IPSA Time Reset Aqua for sensitive skin

How to apply

Questions and answers

What the research says

• Dipotassium glycyrrhizinate-loaded hydroxypropyl chitosan and poly(N-isopropylacrylamide) hydrogels applied to wounds in a mouse full-thickness skin defect model resulted in rapid wound closure, efficient tissue remolding, collagen deposition, and decreased inflammation compared to commercial Tegaderm film and 3M dressing controls.

  Acta Biomaterialia, 2022

• A topical formulation containing panthenol, niacinamide, and dipotassium glycyrrhizate increased skin hydration by 74.1% and reduced transepidermal water loss by 13.5% at 28 days compared to baseline and untreated control in 35 individuals with xerosis.

  Journal of Cosmetic Dermatology, 2026

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Combining 755 nm alexandrite laser with topical licorice gel significantly reduces terminal hair counts compared to alexandrite laser with placebo in women with idiopathic hirsutism.

  Evidence-based Complementary and Alternative Medicine, 2015

• Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo.

  Experimental Dermatology, 2015

• Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide.

  Advanced Science, 2025

• Partially purified paeoniflorin protected human keratinocytes and mouse skin from UV-induced DNA damage and reduced facial wrinkles in human volunteers.

  Journal of Cosmetic Science, 2006

• Paeonia suffruticosa callus extract downregulated inflammatory factors, alleviated DNA damage, and increased total collagen content in in vitro and in vivo evaluations.

  International Journal of Cosmetic Science, 2025

• Topical application of Paeonia lactiflora root extract and paeoniflorin significantly decreases melanin content by 23% to 30% in reconstructed pigmented human epidermis compared to vehicle control.

  International Journal of Cosmetic Science, 2016

Ingredients

Tranexamic Acid, Dipotassium Glycyrrhizate, Sodium Acetylated Hyaluronate, Potassium Ascorbyl Tocopheryl Phosphate, Paeonia Albiflora Root Extract, Water, Dipropylene Glycol, Concentrated Glycerin, Peg Ppg-14 7 Dimethyl Ether, Peg Ppg-17 4 Dimethyl Ether, Sorbitol, Edetate Disodium, Citric Acid, Ppg-13-Decyltetradeceth-24, Methacryloyloxyethyl Phosphorylcholine, Polymer Butyl Methacrylate Copolymer, 1,3 Butylene Glycol, Trisodium Citrate, Sodium Metabisulfite, Rosa Canina Fruit Extract, Origanum Majorana Leaf Extract, Rubus Suavissimus Leaf Extract Raspberry Leaf Extract, Phenoxyethanol

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.