MISSHA Time Revolution Night Repair Ampoule 5X for acne-prone skin
Bifida Lysate Ferment
Niacinamide
Sodium Hyaluronate
Squalane
Extreme Biome
Average
- AverageCombination Skin Fit
- AverageEffectiveness
- HighSafety
Works for acne-prone skin; other serums fit it better.
This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate suitability for your combination skin, as niacinamide helps regulate oil production and glycerin provides hydration, supporting general skin health for acne and blemishes.
- The blend of bifida ferment lysate and various lactobacillus ferments enhances skin barrier resilience and offers soothing benefits, contributing to overall skin improvement.
- The product is safe for your skin, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing components.
How to apply
- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
People Say
★4.7Overall rating based on 700+ reviewsUsers consistently praise this ampoule as a powerful anti-aging treatment that delivers deep hydration and a "glass skin" glow overnight, often comparing it favorably to the much more expensive Estée Lauder Advanced Night Repair. It is particularly effective for dry, mature, and sensitive skin types, helping to smooth rough texture and plump fine lines, though a minority of users with sensitivities to fermented ingredients or essential oils experienced irritation.
Highlights
Hydration and glow Mostly Mentioned
- “leaves my skin hydrated, soft, and glowy”
- “woke up with plump and glowy skin”
- “restores elasticity and radiance”
- “deeply moisturizes without being heavy”
Estée Lauder dupe Often Mentioned
- “best dupe for Estée Lauder's ANR”
- “works better than much more expensive serums”
- “fraction of the price of high-end brands”
- “similar texture to ANR but affordable”
Improves skin texture Often Mentioned
- “makes my skin so smooth”
- “softens rough texture overnight”
- “skin feels velvety soft”
- “helped evening out texture”
Fast absorption Sometimes Noted
- “absorbs pretty quickly”
- “non-sticky feel when massaged in”
- “layers nicely with other products”
- “lightweight and sinks in fast”
Scent irritation Sometimes Noted
- “smell is a bit strong”
- “contains essential oils like lavender and bergamot”
- “scent might be irritating for some”
- “wish it was fragrance-free”
Breakouts or irritation Rarely Noted
- “caused small bumps”
- “broke me out after a few days”
- “too sensitizing for my reactive skin”
- “reaction to the fermented ingredients”
Opaque packaging Rarely Noted
- “can't tell how much product is left”
- “bottle is too dark to see inside”
- “ran out unexpectedly”
- “hard to gauge remaining amount”
Sticky finish Rarely Noted
- “slightly sticky when it absorbs”
- “sits on top of my skin”
- “feels a bit tacky”
- “hair sticks to face after application”
Sources: lovi.care, iherb.com, misshaus.com, sokoglam.com, yesstyle.com, walmart.com, and more
Questions and answers
How well does MISSHA Night Repair Ampoule 5X work for acne-prone skin?
This treatment is an average fit for acne-prone skin, as niacinamide helps control oil and glycerin provides light hydration. Ferments like bifida lysate ferment help soothe the skin and strengthen its barrier with a low risk of irritation. For this skin type, a product needs effective ingredients like niacinamide and zinc or propolis that balance hydration and oil without causing breakouts.
Clinical, Cosmetic and Investigational Dermatology, 2017Journal of Cosmetic Dermatology, 2023
Which ingredients make this serum a good fit for acne-prone skin?
This serum works for acne-prone skin because niacinamide helps balance oil production while glycerin provides gentle hydration. Additionally, bifida ferment lysate and various lactobacillus ferments strengthen the skin barrier and help calm the skin without causing irritation. For an even better fit, acne-prone skin needs targeted blemish-fighting ingredients like propolis or zinc PCA alongside balanced hydration that controls oiliness without causing dryness.
Clinical, Cosmetic and Investigational Dermatology, 2017Journal of Cosmetic Dermatology, 2023
What does Bifida Ferment Lysate do for acne-prone skin?
Bifida Ferment Lysate helps acne-prone skin by calming redness and keeping the skin barrier strong. This ingredient may also support the skin's defenses against irritation, making it less likely to flare up.
Journal of Cosmetic Dermatology, 2023Experimental Dermatology, 2010
What does Niacinamide do for acne-prone skin?
Niacinamide helps acne-prone skin by reducing both inflamed and uninflamed breakouts and calming redness. It is also very helpful for keeping oily skin balanced by cutting down on excess oil production, and it is well tolerated by most people.
Where does this serum go in a skincare routine for acne-prone skin?
This treatment goes in your evening routine after cleansing and toning, and before moisturizing. Acne-prone skin of this type needs products featuring niacinamide to help regulate oil, glycerin for hydration, and soothing ferments to calm blemishes.
Can I use this serum with retinol, and in what order?
You can use this treatment alongside retinol by applying the serum first and letting it absorb before putting on your retinol. This product is unlikely to cause irritation due to its soothing ingredients, but acne-prone skin often does best with lightweight, oil-balancing ingredients and barrier-strengthening ferments.
How often should I use this serum?
You can use this treatment in the evening as part of your routine. Acne-prone skin needs products with niacinamide to help regulate oil, glycerin for hydration, and soothing fermented ingredients like bifida ferment lysate.
Clinical, Cosmetic and Investigational Dermatology, 2023Clinical, Cosmetic and Investigational Dermatology, 2017
Can this serum clog pores, cause breakouts or purging for acne-prone skin?
This serum is unlikely to clog pores or cause breakouts for acne-prone skin, as it has a low risk of causing blemishes and contains soothing ingredients. However, because it offers only an average fit for this skin type, acne-prone skin typically needs lighter formulas with ingredients like niacinamide and salicylic acid to better control oil and keep pores clear.
Is this serum fragrance-free and alcohol-free?
It has no drying alcohol and contains fragrance (limonene).
What the research says
A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro.
Journal of Cosmetic Dermatology, 2023Hyaluronic acid extracts are safe and efficacious products for skin repair when used in tissue regeneration alone or in combination with herbal or Western medicine.
Journal of Pharmacy & Pharmaceutical Sciences, 2015Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.
Journal of Drugs in Dermatology, 2011Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.
Clinical Oral Investigations, 2022Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.
BMC Oral Health, 2019Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.
Molecules, 2025Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.
Antioxidants, 2025
Ingredients
Bifida Lysate Ferment, Butylene Glycol, Glycerin, Propanediol, Betaine, Water, Niacinamide, Pentylene Glycol, 1,2-Hexanediol, Diethoxyethyl Succinate, Chondrus Crispus Extract, Squalane, Panthenol, Polyglyceryl-10 Laurate, Saccharum Officinarum Extract, Hydrogenated Lecithin, Carbomer, Tromethamine, Xanthan Gum, Polyquaternium-51, Ethylhexylglycerin, Adenosine, Dextrin, Theobroma Cacao Extract, Bergamot Oil Fruit, Disodium Edta, Sodium Hyaluronate, Lactobacillus Ferment, Lactobacillus Lysate Ferment, Bifida Ferment Filtrate, Lactobacillus Acerola Cherry Ferment, Lactobacillus Punica Granatum Extract Fruit Ferment, Lactobacillus Soybean Extract Ferment, Lactococcus Ferment, Lactococcus Lysate Ferment, Leuconostoc Radish Root Ferment Filtrate, Pelargonium Graveolens Oil Flower, Beta Vulgaris Root Extract, Brassica Oleracea Capitata Leaf Extract, Daucus Carota Sativa Root Extract Carrot Root Extract, Solanum Melongena Fruit Extract, Blueberry Fruit Extract, Helianthus Annuus Seed Oil Sunflower Seed Oil, Citrus Aurantium Dulcis Peel Oil, Lavandula Angustifolia Oil Lavender Oil, Lupinus Albus Seed Extract, Aspergillus Ferment, Swiftlet Nest Extract, Anthemis Nobilis Oil Flower, Sandalwood Oil, Tocopherol, Ceramide Np, Cholesterol, Limonene
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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