# Medimine Phyto Enzyme Powder Wash for oily skin

**Lovi Fit: Superior fit for oily skin.**
Oily Skin Fit: High · Effectiveness: Superior · Safety: Excellent.

Page: https://lovi.care/skincare/sg/p/medimine/phyto-enzyme-powder-wash/for/oily-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Brand: Medimine
Category: [Exfoliants](https://lovi.care/skincare/sg/best/exfoliators)

This fit is calculated for the concerns frequently associated with oily skin: shine, enlarged pores, blackheads, and blemishes. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best products for oily skin.

## Why this fit

- Excellent for your oily skin, this product's papain and niacinamide offer effective exfoliation and oil regulation, addressing your primary concern of oily shine. Citric acid further aids in refining skin texture and pore appearance.
- The inclusion of soothing ingredients like Chamomilla Recutita Flower Extract and Glycyrrhiza Glabra Root Extract ensures a gentle experience, minimizing any potential for irritation on your oily skin.
- This formula is safe for your skin, as it contains no harsh or prohibited ingredients and is specifically designed to be non-irritating for oily skin types.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sg/p/medimine/phyto-enzyme-powder-wash/for/oily-skin): Superior (this page)
- [Dry skin](https://lovi.care/skincare/sg/p/medimine/phyto-enzyme-powder-wash/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/sg/p/medimine/phyto-enzyme-powder-wash/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/sg/p/medimine/phyto-enzyme-powder-wash/for/sensitive-skin): Superior
- [Acne-prone skin](https://lovi.care/skincare/sg/p/medimine/phyto-enzyme-powder-wash/for/acne-prone-skin): Superior
- [Skin with dark spots](https://lovi.care/skincare/sg/p/medimine/phyto-enzyme-powder-wash/for/dark-spots): Superior
- [Mature skin](https://lovi.care/skincare/sg/p/medimine/phyto-enzyme-powder-wash/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/sg/p/medimine/phyto-enzyme-powder-wash/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/sg/p/medimine/phyto-enzyme-powder-wash/for/oily-acne-prone-skin): Superior

## Key ingredients

Papain, Pearl Extract, Niacinamide, Licorice Root Extract, Chamomile Flower Extract

## What the research says

- Daily treatment with a facial serum containing multiple acids reduced post-inflammatory hyperchromia lesion grade and number by 29.4% at 56 days, and decreased skin oiliness by 30.7% at 7 days in Brazilian patients with acne vulgaris. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33617668/))
- A fixed combination of hydroxypinacolone retinoate, retinol glycospheres, and papain glycospheres in aqueous gel applied once daily for 12 weeks achieved a 41% mean reduction in GAGS score and a 40.8% mean reduction in total lesions, with 15.3% of patients experiencing mild to moderate local side effects, in 94 evaluable patients with comedonal-papular, mild to moderate acne of the face. ([Giornale Italiano Di Dermatologia E Venereologia, 2015](https://pubmed.ncbi.nlm.nih.gov/25876142/))
- A novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid showed similar tolerance and efficacy compared with clindamycin 1% and benzoyl peroxide 5% gel in subjects with acne vulgaris. ([Journal of Drugs in Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23545907/))
- Apigenin protects against UVA-induced cytotoxicity and senescence in normal human dermal fibroblasts, decreases MMP-1 expression, and when applied topically as a cream in human subjects, increases dermal density and elasticity while reducing fine wrinkle length, skin evenness, moisture content, and transepidermal water loss compared to control cream. ([International Journal of Molecular Medicine, 2016](https://pubmed.ncbi.nlm.nih.gov/27279007/))
- Topical papain treatment may slightly decrease pain within 30 minutes in humans stung by Chrysaora chinensis compared to placebo. ([Wilderness & Environmental Medicine, 2016](https://pubmed.ncbi.nlm.nih.gov/26827260/))
- Reflux extraction of Carica papaya leaves yielded higher antioxidant capacity and superior in vitro wound-healing activities including fibroblast proliferation, cell migration, and collagen synthesis in human skin fibroblasts compared to ultrasonic-assisted extraction and agitation. ([Molecules, 2020](https://pubmed.ncbi.nlm.nih.gov/31991676/))
- Carica papaya leaf extracts obtained via supercritical fluid and conventional methods demonstrated antioxidant and cytoprotective effects on skin fibroblasts against oxidative stress, driven by their respective lipophilic and hydrophilic constituents. ([Molecules, 2021](https://pubmed.ncbi.nlm.nih.gov/33803330/))
- Micro and nanosized pearl powders increased skin cell proliferation and migration, accelerated wound closure, enhanced biomechanical strength, improved collagen deposition, and promoted angiogenesis in rats, with nanoscale pearl powder showing the highest efficiency. ([Drug Development and Industrial Pharmacy, 2019](https://pubmed.ncbi.nlm.nih.gov/30950303/))
- Topical pearl extract gel inhibited UV-irritated skin wrinkles, laxity, thickness, and dryness, upregulated antioxidant enzyme activities, decreased MDA levels, and suppressed inflammatory factors in UV-irradiated mice compared to untreated controls, with high-dose PEG showing superior effects to Vitamin E. ([Chemistry & Biodiversity, 2022](https://pubmed.ncbi.nlm.nih.gov/35098641/))
- Seawater pearl powder treatment significantly improves UV-induced photoaging and restores skin tissue structure in mice by reducing MMP-1, enhancing collagen I, inhibiting the MAPK signaling pathway, and scavenging reactive oxygen species. ([Evidence-based Complementary and Alternative Medicine, 2021](https://pubmed.ncbi.nlm.nih.gov/34925534/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Combining 755 nm alexandrite laser with topical licorice gel significantly reduces terminal hair counts compared to alexandrite laser with placebo in women with idiopathic hirsutism. ([Evidence-based Complementary and Alternative Medicine, 2015](https://pubmed.ncbi.nlm.nih.gov/26273313/))
- Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo. ([Experimental Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25381913/))
- Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide. ([Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/))
- Topical chamomile oil combined with a night splint significantly improved the symptomatic and functional status of patients with severe carpal tunnel syndrome compared to placebo, while electrodiagnostic parameters showed no significant changes. ([Complementary Therapies in Clinical Practice, 2015](https://pubmed.ncbi.nlm.nih.gov/26573447/))
- German chamomile solution applied twice a day healed peristomal skin lesions significantly faster than once-a-day 1% hydrocortisone ointment in colostomy patients, with a mean healing time of 8.89 days versus 14.53 days. ([Ostomy/wound Management, 2011](https://pubmed.ncbi.nlm.nih.gov/21617262/))
- Topical chamomile reduces the incidence and delays the occurrence of phlebitis due to amiodarone infusion in coronary care patients compared to a placebo of lanoline. ([Journal of Integrative Medicine, 2017](https://pubmed.ncbi.nlm.nih.gov/28844214/))

## What reviewers say

Based on limited data, users generally praise this powder wash for its ability to dramatically improve skin texture and brightness without causing tightness, often describing it as a "holy grail" for smoothing rough skin. However, experiences are polarized regarding sensitivity; while many find it gentle, a minority report significant irritation and redness, and some struggle with the powder packaging.

- Liked: Smoothes skin texture (mostly mentioned)
- Liked: Brightening effect (often mentioned)
- Liked: Non-stripping (often mentioned)
- Liked: Clears bumps/acne (sometimes noted)
- Disliked: Packaging issues (sometimes noted)
- Disliked: High price (rarely noted)
- Disliked: Makeup removal (rarely noted)
- Disliked: Potential irritation (rarely noted)

## How to apply

- Use your enzyme powder cleanser as part of your AM or PM weekly routine. Start using it 1x per week and increase to daily use if your skin tolerates it well.
- Apply this enzyme powder cleanser in your routine after the regular cleanser and before the hydrating toner, serum, and moisturizer.
- Gently mix the enzyme powder cleanser with water in your hands to create a lather. Massage it softly over your face without rubbing .
- Apply the enzyme powder cleanser to clean, slightly damp skin for the best results .
- Avoid the sensitive eye area and do a patch test before your first use to ensure your skin is happy.
- Video: https://storage.pora.ai/2d8db6e67371d665a6a7736b5ed5d762.mp4

## Questions and answers

### What makes Medimine Phyto Enzyme Powder Wash one of the best fits for oily skin?

Medimine Phyto Enzyme Powder Wash is an exceptional fit for oily skin because papain and niacinamide provide effective exfoliation and oil regulation to tackle oily shine. Citric acid further helps refine skin texture and pore appearance, while chamomile and licorice root extracts keep the experience gentle and calm.
Sources: [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33617668/), [Giornale Italiano Di Dermatologia E Venereologia, 2015](https://pubmed.ncbi.nlm.nih.gov/25876142/)

### Which ingredients make this cleanser a good fit for oily skin?

Papain and niacinamide make this cleanser a great fit because they help exfoliate and control oily shine. Citric acid further helps refine skin texture and pore appearance, while chamomile and licorice root extracts soothe the skin.
Sources: [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33617668/), [Giornale Italiano Di Dermatologia E Venereologia, 2015](https://pubmed.ncbi.nlm.nih.gov/25876142/)

### What does Papain do for oily skin?

Papain helps clear oily skin by gently lifting away dead cells and surface buildup to leave your face feeling smooth. This ingredient helps reduce clogged pores and flakes, though it may occasionally cause mild irritation if your skin barrier is sensitive.
Sources: [Giornale Italiano Di Dermatologia E Venereologia, 2015](https://pubmed.ncbi.nlm.nih.gov/25876142/), [Archives of Dermatological Research, 2001](https://pubmed.ncbi.nlm.nih.gov/11820726/)

### What does Pearl Extract do for oily skin?

Pearl extract helps calm irritated skin and provides antioxidant benefits that protect against everyday environmental stress. For oily skin, a product of this type needs lightweight hydration and ingredients that help manage excess shine without clogging pores.
Sources: [Chemistry & Biodiversity, 2022](https://pubmed.ncbi.nlm.nih.gov/35098641/), [Bio-medical Materials and Engineering, 2015](https://pubmed.ncbi.nlm.nih.gov/26405901/)

### Where does this cleanser go in a skincare routine for oily skin?

This cleanser is used daily in the morning and evening, with the enzyme powder version added to your weekly routine once a week. Lovi routines start exfoliating steps like enzyme powders once a week, and people who tolerate them well can carefully use them more often.

### Can I use it with retinol, and in what order?

You can use this enzyme powder wash alongside your retinol routine by applying it in your weekly or PM routine step on nights when you do not use retinol, as using both active exfoliants together may cause irritation. This gentle powder helps clear oil and smooth skin texture safely without harsh ingredients.

### How often should I use this cleanser?

Start by using this enzyme powder cleanser once a week as part of your routine. If your oily skin tolerates it well and you see good results, you can carefully use it more often.

### Can it clog pores, cause breakouts or purging for oily skin?

This cleanser is unlikely to clog pores, cause breakouts, or lead to purging on oily skin, as it contains papain and niacinamide to help regulate oil and clear out dead skin cells smoothly. Its gentle formula is designed to be non-irritating and uses soothing extracts to keep skin calm while refining your pores.
Sources: [Giornale Italiano Di Dermatologia E Venereologia, 2015](https://pubmed.ncbi.nlm.nih.gov/25876142/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33617668/)

### Is this cleanser fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily skin

- [By Wishtrend Green Tea & Enzyme Powder Wash](https://lovi.care/skincare/sg/p/by-wishtrend/green-tea-and-enzyme-powder-wash/for/oily-skin) — High fit — S$15.41 at YesStyle
- [Fancl Deep Clear Washing Powder](https://lovi.care/skincare/sg/p/fancl/deep-clear-washing-powder/for/oily-skin) — High fit — S$32.83 at YesStyle
- [NEEDLY Mild Enzyme Cleansing Powder](https://lovi.care/skincare/sg/p/needly/mild-enzyme-cleansing-powder/for/oily-skin) — High fit — S$18.03 at YesStyle

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/sg/p/cerave/foaming-facial-cleanser/for/oily-skin) — Superior fit — S$30.40 at Amazon
- Hydrating Toner: [TROIAREUKE H+Cocktail Purifying Ampoule Toner](https://lovi.care/skincare/sg/p/troiareuke/h-cocktail-purifying-ampoule-toner/for/oily-skin) — Superior fit — S$168.51 at Amazon
- Moisturizer: [SKIN1004 Centella Cream](https://lovi.care/skincare/sg/p/skin1004/centella-cream/for/oily-skin) — Superior fit — S$33.87 at Amazon

## Where to buy

No store in Singapore has a checked price for this product, so the page shows none.

## Ingredients

Zea Mays Starch, Sodium Cocoyl Isethionate, Sodium Lauroyl Glutamate, Sorbitol, Papain, Pearl Extract, Chamomilla Recutita Flower Extract Matricaria Flower Extract, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Allantoin, Citric Acid, Disodium Edta, Isopropyl Palmitate, Niacinamide, Betaine
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medimine/phyto-enzyme-powder-wash/for/oily-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medimine/phyto-enzyme-powder-wash/for/oily-skin
- Ireland: https://lovi.care/skincare/ie/p/medimine/phyto-enzyme-powder-wash/for/oily-skin
- Germany: https://lovi.care/skincare/de/p/medimine/phyto-enzyme-powder-wash/for/oily-skin
- France: https://lovi.care/skincare/fr/p/medimine/phyto-enzyme-powder-wash/for/oily-skin
- Italy: https://lovi.care/skincare/it/p/medimine/phyto-enzyme-powder-wash/for/oily-skin
- Netherlands: https://lovi.care/skincare/nl/p/medimine/phyto-enzyme-powder-wash/for/oily-skin
- Spain: https://lovi.care/skincare/es/p/medimine/phyto-enzyme-powder-wash/for/oily-skin
- Canada: https://lovi.care/skincare/ca/p/medimine/phyto-enzyme-powder-wash/for/oily-skin
- Australia: https://lovi.care/skincare/au/p/medimine/phyto-enzyme-powder-wash/for/oily-skin
- Singapore: https://lovi.care/skincare/sg/p/medimine/phyto-enzyme-powder-wash/for/oily-skin (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/p/medimine/phyto-enzyme-powder-wash/for/oily-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medimine/phyto-enzyme-powder-wash/for/oily-skin