# Isntree TW-Real Bifida Ampoule for combination skin

**Lovi Fit: Average fit for combination skin.**
Combination Skin Fit: Superior · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/sg/p/isntree/tw-real-bifida-ampoule/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Brand: [Isntree](https://lovi.care/skincare/sg/brands/isntree)
Category: [Serums and treatments](https://lovi.care/skincare/sg/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for combination skin; other serums fit it better.

## Why this fit

- Offers moderate hydration and plumping for your combination skin, with Bifida Lysate Ferment and Palmitoyl Oligopeptide supporting skin barrier resilience and a smoother appearance, while niacinamide helps to balance oil production in your oily areas.
- Glycerin and sodium hyaluronate provide essential moisture, supporting overall skin health and a more comfortable feel for your combination skin.
- The product is safe for your combination skin, as it contains no harsh or prohibited ingredients and poses no risk of irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sg/p/isntree/tw-real-bifida-ampoule/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/sg/p/isntree/tw-real-bifida-ampoule/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/sg/p/isntree/tw-real-bifida-ampoule/for/combination-skin): Average (this page)
- [Sensitive skin](https://lovi.care/skincare/sg/p/isntree/tw-real-bifida-ampoule/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/sg/p/isntree/tw-real-bifida-ampoule/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/sg/p/isntree/tw-real-bifida-ampoule/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/sg/p/isntree/tw-real-bifida-ampoule/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/sg/p/isntree/tw-real-bifida-ampoule/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/sg/p/isntree/tw-real-bifida-ampoule/for/oily-acne-prone-skin): High

## Key ingredients

Bifida Lysate Ferment, Niacinamide, Sodium Hyaluronate, Hydrolyzed Collagen, Copper Tripeptide-1

## What the research says

- A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo. ([Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/))
- Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality. ([Archives of Facial Plastic Surgery, 2006](https://pubmed.ncbi.nlm.nih.gov/16847171/))
- A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days. ([Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/39449909/))
- The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls. ([Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/))

## What reviewers say

Based on a very large amount of data, users consistently praise this ampoule for its ability to strengthen the skin barrier and provide deep hydration without heaviness, resulting in a "glass skin" glow and smoother texture. It is highly effective for sensitive and dry skin types seeking anti-aging benefits. A small minority of users with acne-prone or very oily skin experienced minor breakouts or found the finish slightly tacky.

- Liked: Lightweight & fast absorbing (mostly mentioned)
- Liked: Hydrating & plumping (often mentioned)
- Liked: Strengthens skin barrier (often mentioned)
- Liked: Gentle & non-irritating (sometimes noted)
- Disliked: No visible results (sometimes noted)
- Disliked: Caused breakouts/irritation (rarely noted)
- Disliked: Texture/finish issues (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Isntree TW-Real Bifida Ampoule work for combination skin?

This ampoule works moderately well for combination skin by offering balanced moisture, supporting the skin barrier, and helping to manage oil in oily areas. A product of this type needs effective ingredients like niacinamide, propolis, or zinc PCA to provide optimal hydration and control oiliness without causing excess shine or dryness.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this ampoule a good fit for combination skin?

Bifida Lysate Ferment and palmitoyl oligopeptide help support your skin barrier and smoother appearance, while niacinamide helps balance oil in your oily areas. Glycerin and sodium hyaluronate provide essential moisture and a more comfortable feel for your combination skin. To work best for this skin, a treatment of this type needs effective ingredients like niacinamide and propolis or zinc PCA that regulate oiliness and enhance radiance without irritation.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/), [Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/)

### What does Bifida Ferment Lysate do for combination skin?

Bifida Ferment Lysate helps strengthen the skin barrier and calm irritation, making it a good fit for combination skin that is prone to sensitivity. This ingredient works by supporting the skin defenses, keeping moisture locked in, and helping to reduce redness.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/), [Experimental Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/19624730/)

### What does Niacinamide do for combination skin?

Niacinamide helps balance oily areas by reducing excess shine and pore size while keeping dry patches hydrated and smooth. It also works to calm redness and even out skin tone, making it very suitable for combination skin.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Where does this ampoule go in a skincare routine for combination skin?

This treatment goes in your evening routine after your cleansing toner and before your moisturizer. Treatments for this skin work best when they include lightweight hydrators like glycerin and hyaluronic acid alongside barrier-supporting ingredients to balance oily and dry areas.

### Can I use this ampoule with retinol, and in what order?

You can use this ampoule with retinol by applying the ampoule after your retinol step to help keep your skin comfortable. To better fit combination skin, this type of product also needs ingredients that deeply balance oil and provide lasting moisture without heaviness.

### How often should I use this ampoule?

Use this ampoule in your evening routine, applying it after your cleansing toner and before your moisturizer. This product works for your combination skin, though a product of this type for your skin needs extra balancing and hydrating ingredients to better target both dry and oily areas.

### Can this ampoule clog pores, cause breakouts or purging for combination skin?

This ampoule is unlikely to cause breakouts or clog pores on combination skin, as it contains no harsh ingredients and has a safe profile with only a low risk of complaints. Glycerin and sodium hyaluronate help keep your skin comfortable and hydrated without heavy oils.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this ampoule fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for combination skin

- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/sg/p/skin1004/probio-cica-intensive-ampoule/for/combination-skin) — High fit — S$28.55 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vitamin-c-serum/for/combination-skin) — High fit — S$50.41 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vita-c-serum/for/combination-skin) — High fit — S$50.41 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/sg/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — S$30.00 at Amazon
- Hydrating Toner: [Whamisa Organic Flowers Toner Deep Rich](https://lovi.care/skincare/sg/p/whamisa/organic-flowers-toner-deep-rich/for/combination-skin) — Superior fit — S$64.81 at Amazon
- SPF: [CeraVe AM Facial Moisturizing Lotion](https://lovi.care/skincare/sg/p/cerave/am-facial-moisturizing-lotion-spf-30/for/combination-skin) — Superior fit — S$28.72 at Amazon

## Where to buy

- Amazon.sg: S$28.38 (https://www.amazon.sg/dp/B082TWZNYB?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- YesStyle: S$16.57 (https://www.yesstyle.com/en/isntree-tw-real-bifida-ampoule/info.html/pid.1112818258?curr=SGD&rco=SG)
Prices checked 17 Oct – 5 Nov 2026.

## Ingredients

Bifida Lysate Ferment, Dipropylene Glycol, Niacinamide, Glycerin, Lactobacillus Pumpkin Extract Ferment, Lactobacillus Soybean Extract Ferment, Rice Ferment Filtrate Sake Ferment Filtrate, Sodium Hyaluronate, Hydrolyzed Collagen, Willow Bark Extract, Origanum Vulgare Leaf Extract, Cinnamomum Cassia Bark Extract, Portulaca Oleracea Extract, Chamaecyparis Obtusa Leaf Extract, Beta-Glucan, Palmitoyl Oligopeptide, Copper Tripeptide-1, Acetyl Hexapeptide-8, Allantoin, Hydroxyethylcellulose, Panthenol, Carbomer, Arginine, Butylene Glycol, Scutellaria Baicalensis Root Extract, Illicium Verum Fruit Extract Anise Fruit Extract, Adenosine, 1,2-Hexanediol, Disodium Edta
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/isntree/tw-real-bifida-ampoule/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/isntree/tw-real-bifida-ampoule/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/isntree/tw-real-bifida-ampoule/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/isntree/tw-real-bifida-ampoule/for/combination-skin
- France: https://lovi.care/skincare/fr/p/isntree/tw-real-bifida-ampoule/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/isntree/tw-real-bifida-ampoule/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/isntree/tw-real-bifida-ampoule/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/isntree/tw-real-bifida-ampoule/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/isntree/tw-real-bifida-ampoule/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/isntree/tw-real-bifida-ampoule/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/isntree/tw-real-bifida-ampoule/for/combination-skin (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/p/isntree/tw-real-bifida-ampoule/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/isntree/tw-real-bifida-ampoule/for/combination-skin