# Medicube Triple Collagen Serum for sensitive skin

**Lovi Fit: High fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/sg/p/medicube/triple-collagen-serum/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Brand: [Medicube](https://lovi.care/skincare/sg/brands/medicube)
Category: [Serums and treatments](https://lovi.care/skincare/sg/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for sensitive skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your normal skin, this serum effectively addresses redness and irritation with niacinamide and collagen extracts that support barrier function and reduce inflammation.
- The formula provides excellent plumping and elasticity benefits due to a high concentration of various collagen types and sodium hyaluronate derivatives, enhancing overall skin volume.
- The safety profile is excellent for your sensitive skin, as it contains soothing ingredients like niacinamide and glycerin and lacks harsh or prohibited substances.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sg/p/medicube/triple-collagen-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/sg/p/medicube/triple-collagen-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/sg/p/medicube/triple-collagen-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/sg/p/medicube/triple-collagen-serum/for/sensitive-skin): High (this page)
- [Acne-prone skin](https://lovi.care/skincare/sg/p/medicube/triple-collagen-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/sg/p/medicube/triple-collagen-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/sg/p/medicube/triple-collagen-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/sg/p/medicube/triple-collagen-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/sg/p/medicube/triple-collagen-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Triple Collagen Complex, Sodium Hyaluronate, Niacinamide, Collagen Extract, Adenosine

## What the research says

- Both oral and topical collagen supplements help delay the skin aging process by improving moisture, elasticity, and hydration, with no differences arising between the two types of collagen. ([Dermatology Practical & Conceptual, 2022](https://pubmed.ncbi.nlm.nih.gov/35223163/))
- The use of cosmetic products containing collagen or its peptides improves the general condition of the skin, reduces wrinkle depth, improves hydration and density, reduces transepithelial water loss, and delays the aging process, while oral bioactive collagen peptides also reduce nail breakage. ([Current Issues in Molecular Biology, 2024](https://pubmed.ncbi.nlm.nih.gov/38534748/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))

## What reviewers say

Users frequently report this serum provides deep hydration, leading to a plumped, radiant complexion often described as 'glass skin'. It is well-loved for its smooth, non-greasy texture and effectiveness in diminishing fine lines, making it a great base for makeup. Some users find the fragrance to be strong and occasionally encounter issues with the packaging.

- Liked: Deep hydration (mostly mentioned)
- Liked: Glow and radiance (often mentioned)
- Liked: Good texture (sometimes noted)
- Liked: Plumping and anti-aging (sometimes noted)
- Disliked: Packaging issues (sometimes noted)
- Disliked: Strong fragrance (sometimes noted)
- Liked: Makeup compatibility (rarely noted)
- Disliked: Skin sensitivity (rarely noted)
- Disliked: Slightly sticky (rarely noted)
- Disliked: Small quantity (rarely noted)

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Medicube Triple Collagen Serum a great fit for sensitive skin?

Medicube Triple Collagen Serum is a great fit for sensitive skin because it helps calm redness and irritation with soothing ingredients like niacinamide and glycerin. Its gentle formula is very safe for easily irritated skin and avoids harsh substances while providing great moisture and elasticity benefits.
Sources: [Dermatology Practical & Conceptual, 2022](https://pubmed.ncbi.nlm.nih.gov/35223163/), [Current Issues in Molecular Biology, 2024](https://pubmed.ncbi.nlm.nih.gov/38534748/)

### Which ingredients make this serum a good fit for sensitive skin?

Niacinamide and glycerin make this serum a great fit for sensitive skin by soothing irritation and supporting the skin barrier. The formula is very safe for this skin type because it leaves out harsh substances.

### What does Triple Collagen do for sensitive skin?

Triple Collagen helps improve roughness, dryness, and irritation while keeping sensitive skin smooth and calm. This ingredient supports skin barrier function and helps reduce redness in sensitive types.
Sources: [International Journal of Cosmetic Science, 2009](https://pubmed.ncbi.nlm.nih.gov/19496838/)

### What does Hyaluronic Acid do for sensitive skin?

Hyaluronic acid helps calm and hydrate sensitive skin while supporting the skin barrier to keep it soft and comfortable. Clinical studies show it improves surface moisture and reduces dryness, roughness, and redness without irritation.
Sources: [Journal of Drugs in Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41037531/), [Journal of Cosmetic Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29356277/)

### Where does this serum go in a skincare routine for sensitive skin?

This serum goes in the evening routine after your toner and before your moisturizer. Putting it in the evening helps keep your routine simple and adds extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

Yes, you can use this serum with retinol by applying it after your retinol treatment to help soothe and hydrate your skin. This formula contains gentle, calming ingredients like niacinamide and glycerin that are very unlikely to cause irritation when paired with stronger products.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/)

### How often should I use this serum?

This serum is a great fit for your sensitive skin and is used in the evening routine. It is a safe and gentle option that helps calm redness while improving moisture and elasticity.
Sources: [Dermatology Practical & Conceptual, 2022](https://pubmed.ncbi.nlm.nih.gov/35223163/), [Current Issues in Molecular Biology, 2024](https://pubmed.ncbi.nlm.nih.gov/38534748/)

### Can this serum clog pores, cause breakouts or purging for sensitive skin?

This serum is unlikely to clog pores or cause breakouts for sensitive skin because it lacks heavy or harsh substances and has a very safe formula. It helps calm your skin while keeping it soft and smooth without causing irritation.

### Is this serum fragrance-free and alcohol-free?

It contains fragrance (linalool and limonene) and drying alcohol (alcohol denat).

## Alternatives for sensitive skin

- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vitamin-c-serum/for/sensitive-skin) — High fit — S$50.41 at Amazon
- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/sg/p/skin1004/probio-cica-intensive-ampoule/for/sensitive-skin) — High fit — S$28.55 at Amazon
- [PCA Skin C&E Advanced with Hexylresorcinol and Silymarin](https://lovi.care/skincare/sg/p/pca-skin/c-and-e-advanced/for/sensitive-skin) — Average fit — S$192.38 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/sg/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — S$30.00 at Amazon
- Soothing Toner: [One Thing Centella Asiatica Extract Toner](https://lovi.care/skincare/sg/p/one-thing/centella-asiatica-extract-toner/for/sensitive-skin) — Superior fit — S$30.07 at Amazon
- Moisturizer with Sun Protection: [ISDIN Eryfotona Actinica SPF 50+](https://lovi.care/skincare/sg/p/isdin/eryfotona-actinica-spf-50/for/sensitive-skin) — Superior fit — S$110.01 at Amazon

## Where to buy

- YesStyle: S$28.12 (https://www.yesstyle.com/en/medicube-triple-collagen-serum-55ml/info.html/pid.1137573727?curr=SGD&rco=SG)
Prices checked 13 Oct 2026.

## Ingredients

Water, Glycerin, Butylene Glycol, Cetyl Ethylhexanoate, Niacinamide, Glycereth-26, Alcohol Denat, 1,2-Hexanediol, Trehalose, Carbomer, Cetearyl Olivate, Tromethamine, Sorbitan Olivate, Ethylhexylglycerin, Collagen Extract, Adenosine, Disodium Edta, Atelocollagen, Desamido Collagen, Hydrolyzed Collagen, Sodium Hyaluronate, Water-Soluble Collagen, Sodium Hyaluronate Crosspolymer, Hydrolyzed Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid, Collagen, Collagen Amino Acids, Sodium Acetylated Hyaluronate, Procollagen, Cyclopentasiloxane, Hydroxypropyltrimonium Hyaluronate, Cyclohexasiloxane, Dimethicone, Benzyl Benzoate, Linalool, Limonene
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/triple-collagen-serum/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/triple-collagen-serum/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/triple-collagen-serum/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/medicube/triple-collagen-serum/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/medicube/triple-collagen-serum/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/medicube/triple-collagen-serum/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/triple-collagen-serum/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/medicube/triple-collagen-serum/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/triple-collagen-serum/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/medicube/triple-collagen-serum/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/triple-collagen-serum/for/sensitive-skin (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/triple-collagen-serum/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/triple-collagen-serum/for/sensitive-skin