# Medicube PDRN Pink Peptide Serum for dry sensitive skin

**Lovi Fit: Average fit for dry sensitive skin.**
Dry Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/sg/p/medicube/pdrn-pink-peptide-serum/for/dry-sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Brand: [Medicube](https://lovi.care/skincare/sg/brands/medicube)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/sg/best/moisturizers)

This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for dry sensitive skin; other moisturizers fit it better.

## Why this fit

- This serum offers moderate benefits for your dry and sensitive skin, as hyaluronic acid and glycerin provide essential hydration, while hydrolyzed collagen and atelocollagen support barrier repair. Salmon egg extract and sodium DNA contribute to skin plumping and overall revitalization.
- Niacinamide and copper tripeptide-1 further enhance skin health by addressing texture and promoting a smoother complexion.
- The product is safe for your skin, with no harsh ingredients that could cause irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sg/p/medicube/pdrn-pink-peptide-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/sg/p/medicube/pdrn-pink-peptide-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/sg/p/medicube/pdrn-pink-peptide-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/sg/p/medicube/pdrn-pink-peptide-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/sg/p/medicube/pdrn-pink-peptide-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/sg/p/medicube/pdrn-pink-peptide-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/sg/p/medicube/pdrn-pink-peptide-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/sg/p/medicube/pdrn-pink-peptide-serum/for/dry-sensitive-skin): Average (this page)
- [Oily acne-prone skin](https://lovi.care/skincare/sg/p/medicube/pdrn-pink-peptide-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Niacinamide, Hydrolyzed Collagen, Sodium Dna

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Treatment with salmon egg extract at concentrations of 1% and 5% significantly improved wrinkles, pigmentation, redness, brightness, and hydration in 66 healthy female volunteers in a dose- and time-dependent manner compared to baseline. ([International Journal of Cosmetic Science, 2013](https://pubmed.ncbi.nlm.nih.gov/23738607/))
- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Topical application of Low-Peony PDRN enhanced barrier recovery and improved periorbital skin elasticity in human subjects. ([International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/))
- Polydeoxyribonucleotide promotes skin regeneration by increasing ERK phosphorylation, collagen accumulation, and cell proliferation and migration in fibroblasts while inhibiting ERK phosphorylation and inflammatory cytokine expression in keratinocytes. ([Molecular Medicine Reports, 2023](https://pubmed.ncbi.nlm.nih.gov/37350391/))
- A topical mixture of polydeoxyribonucleotide, vitamin C, and niacinamide delivered via a microneedling therapy system decreased skin pigmentation and increased skin elasticity by attenuating melanogenesis and the destruction of collagen and elastin fibers in a UV-B-radiated animal model. ([Molecules, 2022](https://pubmed.ncbi.nlm.nih.gov/35209068/))

## What reviewers say

Based on a very large amount of data, this serum is highly praised for delivering intense hydration and a radiant "glass skin" glow, with users frequently reporting immediate improvements in skin plumpness and elasticity. The viscous texture is often noted for its barrier-repairing qualities. A polarizing feature is the distinct scent, described as floral and fishy, which some users find unpleasant.

- Liked: Deep hydration (mostly mentioned)
- Liked: Radiant glow (often mentioned)
- Liked: Smoother texture (often mentioned)
- Liked: Soothing and gentle (sometimes noted)
- Disliked: Unpleasant scent (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Small quantity (rarely noted)
- Disliked: Sticky finish (rarely noted)

## How to apply

- Could be used as part of your AM or PM routine. Start using this moisturizer 3 times a week and move to daily use if your dry skin tolerates it well.
- Apply this moisturizer after cleansing and toner in the morning, or after your serum in the evening. Always pair it with SPF in the morning.
- Gently press a small amount of the moisturizer into your skin. Avoid rubbing it harshly to protect your sensitive skin.
- Apply the moisturizer on slightly damp skin to help with hydration absorption. This also works well for dry and flaky skin types.
- Do a patch test before your first use. Avoid the eye area to prevent any irritation.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does medicube PDRN Pink Peptide Serum work for dry sensitive skin?

This serum works moderately well for dry sensitive skin, as hyaluronic acid and glycerin help provide hydration while collagen supports the skin barrier. To fit this skin type best, a moisturizing treatment needs a rich blend of deep hydrators and soothing ingredients that lock in moisture and calm dryness without irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for dry sensitive skin?

This serum works for dry skin because hyaluronic acid and glycerin quench dryness, while hydrolyzed collagen and sodium DNA help repair and plump the skin. A moisturizing treatment for this skin type needs a rich blend of deep hydrators and soothing extracts to deliver lasting moisture and relieve flakiness without irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Niacinamide do for dry sensitive skin?

Niacinamide helps dry sensitive skin by calming irritation and keeping moisture locked in so your face feels soft and smooth. It works to build up your skin barrier and calm redness while being very gentle and unlikely to cause irritation.
Sources: [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/), [International Journal of Pharmaceutics, 2013](https://pubmed.ncbi.nlm.nih.gov/23220080/)

### What does Hydrolyzed Collagen do for dry sensitive skin?

Hydrolyzed collagen helps make dry skin feel much more smooth and hydrated while helping to calm sensitive areas. Regular use over a few weeks significantly improves moisture levels and helps keep the skin barrier strong and comfortable.
Sources: [Cureus, 2023](https://pubmed.ncbi.nlm.nih.gov/38192916/), [International Journal of Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33742704/)

### Where does this serum go in a skincare routine for dry sensitive skin?

This serum goes in the evening routine after your toner and before your moisturizer. Dry and sensitive skin needs a product of this type to include extra soothing ingredients and rich hydrators to calm irritation and deeply nourish dry areas.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to give your skin hydration, and following with retinol once it absorbs. This type of skin benefits from adding a rich moisturizer afterwards to lock in hydration and protect the skin barrier.

### How often should I use this serum?

This serum works well in your evening routine, where you can apply it daily after cleansing and toning. It is safe for your skin with no harsh ingredients that could cause irritation, but to get the best fit for dry sensitive skin, a product of this type needs rich moisturizing ingredients like ceramides, squalane, or shea butter to deeply comfort and protect dry areas.

### Can this serum clog pores, cause breakouts or purging for dry sensitive skin?

Breakouts from this serum are unlikely for dry sensitive skin, as it contains no harsh ingredients that typically cause irritation. However, because this is an average fit, dry skin of this type needs a product packed with richer oils and heavy hydrators to truly stay soft and smooth.

### Can I use this serum around the eyes or on my body?

Yes, you can use this moisturizing treatment around your eyes and on your body because its safety profile is very good and it is unlikely to cause irritation. To properly care for dry and sensitive skin in delicate areas like the eyelids, a product of this type needs rich hydrating ingredients like hyaluronic acid and glycerin alongside soothing barrier-repair agents to keep the skin soft and comfortable.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for dry sensitive skin

- [COSRX Hydrium Triple Hyaluronic Moisture Ampoule](https://lovi.care/skincare/sg/p/cosrx/hydrium-triple-hyaluronic-moisture-ampoule/for/dry-sensitive-skin) — Superior fit — S$21.96 at YesStyle

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/sg/p/cerave/hydrating-facial-cleanser/for/dry-sensitive-skin) — Superior fit — S$25.06 at Amazon
- Soothing Toner: [Mario Badescu Facial Spray with Aloe, Chamomile and Lavender](https://lovi.care/skincare/sg/p/mario-badescu/facial-spray-with-aloe-chamomile-and-lavender/for/dry-sensitive-skin) — High fit — S$34.52 at Amazon
- Moisturizer with Sun Protection: [Dr.G Green Mild Up Sun+](https://lovi.care/skincare/sg/p/dr-g/green-mild-up-sun/for/dry-sensitive-skin) — Superior fit — S$59.06 at Amazon

## Where to buy

- Amazon.sg: S$37.93 (https://www.amazon.sg/dp/B0HMWFT2KG?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- YesStyle: S$29.41 (https://www.yesstyle.com/en/medicube-pdrn-pink-peptide-serum-30ml/info.html/pid.1129886159?curr=SGD&rco=SG)
Prices checked 13 Oct – 4 Nov 2026.

## Ingredients

Water, Disodium Edta, Niacinamide, Hydrolyzed Collagen, Sodium Dna, Milt Extract, Copper Tripeptide-1, Acetyl Hexapeptide-8, Palmitoyl Pentapeptide-4, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Butylene Glycol, 1,2-Hexanediol, Glycerin, Dipropylene Glycol, Polyglycerin-3, Glyceryl Acrylate Acrylic Acid Copolymer, Pvm Ma Copolymer, Hyaluronic Acid, Ethylhexylglycerin, Glycereth-26, Adenosine, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Isopropyl Myristate, Ubiquinone, Caprylyl Glycol, Tromethamine, Sodium Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Polyisobutene, Caprylyl Capryl Glucoside, Sorbitan Oleate, Atelocollagen, Salmon Egg Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/pdrn-pink-peptide-serum/for/dry-sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/pdrn-pink-peptide-serum/for/dry-sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/pdrn-pink-peptide-serum/for/dry-sensitive-skin
- Germany: https://lovi.care/skincare/de/p/medicube/pdrn-pink-peptide-serum/for/dry-sensitive-skin
- France: https://lovi.care/skincare/fr/p/medicube/pdrn-pink-peptide-serum/for/dry-sensitive-skin
- Italy: https://lovi.care/skincare/it/p/medicube/pdrn-pink-peptide-serum/for/dry-sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/pdrn-pink-peptide-serum/for/dry-sensitive-skin
- Spain: https://lovi.care/skincare/es/p/medicube/pdrn-pink-peptide-serum/for/dry-sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/pdrn-pink-peptide-serum/for/dry-sensitive-skin
- Australia: https://lovi.care/skincare/au/p/medicube/pdrn-pink-peptide-serum/for/dry-sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/pdrn-pink-peptide-serum/for/dry-sensitive-skin (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/pdrn-pink-peptide-serum/for/dry-sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/pdrn-pink-peptide-serum/for/dry-sensitive-skin