# Medicube Zero Pore Cream 2.0 for dry skin

**Lovi Fit: Average fit for dry skin.**
Dry Skin Fit: Average · Effectiveness: Average · Safety: Excellent.

Page: https://lovi.care/skincare/sg/p/medicube/zero-pore-cream-2-0/for/dry-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Brand: [Medicube](https://lovi.care/skincare/sg/brands/medicube)
Category: [Serums and treatments](https://lovi.care/skincare/sg/best/serums)

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for dry skin; other serums fit it better.

## Why this fit

- Offers moderate suitability for your dry skin, as glycerin and squalane provide humectant and emollient actions, but it lacks sufficient occlusive ingredients for optimal hydration.
- The presence of niacinamide and centella asiatica extract offers excellent pore treatment and soothing effects, which are beneficial general skincare aspects.
- The safety profile is excellent, with no risks of irritation for your dry skin due to the absence of harsh ingredients and the inclusion of soothing components like niacinamide and Centella Asiatica Extract.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sg/p/medicube/zero-pore-cream-2-0/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/sg/p/medicube/zero-pore-cream-2-0/for/dry-skin): Average (this page)
- [Combination skin](https://lovi.care/skincare/sg/p/medicube/zero-pore-cream-2-0/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/sg/p/medicube/zero-pore-cream-2-0/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/sg/p/medicube/zero-pore-cream-2-0/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/sg/p/medicube/zero-pore-cream-2-0/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/sg/p/medicube/zero-pore-cream-2-0/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/sg/p/medicube/zero-pore-cream-2-0/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/sg/p/medicube/zero-pore-cream-2-0/for/oily-acne-prone-skin): High

## Key ingredients

Niacinamide, Salicylic Acid, Sodium Hyaluronate, Willow Bark Extract, Oil Tree

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Cryotherapy with liquid nitrogen achieved a higher cure rate (39%) than salicylic acid (24%) and a wait-and-see approach (16%) for cutaneous warts at 13 weeks in primary care patients. ([CMAJ, 2010](https://pubmed.ncbi.nlm.nih.gov/20837684/))
- A moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid significantly reduced noninflammatory, inflammatory, and total acne lesion counts compared to a vehicle control in Thai patients during a 12-week maintenance phase. ([BioMed Research International, 2020](https://pubmed.ncbi.nlm.nih.gov/33150170/))
- Treatment with 2% supramolecular salicylic acid hydrogel resulted in a regression and markedly improvement rate of 51.01% compared to 43.10% for Adapaline gel in patients with mild to moderate facial acne vulgaris, showing no significant difference in efficacy. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590107/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- A botanical face cleanser with hops and willow bark extract continuously reduced skin sebum levels without reactive seborrhea after treatment in 21 healthy volunteers compared to a sodium laureth sulfate cleanser, with neither cleanser causing skin irritation. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30022595/))
- Bioactive lipid nanocarriers co-loaded with willow bark or ivy leaf extracts and UV-filters provided pronounced UVA photoprotection up to an SPF-equivalent value of 13 and a maximum in vivo skin hydration effect of 97% when prepared with pomegranate oil. ([Nanomaterials, 2022](https://pubmed.ncbi.nlm.nih.gov/35889587/))
- A topical serum containing 0.5% salicin applied twice daily reduced visible signs of skin aging, including wrinkles and tactile roughness, in 30 female subjects over 12 weeks compared to baseline. ([Journal of Cosmetic Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20883292/))
- Topical lycopene-enriched virgin olive oil provides effective pain relief similar to a placebo in patients with burning mouth syndrome, showing a strong placebo effect. ([Journal of Oral Rehabilitation, 2014](https://pubmed.ncbi.nlm.nih.gov/24612248/))

## Why other serums fit dry skin better

- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Treatment with 14% ferulic acid and 12% l-ascorbic acid significantly reduced pigmentation and erythema while improving hydration and elasticity in 20 women with photoaged skin, with neither acid proving definitively more effective overall though ascorbic acid showed slightly greater skin lightening. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/34877760/))

## What reviewers say

Based on a very large amount of data, users with combination and oily skin frequently praise this cream for its ability to balance sebum production while providing deep hydration without a sticky finish. Many report smoother skin texture and a fresh feeling. However, a significant number of reviewers note that visible reduction in pore size is subtle or non-existent despite the product's claims.

- Liked: Excellent hydration (mostly mentioned)
- Liked: Pleasant texture (often mentioned)
- Disliked: Ineffective on pores (often mentioned)
- Liked: Sebum control (sometimes noted)
- Liked: Skin smoothing (sometimes noted)
- Disliked: Strong scent (sometimes noted)
- Disliked: Heavy for some (rarely noted)
- Disliked: Potential irritation (rarely noted)

## How to apply

- Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
- Place the serum after cleansing and toner, but right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on slightly damp skin to help lock in extra moisture.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does medicube Zero Pore Cream work for dry skin?

This cream works moderately well for dry skin, as ingredients like glycerin and squalane help keep skin soft and smooth, though it lacks enough heavy sealants to lock in moisture for long-lasting hydration. It has an excellent safety profile with soothing components that are unlikely to cause irritation. Treatments that fit dry skin better need rich hydrating and barrier-supporting ingredients like ceramides, propolis, or heavy sealing agents to prevent moisture loss.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this cream a good fit for dry skin?

Glycerin, squalane, and sodium hyaluronate make this cream a moderate fit for your dry skin by helping draw in and hold moisture. To work best for dry skin, this type of product also needs heavy moisturizing sealants like ceramides, propolis, or plant oils to lock in hydration.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Niacinamide do for dry skin?

Niacinamide helps dry skin by strengthening the skin barrier, increasing hydration, and reducing water loss. It supports ceramide production and helps keep the surface smooth and calm. This ingredient tends to be very well tolerated and is unlikely to irritate dry skin.
Sources: [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/), [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/42108609/)

### What does Salicylic Acid do for dry skin?

Salicylic acid is generally not a good fit for dry skin, as it is meant to clear out pores and remove dead skin rather than hydrate. Because dry skin needs soothing and moisture rather than exfoliation, a product for dry skin needs nourishing ingredients like urea to lock in moisture and keep the skin soft.

### Where does this cream go in a skincare routine for dry skin?

This treatment goes in the evening routine, after cleansing and before moisturizing, to keep things simple and safe around sun exposure. Dry skin needs a product of this type that brings heavy-duty sealing ingredients to lock in moisture alongside hydrating and soothing components.

### Can I use this cream with retinol, and in what order?

You can use this cream in the evening after your retinol product, as its soothing ingredients and lack of harsh components help keep irritation unlikely. Dry skin of this type needs rich, sealing ingredients like heavy oils or butters to lock in hydration effectively.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/)

### How often should I use this cream?

You can use this treatment in the evening as part of your dry skin routine. Dry skin needs a product with heavier sealing ingredients to lock in hydration and keep it soft.

### Can this cream clog pores, cause breakouts or purging for dry skin?

This cream is unlikely to cause breakouts or clog pores for dry skin, as its safety profile is excellent and it lacks harsh ingredients. It brings soothing components like niacinamide and Centella Asiatica Extract to help calm your skin.

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for dry skin

- [ma:nyo Bifida Biome Complex Ampoule](https://lovi.care/skincare/sg/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-skin) — Superior fit — S$40.09 at Amazon
- [SKIN1004 Madagascar Centella Tone Brightening Capsule Ampoule](https://lovi.care/skincare/sg/p/skin1004/madagascar-centella-tone-brightening-capsule-ampoule/for/dry-skin) — Superior fit — S$54.11 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vitamin-c-serum/for/dry-skin) — Superior fit — S$50.41 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/sg/p/cerave/hydrating-facial-cleanser/for/dry-skin) — Superior fit — S$25.06 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/sg/p/cosrx/propolis-synergy-toner/for/dry-skin) — Superior fit — S$41.07 at Amazon
- Moisturizer: [d'Alba First Spray Serum](https://lovi.care/skincare/sg/p/d-alba/first-spray-serum/for/dry-skin) — Superior fit — S$25.94 at Amazon

## Where to buy

- YesStyle: S$33.39 (https://www.yesstyle.com/en/medicube-zero-pore-cream-2-0-50ml/info.html/pid.1069062329?curr=SGD&rco=SG)
Prices checked 14 Oct 2026.

## Ingredients

Water, Glycerin, Niacinamide, Butylene Glycol, Cyclopentasiloxane, Dimethicone, Cyclohexasiloxane, Sodium Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Isohexadecane, Polysorbate 80, Squalane, Tocopheryl Acetate, Panthenol, Allantoin, Centella Asiatica Extract, Camellia Sinensis Leaf Extract, Portulaca Oleracea Extract, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Scutellaria Baicalensis Root Extract, Polygonum Cuspidatum Root Extract, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Chamomilla Recutita Flower Extract Matricaria Flower Extract, Coptis Japonica Root Extract, Adenosine, Ethylhexylglycerin, Caprylyl Glycol, 1,2-Hexanediol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/zero-pore-cream-2-0/for/dry-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/zero-pore-cream-2-0/for/dry-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/zero-pore-cream-2-0/for/dry-skin
- Germany: https://lovi.care/skincare/de/p/medicube/zero-pore-cream-2-0/for/dry-skin
- France: https://lovi.care/skincare/fr/p/medicube/zero-pore-cream-2-0/for/dry-skin
- Italy: https://lovi.care/skincare/it/p/medicube/zero-pore-cream-2-0/for/dry-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/zero-pore-cream-2-0/for/dry-skin
- Spain: https://lovi.care/skincare/es/p/medicube/zero-pore-cream-2-0/for/dry-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/zero-pore-cream-2-0/for/dry-skin
- Australia: https://lovi.care/skincare/au/p/medicube/zero-pore-cream-2-0/for/dry-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/zero-pore-cream-2-0/for/dry-skin (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/zero-pore-cream-2-0/for/dry-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/zero-pore-cream-2-0/for/dry-skin