MISSHA Super Aqua Ultra Hyalron Cream for mature skin

How to apply

Questions and answers

What the research says

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone.

  Dermatologic Therapy, 2022

• Adenosine-loaded dissolving microneedle patches showed similar or better efficacy on skin wrinkles, dermal density, elasticity, and hydration compared to adenosine cream in 22 female subjects.

  International Journal of Cosmetic Science, 2018

• Horse oil-spread and adenosine-loaded dissolving microneedle patches significantly improved skin elasticity, hydration, dermal density, and wrinkles compared with adenosine-loaded dissolving microneedle patches in 20 women without causing adverse events.

  Journal of Cosmetic Dermatology, 2019

• Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants.

  International Journal of Molecular Sciences, 2026

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

• The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

  Journal of Cosmetic Dermatology, 2020

• Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

  International Journal of Cosmetic Science, 2001

• Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.

  Journal of Drugs in Dermatology, 2012

• A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events.

  Lasers in Medical Science, 2025

• A skin barrier restoring cream with shea butter, silkflo, and vitamin E increased type I procollagen synthesis, enhanced antioxidant enzyme activity, decreased reactive oxygen species generation, and promoted hyaluronic acid production in H2O2-stimulated human keratinocyte cells compared to untreated cells.

  International Journal of Cosmetic Science, 2025

Ingredients

Water, Butylene Glycol, Glycerin, Niacinamide, Phenyl Trimethicone, 1,2-Hexanediol, Cetyl Ethylhexanoate, Pentaerythrityl Tetraethylhexanoate, Pentylene Glycol, Cetearyl Alcohol, Butyrospermum Parkii Butter Shea Butter, Panthenol, Raffinose, Ammonium Acryloyldimethyltaurate Vp Copolymer, Jojoba Seed Oil, Dimethicone Vinyl Dimethicone Crosspolymer, Tromethamine, Carbomer, Cetearyl Glucoside, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Xanthan Gum, Ethylhexylglycerin, Caprylyl Glycol, Bergamot Oil Fruit, Adenosine, Sodium Phytate, Lavandula Angustifolia Oil Lavender Oil, Citrus Aurantium Dulcis Peel Oil, Silica, Sodium Hyaluronate, Hydrolyzed Hibiscus Esculentus Extract, Lupinus Albus Seed Extract, Moringa Oleifera Seed Extract, Trehalose, Glyceryl Glucoside, Pinus Sylvestris Oil Leaf, Propanediol, Hydrogenated Lecithin, Xylitylglucoside, Ceramide Np, Anhydroxylitol, Glucose, Sucrose Stearate, Xylitol, Hydroxypropyltrimonium Hyaluronate, Stearic Acid, Palmitic Acid, Sucrose Palmitate, Benzyl Glycol, Hydrolyzed Glycosaminoglycans, Cholesterol, Macadamia Ternifolia Seed Oil, Olea Europaea Oil Fruit Olive Oil Fruit, Vitis Vinifera Seed Oil Grape Seed Oil, Sodium Hyaluronate Crosspolymer, Hydrolyzed Hyaluronic Acid, Glyceryl Caprylate, Glycosphingolipids, Sodium Acetylated Hyaluronate, Actinidia Polygama Fruit Extract, Hydrolyzed Sodium Hyaluronate, Potassium Hyaluronate, Limonene, Linalool

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.