# NEOGEN Dermalogy Real Vitamin C Serum for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vitamin-c-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Brand: [NEOGEN Dermalogy](https://lovi.care/skincare/sg/brands/neogen-dermalogy)
Category: [Serums and treatments](https://lovi.care/skincare/sg/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for mature skin; a few serums fit it even better.

## Why this fit

- Excellent for your normal skin, this serum effectively targets wrinkles and fine lines with Sodium Ascorbyl Phosphate and Ascorbic Acid, which boost collagen production and provide antioxidant protection. Ferulic Acid further enhances the stability and efficacy of these vitamins, contributing to a more youthful appearance.
- Niacinamide and Panthenol offer additional soothing and hydrating benefits, supporting overall skin health and comfort.
- The formulation is safe for your normal skin, containing no harsh ingredients and including Tocopheryl Acetate for added antioxidant and skin-conditioning properties.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vitamin-c-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vitamin-c-serum/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vitamin-c-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vitamin-c-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vitamin-c-serum/for/acne-prone-skin): Superior
- [Skin with dark spots](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vitamin-c-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vitamin-c-serum/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vitamin-c-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vitamin-c-serum/for/oily-acne-prone-skin): Superior

## Key ingredients

Ascorbic Acid, Kakadu C-Plex, Niacinamide, Sodium Hyaluronate, Ferulic Acid

## What the research says

- Transdermal emulgel preparations containing 5% ascorbic acid and sodium ascorbyl phosphate both effectively reduced wrinkle depth and enhanced skin elasticity in human volunteers with no statistically significant difference between them. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/32383548/))
- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))
- Combining fractional microneedle radiofrequency with a topical antioxidant serum significantly reduced wrinkle severity by 29.9% versus 18.0%, increased elasticity by 12.9% versus 2.3%, and improved aesthetic outcomes in 31 participants compared to radiofrequency and placebo. ([The Journal of Dermatological Treatment, 2025](https://pubmed.ncbi.nlm.nih.gov/40464749/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- Co-encapsulation of alpha-tocopherol and alpha-tocopheryl acetate in nanostructured lipid carrier gel formulations significantly enhanced moisture retention up to 68% and improved skin elasticity in human volunteers compared to a solution gel. ([Scientific Reports, 2025](https://pubmed.ncbi.nlm.nih.gov/41309687/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Treatment with 14% ferulic acid and 12% l-ascorbic acid significantly reduced pigmentation and erythema while improving hydration and elasticity in 20 women with photoaged skin, with neither acid proving definitively more effective overall though ascorbic acid showed slightly greater skin lightening. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/34877760/))
- Pretreatment with a topical antioxidant mixture of vitamin C, ferulic acid, and phloretin attenuated ultraviolet-induced sunburn cell formation, thymine dimer formation, matrix metalloproteinase-9 expression, p53 protein expression, and the suppression of CD1a-expressing Langerhans cells in human skin compared to vehicle control. ([Journal of Cosmetic Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19146606/))
- Topical ferulic acid-containing formulations effectively reduce skin erythema, hyperpigmentation, and signs of aging in adults compared to baseline or alternative conditions. ([The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40538529/))

## What reviewers say

Based on a very large amount of data, this serum is widely praised for its stable, lightweight formula that effectively brightens dull complexions and fades hyperpigmentation while providing hydration. While generally well-tolerated, a subset of users with sensitive skin reported breakouts or irritation, and some experienced issues with the product arriving oxidized.

- Liked: Brightens skin tone (mostly mentioned)
- Liked: Lightweight texture (often mentioned)
- Liked: Gentle/Stable (sometimes noted)
- Liked: Hydrating formula (sometimes noted)
- Disliked: Causes breakouts (rarely noted)
- Disliked: Oxidation issues (rarely noted)
- Disliked: Sensitizing (rarely noted)
- Disliked: Sticky residue (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes the Neogen Real Vitamin C Serum a great fit for mature skin?

This serum is a great fit because Ascorbic Acid and Sodium Ascorbyl Phosphate boost collagen to smooth out wrinkles and fine lines, while Ferulic Acid boosts their stability and effectiveness. Niacinamide and Panthenol add extra soothing and hydrating benefits to keep mature skin comfortable and supported.
Sources: [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/32383548/), [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### Which ingredients make this serum a good fit for mature skin?

This serum is a great fit for mature skin because Ascorbic Acid and Sodium Ascorbyl Phosphate boost collagen to smooth out fine lines, while Ferulic Acid helps stabilize these vitamins for better results. Niacinamide, panthenol, and sodium hyaluronate also provide essential hydration and keep the skin feeling soft and comfortable.
Sources: [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/32383548/), [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### What does Vitamin C do for mature skin?

Vitamin C helps mature skin by smoothing out wrinkles, brightening dark spots, and boosting firmness. It works by encouraging collagen production to keep skin looking youthful and radiant.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37128827/)

### What does Kakadu Plum do for mature skin?

Kakadu plum helps mature skin by providing a high amount of antioxidants that protect against daily stress and support a healthy, smooth look. Because it is packed with beneficial plant compounds, it may improve skin firmness and keep it looking vibrant.
Sources: [Journal of Ethnopharmacology, 2021](https://pubmed.ncbi.nlm.nih.gov/33189842/), [Foods, 2022](https://pubmed.ncbi.nlm.nih.gov/36553779/)

### Where does this serum go in a skincare routine for mature skin?

This serum goes in the evening routine, placed after cleansing and before moisturizing for simplicity and extra safety around sun exposure. Some vitamin C serums like this one may also be used in the morning or twice a day when well tolerated.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying them on alternate nights or using this vitamin C in the morning and retinol at night. Because both ingredients are active, separating them helps keep your skin calm and prevents irritation.

### How often should I use this serum?

Use this serum in your evening routine, as Lovi routines place treatments in the evening for simplicity and extra safety around sun exposure. Some of these treatments may also be used in the morning or twice a day if your skin tolerates them well.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores or cause breakouts for mature skin. Reviewers rarely mention breakouts, and the formulation is free of heavy, pore-clogging oils that typically trigger blemishes.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — S$50.41 at Amazon
- [PCA Skin C&E Strength Max](https://lovi.care/skincare/sg/p/pca-skin/c-and-e-strength-max/for/mature-skin) — High fit — S$179.75 at Amazon
- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/sg/p/skin1004/probio-cica-intensive-ampoule/for/mature-skin) — High fit — S$28.55 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/sg/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — S$30.00 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/sg/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — S$41.07 at Amazon
- SPF: [ISDIN Eryfotona Actinica SPF 50+](https://lovi.care/skincare/sg/p/isdin/eryfotona-actinica-spf-50/for/mature-skin) — Superior fit — S$110.01 at Amazon

## Where to buy

- Amazon.sg: S$50.41 (https://www.amazon.sg/dp/B07Q98WBNM?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- YesStyle: S$33.07 (https://www.yesstyle.com/en/neogen-dermalogy-real-vitamin-c-serum-renewed-32g/info.html/pid.1114519951?curr=SGD&rco=SG)
Prices checked 16 Oct – 4 Nov 2026.

## Ingredients

Water, Glycerin, Sodium Ascorbyl Phosphate, Isopentyldiol, Butylene Glycol, 1,2-Hexanediol, Niacinamide, Dipropylene Glycol, Terminalia Ferdinandiana Fruit Extract, Morinda Citrifolia Extract, Celery Stem Extract, Brassica Oleracea Acephala Leaf Extract, Cichorium Intybus Leaf Extract, Citric Acid, Octyldodeceth-16, Xanthan Gum, Panthenol, Sodium Metabisulfite, Ethylhexylglycerin, Ascorbic Acid, Ferulic Acid, Caprylyl Glycol, Dextrin, Tocopheryl Acetate, Polyglyceryl-4 Caprate, Theobroma Cacao Extract, Coptis Japonica Root Extract, Persea Gratissima Oil Avocado Oil, Pistacia Vera Seed Oil, Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/neogen-dermalogy/real-vitamin-c-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/neogen-dermalogy/real-vitamin-c-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/neogen-dermalogy/real-vitamin-c-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/neogen-dermalogy/real-vitamin-c-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/neogen-dermalogy/real-vitamin-c-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/neogen-dermalogy/real-vitamin-c-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/neogen-dermalogy/real-vitamin-c-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/neogen-dermalogy/real-vitamin-c-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/neogen-dermalogy/real-vitamin-c-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/neogen-dermalogy/real-vitamin-c-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vitamin-c-serum/for/mature-skin (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/p/neogen-dermalogy/real-vitamin-c-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/neogen-dermalogy/real-vitamin-c-serum/for/mature-skin