# iS Clinical Active Serum for dry skin

**Lovi Fit: Low fit for dry skin.**
Dry Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/sg/p/is-clinical/active-serum/for/dry-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Brand: [iS Clinical](https://lovi.care/skincare/sg/brands/is-clinical)
Category: [Serums and treatments](https://lovi.care/skincare/sg/best/serums)

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A weak match for dry skin; the serums alongside fit it better.

## Why this fit

- Offers moderate exfoliation for your dry skin due to willow bark extract and saccharum officinarum extract, which help decongest pores, but lacks sufficient emollient ingredients for optimal hydration.
- Glycerin and butylene glycol provide some hydration, which is beneficial for dry or flaky skin, but the overall formulation does not fully address your primary concerns.
- The product is safe for your dry skin as it contains no harsh or prohibited ingredients that would cause irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sg/p/is-clinical/active-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/sg/p/is-clinical/active-serum/for/dry-skin): Low (this page)
- [Combination skin](https://lovi.care/skincare/sg/p/is-clinical/active-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/sg/p/is-clinical/active-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/sg/p/is-clinical/active-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/sg/p/is-clinical/active-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/sg/p/is-clinical/active-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/sg/p/is-clinical/active-serum/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/sg/p/is-clinical/active-serum/for/oily-acne-prone-skin): High

## Key ingredients

Saccharum Officinarum Extract, Vaccinium Myrtillus Extract, Arbutin, Willow Bark Extract, Polyporus Umbellatus Extract Mushroom Extract

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Polyvinyl pyrrolidone-K90/Eudragit RL100 dissolving microneedle patches loaded with alpha-arbutin and resveratrol enhanced intradermal delivery by approximately 2.6 times compared to cream and slightly decreased the melanin index in human participants without causing skin irritation. ([Biomaterials Science, 2023](https://pubmed.ncbi.nlm.nih.gov/37183632/))
- A botanical face cleanser with hops and willow bark extract continuously reduced skin sebum levels without reactive seborrhea after treatment in 21 healthy volunteers compared to a sodium laureth sulfate cleanser, with neither cleanser causing skin irritation. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30022595/))
- Repeated short-contact 70% glycolic acid peels provided superior results in atrophic acne scars compared to daily low-strength glycolic acid cream or placebo in 58 women over 24 weeks. ([International Journal of Dermatology, 2000](https://pubmed.ncbi.nlm.nih.gov/11095203/))
- Fermented bilberry extract improved wrinkle depth, skin smoothness, roughness, firmness, elasticity, antioxidant capacity, and complexion evenness compared to a placebo in 66 subjects over 84 days. ([Nutrients, 2024](https://pubmed.ncbi.nlm.nih.gov/39064646/))
- Topical application of oil-in-water creams containing wild bilberry leaves extract and seeds oil produced significant beneficial effects on the skin of healthy human volunteers. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/33809607/))
- Bilberry fruit extract incorporated into chitosan-based hydrogels demonstrated antioxidant, anti-hyaluronidase, and anti-tyrosinase activities, supporting their potential use in topical anti-aging preparations. ([Antioxidants, 2024](https://pubmed.ncbi.nlm.nih.gov/38247529/))
- A non-hydroquinone topical formulation (SKNB19) improved hyperpigmentation by 28.5% in patient self-assessment and 27% in independent reviewer assessment compared with 4% hydroquinone in 18 adult subjects, while showing significantly less irritation and better tolerability. ([Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/33022197/))
- Encapsulation of alpha arbutin in an optimized ethosomal gel significantly improved skin melanin reduction, moisture content, and elasticity in human volunteers compared to conventional formulations. ([Heliyon, 2023](https://pubmed.ncbi.nlm.nih.gov/37681127/))
- Combining a home-based radiofrequency device and arbutin cream reduced mMASI scores by 25.6% and melanin index by 22.8% at 8 weeks compared to baseline in 38 participants. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/39918262/))
- Bioactive lipid nanocarriers co-loaded with willow bark or ivy leaf extracts and UV-filters provided pronounced UVA photoprotection up to an SPF-equivalent value of 13 and a maximum in vivo skin hydration effect of 97% when prepared with pomegranate oil. ([Nanomaterials, 2022](https://pubmed.ncbi.nlm.nih.gov/35889587/))
- A topical serum containing 0.5% salicin applied twice daily reduced visible signs of skin aging, including wrinkles and tactile roughness, in 30 female subjects over 12 weeks compared to baseline. ([Journal of Cosmetic Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20883292/))
- A novel emulsion containing niacinamide, lens esculenta seed extract, and white willow bark extract effectively improved acne, blackheads, and conspicuous facial pores in 30 subjects with oily skin. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38140770/))
- White button mushroom extract treatment increased VEGF densities, EGF, PCNA, and collagen fibers, while decreasing apoptotic cells and limiting TGF-beta and CD4 reactions in ICR mice and chorioallantoic culture, indicating beneficial effects on skin regeneration and injury. ([Microscopy Research and Technique, 2012](https://pubmed.ncbi.nlm.nih.gov/22581761/))

## Why other serums fit dry skin better

- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Treatment with 14% ferulic acid and 12% l-ascorbic acid significantly reduced pigmentation and erythema while improving hydration and elasticity in 20 women with photoaged skin, with neither acid proving definitively more effective overall though ascorbic acid showed slightly greater skin lightening. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/34877760/))

## What reviewers say

Users consistently praise this serum as a "holy grail" multitasker that effectively targets adult acne while simultaneously smoothing fine lines and uneven texture. While the potent "tingling" sensation confirms its activity for most, the high price point and potential for dryness are common considerations for new users.

- Liked: Clears Acne & Breakouts (mostly mentioned)
- Liked: Improves Texture & Tone (often mentioned)
- Disliked: High Price Point (often mentioned)
- Liked: Anti-Aging Benefits (sometimes noted)
- Liked: Fast Visible Results (sometimes noted)
- Disliked: Intense Tingling Sensation (sometimes noted)
- Disliked: Drying for Some (rarely noted)
- Disliked: Risk of Counterfeits (rarely noted)

## How to apply

- Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
- Place the serum after cleansing and toner, but right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on slightly damp skin to help lock in extra moisture.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### Why is iS Clinical Active Serum a weak match for dry skin?

iS Clinical Active Serum is a weak match for your dry skin because it offers only moderate exfoliation and lacks sufficient softening ingredients for optimal hydration. A treatment for dry skin needs rich, soothing ingredients that provide deep hydration and support the skin barrier, such as ceramides, peptides, and niacinamide.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a poor fit for dry skin?

This serum is a weak match for your dry skin because it lacks sufficient soft, moisturizing ingredients to provide optimal hydration and fully address your skin needs. A treatment for dry skin needs rich, soothing ingredients that provide deep hydration and support the skin barrier, such as ceramides, niacinamide, peptides, or vitamin C.

### What does Sugarcane Extract do for dry skin?

Sugarcane Extract helps smooth dry skin by gently sweeping away dead flakes so moisturizers can sink in better. It is unlikely to irritate when used in moderation, making skin feel soft and refreshed.

### What does Bilberry Fruit Extract do for dry skin?

Bilberry fruit extract helps hydrate dry skin while improving its smoothness and overall texture. It also provides antioxidant protection that supports a healthy complexion and keeps skin feeling soft.
Sources: [Nutrients, 2024](https://pubmed.ncbi.nlm.nih.gov/39064646/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/33809607/)

### Where does this serum go in a skincare routine for dry skin?

This treatment goes in the evening routine after cleansing and before moisturizing, starting once a week so your skin can adjust. A product for this skin needs rich softening ingredients that add deep hydration to properly soothe and comfort dry areas.

### Can I use this serum with retinol, and in what order?

This serum may be used in your routine, but dry skin needs a product that includes plenty of rich hydrating and softening ingredients to keep your skin smooth and comfortable.

### How often should I use this serum?

You can use this treatment once a week in the evening, as dry skin needs extra rich, softening ingredients and soothing hydrators like ceramides and plant oils to stay comfortable.

### Can this serum clog pores, cause breakouts or purging for dry skin?

This serum is unlikely to clog pores or cause breakouts on dry skin, as it contains ingredients that help clear out pores without harsh or irritating substances. However, because it lacks enough rich moisturizing ingredients, a treatment of this type needs added heavy hydrating creams and nourishing oils to keep dry skin comfortable and soft.

### Is this serum fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (alcohol denat).

## Alternatives for dry skin

- [ma:nyo Bifida Biome Complex Ampoule](https://lovi.care/skincare/sg/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-skin) — Superior fit — S$40.09 at Amazon
- [SKIN1004 Madagascar Centella Tone Brightening Capsule Ampoule](https://lovi.care/skincare/sg/p/skin1004/madagascar-centella-tone-brightening-capsule-ampoule/for/dry-skin) — Superior fit — S$54.11 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vitamin-c-serum/for/dry-skin) — Superior fit — S$50.41 at Amazon

## Routine for dry skin

### AM

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/sg/p/cerave/hydrating-facial-cleanser/for/dry-skin) — Superior fit — S$25.06 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/sg/p/cosrx/propolis-synergy-toner/for/dry-skin) — Superior fit — S$41.07 at Amazon
- Moisturizer: [d'Alba First Spray Serum](https://lovi.care/skincare/sg/p/d-alba/first-spray-serum/for/dry-skin) — Superior fit — S$25.94 at Amazon
- SPF: [Thinkbaby Safe Sunscreen SPF 50+](https://lovi.care/skincare/sg/p/thinkbaby/safe-sunscreen-spf-50/for/dry-skin) — Superior fit — S$21.09 at Amazon

### PM

- Pre-Cleanser: [MISSHA Ultra Hyalon Cleansing Cream](https://lovi.care/skincare/sg/p/missha/ultra-hyalon-cleansing-cream/for/dry-skin) — Superior fit — S$39.68 at Amazon
- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/sg/p/cerave/hydrating-facial-cleanser/for/dry-skin) — Superior fit — S$25.06 at Amazon
- Serum or Treatment: [Peach & Lily Glass Skin Refining Serum](https://lovi.care/skincare/sg/p/peach-and-lily/glass-skin-refining-serum/for/dry-skin) — Superior fit — S$63.44 at Amazon
- Moisturizer: [d'Alba First Spray Serum](https://lovi.care/skincare/sg/p/d-alba/first-spray-serum/for/dry-skin) — Superior fit — S$25.94 at Amazon

### Weekly

- Pre-Cleanser: [MISSHA Ultra Hyalon Cleansing Cream](https://lovi.care/skincare/sg/p/missha/ultra-hyalon-cleansing-cream/for/dry-skin) — Superior fit — S$39.68 at Amazon
- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/sg/p/cerave/hydrating-facial-cleanser/for/dry-skin) — Superior fit — S$25.06 at Amazon
- Nourishing Mask: [Mediheal Collagen Essential Mask](https://lovi.care/skincare/sg/p/mediheal/collagen-essential-mask/for/dry-skin) — Superior fit — S$62.94 at Amazon
- Serum or Treatment: [Peach & Lily Glass Skin Refining Serum](https://lovi.care/skincare/sg/p/peach-and-lily/glass-skin-refining-serum/for/dry-skin) — Superior fit — S$63.44 at Amazon
- Moisturizer: [d'Alba First Spray Serum](https://lovi.care/skincare/sg/p/d-alba/first-spray-serum/for/dry-skin) — Superior fit — S$25.94 at Amazon

## Where to buy

- Amazon.sg: S$151.69 (https://www.amazon.sg/dp/B007PFIOUQ?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Glycerin, Butylene Glycol, Alcohol Denat, Saccharum Officinarum Extract, Vaccinium Myrtillus Leaf Extract Fruit, Triethanolamine, Willow Bark Extract, Glyceryl Polyacrylate, Arbutin, Polyporus Umbellatus Extract Mushroom Extract, Menthol, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/is-clinical/active-serum/for/dry-skin
- United Kingdom: https://lovi.care/skincare/uk/p/is-clinical/active-serum/for/dry-skin
- Ireland: https://lovi.care/skincare/ie/p/is-clinical/active-serum/for/dry-skin
- Germany: https://lovi.care/skincare/de/p/is-clinical/active-serum/for/dry-skin
- France: https://lovi.care/skincare/fr/p/is-clinical/active-serum/for/dry-skin
- Italy: https://lovi.care/skincare/it/p/is-clinical/active-serum/for/dry-skin
- Netherlands: https://lovi.care/skincare/nl/p/is-clinical/active-serum/for/dry-skin
- Spain: https://lovi.care/skincare/es/p/is-clinical/active-serum/for/dry-skin
- Canada: https://lovi.care/skincare/ca/p/is-clinical/active-serum/for/dry-skin
- Australia: https://lovi.care/skincare/au/p/is-clinical/active-serum/for/dry-skin
- Singapore: https://lovi.care/skincare/sg/p/is-clinical/active-serum/for/dry-skin (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/p/is-clinical/active-serum/for/dry-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/is-clinical/active-serum/for/dry-skin