MARY & MAY 6 Peptide Complex Serum for mature skin
Copper Tripeptide-1
Hexapeptide-11
Hexapeptide-9
Palmitoyl Pentapeptide-4
Palmitoyl Tripeptide-1
High
- SuperiorNormal Skin Fit
- HighEffectiveness
- HighSafety
One of the best serums for mature skin.
This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Excellent suitability for your normal skin is provided by multiple peptides like copper tripeptide-1 and hexapeptide-11, which support collagen stimulation and extracellular matrix synthesis.
- The serum offers moderate benefits for wrinkles and fine lines due to the presence of peptides like copper tripeptide-1 and palmitoyl pentapeptide-4 in concentrations that support collagen production.
- The safety profile is excellent, with no risks of irritation for your normal skin due to the absence of prohibited or harsh ingredients.
How to apply
- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
People Say
★4.6Overall rating based on 2.4k+ reviewsBased on a very large amount of data, users with diverse skin types consistently praise this serum for its lightweight hydration and ability to plump the skin without irritation. While it is not a miracle cure for deep wrinkles, the majority of users report smoother skin texture, improved elasticity, and a reduction in fine lines after consistent use.
Highlights
Lightweight & fast-absorbing Mostly Mentioned
- “absorbs instantly without stickiness”
- “watery texture sinks right in”
- “perfect for layering”
- “leaves no greasy residue”
Gentle & non-irritating Often Mentioned
- “great for my sensitive skin”
- “no stinging or redness”
- “fragrance-free and soothing”
- “didn't break me out”
Hydrating & plumping Often Mentioned
- “skin feels bouncy and soft”
- “plumps up fine lines”
- “provides a nice glow”
- “keeps skin moist all day”
Good value Sometimes Noted
- “better than expensive brands”
- “great price point”
- “affordable peptide option”
- “high quality for the cost”
Subtle or slow results Sometimes Noted
- “didn't see drastic changes”
- “takes months to notice difference”
- “good for maintenance but not a facelift”
- “no miracle for deep wrinkles”
Consumed quickly Rarely Noted
- “bottle finished in 3 weeks”
- “skin drinks it up so I use a lot”
- “small bottle for the amount needed”
Rare skin reactions Rarely Noted
- “caused tiny red bumps”
- “broke me out on forehead”
- “slight itching after application”
- “triggered fungal acne”
Texture too watery Rarely Noted
- “runs down my face quickly”
- “hard to control the dropper”
- “wish it was slightly thicker”
- “feels like water”
Sources: lovi.care, iherb.com, yesstyle.com, skinsort.com, reddit.com, youtube.com, and more
Questions and answers
What makes Mary & May 6 Peptide Complex Serum a great fit for mature skin?
Mary & May 6 Peptide Complex Serum is a great fit because it contains multiple peptides like copper tripeptide-1 and hexapeptide-11, which help support collagen and improve skin elasticity. It also has a very safe formula with no harsh ingredients, meaning it is unlikely to cause irritation on normal skin.
Which ingredients make this serum a good fit for mature skin?
This serum is a great fit for mature skin because it contains multiple peptides like copper tripeptide-1, hexapeptide-11, and palmitoyl pentapeptide-4. These ingredients support collagen production and help keep skin firm while smoothing out the look of fine lines and wrinkles. It is also very safe and unlikely to cause any irritation.
International Journal of Cosmetic Science, 2005Redox Biology, 2015
What does Copper Tripeptide-1 do for mature skin?
Copper Tripeptide-1 helps improve mature skin by smoothing out fine lines and wrinkles while boosting firmness and elasticity. It also helps calm irritation, protects against daily damage, and supports a stronger skin barrier.
Journal of Biomaterials Science. Polymer Edition, 2008Skin Research and Technology, 2026
What does Hexapeptide-11 do for mature skin?
Hexapeptide-11 helps improve skin firmness and elasticity in mature skin by supporting collagen production and defending cells against oxidative stress. This ingredient protects against premature aging and helps keep the skin looking smooth and youthful.
Where does it go in a skincare routine for mature skin?
This treatment goes in your evening routine, applied after cleansing and toning and before your moisturizer. Putting it in the evening keeps things simple and provides extra safety around sun exposure, while helping smooth wrinkles and fine lines.
Can I use this serum with retinol, and in what order?
You can use this treatment alongside retinol by applying the retinol first and following it with this peptide serum, or by using them on alternating nights to keep your skin calm and smooth. This approach helps you gain the wrinkle-smoothing benefits of both ingredients while maintaining a very safe routine.
International Journal of Cosmetic Science, 2005Redox Biology, 2015
How often should I use it?
Use this serum in your evening routine, applying it after your cleansing toner and before your moisturizer. It is a great fit for mature skin, helping to smooth fine lines safely and without irritation.
International Journal of Cosmetic Science, 2005Redox Biology, 2015
Can this serum clog pores, cause breakouts or purging for mature skin?
This serum is unlikely to clog pores or cause breakouts for mature skin because it has an excellent safety profile without harsh ingredients. It is also not an active exfoliant, so it will not cause purging.
Is it fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
Hexapeptide-11 activated proteasome, autophagy, chaperones, and antioxidant response genes, protected fibroblasts against oxidative-stress-mediated premature cellular senescence, and improved skin elasticity in human subjects.
Redox Biology, 2015The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls.
Skin Research and Technology, 2026Topical palmitoyl pentapeptide (pal-KTTKS) provided significant improvement versus placebo control in the reduction of wrinkles and fine lines in Caucasian female subjects.
International Journal of Cosmetic Science, 2005A functionalized dendrimer nanocarrier delivers active ingredients into the dermis and enhances collagen production in human dermal fibroblasts by co-delivering all-trans retinol and palmitoyl pentapeptide-4.
Acta Biomaterialia, 2025Combined therapy using a topical hyaluronic acid-niacinamide-Matrixyl serum and a multimodal facial device decreased TruSkin age by five years and reduced wrinkles more effectively than the serum alone in a 41-year-old woman with moderate facial aging over 12 weeks.
Cureus, 2026Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality.
Archives of Facial Plastic Surgery, 2006A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days.
Cureus, 2024Copper applied transdermally as a tripeptide on human skin ex vivo permeated the tissue and was retained in amounts potentially effective for treating inflammatory diseases.
Inflammation Research, 2010Hexapeptide-11 reversibly downregulated ATM and p53 protein expression in intrinsically aged fibroblasts, extrinsically aged fibroblasts, and extrinsically aged dermal papillae cells at concentrations between 0.1% and 1.0% in vitro, thereby influencing the onset of cellular senescence.
Journal of Cosmetic Science, 2013Topical treatment with cyclized hexapeptide-9 significantly reduced wrinkles and roughness in crow's feet and forehead compared to vehicle, and generally outperformed retinol in healthy volunteers with aging skin.
Journal of Cosmetic Dermatology, 2025A chemically synthesized homotrimeric collagen peptide exhibited high purity, a stable triple-helical conformation, and excellent thermal stability, while safely enhancing collagen and elastin synthesis in fibroblasts in vitro and increasing skin collagen content, improving skin structure, and enhancing microvessel density in BALB/c mice in vivo.
Frontiers in Bioengineering and Biotechnology, 2025The addition of soybean peptide and collagen peptide to normal human dermal fibroblasts increased collagen synthesis and gene expression related to collagen formation, with the highest collagen levels observed when both peptides were added together compared to individual additions.
International Journal of Food Sciences and Nutrition, 2012A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo.
Journal of Cosmetic Dermatology, 2015Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants.
Journal of Cosmetic Dermatology, 2026Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components.
International Journal of Cosmetic Science, 2026
Ingredients
Water, Glycereth-26, 1,2-Hexanediol, Butylene Glycol, Glycerin, Arginine, Carbomer, Ethylhexylglycerin, Polyglyceryl-10 Laurate, Adenosine, Caprylyl Glycol, Copper Tripeptide-1, Hexapeptide-11, Hexapeptide-9, Palmitoyl Pentapeptide-4, Palmitoyl Tripeptide-1, Tripeptide-1
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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