# ma:nyo Bifida Biome Ampoule Toner for oily acne-prone skin

**Lovi Fit: Superior fit for oily acne-prone skin.**
Oily Skin Fit: Superior · Effectiveness: Superior · Safety: Excellent.

Page: https://lovi.care/skincare/sg/p/ma-nyo/bifida-biome-ampoule-toner/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Brand: [ma:nyo](https://lovi.care/skincare/sg/brands/ma-nyo)
Category: [Toners](https://lovi.care/skincare/sg/best/toners)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best toners for oily acne-prone skin.

## Why this fit

- Excellent suitability for your oily skin and acne, blemishes, and breakouts is provided by Lactobacillus Lysate Ferment and Bifida Ferment Filtrate, which offer superb seboregulation and barrier repair while reducing inflammation.
- The formula also provides excellent hydration due to multiple fermented ingredients that moisturize and enhance barrier resilience, further supporting your skin's health.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the presence of soothing components like Allantoin, Panthenol, and Ceramides.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sg/p/ma-nyo/bifida-biome-ampoule-toner/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/sg/p/ma-nyo/bifida-biome-ampoule-toner/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/sg/p/ma-nyo/bifida-biome-ampoule-toner/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/sg/p/ma-nyo/bifida-biome-ampoule-toner/for/sensitive-skin): Superior
- [Acne-prone skin](https://lovi.care/skincare/sg/p/ma-nyo/bifida-biome-ampoule-toner/for/acne-prone-skin): Superior
- [Skin with dark spots](https://lovi.care/skincare/sg/p/ma-nyo/bifida-biome-ampoule-toner/for/dark-spots): Superior
- [Mature skin](https://lovi.care/skincare/sg/p/ma-nyo/bifida-biome-ampoule-toner/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/sg/p/ma-nyo/bifida-biome-ampoule-toner/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/sg/p/ma-nyo/bifida-biome-ampoule-toner/for/oily-acne-prone-skin): Superior (this page)

## Key ingredients

Bifida Lysate Ferment, Sodium Hyaluronate, Ceramide Np, Allantoin, Panthenol

## What the research says

- Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016](https://pubmed.ncbi.nlm.nih.gov/27475700/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/))
- An overnight patch containing Allium cepa extract and allantoin safely promotes scar healing after dermatologic surgery, resulting in significantly greater reductions in observer- and patient-assessed POSAS scores compared to no treatment. ([Aesthetic Plastic Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29948103/))
- Prophylactic application of a topical scar gel containing Allium cepae extract, allantoin, and heparin significantly improves patient-assessed scar color, stiffness, and irregularity compared to no treatment in women following a cesarean section. ([Journal of Drugs in Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/24509969/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans. ([Arzneimittel-Forschung, 2000](https://pubmed.ncbi.nlm.nih.gov/10965426/))
- Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two. ([Auris, Nasus, Larynx, 2020](https://pubmed.ncbi.nlm.nih.gov/32067777/))

## What reviewers say

This toner is highly praised for its ability to deeply hydrate and strengthen the skin barrier, making it suitable for sensitive and dry skin types. Most users find it soothing and plumping. A small number of users with sensitivities to fermented ingredients experienced breakouts or found it to be less effective than expected.

- Liked: Deeply hydrating (mostly mentioned)
- Liked: Excellent texture (often mentioned)
- Liked: Soothing and calming (often mentioned)
- Liked: Barrier support (sometimes noted)
- Liked: Great value (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: No results (rarely noted)
- Disliked: Texture too light (rarely noted)
- Disliked: Witch hazel concerns (rarely noted)

## How to apply

- Could be used as part of your AM or PM routine. Start using it 3 times a week and move to daily use if your skin feels fine.
- Apply your hydrating toner after cleansing and before putting on your moisturizer or SPF.
- Gently press 2-3 drops of the hydrating toner into your skin with your hands. Let it ⏱absorb for a minute before adding your next product.
- Applying the hydrating toner on slightly damp skin helps your face absorb it better. This keeps your oily skin balanced and hydrated.
- Be sure to avoid the eye area when applying. Do a patch test before your first use to check for any reaction.
- Video: https://storage.pora.ai/25abe7eb181ba53153fd15de2058c2a9.mp4

## Questions and answers

### What makes ma:nyo Bifida Biome Ampoule Toner one of the best fits for oily acne-prone skin?

This toner is one of the best fits for your oily acne-prone skin because it balances oil, calms breakouts, and strengthens your skin barrier without causing irritation. Fermented ingredients and panthenol help deliver lightweight moisture while keeping your skin calm and comfortable.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/)

### Which ingredients make this toner a good fit for oily acne-prone skin?

This toner is a great fit because Lactobacillus Lysate Ferment and Bifida Ferment Filtrate help control excess oil and calm breakouts. It also includes allantoin and panthenol to soothe your skin without causing irritation.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/)

### What does Bifida Ferment Lysate do for oily acne-prone skin?

Bifida Ferment Lysate helps calm oily acne-prone skin by strengthening your skin barrier and lowering irritation. It is unlikely to clog pores and may help keep your skin feeling smooth and balanced.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/), [Experimental Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/19624730/)

### What does Hyaluronic Acid do for oily acne-prone skin?

Hyaluronic acid helps calm oily acne-prone skin by reducing sebum production and lipid synthesis in sebaceous glands. It also supports skin barrier function and improves hydration while helping deliver treatments without causing irritation.
Sources: [The Journal of Investigative Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28163068/), [Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35796638/)

### Where does this toner go in a skincare routine for oily acne-prone skin?

This hydrating toner fits in the morning routine right after cleansing and before your moisturizer, and can also be used after a cleansing mask in your weekly routine. It helps balance oil and calm blemishes while keeping your skin hydrated without any irritation.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/)

### Can I use this toner with retinol, and in what order?

You can use this toner with your retinol, applying the toner first to hydrate your skin and help calm any dryness or irritation. The formula is very safe and unlikely to cause issues, as it includes soothing ingredients that support your skin barrier during active treatments.
Sources: [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37276158/), [The Journal of Dermatological Treatment, 2016](https://pubmed.ncbi.nlm.nih.gov/26293170/)

### How often should I use this toner?

You can use this hydrating toner daily in your morning routine after cleansing and before moisturizing. It helps manage oil and calm breakouts while keeping your skin comfortable, with little likelihood of irritation.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/)

### Can this toner clog pores, cause breakouts or purging for oily acne-prone skin?

This toner is unlikely to clog pores or cause breakouts because it has an excellent safety profile and uses soothing ingredients like allantoin and panthenol that calm the skin. Only a few reviewers mentioned breakouts, and the fermented ingredients help balance oil and reduce redness without heavy oils.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/)

### Is this toner fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily acne-prone skin

- [Nature Republic Aloe Vera 90% Toner](https://lovi.care/skincare/sg/p/nature-republic/soothing-and-moisture-aloe-vera-90-toner/for/oily-acne-prone-skin) — High fit — S$32.26 at Amazon
- [COSRX Propolis Synergy Toner](https://lovi.care/skincare/sg/p/cosrx/full-fit-propolis-synergy-toner/for/oily-acne-prone-skin) — High fit — S$41.07 at Amazon
- [Etude House Soon Jung pH 5.5 Relief Toner](https://lovi.care/skincare/sg/p/etude-house/soon-jung-ph-5-5-relief-toner/for/oily-acne-prone-skin) — High fit — S$35.86 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/sg/p/cerave/foaming-facial-cleanser/for/oily-acne-prone-skin) — Superior fit — S$30.40 at Amazon
- SPF: [make p:rem UV Defense Me Blue Ray Sun Cream](https://lovi.care/skincare/sg/p/make-p-rem/uv-defense-me-blue-ray-sun-cream/for/oily-acne-prone-skin) — Superior fit — S$41.48 at Amazon
- Pre-Cleanser: [MISSHA Ultra Hyalon Cleansing Cream](https://lovi.care/skincare/sg/p/missha/ultra-hyalon-cleansing-cream/for/oily-acne-prone-skin) — Superior fit — S$39.68 at Amazon

## Where to buy

- Amazon.sg: S$36.16 (https://www.amazon.sg/dp/B08DTVXXXQ?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- YesStyle: S$22.42 (https://www.yesstyle.com/en/ma-nyo-bifida-biome-ampoule-toner-210ml-210ml/info.html/pid.1135224439?curr=SGD&rco=SG)
Prices checked 17 Oct – 6 Nov 2026.

## Ingredients

Water, Butylene Glycol, Glycerin, Propanediol, Pentylene Glycol, Witch Hazel Water, Lactobacillus Lysate Ferment, Lactococcus Lysate Ferment, Lactobacillus Pumpkin Extract Ferment, Saccharomyces Ferment Filtrate, Betaine, Allantoin, Panthenol, Ceramide Np, Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid, Hydrolyzed Glycosaminoglycans, Sodium Hyaluronate Crosspolymer, Hydrogenated Lecithin, Bifida Ferment Filtrate, Bifida Lysate Ferment, Xylitol, Anhydroxylitol, Xylitylglucoside, Glucose, 1,2-Hexanediol, Willow Bark Extract, Lactobionic Acid, Saccharum Officinarum Extract, Cutibacterium Granulosum Extract Ferment Filtrate, Fructose, Fructooligosaccharides, Caprylic Capric Triglyceride, Benzyl Glycol, Tocopherol, Ethylhexylglycerin, Xanthan Gum, Disodium Edta, Chondrus Crispus Extract, Chlorella Vulgaris Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/ma-nyo/bifida-biome-ampoule-toner/for/oily-acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/ma-nyo/bifida-biome-ampoule-toner/for/oily-acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/ma-nyo/bifida-biome-ampoule-toner/for/oily-acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/ma-nyo/bifida-biome-ampoule-toner/for/oily-acne-prone-skin
- France: https://lovi.care/skincare/fr/p/ma-nyo/bifida-biome-ampoule-toner/for/oily-acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/ma-nyo/bifida-biome-ampoule-toner/for/oily-acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/ma-nyo/bifida-biome-ampoule-toner/for/oily-acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/ma-nyo/bifida-biome-ampoule-toner/for/oily-acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/ma-nyo/bifida-biome-ampoule-toner/for/oily-acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/ma-nyo/bifida-biome-ampoule-toner/for/oily-acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/ma-nyo/bifida-biome-ampoule-toner/for/oily-acne-prone-skin (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/p/ma-nyo/bifida-biome-ampoule-toner/for/oily-acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/ma-nyo/bifida-biome-ampoule-toner/for/oily-acne-prone-skin