make p:rem UV Defense Me No Sebum Sun Cream for acne-prone skin

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Questions and answers

What the research says

• Biomimetic hyaluronic acid-stabilized zinc oxide nanoparticles selectively inhibited C. acnes, outperformed erythromycin in preclinical acne models, and safely reduced acne lesions and redness in a clinical trial.

  Journal of Controlled Release, 2025

• Topical 0.5% hyaluronic-ZnO nanogel applied twice daily reduced inflammatory-lesion counts by 58% at week four in human subjects compared to baseline without causing erythema.

  Biomedicines, 2025

• Optimized transfersomes loaded with epigallocatechin-3-gallate and hyaluronic acid increased cell viability while reducing lipid peroxidation, intracellular ROS, and MMP expression in HaCaT cells, and exhibited higher skin permeation and deposition compared to plain EGCG.

  Drug Delivery, 2017

• Nels cream achieved a similar reduction in inflammatory and noninflammatory lesion counts compared to 5% benzoyl peroxide in acne vulgaris patients, but caused significantly fewer side-effects such as peeling and dryness.

  Clinical and Experimental Dermatology, 2000

• Topically applied coated and uncoated zinc oxide nanoparticles under flexing and massage are retained in the stratum corneum with no significant penetration into the viable epidermis and no cellular toxicity in human skin.

  Nanomedicine, 2016

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Topical treatment with Geranium thunbergii extract lotion improved skin elasticity and reduced skin wrinkling scores compared to placebo in healthy Japanese women by inhibiting HYBID-mediated hyaluronan degradation and down-regulating HYBID expression.

  Journal of Cosmetic Dermatology, 2019

• Geranium and Calendula essential oil-loaded ethanolic lipid vesicular creams exhibited notable antioxidant capacity, sun protection factor values of 10.26 and 18.54, and collagenase and elastase inhibition capacity compared to nonvesicular creams.

  BioMed Research International, 2021

• Electrospun poly (vinyl butyral-co-vinyl alcohol-co-vinyl acetate) patches loaded with evening primrose oil applied to the forearm of volunteers for 6 hours increased skin moisture, with pore size, shape, and fiber diameter influencing oil transport.

  Biomaterials Advances, 2022

• A topical preparation containing urea, sunflower oil, evening primrose oil, wheat germ oil, and sodium pyruvate led to clinical improvement after a month in diverse hyperkeratotic skin conditions except pityriasis lichenoides.

  Medicina Cutanea Ibero-latino-americana, 1986

• Oenothera biennis cell culture aqueous extract promoted matrix collagen contraction, actin polymerization, and essential extracellular matrix protein production by increasing MYLK gene expression in in vitro, cell, and ex vivo skin aging models.

  Metabolites, 2021

• ANT1 soybean extract cream ameliorated complications and enhanced skin recovery after Nd:YAG laser therapy in 45 Asian women, with higher concentrations significantly reducing wrinkles, spots, and pores compared to placebo.

  Annals of Plastic Surgery, 2018

• Genistein and daidzein inhibited UVB-induced hydrogen peroxide production in keratinocytes acting as free radical scavengers with negligible skin disruption, whereas glycitein showed no protective activity.

  International Journal of Pharmaceutics, 2008

• A phytoestrogen-enriched cosmetic formulation containing biotransformed soybean extract increased collagen-I expression in fibroblast cells and skin explants in an estrogen receptor beta-dependent manner without harming skin microbiota.

  Brazilian Journal of Medical and Biological Research = Revista Brasileira de Pesquisas Medicas E Biologicas, 2023

Ingredients

Water, Zinc Oxide, Cyclohexasiloxane, Butyloctyl Salicylate, Propanediol, Propylheptyl Caprylate, Isododecane, Caprylyl Methicone, Polyglyceryl-3 Polydimethylsiloxyethyl Dimethicone, Methyl Methacrylate Crosspolymer, Methyl Trimethicone, Pelargonium Graveolens Extract, Oenothera Biennis Flower Extract, Ulmus Davidiana Root Extract, Pinus Palustris Leaf Extract, Pueraria Lobata Root Extract, Bacillus Soybean Extract Ferment, Juniperus Virginiana Oil, Litsea Cubeba Oil Fruit, Sodium Hyaluronate, Vetiveria Zizanoides Oil Root, Elettaria Cardamomum Seed Extract, Nymphaea Caerulea Flower Extract, Disteardimonium Hectorite, Magnesium Sulfate, Triethoxycaprylylsilane, 2-Hexanediol, Polyglyceryl-2 Dipolyhydroxystearate, Polymethylsilsesquioxane, Lauryl Polyglyceryl-3 Polydimethylsiloxyethyl Dimethicone, Glyceryl Caprylate, Caprylyl Glycol, Ethylhexylglycerin, Tocopherol, Butylene Glycol, Folic Acid

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.