# Lancôme Rénergie H.P.N. 300-Peptide Cream for dry sensitive skin

**Lovi Fit: Average fit for dry sensitive skin.**
Dry Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/sg/p/lancome/renergie-h-p-n-300-peptide-cream/for/dry-sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Brand: [Lancôme](https://lovi.care/skincare/sg/brands/lancome)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/sg/best/moisturizers)

This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for dry sensitive skin; other moisturizers fit it better.

## Why this fit

- Offers excellent moisturizing and anti-aging effects for your dry and sensitive skin due to the presence of hydrolyzed hyaluronic acid and adenosine, which hydrate and smooth fine lines. Theobroma grandiflorum seed butter and glycerin further enhance its emollient and humectant properties, making it highly suitable for dry skin.
- While it provides general skincare benefits, the formulation is primarily supportive for your dry or flaky skin, rather than directly targeting severe dryness or flakiness.
- The product has a favorable safety profile with no risks of irritation, as it is free from prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sg/p/lancome/renergie-h-p-n-300-peptide-cream/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/sg/p/lancome/renergie-h-p-n-300-peptide-cream/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/sg/p/lancome/renergie-h-p-n-300-peptide-cream/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/sg/p/lancome/renergie-h-p-n-300-peptide-cream/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/sg/p/lancome/renergie-h-p-n-300-peptide-cream/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/sg/p/lancome/renergie-h-p-n-300-peptide-cream/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/sg/p/lancome/renergie-h-p-n-300-peptide-cream/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/sg/p/lancome/renergie-h-p-n-300-peptide-cream/for/dry-sensitive-skin): Average (this page)
- [Oily acne-prone skin](https://lovi.care/skincare/sg/p/lancome/renergie-h-p-n-300-peptide-cream/for/oily-acne-prone-skin): Average

## Key ingredients

Peptides, Sodium Hyaluronate, Niacinamide, Hydrolyzed Lupine Protein, Adenosine

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Profhilo treatment led to significant improvements in superficial skin hydration and transepidermal water loss over time in Chinese females, while demonstrating good product tolerability. ([Aesthetic Plastic Surgery, 2026](https://pubmed.ncbi.nlm.nih.gov/40921777/))
- Hyaluronic acid extracts are safe and efficacious products for skin repair when used in tissue regeneration alone or in combination with herbal or Western medicine. ([Journal of Pharmacy & Pharmaceutical Sciences, 2015](https://pubmed.ncbi.nlm.nih.gov/25877441/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))

## Why other moisturizers fit dry sensitive skin better

- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Nanoemulsions containing Macadamia integrifolia seed oil successfully enhanced skin hydration and reduced wrinkles in human volunteers, outperforming conventional emulsions in skin hydration enhancement. ([Nanomaterials, 2024](https://pubmed.ncbi.nlm.nih.gov/38668218/))

## What reviewers say

Based on a very large amount of data, this rich cream is highly recommended for mature and dry skin, effectively plumping, firming, and smoothing without greasiness, leading to a radiant complexion. Some users noted sensitivity to the fragrance and found the price to be high.

- Liked: Luxurious non-greasy texture (mostly mentioned)
- Liked: Deep hydration (often mentioned)
- Liked: Visible anti-aging results (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Pleasant fragrance (sometimes noted)
- Liked: Refillable packaging (sometimes noted)
- Disliked: Heavy for oily skin (rarely noted)
- Disliked: Lack of dramatic results (rarely noted)
- Disliked: Skin irritation (rarely noted)
- Disliked: Strong fragrance (rarely noted)

## How to apply

- Could be used as part of your AM or PM routine. Start using this moisturizer 3 times a week and move to daily use if your dry skin tolerates it well.
- Apply this moisturizer after cleansing and toner in the morning, or after your serum in the evening. Always pair it with SPF in the morning.
- Gently press a small amount of the moisturizer into your skin. Avoid rubbing it harshly to protect your sensitive skin.
- Apply the moisturizer on slightly damp skin to help with hydration absorption. This also works well for dry and flaky skin types.
- Do a patch test before your first use. Avoid the eye area to prevent any irritation.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Lancôme Rénergie H.P.N. 300-Peptide Cream work for dry sensitive skin?

Lancome Renergie H.P.N. 300-Peptide Cream works reasonably well for dry sensitive skin, providing general hydration and smoothing fine lines without causing irritation. However, because it is primarily supportive rather than directly targeting severe dryness, a product for this skin needs rich nourishing ingredients, deep moisture retention, and strong skin barrier support to provide optimal hydration.

### Which ingredients make this cream a good fit for dry sensitive skin?

This cream is a good fit for dry sensitive skin because it contains hydrolyzed hyaluronic acid, glycerin, and adenosine, which help hydrate skin and smooth fine lines. To fit this skin type even better, a moisturizing treatment needs highly effective, soothing ingredients that provide deep hydration and nourishment, along with rich skin softeners and moisture-binding agents that support the skin barrier without any risk of irritation.

### What do Peptides do for dry sensitive skin?

Peptides help hydrate dry sensitive skin while smoothing the look of fine lines and keeping the surface calm. They may also improve skin elasticity, though some types need enhanced delivery systems to deeply penetrate the skin barrier.
Sources: [Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/), [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/40565185/)

### What does Hyaluronic Acid do for dry sensitive skin?

Hyaluronic acid is a great fit for dry, sensitive skin because it brings a large boost in hydration, making the skin feel soft and smooth while improving barrier function. It helps calm tightness and dryness, and is unlikely to cause irritation.
Sources: [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/), [Dermatology and Therapy, 2021](https://pubmed.ncbi.nlm.nih.gov/34176098/)

### Where does this cream go in a skincare routine for dry sensitive skin?

This treatment goes in the evening routine, as a step before your moisturizer. While it offers good hydration and smoothing effects, this skin type needs a richer product with heavy butters and oils to truly comfort severe dryness.

### Can I use this cream with retinol, and in what order?

You can use this cream alongside retinol by applying the retinol first and following with this treatment to help keep your dry sensitive skin soft and comfortable. This product has a safe profile without harsh ingredients, and using a hydrating moisturizer with retinol is unlikely to cause irritation while supporting your skin barrier.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this cream?

You can use this moisturizing treatment twice daily to help hydrate dry skin and smooth fine lines. While it provides good moisture, dry and sensitive skin needs products rich in barrier-repairing lipids and soothing agents to fully relieve severe dryness and flakiness.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for dry sensitive skin?

This cream is unlikely to clog pores or cause breakouts for dry sensitive skin, as it has a safe formula free from harsh ingredients that might cause irritation. However, a product for this skin needs rich hydrating and softening ingredients like hyaluronic acid and shea butter to fully comfort very dry areas without heavy oils.

### Can I use this cream around the eyes or on my body?

You can use this cream on the thin skin around your eyes and on your body, but dry sensitive skin needs a product with rich butters and oils that directly treat severe dryness and flakiness.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this cream fragrance-free and alcohol-free?

It contains fragrance (benzyl alcohol, geraniol, limonene, and parfum) and drying alcohol (alcohol denat).

## Alternatives for dry sensitive skin

- [L'Occitane Immortelle Divine Cream](https://lovi.care/skincare/sg/p/l-occitane/immortelle-divine-cream/for/dry-sensitive-skin) — Superior fit — S$103.92 at Amazon
- [Sulwhasoo Ginseng Renewing Cream Ex](https://lovi.care/skincare/sg/p/sulwhasoo/ginseng-renewing-cream-ex/for/dry-sensitive-skin) — High fit — S$73.41 at Amazon
- [LANEIGE Water Bank Moisture Cream](https://lovi.care/skincare/sg/p/laneige/water-bank-moisture-cream/for/dry-sensitive-skin) — High fit — S$38.31 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/sg/p/cerave/hydrating-facial-cleanser/for/dry-sensitive-skin) — Superior fit — S$25.06 at Amazon
- Soothing Toner: [Mario Badescu Facial Spray with Aloe, Chamomile and Lavender](https://lovi.care/skincare/sg/p/mario-badescu/facial-spray-with-aloe-chamomile-and-lavender/for/dry-sensitive-skin) — High fit — S$34.52 at Amazon
- Moisturizer with Sun Protection: [Dr.G Green Mild Up Sun+](https://lovi.care/skincare/sg/p/dr-g/green-mild-up-sun/for/dry-sensitive-skin) — Superior fit — S$59.06 at Amazon

## Where to buy

No store in Singapore has a checked price for this product, so the page shows none.

## Ingredients

Water, Glycerin, Dimethicone, Cetearyl Alcohol, Theobroma Grandiflorum Seed Butter, Alcohol Denat, Cetearyl Isononanoate, Niacinamide, Glyceryl Stearate, Peg-100 Stearate, Isopropyl Palmitate, Octyldodecanol, Cyclodextrin, Hydrolyzed Lupine Protein, Pisum Sativum Extract, Adenosine, Capryloyl Salicylic Acid, Hydrolyzed Hyaluronic Acid, Hydrolyzed Linseed Extract, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Trisodium Ethylenediamine Disuccinate, Tocopheryl Acetate, Alba Cera, Beeswax, Cire Dabeille, Orbignya Oleifera Seed Oil, Jojoba Butter, Cetearyl Glucoside, Citric Acid, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Polysorbate 60, Potassium Cetyl Phosphate, Sorbitan Isostearate, Tocopherol, Dimethicone Polyglycerin-3 Crosspolymer, Benzyl Alcohol, Geraniol, Limonene, Chlorphenesin, Dipropylene Glycol, Phenoxyethanol, Sodium Benzoate, Parfum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/lancome/renergie-h-p-n-300-peptide-cream/for/dry-sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/lancome/renergie-h-p-n-300-peptide-cream/for/dry-sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/lancome/renergie-h-p-n-300-peptide-cream/for/dry-sensitive-skin
- Germany: https://lovi.care/skincare/de/p/lancome/renergie-h-p-n-300-peptide-cream/for/dry-sensitive-skin
- France: https://lovi.care/skincare/fr/p/lancome/renergie-h-p-n-300-peptide-cream/for/dry-sensitive-skin
- Italy: https://lovi.care/skincare/it/p/lancome/renergie-h-p-n-300-peptide-cream/for/dry-sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/lancome/renergie-h-p-n-300-peptide-cream/for/dry-sensitive-skin
- Spain: https://lovi.care/skincare/es/p/lancome/renergie-h-p-n-300-peptide-cream/for/dry-sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/lancome/renergie-h-p-n-300-peptide-cream/for/dry-sensitive-skin
- Australia: https://lovi.care/skincare/au/p/lancome/renergie-h-p-n-300-peptide-cream/for/dry-sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/lancome/renergie-h-p-n-300-peptide-cream/for/dry-sensitive-skin (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/p/lancome/renergie-h-p-n-300-peptide-cream/for/dry-sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/lancome/renergie-h-p-n-300-peptide-cream/for/dry-sensitive-skin