# NATURIUM Niacinamide Serum 12% Plus Zinc 2% for combination skin

**Lovi Fit: High fit for combination skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/sg/p/naturium/niacinamide-serum-12-plus-zinc-2/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Brand: [NATURIUM](https://lovi.care/skincare/sg/brands/naturium)
Category: [Serums and treatments](https://lovi.care/skincare/sg/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best serums for combination skin.

## Why this fit

- Highly suitable for your combination skin, this serum effectively addresses oily shine with high concentrations of niacinamide and zinc PCA to regulate sebum production and calm inflammation.
- The inclusion of sodium hyaluronate and glycerin provides essential hydration, supporting your skin's moisture balance without exacerbating oiliness.
- The product is safe for your skin, featuring a gentle formula with soothing ingredients and no harsh components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sg/p/naturium/niacinamide-serum-12-plus-zinc-2/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/sg/p/naturium/niacinamide-serum-12-plus-zinc-2/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/sg/p/naturium/niacinamide-serum-12-plus-zinc-2/for/combination-skin): High (this page)
- [Sensitive skin](https://lovi.care/skincare/sg/p/naturium/niacinamide-serum-12-plus-zinc-2/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/sg/p/naturium/niacinamide-serum-12-plus-zinc-2/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/sg/p/naturium/niacinamide-serum-12-plus-zinc-2/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/sg/p/naturium/niacinamide-serum-12-plus-zinc-2/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/sg/p/naturium/niacinamide-serum-12-plus-zinc-2/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/sg/p/naturium/niacinamide-serum-12-plus-zinc-2/for/oily-acne-prone-skin): High

## Key ingredients

Niacinamide, Zinc Pca, Sodium Hyaluronate, Tocopheryl Acetate Vitamin E, Glycerin

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate. ([Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Zinc PCA inhibits UVA-induced matrix metalloproteinase-1 production through suppressed AP-1 activation and enhances type I collagen synthesis by increasing SVCT2 mRNA expression in cultured normal human dermal fibroblasts. ([International Journal of Cosmetic Science, 2012](https://pubmed.ncbi.nlm.nih.gov/21834944/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40642809/))
- Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590207/))
- A topical antioxidant serum significantly reduced air pollution-induced skin pigmentation and proinflammatory gene expression ex vivo, and improved skin aging signs in 40 healthy adult females after 90 days of daily use. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35150043/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))

## What reviewers say

Based on a very large amount of data, this serum is highly effective for oily and acne-prone skin, with users frequently reporting minimized pores, controlled oil production, and smoother skin texture. Some users, particularly those with sensitive skin, experience irritation, stinging, or breakouts due to the high concentration of niacinamide. A small number of users also noted a sticky residue or saw no visible results.

- Liked: Controls oil (mostly mentioned)
- Liked: Lightweight, absorbs fast (often mentioned)
- Liked: Minimizes pores (often mentioned)
- Liked: Smooths texture (often mentioned)
- Liked: Brightens tone (sometimes noted)
- Disliked: Causes breakouts (sometimes noted)
- Disliked: Too strong (sometimes noted)
- Disliked: Causes irritation (rarely noted)
- Disliked: No results (rarely noted)
- Disliked: Sticky residue (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Naturium Niacinamide Serum 12% Plus Zinc 2% a great fit for combination skin?

This serum is a great fit for your combination skin because high concentrations of niacinamide and zinc PCA help control oily shine and calm inflammation. At the same time, sodium hyaluronate and glycerin keep your skin balanced by providing essential moisture without adding extra oil.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for combination skin?

This serum is a great fit for combination skin because it uses niacinamide and zinc PCA to calm oily shine and balance oil production. It also includes sodium hyaluronate and glycerin to provide essential hydration to dry areas without making the skin greasy.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Niacinamide do for combination skin?

Niacinamide helps balance oily areas by reducing excess shine and pore size while keeping dry patches hydrated and smooth. It also works to calm redness and even out skin tone, making it very suitable for combination skin.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### What does Zinc PCA do for combination skin?

Zinc PCA helps keep combination skin clear by balancing oil and calming redness. This ingredient is unlikely to irritate your skin and works well to reduce blemishes in oily areas without drying out your face.
Sources: [The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32983333/), [Journal of Drugs in Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23652948/)

### Where does this serum go in a skincare routine for combination skin?

This treatment serum goes in the evening routine after cleansing and before moisturizing, which keeps things simple and safe around sun exposure. Some serums can also be used in the morning or twice a day.

### Can I use this serum with retinol, and in what order?

Yes, you can use this serum with retinol by applying the serum first to keep your skin calm and hydrated, followed by your retinol. This gentle formula is unlikely to cause irritation when paired with retinoids, helping to maintain your skin's moisture balance.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/)

### How often should I use this serum?

This serum is used in your evening routine, starting once a week and moving to more often as your skin tolerates it well.

### Can this serum clog pores, cause breakouts or purging for combination skin?

This serum is a great fit for your combination skin, but reviewers do sometimes report breakouts from it. While ingredients like vitamin E generally show a safe profile for pores, individual reactions can vary, so you may want to patch test first.
Sources: [Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for combination skin

- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/sg/p/skin1004/probio-cica-intensive-ampoule/for/combination-skin) — High fit — S$28.55 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vitamin-c-serum/for/combination-skin) — High fit — S$50.41 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vita-c-serum/for/combination-skin) — High fit — S$50.41 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/sg/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — S$30.00 at Amazon
- Hydrating Toner: [Whamisa Organic Flowers Toner Deep Rich](https://lovi.care/skincare/sg/p/whamisa/organic-flowers-toner-deep-rich/for/combination-skin) — Superior fit — S$64.81 at Amazon
- SPF: [CeraVe AM Facial Moisturizing Lotion](https://lovi.care/skincare/sg/p/cerave/am-facial-moisturizing-lotion-spf-30/for/combination-skin) — Superior fit — S$28.72 at Amazon

## Where to buy

No store in Singapore has a checked price for this product, so the page shows none.

## Ingredients

Water, Niacinamide, Propanediol, Glycerin, Zinc Pca, Polyacrylate Crosspolymer-11, Sodium Hyaluronate, Dimethicone, Caprylyl Glycol, Phenoxyethanol, Xanthan Gum, Potassium Sorbate, Glyceryl Polyacrylate, Tocopheryl Acetate, Hexylene Glycol, Citric Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/naturium/niacinamide-serum-12-plus-zinc-2/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/naturium/niacinamide-serum-12-plus-zinc-2/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/naturium/niacinamide-serum-12-plus-zinc-2/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/naturium/niacinamide-serum-12-plus-zinc-2/for/combination-skin
- France: https://lovi.care/skincare/fr/p/naturium/niacinamide-serum-12-plus-zinc-2/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/naturium/niacinamide-serum-12-plus-zinc-2/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/naturium/niacinamide-serum-12-plus-zinc-2/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/naturium/niacinamide-serum-12-plus-zinc-2/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/naturium/niacinamide-serum-12-plus-zinc-2/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/naturium/niacinamide-serum-12-plus-zinc-2/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/naturium/niacinamide-serum-12-plus-zinc-2/for/combination-skin (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/p/naturium/niacinamide-serum-12-plus-zinc-2/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/naturium/niacinamide-serum-12-plus-zinc-2/for/combination-skin