first-spray-serum/for/dry-skin) — Superior fit — S$25.94 at Amazon

## Where to buy

No store in Singapore has a checked price for this product, so the page shows none.

## Ingredients

Water, Tetrahexyldecyl Ascorbate, Dimethicone, Glycerin, C9-12 Alkane, Ascorbyl Glucoside, Silica, Pyrus Malus Fruit Extract, Hydrogenated Lecithin, Polyglyceryl-6 Polyricinoleate, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Xanthan Gum, Rice Bran Extract, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Cetyl Alcohol, Caprylyl Glycol, Lysine Carboxymethyl Cysteinate, Coco Caprylate Caprate, Tocopherol, Glutathione, Sodium Citrate, Sodium Phytate, Hexylene Glycol, Ethylhexylglycerin, Helianthus Annuus Seed Extract Sunflower Seed Extract, Urea, Mannitol, Caprylic Capric Triglyceride, Sodium Pca, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Polysorbate 60, Sorbitan Isostearate, Trehalose, Ascorbic Acid, Glucose, Vanilla Planifolia Fruit Extract, Polyquaternium-51, Ergothioneine, Triacetin, Sodium Hyaluronate, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/dry-skin
- United Kingdom: https://lovi.care/skincare/uk/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/dry-skin
- Ireland: https://lovi.care/skincare/ie/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/dry-skin
- Germany: https://lovi.care/skincare/de/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/dry-skin
- France: https://lovi.care/skincare/fr/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/dry-skin
- Italy: https://lovi.care/skincare/it/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/dry-skin
- Netherlands: https://lovi.care/skincare/nl/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/dry-skin
- Spain: https://lovi.care/skincare/es/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/dry-skin
- Canada: https://lovi.care/skincare/ca/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/dry-skin
- Australia: https://lovi.care/skincare/au/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/dry-skin
- Singapore: https://lovi.care/skincare/sg/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/dry-skin (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/dry-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/dry-skin