# Medicube Zero Pore One Day Serum for sensitive skin

**Lovi Fit: Average fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/sg/p/medicube/zero-pore-one-day-serum/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Brand: [Medicube](https://lovi.care/skincare/sg/brands/medicube)
Category: [Exfoliants](https://lovi.care/skincare/sg/best/exfoliators)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for sensitive skin; other products fit it better.

## Why this fit

- Offers moderate exfoliation and hydration suitable for your normal skin, with gluconolactone and salicylic acid gently addressing redness and irritation by providing mild chemical exfoliation. Niacinamide further supports your skin barrier, enhancing overall comfort.
- The inclusion of lactic acid and glycolic acid contributes to smoothing skin texture and refining pores, complementing the primary benefits for your skin concerns.
- The product is safe for your sensitive skin, as it lacks harsh ingredients and has no risk of irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sg/p/medicube/zero-pore-one-day-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/sg/p/medicube/zero-pore-one-day-serum/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/sg/p/medicube/zero-pore-one-day-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/sg/p/medicube/zero-pore-one-day-serum/for/sensitive-skin): Average (this page)
- [Acne-prone skin](https://lovi.care/skincare/sg/p/medicube/zero-pore-one-day-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/sg/p/medicube/zero-pore-one-day-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/sg/p/medicube/zero-pore-one-day-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/sg/p/medicube/zero-pore-one-day-serum/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/sg/p/medicube/zero-pore-one-day-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Aha, Bha, Pha, Niacinamide, Salicylic Acid

## What the research says

- Combining 10% gluconolactone chemical peeling with oxybrasion or microneedle mesotherapy increased skin hydration and decreased sebum, pH, and TEWL in twenty-one Caucasian women, with no significant differences between the two methods. ([Skin Research and Technology, 2023](https://pubmed.ncbi.nlm.nih.gov/37357656/))
- Gluconolactone 14% solution significantly improved mild to moderate acne by reducing inflamed and non-inflamed lesions similarly to 5% benzoyl peroxide, but with fewer side-effects in 150 patients. ([The Australasian Journal of Dermatology, 1992](https://pubmed.ncbi.nlm.nih.gov/1303072/))
- Topical application of 1-1.5% glycolic acid suppresses UVB-induced inflammation by modulating NF-κB signaling pathways in human keratinocytes and mouse dorsal skin. ([Journal of Dermatological Science, 2017](https://pubmed.ncbi.nlm.nih.gov/28330776/))
- A combination of dermapen and glycolic acid peel significantly decreased acne scar grades and resulted in higher patient satisfaction compared to either monotherapy in 30 patients. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30548170/))
- Cryotherapy with liquid nitrogen achieved a higher cure rate (39%) than salicylic acid (24%) and a wait-and-see approach (16%) for cutaneous warts at 13 weeks in primary care patients. ([CMAJ, 2010](https://pubmed.ncbi.nlm.nih.gov/20837684/))
- A moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid significantly reduced noninflammatory, inflammatory, and total acne lesion counts compared to a vehicle control in Thai patients during a 12-week maintenance phase. ([BioMed Research International, 2020](https://pubmed.ncbi.nlm.nih.gov/33150170/))
- Treatment with 2% supramolecular salicylic acid hydrogel resulted in a regression and markedly improvement rate of 51.01% compared to 43.10% for Adapaline gel in patients with mild to moderate facial acne vulgaris, showing no significant difference in efficacy. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590107/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))

## What reviewers say

Based on a very large amount of data, users with oily and combination skin frequently praise this serum for refining rough texture and minimizing enlarged pores, often describing a blurring effect that serves as a good makeup base. While the 'one day' claim is often viewed as marketing hyperbole, consistent use reportedly yields smoother skin and reduced sebum production, though the product's sticky finish is a polarizing feature.

- Liked: Smoothes texture (mostly mentioned)
- Disliked: Sticky finish (mostly mentioned)
- Liked: Tightens pores (often mentioned)
- Liked: Controls oil (sometimes noted)
- Liked: Hydrating formula (sometimes noted)
- Disliked: Causes irritation (sometimes noted)
- Disliked: Price vs quantity (rarely noted)
- Disliked: Unpleasant scent (rarely noted)

## How to apply

- Use your exfoliant PM once a week to help with redness and irritation. Start slowly and only increase frequency if your skin feels happy and comfortable.
- Apply the exfoliant after cleansing and toner , but always before your moisturizer . This ensures the product absorbs properly into the skin.
- Gently press 2-3 drops of the exfoliant into your skin without rubbing . Let it absorb for a minute before moving on.
- Since your skin is sensitive , apply the exfoliant on completely dry skin for the best tolerance. This helps prevent any extra stinging or discomfort.
- Always do a patch test before your first use and avoid the delicate eye area .
- Video: https://storage.pora.ai/028e5e793422a3b665c02ff502cf5a68.mp4

## Questions and answers

### How well does the Zero Pore One Day Serum work for sensitive skin?

This serum works reasonably well for sensitive skin, offering moderate exfoliation and hydration with gentle acids and niacinamide that help calm redness. However, an exfoliant treatment for this skin needs exceptionally well-suited ingredients providing optimal benefits for redness without irritation, along with strong antioxidants, soothing agents, and reliable skin-repairing components.
Sources: [Skin Research and Technology, 2023](https://pubmed.ncbi.nlm.nih.gov/37357656/)

### Which ingredients make this serum a good fit for sensitive skin?

Gluconolactone, salicylic acid, and niacinamide help make this serum a fit for sensitive skin by gently addressing redness and supporting the skin barrier for enhanced comfort. Because other products fit this skin type even better, an exfoliant of this type needs effective ingredients that calm redness while posing no irritation risk and remaining highly compatible with normal skin.
Sources: [Skin Research and Technology, 2023](https://pubmed.ncbi.nlm.nih.gov/37357656/)

### What does Alpha Hydroxy Acid do for sensitive skin?

Alpha hydroxy acids help smooth and brighten sensitive skin when you choose gentler forms like polyhydroxy acids or carefully formulated derivatives that are less likely to cause irritation. They improve hydration and soften lines while keeping the skin calm.
Sources: [Clinics in Dermatology, 2009](https://pubmed.ncbi.nlm.nih.gov/19695482/), [Cutis, 2004](https://pubmed.ncbi.nlm.nih.gov/15002656/)

### What does Bha do for sensitive skin?

BHA helps keep sensitive or oily skin calm and clear by gently clearing out pores and lowering extra oil without causing a lot of irritation. Clinical studies show that regular use can improve breakouts and keep the skin barrier feeling comfortable.
Sources: [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40682377/), [European Review for Medical and Pharmacological Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/26875890/)

### Where does this serum go in a skincare routine for sensitive skin?

This serum goes in your evening routine, applied after cleansing and toning and before moisturizing. Sensitive skin works best with products of this type that provide gentle acids and soothing ingredients to keep skin calm while smoothing texture.

### Can I use it with retinol, and in what order?

It is best not to use this exfoliant treatment in the same routine as retinol, as combining them may cause redness and irritation on sensitive skin. Instead, you can alternate nights or use the retinol on a different day to keep your skin calm and comfortable.

### How often should I use this serum?

Start by using this serum once a week in the evening, and if your sensitive skin tolerates it well and shows good results, you can carefully use it more often. An average fit for your skin needs gentle acids like gluconolactone and soothing ingredients like allantoin and centella asiatica to keep skin calm while smoothing texture.

### Can it clog pores, cause breakouts or purging for sensitive skin?

This exfoliant treatment works for your sensitive skin, though other products fit it better because they use gentler acids and soothing ingredients that keep redness and irritation away.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for sensitive skin

- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vitamin-c-serum/for/sensitive-skin) — High fit — S$50.41 at Amazon
- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/sg/p/skin1004/probio-cica-intensive-ampoule/for/sensitive-skin) — High fit — S$28.55 at Amazon
- [PCA Skin C&E Advanced with Hexylresorcinol and Silymarin](https://lovi.care/skincare/sg/p/pca-skin/c-and-e-advanced/for/sensitive-skin) — Average fit — S$192.38 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/sg/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — S$30.00 at Amazon
- Soothing Toner: [One Thing Centella Asiatica Extract Toner](https://lovi.care/skincare/sg/p/one-thing/centella-asiatica-extract-toner/for/sensitive-skin) — Superior fit — S$30.07 at Amazon
- Moisturizer with Sun Protection: [ISDIN Eryfotona Actinica SPF 50+](https://lovi.care/skincare/sg/p/isdin/eryfotona-actinica-spf-50/for/sensitive-skin) — Superior fit — S$110.01 at Amazon

## Where to buy

- YesStyle: S$29.54 (https://www.yesstyle.com/en/medicube-zero-pore-one-day-peptide-serum-30ml/info.html/pid.1137456823?curr=SGD&rco=SG)
Prices checked 13 Oct 2026.

## Ingredients

Water, Gluconolactone, Methylpropanediol, Glycerin, Propanediol, Tromethamine, Polyglycerin-3, Niacinamide, 1,2-Hexanediol, Citric Acid, Dimethicone, Butylene Glycol, C12-14 Pareth-12, Hydroxyethylcellulose, Salicylic Acid, Ammonium Acryloyldimethyltaurate Vp Copolymer, Sodium Polyacryloyldimethyl Taurate, Lecithin, Allantoin, Lactic Acid, Glycolic Acid, Ethylhexylglycerin, Adenosine, Dextrin, Indigofera Tinctoria Extract, Sodium Hyaluronate, Sodium Citrate, Hemerocallis Fulva Flower Extract, Gardenia Fruit Extract, Hydrolyzed Hyaluronic Acid, Hydrolyzed Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Trisodium Phosphate, Of Myosotis Sylvatica Extract, Pentylene Glycol, Hydroxypropyltrimonium Hyaluronate, Sodium Acetylated Hyaluronate, Centella Asiatica Extract, Madecassoside, Lactobacillus Lysate Ferment, Dandelion Leaf Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/zero-pore-one-day-serum/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/zero-pore-one-day-serum/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/zero-pore-one-day-serum/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/medicube/zero-pore-one-day-serum/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/medicube/zero-pore-one-day-serum/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/medicube/zero-pore-one-day-serum/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/zero-pore-one-day-serum/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/medicube/zero-pore-one-day-serum/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/zero-pore-one-day-serum/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/medicube/zero-pore-one-day-serum/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/zero-pore-one-day-serum/for/sensitive-skin (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/zero-pore-one-day-serum/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/zero-pore-one-day-serum/for/sensitive-skin