# iS Clinical Hydra-Cool Serum for combination skin

**Lovi Fit: Average fit for combination skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/sg/p/is-clinical/hydra-cool-serum/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Brand: [iS Clinical](https://lovi.care/skincare/sg/brands/is-clinical)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/sg/best/moisturizers)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for combination skin; other moisturizers fit it better.

## Why this fit

- Offers moderate hydration for your combination skin, as sodium hyaluronate and pantothenic acid provide humectant action and support barrier repair, though it does not directly address oily shine.
- Asiaticoside and menthol offer soothing benefits, which are generally beneficial for combination skin.
- The product is safe for your skin, with no risks of irritation due to the absence of harsh ingredients and the presence of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sg/p/is-clinical/hydra-cool-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/sg/p/is-clinical/hydra-cool-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/sg/p/is-clinical/hydra-cool-serum/for/combination-skin): Average (this page)
- [Sensitive skin](https://lovi.care/skincare/sg/p/is-clinical/hydra-cool-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/sg/p/is-clinical/hydra-cool-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/sg/p/is-clinical/hydra-cool-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/sg/p/is-clinical/hydra-cool-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/sg/p/is-clinical/hydra-cool-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/sg/p/is-clinical/hydra-cool-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Sodium Hyaluronate, Asiaticoside, Madecassic Acid, Menthol, Pantothenic Acid

## What the research says

- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- Cooling skin temperature or applying topical menthol reduced histamine-induced itch intensity and flare diameters in healthy male volunteers. ([Neuroscience Letters, 1995](https://pubmed.ncbi.nlm.nih.gov/7624016/))
- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- The novel high-payload nanosuspension system of Centella asiatica extract increased skin accumulation of asiatic acid, madecassic acid, and asiaticoside by 5-, 4-, and 4.5-fold respectively compared to a marketed cream in porcine skin, with no local skin irritation in normal rats. ([International Journal of Nanomedicine, 2021](https://pubmed.ncbi.nlm.nih.gov/34764648/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Coadministration of 40% topical L-menthol with 10% trans-cinnamaldehyde reduced spontaneous pain intensity, neurogenic inflammation, primary and secondary mechanical hyperalgesia, and heat hyperalgesia, but not cold hyperalgesia, in 14 healthy volunteers. ([The Journal of Pain, 2016](https://pubmed.ncbi.nlm.nih.gov/27260636/))
- Topical application of menthol-based cooling gel decreased intramuscular temperature by 1.9 °C and increased cutaneous blood flow by 0.3 ml/min in healthy males compared to placebo gel. ([International Journal of Sports Physical Therapy, 2018](https://pubmed.ncbi.nlm.nih.gov/30038834/))
- Topical L-menthol and trans-cinnamaldehyde administered individually and in combination on the volar forearm of healthy volunteers induced distinct somatosensory and vasomotor effects, where L-menthol reduced the axon-reflex-flare and altered the mechanical hyperalgesia caused by trans-cinnamaldehyde. ([European Journal of Pain, 2014](https://pubmed.ncbi.nlm.nih.gov/24664788/))
- Panthenyl triacetate (PTA) demonstrated skin de-acetylation into panthenol, stimulated energetic and synthesis metabolic pathways, and achieved a statistically significant improvement in wound healing after 72 hours compared to saline treatment in human volunteers, outperforming panthenol in long-lasting wound healing action. ([Journal of Cosmetic Science, 2012](https://pubmed.ncbi.nlm.nih.gov/22487447/))
- A comprehensive topical regimen incorporating niacinamide, Pro-Xylane, and panthenol following PicoWay laser treatment decreased transepidermal water loss, increased hydration and skin elasticity, reduced wrinkles and redness, and improved skin tone in 88 Chinese females compared to a standard care control group. ([Lasers in Medical Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42686896/))
- Formulations containing 1.0% and 5.0% panthenol decreased transepidermal water loss after 30-day applications on healthy subjects compared to control and vehicle. ([Journal of Cosmetic Science, 2011](https://pubmed.ncbi.nlm.nih.gov/21982351/))

## Why other moisturizers fit combination skin better

- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))
- A peel-off facial mask containing myoinositol and trehalose-loaded liposomes improved adult female acne by decreasing lesion counts, sebum production, GAGS scores, and local androgen levels while increasing beclin-1 levels. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28342238/))
- Gluconolactone chemical peels lower skin pH and transepidermal water loss while demonstrating seboregulatory properties in 16 female subjects. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37335807/))

## What reviewers say

This serum is widely praised as a "drink of water" for the skin, excelling at soothing irritation, redness, and sunburns while providing lightweight hydration. It is particularly favored by users with acne-prone and sensitive skin for its ability to calm inflammation without clogging pores, though some find it insufficient for extremely dry skin types.

- Liked: Soothing & Cooling (mostly mentioned)
- Liked: Lightweight Hydration (often mentioned)
- Disliked: High price (often mentioned)
- Liked: Acne-Safe (sometimes noted)
- Liked: Versatile Use (sometimes noted)
- Disliked: Insufficient moisture (rarely noted)
- Disliked: Menthol sensitivity (rarely noted)
- Disliked: Texture issues (rarely noted)

## How to apply

- Use this moisturizer in your AM and PM routine every day to control shine. Always pair with SPF in the morning.
- Apply this moisturizer after your cleanser and toner, right before your morning SPF.
- Gently press a small amount of the moisturizer into your skin and avoid harsh rubbing. Let it ⏳absorb for a minute.
- Apply the moisturizer on slightly damp skin to help it lock in moisture better. This keeps your combination skin balanced.
- Avoid the eye area when applying the moisturizer. Do a patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does iS Clinical Hydra-Cool Serum work for combination skin?

This serum works moderately well for your combination skin by giving it comfortable moisture and a soothing feel, though it does not directly help with oily shine. To work best for this skin type, a moisturizing treatment needs ingredients that balance hydration and control oil without causing irritation.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Which ingredients make this serum a good fit for combination skin?

Sodium hyaluronate and pantothenic acid make this serum a good fit by providing moderate hydration and supporting barrier repair, while asiaticoside and menthol offer soothing benefits. To work even better for combination skin, a product of this type needs additional ingredients that help control oily shine, such as niacinamide, peptides, ceramides, and hyaluronic acid.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/)

### What does Hyaluronic Acid do for combination skin?

Hyaluronic acid is a great fit for combination skin because it quenches dry areas with a boost of hydration while keeping oily zones balanced. Regular use helps smooth out fine lines and makes your skin feel soft and plump without causing irritation.
Sources: [Dermatology and Therapy, 2021](https://pubmed.ncbi.nlm.nih.gov/34176098/), [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/)

### What does Asiaticoside do for combination skin?

Asiaticoside helps keep combination skin calm and balanced while supporting moisture levels without feeling heavy. This ingredient is unlikely to cause irritation and may improve skin barrier function, which is especially helpful for areas that need extra repair.
Sources: [International Journal of Nanomedicine, 2021](https://pubmed.ncbi.nlm.nih.gov/34764648/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Where does this serum go in a skincare routine for combination skin?

This treatment goes in the evening routine after your cleansing toner and before your moisturizer, for simplicity and extra safety around sun exposure. A product of this type for combination skin needs ingredients that provide moderate hydration while also addressing oily shine and supporting barrier repair.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to help hydrate and calm your skin before the retinol. This type of combination for combination skin needs soothing ingredients and lightweight moisture that supports the skin barrier without adding heavy oils or greasy shine.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### How often should I use this serum?

You can use this serum in your evening routine, as treatments fit best there for simplicity and extra safety around sun exposure. If your skin tolerates it well, you may also use it in the morning or twice a day.

### Can this serum clog pores, cause breakouts or purging for combination skin?

This serum is unlikely to clog pores or cause breakouts on combination skin, as it has a safe formula without harsh ingredients. However, because it only gives moderate moisture and does not control oily shine, combination skin generally needs oil-free hydrators with balancing ingredients like niacinamide or lightweight plant extracts.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/)

### Can I use this serum around the eyes or on my body?

You can use this serum around the eyes and on the body because it has a very safe formula, though the skin around the eyes is much thinner than most body areas and needs gentle hydration. A product of this type needs ingredients like sodium hyaluronate and pantothenic acid to keep combination skin moist and balanced without causing irritation.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for combination skin

- [MEDI-PEEL Peptide 9 Volume White Cica All-in-one Essence](https://lovi.care/skincare/sg/p/medi-peel/peptide-9-volume-white-cica-all-in-one-essence/for/combination-skin) — High fit — S$41.73 at Amazon
- [COSRX Hydrium Triple Hyaluronic Moisture Ampoule](https://lovi.care/skincare/sg/p/cosrx/hydrium-triple-hyaluronic-moisture-ampoule/for/combination-skin) — High fit — S$21.96 at YesStyle
- [MISSHA Super Aqua Ultra Hyalron Ampoule](https://lovi.care/skincare/sg/p/missha/super-aqua-ultra-hyalron-ampoule/for/combination-skin) — Average fit — S$23.12 at YesStyle

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/sg/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — S$30.00 at Amazon
- Hydrating Toner: [Whamisa Organic Flowers Toner Deep Rich](https://lovi.care/skincare/sg/p/whamisa/organic-flowers-toner-deep-rich/for/combination-skin) — Superior fit — S$64.81 at Amazon
- SPF: [CeraVe AM Facial Moisturizing Lotion](https://lovi.care/skincare/sg/p/cerave/am-facial-moisturizing-lotion-spf-30/for/combination-skin) — Superior fit — S$28.72 at Amazon

## Where to buy

- Amazon.sg: S$98.30 (https://www.amazon.sg/dp/B002756HAI?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Sodium Hyaluronate, Pantothenic Acid, Pentylene Glycol, Menthol, Phenoxyethanol, Asiaticoside, Polyporus Umbellatus Extract Mushroom Extract, Asiatic Acid, Madecassic Acid, Blue 1 Ci 42090
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/is-clinical/hydra-cool-serum/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/is-clinical/hydra-cool-serum/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/is-clinical/hydra-cool-serum/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/is-clinical/hydra-cool-serum/for/combination-skin
- France: https://lovi.care/skincare/fr/p/is-clinical/hydra-cool-serum/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/is-clinical/hydra-cool-serum/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/is-clinical/hydra-cool-serum/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/is-clinical/hydra-cool-serum/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/is-clinical/hydra-cool-serum/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/is-clinical/hydra-cool-serum/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/is-clinical/hydra-cool-serum/for/combination-skin (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/p/is-clinical/hydra-cool-serum/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/is-clinical/hydra-cool-serum/for/combination-skin